Klf2 (Kruppel-like factor 2 (lung)) - Rat Genome Database
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Gene: Klf2 (Kruppel-like factor 2 (lung)) Mus musculus
Analyze
Symbol: Klf2
Name: Kruppel-like factor 2 (lung)
RGD ID: 1552542
MGI Page MGI
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including erythrocyte maturation; regulation of gene expression; and type I pneumocyte differentiation. Localizes to nucleus. Is expressed in several structures, including early conceptus; heart; sensory organ; skeleton; and tooth. Orthologous to human KLF2 (Kruppel like factor 2); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Krueppel-like factor 2; Lk; Lklf; lung krueppel-like factor
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18477  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,072,906 - 73,075,498 (+)NCBIGRCm39mm39
GRCm38872,319,062 - 72,321,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,319,033 - 72,321,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,842,961 - 74,845,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,248,022 - 75,250,338 (+)NCBImm8
Celera876,656,424 - 76,659,017 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
baicalein  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethyl 3,4-dihydroxybenzoate  (EXP)
ferric oxide  (EXP)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
Genipin  (EXP)
glycidol  (ISO)
hexanal  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
lipopolysaccharide  (EXP)
maneb  (EXP)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
neomycin  (EXP)
nitrofen  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
phenytoin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
platycodin D  (EXP)
propanal  (ISO)
pterostilbene  (ISO)
pyridaben  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
scopolamine  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torcetrapib  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
nucleus  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:7565748   PMID:9242564   PMID:9302292   PMID:9367982   PMID:10349636   PMID:10366853   PMID:10372405   PMID:10409672   PMID:10433980   PMID:10675334   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11375995   PMID:11437453   PMID:12426306   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12897154   PMID:14610273   PMID:14681479   PMID:15239958   PMID:15618518  
PMID:15820306   PMID:15834135   PMID:15835916   PMID:15882861   PMID:15947087   PMID:15980434   PMID:16101293   PMID:16116194   PMID:16141072   PMID:16141073   PMID:16166637   PMID:16571724  
PMID:16855590   PMID:17141159   PMID:17476283   PMID:17548599   PMID:17675555   PMID:18063572   PMID:18070933   PMID:18246069   PMID:18264089   PMID:18287559   PMID:18555530   PMID:18757824  
PMID:18799693   PMID:19041738   PMID:19272164   PMID:19412182   PMID:19491109   PMID:19592277   PMID:19786564   PMID:19951688   PMID:20007774   PMID:20412781   PMID:20427763   PMID:20525885  
PMID:20601952   PMID:20651277   PMID:20691614   PMID:21056461   PMID:21160050   PMID:21187409   PMID:21187410   PMID:21187442   PMID:21267068   PMID:21316587   PMID:21530336   PMID:21565532  
PMID:21610079   PMID:21677750   PMID:21731673   PMID:21873635   PMID:22001906   PMID:22110137   PMID:22143796   PMID:22267843   PMID:22280353   PMID:22327294   PMID:22474254   PMID:22482507  
PMID:22566683   PMID:22783020   PMID:22942434   PMID:23332504   PMID:23335794   PMID:23395513   PMID:23457456   PMID:23499374   PMID:23595884   PMID:23603510   PMID:23754749   PMID:23861552  
PMID:23876886   PMID:23884445   PMID:24155966   PMID:24162775   PMID:24261709   PMID:24391734   PMID:24771858   PMID:24859004   PMID:24874925   PMID:24905170   PMID:24952961   PMID:24979767  
PMID:25052583   PMID:25054639   PMID:25096223   PMID:25150253   PMID:25185079   PMID:25248747   PMID:25359860   PMID:25474999   PMID:25625207   PMID:25646266   PMID:25692701   PMID:26092481  
PMID:26147683   PMID:26226504   PMID:26321140   PMID:26406238   PMID:26426795   PMID:26517044   PMID:26776519   PMID:26902285   PMID:27027284   PMID:27114551   PMID:27302755   PMID:27317905  
PMID:27462110   PMID:27791035   PMID:27814941   PMID:27837103   PMID:27855271   PMID:28167653   PMID:28239661   PMID:28263185   PMID:28348240   PMID:28530714   PMID:28825355   PMID:29056552  
PMID:29150239   PMID:29191808   PMID:29660330   PMID:29723698   PMID:29739838   PMID:29898395   PMID:30037996   PMID:30352852   PMID:30355159   PMID:30429507   PMID:30692179   PMID:30775969  
PMID:30894058   PMID:31112136   PMID:31144355   PMID:31426355   PMID:31729420   PMID:31821872   PMID:31844321   PMID:31866399   PMID:31949051   PMID:33208733  


Genomics

Comparative Map Data
Klf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,072,906 - 73,075,498 (+)NCBIGRCm39mm39
GRCm38872,319,062 - 72,321,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,319,033 - 72,321,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,842,961 - 74,845,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,248,022 - 75,250,338 (+)NCBImm8
Celera876,656,424 - 76,659,017 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
KLF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,324,817 - 16,327,874 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1916,324,826 - 16,328,685 (+)EnsemblGRCh38hg38GRCh38
GRCh381916,324,826 - 16,328,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,435,651 - 16,438,345 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,296,651 - 16,299,345 (+)NCBINCBI36hg18NCBI36
Build 341916,296,650 - 16,299,337NCBI
Celera1916,337,566 - 16,340,260 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,006,724 - 16,007,405 (+)NCBIHuRef
CHM1_11916,435,167 - 16,439,004 (+)NCBICHM1_1
Klf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,223,087 - 19,225,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,223,087 - 19,225,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,084,196 - 19,086,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,941,780 - 17,943,730 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,941,777 - 17,943,728 (-)NCBI
Celera1617,739,313 - 17,741,263 (-)NCBICelera
Cytogenetic Map16p14NCBI
KLF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,792,497 - 16,794,143 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01915,812,506 - 15,815,244 (+)NCBIMhudiblu_PPA_v0panPan3
KLF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,270,714 - 61,273,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,270,733 - 61,273,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,903,997 - 60,904,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,832,013 - 14,834,744 (+)NCBI
ChlSab1.1 Ensembl614,832,029 - 14,837,462 (+)Ensembl
Klf2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,021,865 - 1,023,279 (-)NCBI

Position Markers
Klf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,317,600 - 72,318,354UniSTSGRCm38
GRCm382159,444,067 - 159,445,231UniSTSGRCm38
MGSCv372159,269,803 - 159,270,967UniSTSGRCm37
MGSCv37874,841,499 - 74,842,253UniSTSGRCm37
Celera2165,379,326 - 165,380,480UniSTS
Cytogenetic Map8C1UniSTS
cM Map8 UniSTS
Klf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS
Klf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS
Klf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,320,159 - 72,321,284UniSTSGRCm38
MGSCv37874,844,058 - 74,845,183UniSTSGRCm37
Celera876,657,522 - 76,658,647UniSTS
Cytogenetic Map8C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:178
Interacting mature miRNAs:191
Transcripts:ENSMUST00000067912
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000067912   ⟹   ENSMUSP00000064823
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,319,033 - 72,321,656 (+)Ensembl
RefSeq Acc Id: NM_008452   ⟹   NP_032478
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,072,906 - 73,075,498 (+)NCBI
GRCm38872,319,062 - 72,321,654 (+)ENTREZGENE
MGSCv37874,842,961 - 74,845,553 (+)RGD
Celera876,656,424 - 76,659,017 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032478   ⟸   NM_008452
- UniProtKB: Q60843 (UniProtKB/Swiss-Prot),   Q3V293 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000064823   ⟸   ENSMUST00000067912
Protein Domains
C2H2-type

Promoters
RGD ID:8667465
Promoter ID:EPDNEW_M11764
Type:multiple initiation site
Name:Klf2_1
Description:Mus musculus Kruppel-like factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,319,062 - 72,319,122EPDNEW
RGD ID:6843367
Promoter ID:MM_KWN:54865
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000053998
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,842,791 - 74,843,291 (+)MPROMDB
RGD ID:6848315
Promoter ID:MM_ACW:47950
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B4,   MEF_B6
Transcripts:KLF2.CSEP07-UNSPLICED,   KLF2.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,843,996 - 74,844,632 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1342772 AgrOrtholog
Ensembl Genes ENSMUSG00000055148 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000064823 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000067912 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1342772 ENTREZGENE
NCBI Gene 16598 ENTREZGENE
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KLF2 RGD
PhenoGen Klf2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.26938 ENTREZGENE
UniProt KLF2_MOUSE UniProtKB/Swiss-Prot
  Q3V293 ENTREZGENE, UniProtKB/TrEMBL
  Q60843 ENTREZGENE
UniProt Secondary B2RS60 UniProtKB/Swiss-Prot