Mgmt (O-6-methylguanine-DNA methyltransferase) - Rat Genome Database

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Gene: Mgmt (O-6-methylguanine-DNA methyltransferase) Mus musculus
Analyze
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
RGD ID: 10896
MGI Page MGI
Description: Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-O-methylguanine-DNA methyltransferase; AG; Agat; AGT; AI267024; methylated-DNA--protein-cysteine methyltransferase; MGC107020; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA-alkyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397136,496,315 - 136,732,001 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7136,496,343 - 136,731,995 (+)EnsemblGRCm39 Ensembl
GRCm387136,894,463 - 137,128,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7136,894,614 - 137,130,266 (+)EnsemblGRCm38mm10GRCm38
MGSCv377144,086,294 - 144,319,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367136,789,611 - 136,966,732 (+)NCBIMGSCv36mm8
Celera7136,716,995 - 136,951,061 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map782.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-colchicine  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropropane  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2'-deoxyguanosine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitrofluorene  (ISO)
2-nitropropane  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-dipyridyl disulfide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-acetylaminofluorene  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-carotene  (ISO)
alpha-phellandrene  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
anthracen-2-amine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-carotene  (ISO)
bezafibrate  (EXP)
Biflorin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
carmustine  (EXP,ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroform  (ISO)
chlorohydrocarbon  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dacarbazine  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dichlorine  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfate  (ISO)
disulfiram  (EXP,ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
emodin  (ISO)
fenofibrate  (ISO)
finasteride  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fotemustine  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glutathione  (ISO)
glycidol  (ISO)
guanine  (ISO)
Heliotrine  (ISO)
hydralazine  (ISO)
hydroxyurea  (EXP)
inulin  (EXP)
iodomethane  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lomustine  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethyl-4-nitrosoaniline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nimustine  (EXP,ISO)
nitrogen mustard  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphoramide mustard  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
procarbazine  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silibinin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (EXP,ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
valproic acid  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system. Arnold CN, etal., Int J Cancer. 2007 May 15;120(10):2157-64.
2. CpG island methylation in carcinoid and pancreatic endocrine tumors. Chan AO, etal., Oncogene. 2003 Feb 13;22(6):924-34.
3. Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. Chang HJ, etal., Pathol Oncol Res. 2007;13(4):326-35. Epub 2007 Dec 25.
4. Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma. Choy KW, etal., Neoplasia. 2005 Mar;7(3):200-6.
5. Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin. Dhillon VS, etal., Br J Cancer. 2004 Feb 23;90(4):874-81.
6. Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. House MG, etal., Ann Surg. 2003 Sep;238(3):423-31; discussion 431-2.
7. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Huang J, etal., Carcinogenesis. 2007 Jun;28(6):1314-22. Epub 2007 Jan 18.
8. Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors. Ingold B, etal., PLoS One. 2009;4(3):e4775. Epub 2009 Mar 10.
9. A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. Inoue R, etal., Neurol Res. 2003 Dec;25(8):875-9.
10. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Jiao L, etal., Cancer Detect Prev. 2006;30(3):284-91. Epub 2006 Jul 17.
11. Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas. Kim BH, etal., Arch Pathol Lab Med. 2007 Jun;131(6):923-30.
12. Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors. Kinjo T, etal., Anticancer Res. 2006 Jul-Aug;26(4B):2829-32.
13. Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Kohya N, etal., Ann Surg Oncol. 2002 May;9(4):371-9.
14. Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents. Kokkinakis DM, etal., Cancer Res. 1997 Dec 1;57(23):5360-8.
15. O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Kulke MH, etal., Clin Cancer Res. 2009 Jan 1;15(1):338-45.
16. Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis. Li C, etal., Cancer Lett. 2005 Sep 8;227(1):49-57.
17. Aberrant methylation of different DNA repair genes demonstrates distinct prognostic value for esophageal cancer. Ling ZQ, etal., Dig Dis Sci. 2011 Oct;56(10):2992-3004. doi: 10.1007/s10620-011-1774-z. Epub 2011 Jun 15.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Mollemann M, etal., Int J Cancer. 2005 Jan 20;113(3):379-85.
21. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
22. Inverse correlation between the expression of O6-methylguanine-DNA methyl transferase (MGMT) and p53 in breast cancer. Osanai T, etal., Jpn J Clin Oncol. 2005 Mar;35(3):121-5.
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. Shen J, etal., Carcinogenesis. 2005 Dec;26(12):2131-7. Epub 2005 Jul 13.
27. Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer. Smith-Sorensen B, etal., Oncogene. 2002 Dec 12;21(57):8878-84.
28. Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma. Toshimitsu H, etal., Ann Surg Oncol. 2010 Feb 24.
29. Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. Zhang M, etal., Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2123-7.
Additional References at PubMed
PMID:1371399   PMID:1554415   PMID:1559980   PMID:7532116   PMID:7614694   PMID:7773285   PMID:7789972   PMID:7959747   PMID:8216736   PMID:8268667   PMID:8521419   PMID:8620508  
PMID:8681434   PMID:8892758   PMID:8986768   PMID:9107680   PMID:9192819   PMID:9560238   PMID:9988767   PMID:10349636   PMID:10375003   PMID:10469609   PMID:10512203   PMID:10657972  
PMID:10721710   PMID:11023546   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11376694   PMID:11606727   PMID:11829488   PMID:11996884   PMID:12477932   PMID:12520002   PMID:13679151  
PMID:14610273   PMID:15208683   PMID:15354418   PMID:15489334   PMID:15840001   PMID:16094607   PMID:16141072   PMID:16141073   PMID:17098815   PMID:17116724   PMID:17588756   PMID:17967808  
PMID:18279716   PMID:18281247   PMID:18477655   PMID:18799693   PMID:19029948   PMID:19056675   PMID:19124772   PMID:19139400   PMID:19570237   PMID:19777566   PMID:20732909   PMID:21267068  
PMID:21677750   PMID:21731631   PMID:21873635   PMID:22196440   PMID:22675172   PMID:26238476   PMID:26243310   PMID:27618784   PMID:28753207   PMID:29632181   PMID:31853708   PMID:31951021  
PMID:32325033   PMID:38277015  


Genomics

Comparative Map Data
Mgmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397136,496,315 - 136,732,001 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7136,496,343 - 136,731,995 (+)EnsemblGRCm39 Ensembl
GRCm387136,894,463 - 137,128,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7136,894,614 - 137,130,266 (+)EnsemblGRCm38mm10GRCm38
MGSCv377144,086,294 - 144,319,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367136,789,611 - 136,966,732 (+)NCBIMGSCv36mm8
Celera7136,716,995 - 136,951,061 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map782.07NCBI
MGMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810129,467,241 - 129,770,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10129,467,190 - 129,770,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3710131,265,505 - 131,569,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610131,155,456 - 131,455,358 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410131,155,455 - 131,455,358NCBI
Celera10124,937,282 - 125,237,646 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10124,842,441 - 125,144,551 (+)NCBIHuRef
CHM1_110131,547,584 - 131,847,911 (+)NCBICHM1_1
T2T-CHM13v2.010130,392,352 - 130,697,970 (+)NCBIT2T-CHM13v2.0
Mgmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81201,140,832 - 201,367,481 (+)NCBIGRCr8
mRatBN7.21191,710,980 - 191,937,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1191,710,930 - 191,937,756 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1200,080,430 - 200,306,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01207,225,081 - 207,457,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01199,898,541 - 200,131,185 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01209,237,255 - 209,464,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1209,237,233 - 209,464,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01216,161,345 - 216,388,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41196,629,366 - 196,866,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11196,779,357 - 197,016,929 (+)NCBI
Celera1189,418,812 - 189,644,779 (+)NCBICelera
Cytogenetic Map1q41NCBI
Mgmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554777,102,977 - 7,376,530 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554777,103,035 - 7,375,073 (+)NCBIChiLan1.0ChiLan1.0
MGMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28141,356,414 - 141,663,365 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110141,361,768 - 141,667,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010126,059,701 - 126,365,850 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110130,305,459 - 130,609,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10130,305,485 - 130,609,422 (+)Ensemblpanpan1.1panPan2
MGMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12838,204,611 - 38,427,482 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2838,204,610 - 38,427,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2838,200,970 - 38,481,621 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02838,778,341 - 39,060,486 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2838,778,349 - 39,060,187 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12838,267,067 - 38,546,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02838,254,871 - 38,535,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02838,508,988 - 38,789,325 (+)NCBIUU_Cfam_GSD_1.0
Mgmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072138,634,604 - 8,867,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648616,744,570 - 16,923,543 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648616,744,607 - 16,923,209 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14138,499,309 - 138,771,540 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114138,502,005 - 138,771,543 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214150,607,175 - 150,887,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19122,089,768 - 122,376,320 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604883,466,550 - 83,760,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473717,271,992 - 17,528,889 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473717,271,881 - 17,619,123 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mgmt
8178 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:109
Interacting mature miRNAs:111
Transcripts:ENSMUST00000081510
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse

Markers in Region
M84524  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387137,128,267 - 137,128,365UniSTSGRCm38
MGSCv377144,319,950 - 144,320,048UniSTSGRCm37
Celera7136,951,140 - 136,951,238UniSTS
Cytogenetic Map7F4UniSTS
cM Map766.0UniSTS
Whitehead/MRC_RH71390.25UniSTS
D7Mit209  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387137,018,214 - 137,018,359UniSTSGRCm38
MGSCv377144,209,897 - 144,210,042UniSTSGRCm37
Celera7136,840,688 - 136,840,837UniSTS
Cytogenetic Map7F4UniSTS
cM Map766.0UniSTS
Whitehead Genetic762.3UniSTS
UniSTS:224822  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387137,128,197 - 137,128,365UniSTSGRCm38
MGSCv377144,319,880 - 144,320,048UniSTSGRCm37
Celera7136,951,070 - 136,951,238UniSTS
Cytogenetic Map7F4UniSTS
cM Map766.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001377037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006507409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB092489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB092490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC148997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY344992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S82865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000081510   ⟹   ENSMUSP00000080224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7136,496,343 - 136,731,995 (+)Ensembl
GRCm38.p6 Ensembl7136,894,614 - 137,130,266 (+)Ensembl
RefSeq Acc Id: NM_001377037   ⟹   NP_001363966
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,514,827 - 136,732,001 (+)NCBI
GRCm387136,913,098 - 137,128,188 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001412697   ⟹   NP_001399626
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,526,536 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_001412698   ⟹   NP_001399627
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_001412699   ⟹   NP_001399628
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_001412700   ⟹   NP_001399629
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_001412701   ⟹   NP_001399630
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_001412702   ⟹   NP_001399631
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_001412703   ⟹   NP_001399632
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,724,326 (+)NCBI
RefSeq Acc Id: NM_001412704   ⟹   NP_001399633
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,548,420 - 136,732,001 (+)NCBI
RefSeq Acc Id: NM_008598   ⟹   NP_032624
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
GRCm387136,894,586 - 137,128,188 (+)NCBI
MGSCv377144,086,294 - 144,319,871 (+)RGD
Celera7136,716,995 - 136,951,061 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_182026
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NR_182027
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NR_182028
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,496,315 - 136,732,001 (+)NCBI
RefSeq Acc Id: NR_182029
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,526,536 - 136,732,001 (+)NCBI
RefSeq Acc Id: XM_006507409   ⟹   XP_006507472
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397136,530,603 - 136,729,922 (+)NCBI
GRCm387136,928,872 - 137,128,193 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032624   ⟸   NM_008598
- Peptide Label: isoform 1
- UniProtKB: Q54A49 (UniProtKB/Swiss-Prot),   P26187 (UniProtKB/Swiss-Prot),   Q4VA39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006507472   ⟸   XM_006507409
- Peptide Label: isoform X4
- UniProtKB: Q54A49 (UniProtKB/Swiss-Prot),   P26187 (UniProtKB/Swiss-Prot),   Q4VA39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001363966   ⟸   NM_001377037
- Peptide Label: isoform 1
- UniProtKB: P26187 (UniProtKB/Swiss-Prot),   Q54A49 (UniProtKB/Swiss-Prot),   Q4VA39 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000080224   ⟸   ENSMUST00000081510
RefSeq Acc Id: NP_001399627   ⟸   NM_001412698
- Peptide Label: isoform 3
- UniProtKB: Q4VA39 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399628   ⟸   NM_001412699
- Peptide Label: isoform 3
- UniProtKB: Q4VA39 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399629   ⟸   NM_001412700
- Peptide Label: isoform 3
- UniProtKB: Q4VA39 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399631   ⟸   NM_001412702
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001399630   ⟸   NM_001412701
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001399632   ⟸   NM_001412703
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001399626   ⟸   NM_001412697
- Peptide Label: isoform 2
- UniProtKB: Q4VA39 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399633   ⟸   NM_001412704
- Peptide Label: isoform 1
- UniProtKB: P26187 (UniProtKB/Swiss-Prot),   Q54A49 (UniProtKB/Swiss-Prot),   Q4VA39 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26187-F1-model_v2 AlphaFold P26187 1-211 view protein structure

Promoters
RGD ID:8665921
Promoter ID:EPDNEW_M10991
Type:initiation region
Name:Mgmt_1
Description:Mus musculus O-6-methylguanine-DNA methyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387136,894,586 - 136,894,646EPDNEW
RGD ID:6841522
Promoter ID:MM_KWN:53073
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_008598
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367144,085,939 - 144,086,439 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96977 AgrOrtholog
Ensembl Genes ENSMUSG00000054612 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081510 ENTREZGENE
  ENSMUST00000081510.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methylated DNA-protein cysteine methyltransferase domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MethylDNA_cys_MeTrfase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MethylDNA_cys_MeTrfase_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MethylDNA_cys_MeTrfase_DNAb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MethylG_MeTrfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGMT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96977 ENTREZGENE
NCBI Gene 17314 ENTREZGENE
PANTHER METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/Swiss-Prot
  METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/Swiss-Prot
  METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/TrEMBL
  METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam DNA_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_1N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MGMT RGD
PhenoGen Mgmt PhenoGen
PROSITE MGMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53155 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MGMT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q4VA39 ENTREZGENE, UniProtKB/TrEMBL
  Q54A49 ENTREZGENE
UniProt Secondary Q54A49 UniProtKB/Swiss-Prot