Dpep1 (dipeptidase 1) - Rat Genome Database

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Gene: Dpep1 (dipeptidase 1) Mus musculus
Analyze
Symbol: Dpep1
Name: dipeptidase 1
RGD ID: 733978
MGI Page MGI
Description: Enables beta-lactamase activity and dipeptidase activity. Involved in several processes, including glutathione catabolic process; leukotriene metabolic process; and neutrophil chemotaxis. Predicted to be located in apical part of cell; cell junction; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in genitourinary system; incisor; and lung. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to human DPEP1 (dipeptidase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI327012; beta-lactamase; dipeptidase 1 (renal); DPEP-1; MBD; MBD-1; membrane bound dipeptidase type II; membrane-bound dipeptidase 1; microsomal dipeptidase; renal dipeptidase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,912,974 - 123,928,551 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,912,981 - 123,928,551 (+)EnsemblGRCm39 Ensembl
GRCm388123,186,235 - 123,201,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,186,242 - 123,201,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv378125,710,135 - 125,725,712 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,072,332 - 126,087,314 (+)NCBIMGSCv36mm8
Celera8127,417,731 - 127,433,354 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
cadmium atom  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cilastatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (EXP)
L-methionine  (EXP)
manganese(II) chloride  (ISO)
metformin  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway. Cui X, etal., Cell Death Dis. 2019 Sep 20;10(10):701. doi: 10.1038/s41419-019-1943-0.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8507661   PMID:8663190   PMID:9069116   PMID:9560193   PMID:10349636   PMID:10667344   PMID:11042159   PMID:11076861   PMID:11130978   PMID:12477932   PMID:12738806   PMID:15537664  
PMID:16141072   PMID:16141073   PMID:18287559   PMID:21267068   PMID:21386911   PMID:21677750   PMID:21873635   PMID:29863495   PMID:31442408   PMID:34426578   PMID:35108057  


Genomics

Comparative Map Data
Dpep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,912,974 - 123,928,551 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,912,981 - 123,928,551 (+)EnsemblGRCm39 Ensembl
GRCm388123,186,235 - 123,201,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,186,242 - 123,201,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv378125,710,135 - 125,725,712 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,072,332 - 126,087,314 (+)NCBIMGSCv36mm8
Celera8127,417,731 - 127,433,354 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.08NCBI
DPEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,613,308 - 89,641,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1689,613,308 - 89,638,456 (+)EnsemblGRCh38hg38GRCh38
GRCh371689,679,716 - 89,707,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,214,501 - 88,232,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 341688,214,500 - 88,232,338NCBI
Celera1674,743,127 - 74,769,330 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,374,386 - 75,400,655 (+)NCBIHuRef
CHM1_11691,091,422 - 91,116,106 (+)NCBICHM1_1
T2T-CHM13v2.01695,694,848 - 95,725,329 (+)NCBIT2T-CHM13v2.0
Dpep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21951,209,831 - 51,237,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,219,660 - 51,235,257 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,014,788 - 58,029,351 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01958,694,560 - 58,709,533 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01960,913,384 - 60,927,951 (+)NCBIRnor_WKY
Rnor_6.01955,973,447 - 55,998,830 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,982,740 - 55,998,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,678,990 - 66,706,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,503,467 - 53,518,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,508,370 - 53,523,966 (+)NCBI
Celera1950,455,220 - 50,470,193 (+)NCBICelera
Cytogenetic Map19q12NCBI
Dpep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555413,204,055 - 3,215,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555413,204,421 - 3,215,514 (+)NCBIChiLan1.0ChiLan1.0
DPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11689,971,984 - 89,997,978 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,975,105 - 89,997,978 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01670,365,900 - 70,392,377 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DPEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,909,034 - 63,923,309 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,909,042 - 63,923,492 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,921,890 - 63,936,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,136,884 - 64,151,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,136,892 - 64,151,287 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,156,932 - 64,171,234 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,994,537 - 64,008,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,401,112 - 64,415,426 (-)NCBIUU_Cfam_GSD_1.0
Dpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,625,555 - 24,643,322 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641379,083 - 391,918 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936641379,112 - 384,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6361,197 - 376,616 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16361,187 - 385,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26488,005 - 503,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233484
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,963,509 - 74,987,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,977,290 - 74,987,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023669841183 - 2,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746310,248 - 315,654 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746310,361 - 321,053 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:335
Count of miRNA genes:244
Interacting mature miRNAs:268
Transcripts:ENSMUST00000019422
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120726739130027694Mouse

Markers in Region
AI327012  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388123,201,139 - 123,201,275UniSTSGRCm38
MGSCv378125,725,039 - 125,725,175UniSTSGRCm37
Celera8127,432,681 - 127,432,817UniSTS
Cytogenetic Map8E1UniSTS
cM Map867.0UniSTS
Whitehead/MRC_RH81427.87UniSTS
D13139  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388123,201,074 - 123,201,165UniSTSGRCm38
MGSCv378125,724,974 - 125,725,065UniSTSGRCm37
Celera8127,432,616 - 127,432,707UniSTS
Cytogenetic Map8E1UniSTS
cM Map867.0UniSTS
Whitehead/MRC_RH81428.09UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019422   ⟹   ENSMUSP00000019422
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,912,981 - 123,928,551 (+)Ensembl
GRCm38.p6 Ensembl8123,186,242 - 123,201,812 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212409   ⟹   ENSMUSP00000148823
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,920,690 - 123,927,030 (+)Ensembl
GRCm38.p6 Ensembl8123,193,951 - 123,200,291 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212773   ⟹   ENSMUSP00000148609
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,920,233 - 123,926,401 (+)Ensembl
GRCm38.p6 Ensembl8123,193,494 - 123,199,662 (+)Ensembl
RefSeq Acc Id: NM_007876   ⟹   NP_031902
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398123,912,974 - 123,928,551 (+)NCBI
GRCm388123,186,235 - 123,201,812 (+)ENTREZGENE
MGSCv378125,710,135 - 125,725,712 (+)RGD
Celera8127,417,731 - 127,433,354 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017312558   ⟹   XP_017168047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398123,920,683 - 123,928,551 (+)NCBI
GRCm388123,193,943 - 123,201,812 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031902   ⟸   NM_007876
- Peptide Label: precursor
- UniProtKB: G5E824 (UniProtKB/Swiss-Prot),   P31428 (UniProtKB/Swiss-Prot),   Q3V175 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168047   ⟸   XM_017312558
- Peptide Label: isoform X1
- UniProtKB: G5E824 (UniProtKB/Swiss-Prot),   P31428 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000148609   ⟸   ENSMUST00000212773
RefSeq Acc Id: ENSMUSP00000148823   ⟸   ENSMUST00000212409
RefSeq Acc Id: ENSMUSP00000019422   ⟸   ENSMUST00000019422

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31428-F1-model_v2 AlphaFold P31428 1-410 view protein structure

Promoters
RGD ID:8668551
Promoter ID:EPDNEW_M12307
Type:initiation region
Name:Dpep1_1
Description:Mus musculus dipeptidase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388123,186,306 - 123,186,366EPDNEW
RGD ID:6843044
Promoter ID:MM_KWN:56045
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   Kidney,   Lung
Transcripts:NM_007876
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368125,709,536 - 125,710,322 (+)MPROMDB
RGD ID:6843045
Promoter ID:MM_KWN:56046
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC009NUJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368125,717,521 - 125,718,021 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94917 AgrOrtholog
Ensembl Genes ENSMUSG00000019278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000019422 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148609.2 UniProtKB/TrEMBL
  ENSMUSP00000148823.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019422 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212409.2 UniProtKB/TrEMBL
  ENSMUST00000212773.2 UniProtKB/TrEMBL
InterPro Dipep_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dpep1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13479 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:94917 ENTREZGENE
NCBI Gene 13479 ENTREZGENE
PANTHER PTHR10443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10443:SF38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dpep1 PhenoGen
PROSITE RENAL_DIPEPTIDASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RENAL_DIPEPTIDASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RM32_MOUSE UniProtKB/TrEMBL
  A0A1D5RML1_MOUSE UniProtKB/TrEMBL
  DPEP1_MOUSE UniProtKB/Swiss-Prot
  G5E824 ENTREZGENE
  P31428 ENTREZGENE
  Q3V175 ENTREZGENE, UniProtKB/TrEMBL
  Q99LA8_MOUSE UniProtKB/TrEMBL
UniProt Secondary G5E824 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-18 Dpep1  dipeptidase 1    dipeptidase 1 (renal)  Symbol and/or name change 5135510 APPROVED