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Gene: Map3k5 (mitogen-activated protein kinase kinase kinase 5) Mus musculus
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Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
RGD ID: 1315044
Description: Exhibits MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of MAPK cascade; and positive regulation of cell death. Predicted to localize to several cellular components, including IRE1-TRAF2-ASK1 complex; external side of plasma membrane; and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7420452D20Rik; A; apoptosis signal-regulating kinase 1; AS; ASK; ASK-1; ASK1; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; MGC141518; MGC141519; mitogen activated protein kinase kinase kinase 5
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1019,934,472 - 20,142,753 (+)EnsemblGRCm38mm10GRCm38
GRCm381019,934,101 - 20,142,750 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371019,654,332 - 19,862,556 (+)NCBIGRCm37mm9NCBIm37
MGSCv361019,623,888 - 19,831,139 (+)NCBImm8
Celera1019,821,331 - 20,029,886 (+)NCBICelera
Cytogenetic Map10A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Map3k5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315044
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.