Insr (insulin receptor) - Rat Genome Database

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Gene: Insr (insulin receptor) Mus musculus
Analyze
Symbol: Insr
Name: insulin receptor
RGD ID: 10813
MGI Page MGI
Description: Enables insulin receptor activity. Involved in several processes, including adrenal gland development; insulin receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a positive effect on receptor internalization. Acts upstream of or within several processes, including exocrine pancreas development; male sex determination; and positive regulation of mitotic nuclear division. Located in caveola. Is active in plasma membrane. Is expressed in several structures, including brain; connective tissue; decidua; enteric nervous system; and heart. Used to study diabetic retinopathy and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); hepatocellular carcinoma; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 4932439J01Rik; CD220; D630014A15Rik; I; IR; IR-A; IR-B; RIKEN cDNA D630014A15 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,200,922 - 3,329,649 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,172,061 - 3,329,617 (-)EnsemblGRCm39 Ensembl
GRCm3883,150,922 - 3,279,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,122,061 - 3,279,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,150,922 - 3,279,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,155,669 - 3,279,176 (-)NCBIMGSCv36mm8
Celera83,375,321 - 3,505,728 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46, XY Disorders of Sex Development  (ISO)
AIDS Dementia Complex  (ISO)
Alzheimer's disease  (IDA,ISO)
autism spectrum disorder  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (IMP)
choriocarcinoma  (ISO)
chronic kidney disease  (ISO)
congenital diaphragmatic hernia  (ISO)
diabetes mellitus  (ISO)
diabetic ketoacidosis  (IMP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (IAGP)
Donohue syndrome  (ISO)
esophageal atresia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
familial hyperinsulinemic hypoglycemia 4  (ISO)
familial hyperinsulinemic hypoglycemia 5  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (IMP,ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (IEP,ISO)
hyperglycemia  (ISO)
hyperinsulinism  (IAGP,IMP,ISO)
Insulin Resistance  (IMP,ISO)
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans  (ISO)
Lewy body dementia  (ISO)
lipoatrophic diabetes mellitus  (IMP)
lipodystrophy  (IMP)
lung disease  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IMP,ISO)
Metabolic Syndrome  (IEP)
mucolipidosis type IV  (ISO)
Native American myopathy  (ISO)
Parkinson's disease  (ISO)
PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Protein Deficiency  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
short bowel syndrome  (ISO)
steatotic liver disease  (ISO)
substance-related disorder  (ISO)
type 2 diabetes mellitus  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitrophenol  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
allopurinol  (ISO)
alloxan  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
AP20187  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dapagliflozin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
duvoglustat  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenthion  (EXP)
fenvalerate  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
insulin  (ISO)
isoliquiritigenin  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
linoleic acid  (EXP)
linsidomine  (EXP)
lovastatin  (ISO)
luteolin  (EXP)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
miconazole  (ISO)
molybdate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
orientin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylarsine oxide  (EXP)
phenytoin  (ISO)
picolinic acid  (ISO)
potassium chromate  (ISO)
procyanidin B1  (EXP)
progesterone  (ISO)
puerarin  (EXP)
pyrethrins  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raffinose  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
Rutamarin  (EXP)
rutin  (ISO)
SB 203580  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
thiazolidines  (EXP)
titanium dioxide  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vildagliptin  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IGI)
amyloid-beta clearance  (ISO)
animal organ morphogenesis  (IMP)
cellular response to growth factor stimulus  (IDA)
cellular response to insulin stimulus  (ISO)
cellular response to zinc ion starvation  (ISO)
cerebellum development  (ISO)
dendritic spine maintenance  (ISO)
embryonic liver development  (ISO)
epidermis development  (IMP)
exocrine pancreas development  (IMP)
fat cell differentiation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,ISO)
heart morphogenesis  (ISO)
hippocampus development  (ISO)
insulin receptor signaling pathway  (IDA,IGI,IMP,ISO)
liver development  (ISO)
liver regeneration  (ISO)
male gonad development  (IGI)
male sex determination  (IMP)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of transporter activity  (ISO)
neuron projection maintenance  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of DNA-templated transcription  (IGI)
positive regulation of glucose import  (ISO)
positive regulation of glycogen biosynthetic process  (IMP,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of meiotic cell cycle  (IGI)
positive regulation of mitotic nuclear division  (IMP,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IMP,ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex disassembly  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of respiratory burst  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
receptor internalization  (IDA)
receptor-mediated endocytosis  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of embryonic development  (ISO)
regulation of female gonad development  (IGI)
regulation of gluconeogenesis  (ISO)
regulation of hydrogen peroxide metabolic process  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to resveratrol  (ISO)
response to starvation  (ISO)
response to testosterone  (ISO)
response to tumor necrosis factor  (ISO)
response to vanadate(3-)  (ISO)
response to vitamin D  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
viral entry into host cell  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal breathing pattern  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal cardiac cell glucose uptake  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circadian feeding behavior  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating serum albumin level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal inguinal fat pad morphology  (IAGP)
abnormal insulin clearance  (IAGP)
abnormal lean body mass  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal primary sex determination  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal retina blood vessel pattern  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal vascular plexus formation  (IAGP)
absent corpus luteum  (IAGP)
absent mature ovarian follicles  (IAGP)
absent pancreatic beta cells  (IAGP)
adipose tissue inflammation  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
decreased birth weight  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cardiac cell glucose uptake  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased coronary flow rate  (IAGP)
decreased corpora lutea number  (IAGP)
decreased heart left ventricle posterior wall thickness  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased Leydig cell number  (IAGP)
decreased liver glycogen level  (IAGP)
decreased locomotor activity  (IAGP)
decreased ovulation rate  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased total body fat amount  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased white adipose tissue amount  (IAGP)
dilated cardiomyopathy  (IAGP)
enlarged gallbladder  (IAGP)
enlarged liver  (IAGP)
female infertility  (IAGP)
hepatic steatosis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased bile salt level  (IAGP)
increased body weight  (IAGP)
increased brown fat cell lipid droplet size  (IAGP)
increased cardiac cell glucose uptake  (IAGP)
increased cardiac muscle glycogen level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased energy expenditure  (IAGP)
increased fat cell size  (IAGP)
increased fatty acids level  (IAGP)
increased glycosylated hemoglobin level  (IEA)
increased growth rate  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased mitochondrial size  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased percent body fat/body weight  (IAGP)
increased susceptibility to induced colitis  (IEA)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased triglyceride level  (IAGP)
increased urine glucose level  (IAGP)
increased white adipose tissue amount  (IAGP)
insulin resistance  (IAGP)
ketoacidosis  (IAGP)
ketoaciduria  (IAGP)
liver degeneration  (IAGP)
liver inflammation  (IAGP)
oligozoospermia  (IAGP)
ovary inflammation  (IAGP)
ovotestis  (IAGP)
pancreatic islet hyperplasia  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
primary sex reversal  (IAGP)
reduced male fertility  (IAGP)
skeletal muscle hypotrophy  (IAGP)
small heart  (IAGP)
small liver  (IAGP)
small myocardial fiber  (IAGP)
thin interventricular septum  (IAGP)
thin ventricular wall  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Upregulation of the insulin receptor and type I insulin-like growth factor receptor are early events in hepatocarcinogenesis. Aleem E, etal., Toxicol Pathol. 2011 Apr;39(3):524-43. doi: 10.1177/0192623310396905. Epub 2011 Mar 16.
2. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. Belke DD, etal., J Clin Invest 2002 Mar;109(5):629-39.
3. Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. Ben Lulu S, etal., Pediatr Surg Int. 2010 Jan;26(1):37-44. doi: 10.1007/s00383-009-2520-x.
4. Impaired insulin action but normal insulin receptor activity in diabetic rat liver: effect of vanadate. Blondel O, etal., Am J Physiol. 1990 Mar;258(3 Pt 1):E459-67. doi: 10.1152/ajpendo.1990.258.3.E459.
5. Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. Calle C, etal., BMC Mol Biol. 2008 Jul 18;9:65.
6. Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. Chettouh H, etal., Cancer Res. 2013 Jul 1;73(13):3974-86. doi: 10.1158/0008-5472.CAN-12-3824. Epub 2013 Apr 30.
7. Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. Colomiere M, etal., Eur J Endocrinol. 2009 Apr;160(4):567-78. Epub 2009 Jan 29.
8. IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Diaz LE, etal., Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6.
9. Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy. Ding S, etal., Toxicol Sci. 2017 Oct 1;159(2):290-306. doi: 10.1093/toxsci/kfx093.
10. Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease. Dongiovanni P, etal., Clin Sci (Lond). 2017 Jun 7;131(12):1301-1315. doi: 10.1042/CS20170175. Print 2017 Jun 1.
11. Tissue- and fibre-specific modifications of insulin-signalling molecules in cardiac and skeletal muscle of diabetic rats. Ekladous D, etal., Clin Exp Pharmacol Physiol. 2008 Aug;35(8):971-8. Epub 2008 Apr 21.
12. Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Evert M, etal., Cancer Res. 2004 Nov 1;64(21):8093-100.
13. Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition. Feres NH, etal., Nutrition. 2010 Apr;26(4):441-8. Epub 2009 Oct 31.
14. Structural and functional studies of insulin receptors in human breast cancer. Frittitta L, etal., Breast Cancer Res Treat. 1993;25(1):73-82.
15. Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats. Gan KX, etal., World J Gastroenterol. 2013 Mar 14;19(10):1572-81. doi: 10.3748/wjg.v19.i10.1572.
16. Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. Gerena Y, etal., PLoS One. 2012;7(5):e37358. doi: 10.1371/journal.pone.0037358. Epub 2012 May 22.
17. The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus. Hami J, etal., Brain Struct Funct. 2013 Jan;218(1):73-84. doi: 10.1007/s00429-011-0377-y. Epub 2012 Jan 13.
18. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
19. Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. Herold MJ, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18.
20. Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
21. Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. Hunter SJ and Garvey WT, Am J Med. 1998 Oct;105(4):331-45.
22. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
23. Insulin receptor-overexpressing beta-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. Kim MH, etal., PLoS One. 2013 Jul 9;8(7):e67802. doi: 10.1371/journal.pone.0067802. Print 2013.
24. Mosaic analysis of insulin receptor function. Kitamura T, etal., J Clin Invest 2004 Jan;113(2):209-19.
25. Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. Kotnik K, etal., PLoS ONE. 2009;4(4):e5124. Epub 2009 Apr 2.
26. Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. Kou ZZ, etal., Pain Physician. 2013 Mar-Apr;16(2):E71-83.
27. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Lester-Coll N, etal., J Alzheimers Dis. 2006 Mar;9(1):13-33.
28. Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway. Lin X, etal., Exp Ther Med. 2018 Jul;16(1):204-212. doi: 10.3892/etm.2018.6194. Epub 2018 May 18.
29. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-beta plaque and glial pathology in a mouse model of Alzheimer's disease. Long-Smith CM, etal., Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21.
30. Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. Lopez-Pastor AR, etal., Dis Model Mech. 2019 Feb 7;12(2). pii: dmm.036186. doi: 10.1242/dmm.036186.
31. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Meakin PJ, etal., Nat Commun. 2018 Apr 3;9(1):1306. doi: 10.1038/s41467-018-03755-2.
32. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
35. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Michael MD, etal., Mol Cell 2000 Jul;6(1):87-97.
36. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
37. Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Mulligan AM, etal., Breast Cancer Res Treat. 2007 Nov;106(1):39-47. Epub 2007 Jan 13.
38. TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27.
39. Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice. Murakami K, etal., Biochem Biophys Res Commun. 2011 May 27;409(1):34-9. doi: 10.1016/j.bbrc.2011.04.101. Epub 2011 Apr 28.
40. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. Murugan P, etal., J Biosci. 2008 Mar;33(1):63-72.
41. Differential expression of IGF components and insulin receptor isoforms in human seminoma versus normal testicular tissue. Neuvians TP, etal., Neoplasia. 2005 May;7(5):446-56.
42. Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. Ofer P, etal., Mol Endocrinol. 2015 Dec;29(12):1694-707. doi: 10.1210/me.2015-1073. Epub 2015 Oct 9.
43. Transgenic rescue of insulin receptor-deficient mice. Okamoto H, etal., J Clin Invest 2004 Jul;114(2):214-23.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. Apo A-1 mimetic peptide, L-4F prevents insulin resistance through increased HO-1 and pAMPK in obese mice. Peterson SJ, etal., J Lipid Res. 2009 Mar 26.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
49. Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima Fatty rats. Qin B, etal., Atherosclerosis. 2012 Jun;222(2):409-16. doi: 10.1016/j.atherosclerosis.2012.03.033. Epub 2012 Apr 11.
50. Mouse MP Annotation Import Pipeline RGD automated import pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation. Seki N, etal., Horm Metab Res. 2008 Dec;40(12):833-7. Epub 2008 Oct 16.
54. Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats. Sugimoto K, etal., J Pain. 2008 Mar;9(3):237-45. Epub 2007 Dec 3.
55. Duodenal-jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto-Kakizaki rats. Sun D, etal., Obes Surg. 2013 Nov;23(11):1734-42. doi: 10.1007/s11695-013-0985-0.
56. Altered expression of members of the IGF-axis in clear cell renal cell carcinoma. Takahashi M, etal., Int J Oncol. 2005 Apr;26(4):923-31.
57. Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.
58. Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Thyfault JP, etal., Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18.
59. Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. Tiwari S, etal., J Am Soc Nephrol. 2007 Oct;18(10):2661-71. Epub 2007 Sep 12.
60. Effects of STZ-induced diabetes and fasting on insulin receptor mRNA expression and insulin receptor gene transcription in rat liver. Tozzo E and Desbuquois B, Diabetes. 1992 Dec;41(12):1609-16. doi: 10.2337/diab.41.12.1609.
61. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. Venkateswaran V, etal., J Natl Cancer Inst. 2007 Dec 5;99(23):1793-800. Epub 2007 Nov 27.
62. Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway. Wang Q, etal., Mol Med Rep. 2015 Jan;11(1):151-8. doi: 10.3892/mmr.2014.2762. Epub 2014 Oct 23.
63. Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor. Wang X, etal., Mol Cell Endocrinol. 2015 Nov 15;416:57-69. doi: 10.1016/j.mce.2015.08.021. Epub 2015 Aug 20.
64. [Effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides on non-alcoholic fatty liver disease induced by high-fat diet in mice]. Yao FF, etal., Zhonghua Gan Zang Bing Za Zhi. 2017 Dec 20;25(12):927-933. doi: 10.3760/cma.j.issn.1007-3418.2017.12.008.
65. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
66. Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity. Zhang L, etal., J Transl Med. 2014 Aug 27;12:236. doi: 10.1186/s12967-014-0236-8.
67. Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. Zhou QG, etal., Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1154-65. doi: 10.1152/ajpheart.00407.2012. Epub 2012 Aug 31.
Additional References at PubMed
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Genomics

Comparative Map Data
Insr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,200,922 - 3,329,649 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,172,061 - 3,329,617 (-)EnsemblGRCm39 Ensembl
GRCm3883,150,922 - 3,279,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,122,061 - 3,279,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,150,922 - 3,279,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,155,669 - 3,279,176 (-)NCBIMGSCv36mm8
Celera83,375,321 - 3,505,728 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.82NCBI
INSR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,112,265 - 7,294,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,112,255 - 7,294,414 (-)EnsemblGRCh38hg38GRCh38
GRCh37197,112,276 - 7,294,425 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,063,266 - 7,245,011 (-)NCBINCBI36Build 36hg18NCBI36
Build 34197,067,637 - 7,245,011NCBI
Celera197,049,684 - 7,205,258 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef196,846,024 - 7,028,322 (-)NCBIHuRef
CHM1_1197,111,894 - 7,294,424 (-)NCBICHM1_1
T2T-CHM13v2.0197,103,362 - 7,286,608 (-)NCBIT2T-CHM13v2.0
Insr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,193,193 - 1,330,976 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,197,100 - 1,330,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,861,209 - 1,995,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,484,768 - 2,618,760 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,257,014 - 1,390,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,682,527 - 1,816,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,680,957 - 1,816,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,848,670 - 3,989,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,934,967 - 3,087,691 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,934,966 - 3,087,691 (+)NCBI
Celera123,053,590 - 3,185,991 (-)NCBICelera
Cytogenetic Map12p12NCBI
Insr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,867,400 - 2,009,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,867,400 - 2,011,845 (+)NCBIChiLan1.0ChiLan1.0
INSR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11910,890,695 - 11,075,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,393,407 - 6,578,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,255,444 - 7,411,916 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,260,246 - 7,414,889 (-)Ensemblpanpan1.1panPan2
INSR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,017,261 - 52,136,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,021,887 - 52,136,046 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,822,227 - 51,957,301 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,547,342 - 52,682,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,551,139 - 52,683,109 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12051,751,620 - 51,886,677 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,194,853 - 52,330,054 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,425,027 - 52,560,283 (-)NCBIUU_Cfam_GSD_1.0
Insr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,335,383 - 213,489,477 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,345,306 - 4,453,668 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,345,306 - 4,453,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,797,204 - 71,936,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,797,209 - 71,939,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,388,108 - 72,420,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q11-q21NCBI
INSR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,625,951 - 6,803,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,630,777 - 6,803,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,077,953 - 1,266,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828345,135 - 486,184 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828345,135 - 485,856 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insr
3120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1352
Count of miRNA genes:689
Interacting mature miRNAs:872
Transcripts:ENSMUST00000091291, ENSMUST00000139504
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse

Markers in Region
UniSTS:224303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3883,220,356 - 3,220,519UniSTSGRCm38
MGSCv3783,220,356 - 3,220,519UniSTSGRCm37
Celera83,445,606 - 3,445,769UniSTS
Cytogenetic Map8A1.1UniSTS
Insr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
cM Map81.0UniSTS
D12Wox28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3883,154,522 - 3,154,651UniSTSGRCm38
MGSCv3783,154,522 - 3,154,651UniSTSGRCm37
Celera83,378,921 - 3,379,050UniSTS
Cytogenetic Map8A1.1UniSTS
Igf1r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D1UniSTS
Cytogenetic Map8A1.1UniSTS
Insr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
cM Map81.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001330056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC168068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF030770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY733217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR517528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU346716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC356871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000091291   ⟹   ENSMUSP00000088837
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,200,922 - 3,329,617 (-)Ensembl
GRCm38.p6 Ensembl83,150,922 - 3,279,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,261,101 - 3,329,551 (-)Ensembl
GRCm38.p6 Ensembl83,211,101 - 3,279,551 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207100   ⟹   ENSMUSP00000146818
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,224,795 - 3,242,717 (-)Ensembl
GRCm38.p6 Ensembl83,174,795 - 3,192,717 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,227,833 - 3,231,851 (-)Ensembl
GRCm38.p6 Ensembl83,177,833 - 3,181,851 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208839   ⟹   ENSMUSP00000146651
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,172,061 - 3,209,555 (-)Ensembl
GRCm38.p6 Ensembl83,122,061 - 3,159,555 (-)Ensembl
RefSeq Acc Id: NM_001330056   ⟹   NP_001316985
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,617 (-)NCBI
GRCm3883,150,922 - 3,279,617 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010568   ⟹   NP_034698
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,617 (-)NCBI
GRCm3883,150,922 - 3,279,617 (-)NCBI
MGSCv3783,150,922 - 3,279,617 (-)RGD
Celera83,375,321 - 3,505,728 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508700   ⟹   XP_006508763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,649 (-)NCBI
GRCm3883,150,922 - 3,279,649 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006508701   ⟹   XP_006508764
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,649 (-)NCBI
GRCm3883,150,922 - 3,279,649 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034698   ⟸   NM_010568
- Peptide Label: isoform A preproprotein
- UniProtKB: F8VPU4 (UniProtKB/Swiss-Prot),   P15208 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508764   ⟸   XM_006508701
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006508763   ⟸   XM_006508700
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001316985   ⟸   NM_001330056
- Peptide Label: isoform B preproprotein
- UniProtKB: M4TKR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000088837   ⟸   ENSMUST00000091291
RefSeq Acc Id: ENSMUSP00000146651   ⟸   ENSMUST00000208839
RefSeq Acc Id: ENSMUSP00000146818   ⟸   ENSMUST00000207100
Protein Domains
Fibronectin type-III   Furin-like cysteine-rich   Protein kinase   Receptor L-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15208-F1-model_v2 AlphaFold P15208 1-1372 view protein structure

Promoters
RGD ID:8666309
Promoter ID:EPDNEW_M11186
Type:initiation region
Name:Insr_1
Description:Mus musculus insulin receptor , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3883,279,547 - 3,279,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96575 AgrOrtholog
Ensembl Genes ENSMUSG00000005534 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000091291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000207100.2 UniProtKB/TrEMBL
  ENSMUST00000208839.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_insulin-like_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16337 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96575 ENTREZGENE
NCBI Gene 16337 ENTREZGENE
PANTHER INSULIN RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Insr PhenoGen
PIRSF Insulin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LI30_MOUSE UniProtKB/TrEMBL
  B8Q3N4_MOUSE UniProtKB/TrEMBL
  F8VPU4 ENTREZGENE
  INSR_MOUSE UniProtKB/Swiss-Prot
  M4TKR7 ENTREZGENE, UniProtKB/TrEMBL
  O35466_MOUSE UniProtKB/TrEMBL
  P15208 ENTREZGENE
  Q3TPM5_MOUSE UniProtKB/TrEMBL
  Q3V2X8_MOUSE UniProtKB/TrEMBL
  Q3V313_MOUSE UniProtKB/TrEMBL
UniProt Secondary F8VPU4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Insr  insulin receptor  D630014A15Rik  RIKEN cDNA D630014A15 gene  Data merged from RGD:1614822 737654 PROVISIONAL