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Gene: Map3k5 (mitogen-activated protein kinase kinase kinase 5) Mus musculus
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
RGD ID: 1315044
Description: Exhibits MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of MAPK cascade; and positive regulation of cell death. Predicted to localize to several cellular components, including IRE1-TRAF2-ASK1 complex; external side of plasma membrane; and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7420452D20Rik; A; apoptosis signal-regulating kinase 1; AS; ASK; ASK-1; ASK1; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; MGC141518; MGC141519; mitogen activated protein kinase kinase kinase 5
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1019,934,472 - 20,142,753 (+)EnsemblGRCm38mm10GRCm38
GRCm381019,934,101 - 20,142,750 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371019,654,332 - 19,862,556 (+)NCBIGRCm37mm9NCBIm37
MGSCv361019,623,888 - 19,831,139 (+)NCBImm8
Celera1019,821,331 - 20,029,886 (+)NCBICelera
Cytogenetic Map10A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Map3k5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315044
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.