Insr (insulin receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Insr (insulin receptor) Mus musculus
Analyze
Symbol: Insr
Name: insulin receptor
RGD ID: 10813
MGI Page MGI
Description: Enables insulin receptor activity and protein tyrosine kinase activator activity. Involved in several processes, including adrenal gland development; insulin receptor signaling pathway; and positive regulation of macromolecule biosynthetic process. Acts upstream of with a positive effect on receptor internalization. Acts upstream of or within several processes, including exocrine pancreas development; peptidyl-tyrosine autophosphorylation; and positive regulation of mitotic nuclear division. Located in caveola. Is active in plasma membrane. Is expressed in several structures, including brain; connective tissue; decidua; enteric nervous system; and heart. Used to study diabetic retinopathy and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; hepatocellular carcinoma; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 4932439J01Rik; CD220; D630014A15Rik; I; IR; IR-A; IR-B; RIKEN cDNA D630014A15 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,200,922 - 3,329,649 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,172,061 - 3,329,617 (-)EnsemblGRCm39 Ensembl
GRCm3883,150,922 - 3,279,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,122,061 - 3,279,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,150,922 - 3,279,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,155,669 - 3,279,176 (-)NCBIMGSCv36mm8
Celera83,375,321 - 3,505,728 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-nitrophenol  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alloxan  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
AP20187  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dapagliflozin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
duvoglustat  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenthion  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
insulin  (ISO)
isoliquiritigenin  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
linoleic acid  (EXP)
linsidomine  (EXP)
lovastatin  (ISO)
luteolin  (EXP)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
miconazole  (ISO)
molybdate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
orientin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylarsine oxide  (EXP)
phenytoin  (ISO)
picolinic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
puerarin  (EXP)
quercetin  (ISO)
quercitrin  (ISO)
raffinose  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
Rutamarin  (EXP)
rutin  (ISO)
SB 203580  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
thiazolidines  (EXP)
titanium dioxide  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vildagliptin  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activation of protein kinase B activity  (ISO)
adrenal gland development  (IGI)
alternative mRNA splicing, via spliceosome  (ISO)
amyloid-beta clearance  (ISO)
animal organ morphogenesis  (IMP)
cellular response to growth factor stimulus  (IDA)
cellular response to insulin stimulus  (ISO)
cellular response to zinc ion starvation  (ISO)
cerebellum development  (ISO)
dendritic spine maintenance  (ISO)
embryonic liver development  (ISO)
epidermis development  (IMP)
exocrine pancreas development  (IMP)
fat cell differentiation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,ISO)
heart morphogenesis  (ISO)
hippocampus development  (ISO)
insulin receptor signaling pathway  (IDA,IGI,IMP,ISO)
liver development  (ISO)
liver regeneration  (ISO)
male gonad development  (IGI)
male sex determination  (IMP)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of transporter activity  (ISO)
neuron projection maintenance  (ISO)
peptidyl-tyrosine autophosphorylation  (IDA)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of DNA-templated transcription  (IGI)
positive regulation of glucose import  (ISO)
positive regulation of glycogen biosynthetic process  (IMP,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of meiotic cell cycle  (IGI)
positive regulation of mitotic nuclear division  (IMP,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (IBA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex disassembly  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of respiratory burst  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
receptor internalization  (IDA)
receptor-mediated endocytosis  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of embryonic development  (ISO)
regulation of female gonad development  (IGI)
regulation of gluconeogenesis  (ISO)
regulation of hydrogen peroxide metabolic process  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to resveratrol  (ISO)
response to starvation  (ISO)
response to testosterone  (ISO)
response to tumor necrosis factor  (ISO)
response to vanadate(3-)  (ISO)
response to vitamin D  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
viral entry into host cell  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal breathing pattern  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal cardiac cell glucose uptake  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circadian feeding behavior  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating serum albumin level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal inguinal fat pad morphology  (IAGP)
abnormal insulin clearance  (IAGP)
abnormal lean body mass  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal primary sex determination  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal retina blood vessel pattern  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal vascular plexus formation  (IAGP)
absent corpus luteum  (IAGP)
absent mature ovarian follicles  (IAGP)
absent pancreatic beta cells  (IAGP)
adipose tissue inflammation  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
decreased birth weight  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cardiac cell glucose uptake  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased coronary flow rate  (IAGP)
decreased corpora lutea number  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased Leydig cell number  (IAGP)
decreased liver glycogen level  (IAGP)
decreased locomotor activity  (IAGP)
decreased ovulation rate  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased total body fat amount  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased white adipose tissue amount  (IAGP)
dilated cardiomyopathy  (IAGP)
enlarged gallbladder  (IAGP)
enlarged liver  (IAGP)
female infertility  (IAGP)
hepatic steatosis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased bile salt level  (IAGP)
increased body weight  (IAGP)
increased brown fat cell lipid droplet size  (IAGP)
increased cardiac cell glucose uptake  (IAGP)
increased cardiac muscle glycogen level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased energy expenditure  (IAGP)
increased fat cell size  (IAGP)
increased fatty acids level  (IAGP)
increased glycosylated hemoglobin level  (IEA)
increased growth rate  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased mitochondrial size  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased percent body fat/body weight  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IEA)
increased triglyceride level  (IAGP)
increased urine glucose level  (IAGP)
increased white adipose tissue amount  (IAGP)
insulin resistance  (IAGP)
ketoacidosis  (IAGP)
ketoaciduria  (IAGP)
liver degeneration  (IAGP)
liver inflammation  (IAGP)
oligozoospermia  (IAGP)
ovary inflammation  (IAGP)
ovotestis  (IAGP)
pancreatic islet hyperplasia  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
primary sex reversal  (IAGP)
reduced male fertility  (IAGP)
skeletal muscle hypotrophy  (IAGP)
small heart  (IAGP)
small liver  (IAGP)
small myocardial fiber  (IAGP)
thin interventricular septum  (IAGP)
thin ventricular wall  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Upregulation of the insulin receptor and type I insulin-like growth factor receptor are early events in hepatocarcinogenesis. Aleem E, etal., Toxicol Pathol. 2011 Apr;39(3):524-43. doi: 10.1177/0192623310396905. Epub 2011 Mar 16.
2. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. Belke DD, etal., J Clin Invest 2002 Mar;109(5):629-39.
3. Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. Ben Lulu S, etal., Pediatr Surg Int. 2010 Jan;26(1):37-44. doi: 10.1007/s00383-009-2520-x.
4. Impaired insulin action but normal insulin receptor activity in diabetic rat liver: effect of vanadate. Blondel O, etal., Am J Physiol. 1990 Mar;258(3 Pt 1):E459-67. doi: 10.1152/ajpendo.1990.258.3.E459.
5. Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. Calle C, etal., BMC Mol Biol. 2008 Jul 18;9:65.
6. Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. Chettouh H, etal., Cancer Res. 2013 Jul 1;73(13):3974-86. doi: 10.1158/0008-5472.CAN-12-3824. Epub 2013 Apr 30.
7. Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. Colomiere M, etal., Eur J Endocrinol. 2009 Apr;160(4):567-78. Epub 2009 Jan 29.
8. IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Diaz LE, etal., Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6.
9. Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy. Ding S, etal., Toxicol Sci. 2017 Oct 1;159(2):290-306. doi: 10.1093/toxsci/kfx093.
10. Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease. Dongiovanni P, etal., Clin Sci (Lond). 2017 Jun 7;131(12):1301-1315. doi: 10.1042/CS20170175. Print 2017 Jun 1.
11. Tissue- and fibre-specific modifications of insulin-signalling molecules in cardiac and skeletal muscle of diabetic rats. Ekladous D, etal., Clin Exp Pharmacol Physiol. 2008 Aug;35(8):971-8. Epub 2008 Apr 21.
12. Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Evert M, etal., Cancer Res. 2004 Nov 1;64(21):8093-100.
13. Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition. Feres NH, etal., Nutrition. 2010 Apr;26(4):441-8. Epub 2009 Oct 31.
14. Structural and functional studies of insulin receptors in human breast cancer. Frittitta L, etal., Breast Cancer Res Treat. 1993;25(1):73-82.
15. Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats. Gan KX, etal., World J Gastroenterol. 2013 Mar 14;19(10):1572-81. doi: 10.3748/wjg.v19.i10.1572.
16. Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. Gerena Y, etal., PLoS One. 2012;7(5):e37358. doi: 10.1371/journal.pone.0037358. Epub 2012 May 22.
17. The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus. Hami J, etal., Brain Struct Funct. 2013 Jan;218(1):73-84. doi: 10.1007/s00429-011-0377-y. Epub 2012 Jan 13.
18. Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. Herold MJ, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18.
19. Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
20. Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. Hunter SJ and Garvey WT, Am J Med. 1998 Oct;105(4):331-45.
21. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
22. Insulin receptor-overexpressing beta-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. Kim MH, etal., PLoS One. 2013 Jul 9;8(7):e67802. doi: 10.1371/journal.pone.0067802. Print 2013.
23. Mosaic analysis of insulin receptor function. Kitamura T, etal., J Clin Invest 2004 Jan;113(2):209-19.
24. Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. Kotnik K, etal., PLoS ONE. 2009;4(4):e5124. Epub 2009 Apr 2.
25. Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. Kou ZZ, etal., Pain Physician. 2013 Mar-Apr;16(2):E71-83.
26. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Lester-Coll N, etal., J Alzheimers Dis. 2006 Mar;9(1):13-33.
27. Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway. Lin X, etal., Exp Ther Med. 2018 Jul;16(1):204-212. doi: 10.3892/etm.2018.6194. Epub 2018 May 18.
28. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-beta plaque and glial pathology in a mouse model of Alzheimer's disease. Long-Smith CM, etal., Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21.
29. Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. Lopez-Pastor AR, etal., Dis Model Mech. 2019 Feb 7;12(2). pii: dmm.036186. doi: 10.1242/dmm.036186.
30. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Meakin PJ, etal., Nat Commun. 2018 Apr 3;9(1):1306. doi: 10.1038/s41467-018-03755-2.
31. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
32. MGDs mouse GO annotations MGD data from the GO Consortium
33. MGD IEA MGD IEA
34. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Michael MD, etal., Mol Cell 2000 Jul;6(1):87-97.
35. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
36. Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Mulligan AM, etal., Breast Cancer Res Treat. 2007 Nov;106(1):39-47. Epub 2007 Jan 13.
37. TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27.
38. Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice. Murakami K, etal., Biochem Biophys Res Commun. 2011 May 27;409(1):34-9. doi: 10.1016/j.bbrc.2011.04.101. Epub 2011 Apr 28.
39. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. Murugan P, etal., J Biosci. 2008 Mar;33(1):63-72.
40. Differential expression of IGF components and insulin receptor isoforms in human seminoma versus normal testicular tissue. Neuvians TP, etal., Neoplasia. 2005 May;7(5):446-56.
41. Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. Ofer P, etal., Mol Endocrinol. 2015 Dec;29(12):1694-707. doi: 10.1210/me.2015-1073. Epub 2015 Oct 9.
42. Transgenic rescue of insulin receptor-deficient mice. Okamoto H, etal., J Clin Invest 2004 Jul;114(2):214-23.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Apo A-1 mimetic peptide, L-4F prevents insulin resistance through increased HO-1 and pAMPK in obese mice. Peterson SJ, etal., J Lipid Res. 2009 Mar 26.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
47. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
48. Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima Fatty rats. Qin B, etal., Atherosclerosis. 2012 Jun;222(2):409-16. doi: 10.1016/j.atherosclerosis.2012.03.033. Epub 2012 Apr 11.
49. Mouse MP Annotation Import Pipeline RGD automated import pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation. Seki N, etal., Horm Metab Res. 2008 Dec;40(12):833-7. Epub 2008 Oct 16.
53. Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats. Sugimoto K, etal., J Pain. 2008 Mar;9(3):237-45. Epub 2007 Dec 3.
54. Duodenal-jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto-Kakizaki rats. Sun D, etal., Obes Surg. 2013 Nov;23(11):1734-42. doi: 10.1007/s11695-013-0985-0.
55. Altered expression of members of the IGF-axis in clear cell renal cell carcinoma. Takahashi M, etal., Int J Oncol. 2005 Apr;26(4):923-31.
56. Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.
57. Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Thyfault JP, etal., Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18.
58. Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. Tiwari S, etal., J Am Soc Nephrol. 2007 Oct;18(10):2661-71. Epub 2007 Sep 12.
59. Effects of STZ-induced diabetes and fasting on insulin receptor mRNA expression and insulin receptor gene transcription in rat liver. Tozzo E and Desbuquois B, Diabetes. 1992 Dec;41(12):1609-16. doi: 10.2337/diab.41.12.1609.
60. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. Venkateswaran V, etal., J Natl Cancer Inst. 2007 Dec 5;99(23):1793-800. Epub 2007 Nov 27.
61. Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway. Wang Q, etal., Mol Med Rep. 2015 Jan;11(1):151-8. doi: 10.3892/mmr.2014.2762. Epub 2014 Oct 23.
62. Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor. Wang X, etal., Mol Cell Endocrinol. 2015 Nov 15;416:57-69. doi: 10.1016/j.mce.2015.08.021. Epub 2015 Aug 20.
63. [Effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides on non-alcoholic fatty liver disease induced by high-fat diet in mice]. Yao FF, etal., Zhonghua Gan Zang Bing Za Zhi. 2017 Dec 20;25(12):927-933. doi: 10.3760/cma.j.issn.1007-3418.2017.12.008.
64. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
65. Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity. Zhang L, etal., J Transl Med. 2014 Aug 27;12:236. doi: 10.1186/s12967-014-0236-8.
66. Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. Zhou QG, etal., Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1154-65. doi: 10.1152/ajpheart.00407.2012. Epub 2012 Aug 31.
Additional References at PubMed
PMID:1317321   PMID:1347472   PMID:1375946   PMID:1660482   PMID:1675193   PMID:1701096   PMID:1733675   PMID:1968046   PMID:2067848   PMID:2557333   PMID:2602374   PMID:2852162  
PMID:3066742   PMID:7821728   PMID:7983060   PMID:8034026   PMID:8083370   PMID:8141246   PMID:8226859   PMID:8448209   PMID:8528241   PMID:8559144   PMID:8612577   PMID:8621530  
PMID:9013772   PMID:9038347   PMID:9062339   PMID:9281335   PMID:9285413   PMID:9342439   PMID:9344654   PMID:9398630   PMID:9447983   PMID:9498650   PMID:9806552   PMID:9844629  
PMID:10025399   PMID:10078198   PMID:10100151   PMID:10196204   PMID:10199397   PMID:10349636   PMID:10545524   PMID:10567556   PMID:10642598   PMID:10862794   PMID:11000114   PMID:11042159  
PMID:11076861   PMID:11114734   PMID:11118016   PMID:11159375   PMID:11181540   PMID:11217851   PMID:11272177   PMID:11459778   PMID:11463381   PMID:11463843   PMID:11557972   PMID:11602628  
PMID:11782469   PMID:11897010   PMID:11897712   PMID:11964401   PMID:11997497   PMID:12036959   PMID:12101187   PMID:12110165   PMID:12138094   PMID:12163490   PMID:12219087   PMID:12242462  
PMID:12431980   PMID:12459269   PMID:12466851   PMID:12477932   PMID:12488434   PMID:12543978   PMID:12588884   PMID:12595588   PMID:12612081   PMID:12727929   PMID:12738623   PMID:12750405  
PMID:12764141   PMID:12765966   PMID:12788932   PMID:12813019   PMID:12917015   PMID:14519599   PMID:14562105   PMID:14610273   PMID:14628051   PMID:14684612   PMID:14691140   PMID:14698815  
PMID:14698816   PMID:14981233   PMID:15031294   PMID:15063759   PMID:15131119   PMID:15131120   PMID:15169905   PMID:15249583   PMID:15254900   PMID:15372107   PMID:15448096   PMID:15546857  
PMID:15546994   PMID:15650270   PMID:15664450   PMID:15713666   PMID:15782199   PMID:15855332   PMID:15864351   PMID:15895078   PMID:16127460   PMID:16141072   PMID:16141073   PMID:16176826  
PMID:16216265   PMID:16294222   PMID:16314505   PMID:16322793   PMID:16428347   PMID:16455755   PMID:16485043   PMID:16513830   PMID:16581002   PMID:16581003   PMID:16581004   PMID:16602821  
PMID:16626396   PMID:16642022   PMID:16644916   PMID:16672634   PMID:16804073   PMID:16973725   PMID:17003275   PMID:17086487   PMID:17189427   PMID:17264162   PMID:17299086   PMID:17316549  
PMID:17416680   PMID:17417601   PMID:17475934   PMID:17492627   PMID:17545163   PMID:17550779   PMID:17556363   PMID:17597619   PMID:17615553   PMID:17625112   PMID:17641087   PMID:17699617  
PMID:17711985   PMID:17767907   PMID:17855343   PMID:17904393   PMID:17950578   PMID:17975745   PMID:18001293   PMID:18006633   PMID:18056790   PMID:18162531   PMID:18172021   PMID:18174274  
PMID:18249172   PMID:18250099   PMID:18256806   PMID:18288891   PMID:18391093   PMID:18406794   PMID:18424559   PMID:18451994   PMID:18477811   PMID:18480052   PMID:18535291   PMID:18587407  
PMID:18650937   PMID:18719589   PMID:18728232   PMID:18823366   PMID:18835939   PMID:18838380   PMID:19001411   PMID:19007875   PMID:19027012   PMID:19029027   PMID:19051206   PMID:19122674  
PMID:19136656   PMID:19188430   PMID:19237663   PMID:19246539   PMID:19273608   PMID:19273907   PMID:19342603   PMID:19356716   PMID:19390571   PMID:19406747   PMID:19406948   PMID:19406949  
PMID:19438210   PMID:19439231   PMID:19443198   PMID:19524295   PMID:19541767   PMID:19560437   PMID:19575708   PMID:19607904   PMID:19744489   PMID:19744960   PMID:19759515   PMID:19794138  
PMID:19815552   PMID:19851056   PMID:19933998   PMID:19956695   PMID:20032056   PMID:20061388   PMID:20103707   PMID:20103709   PMID:20176725   PMID:20360006   PMID:20374961   PMID:20407209  
PMID:20457905   PMID:20547974   PMID:20628204   PMID:20655470   PMID:20655471   PMID:20816095   PMID:20889126   PMID:20930167   PMID:20947509   PMID:20971769   PMID:21109191   PMID:21139139  
PMID:21179166   PMID:21190963   PMID:21239487   PMID:21266328   PMID:21267068   PMID:21284985   PMID:21317296   PMID:21346174   PMID:21429986   PMID:21474992   PMID:21486933   PMID:21632071  
PMID:21641549   PMID:21641553   PMID:21642975   PMID:21681845   PMID:21873635   PMID:21908618   PMID:21908931   PMID:21990313   PMID:22055502   PMID:22057897   PMID:22076926   PMID:22140505  
PMID:22199371   PMID:22200571   PMID:22253415   PMID:22288475   PMID:22308370   PMID:22319636   PMID:22428016   PMID:22661254   PMID:22682225   PMID:22692545   PMID:22733750   PMID:22751693  
PMID:22814664   PMID:22958919   PMID:22980982   PMID:22989885   PMID:23089224   PMID:23089336   PMID:23119079   PMID:23129807   PMID:23195676   PMID:23252577   PMID:23300479   PMID:23321074  
PMID:23348915   PMID:23349480   PMID:23349484   PMID:23349485   PMID:23351020   PMID:23354051   PMID:23375376   PMID:23382219   PMID:23392256   PMID:23474485   PMID:23515050   PMID:23518924  
PMID:23558339   PMID:23671263   PMID:23673657   PMID:23677929   PMID:23722907   PMID:23723425   PMID:23728177   PMID:23747309   PMID:23839944   PMID:23886629   PMID:23906066   PMID:23907538  
PMID:23957783   PMID:23982156   PMID:24078630   PMID:24258027   PMID:24302626   PMID:24326453   PMID:24375641   PMID:24379345   PMID:24391734   PMID:24398690   PMID:24401271   PMID:24462248  
PMID:24516236   PMID:24567360   PMID:24703698   PMID:24843127   PMID:24942009   PMID:24952961   PMID:24963495   PMID:25116708   PMID:25125486   PMID:25131199   PMID:25164678   PMID:25205222  
PMID:25233421   PMID:25246545   PMID:25249504   PMID:25269484   PMID:25295420   PMID:25307860   PMID:25379404   PMID:25394660   PMID:25598343   PMID:25625589   PMID:25643582   PMID:25685696  
PMID:25694511   PMID:25733901   PMID:25754093   PMID:25780937   PMID:25797178   PMID:25849138   PMID:25902782   PMID:25936582   PMID:25946091   PMID:25963408   PMID:25963540   PMID:25981038  
PMID:26063811   PMID:26096452   PMID:26100875   PMID:26141512   PMID:26251471   PMID:26340929   PMID:26369386   PMID:26387534   PMID:26475121   PMID:26496610   PMID:26511317   PMID:26567220  
PMID:26573296   PMID:26615883   PMID:26668316   PMID:26701651   PMID:26861781   PMID:26868295   PMID:26888756   PMID:27052174   PMID:27150392   PMID:27155659   PMID:27207510   PMID:27207537  
PMID:27213816   PMID:27246738   PMID:27322061   PMID:27346353   PMID:27374329   PMID:27391439   PMID:27408774   PMID:27414981   PMID:27435064   PMID:27462832   PMID:27518562   PMID:27525440  
PMID:27526875   PMID:27535223   PMID:27562101   PMID:27600278   PMID:27689415   PMID:27703010   PMID:27760050   PMID:27861515   PMID:27905925   PMID:27926856   PMID:28065828   PMID:28096258  
PMID:28115707   PMID:28138037   PMID:28322786   PMID:28345670   PMID:28380381   PMID:28385803   PMID:28407051   PMID:28456145   PMID:28459466   PMID:28526921   PMID:28544360   PMID:28591635  
PMID:28591779   PMID:28591806   PMID:28683263   PMID:28687614   PMID:28768176   PMID:28923931   PMID:28931726   PMID:28938444   PMID:29031500   PMID:29040448   PMID:29186427   PMID:29212950  
PMID:29300910   PMID:29320745   PMID:29401624   PMID:29584446   PMID:29649429   PMID:29664737   PMID:29712668   PMID:29795194   PMID:29796592   PMID:29907811   PMID:30033199   PMID:30070361  
PMID:30084987   PMID:30135311   PMID:30174303   PMID:30230471   PMID:30240435   PMID:30292429   PMID:30332298   PMID:30376348   PMID:30418175   PMID:30451856   PMID:30459233   PMID:30543793  
PMID:30559346   PMID:30574832   PMID:30576429   PMID:30635569   PMID:30644120   PMID:30734928   PMID:30765523   PMID:30798001   PMID:30805422   PMID:30807215   PMID:30893295   PMID:30909860  
PMID:30955890   PMID:30996131   PMID:31031093   PMID:31088290   PMID:31154478   PMID:31199472   PMID:31217420   PMID:31264358   PMID:31309261   PMID:31318893   PMID:31391336   PMID:31541682  
PMID:31543404   PMID:31562314   PMID:31671785   PMID:31713233   PMID:31908002   PMID:32005828   PMID:32046161   PMID:32058943   PMID:32156724   PMID:32167474   PMID:32173454   PMID:32183843  
PMID:32198362   PMID:32325033   PMID:32350271   PMID:32382087   PMID:32401607   PMID:32478834   PMID:32483283   PMID:32546815   PMID:32554809   PMID:32601248   PMID:32629174   PMID:32694718  
PMID:32816962   PMID:32975906   PMID:33077977   PMID:33296651   PMID:33400689   PMID:33440156   PMID:33505018   PMID:33835598   PMID:34037749   PMID:34198511   PMID:34271222   PMID:34282152  
PMID:34292642   PMID:34343133   PMID:34429546   PMID:34440804   PMID:34460911   PMID:34473648   PMID:34896640   PMID:34914893   PMID:34919671   PMID:34921686   PMID:35044446   PMID:35084365  
PMID:35108514   PMID:35136059   PMID:35177603   PMID:35248691   PMID:35328354   PMID:35417722   PMID:35523180   PMID:35733999   PMID:35741102   PMID:35806430   PMID:35874829   PMID:35921893  
PMID:35940390   PMID:35964946   PMID:36055580   PMID:36125265  


Genomics

Comparative Map Data
Insr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,200,922 - 3,329,649 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,172,061 - 3,329,617 (-)EnsemblGRCm39 Ensembl
GRCm3883,150,922 - 3,279,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,122,061 - 3,279,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,150,922 - 3,279,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,155,669 - 3,279,176 (-)NCBIMGSCv36mm8
Celera83,375,321 - 3,505,728 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.82NCBI
INSR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,112,265 - 7,294,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl197,112,255 - 7,294,414 (-)EnsemblGRCh38hg38GRCh38
GRCh37197,112,276 - 7,294,425 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,063,266 - 7,245,011 (-)NCBINCBI36Build 36hg18NCBI36
Build 34197,067,637 - 7,245,011NCBI
Celera197,049,684 - 7,205,258 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef196,846,024 - 7,028,322 (-)NCBIHuRef
CHM1_1197,111,894 - 7,294,424 (-)NCBICHM1_1
T2T-CHM13v2.0197,103,362 - 7,286,608 (-)NCBIT2T-CHM13v2.0
Insr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,193,193 - 1,330,976 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,197,100 - 1,330,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,861,209 - 1,995,191 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0122,484,768 - 2,618,760 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0121,257,014 - 1,390,911 (-)NCBIRnor_WKY
Rnor_6.0121,682,527 - 1,816,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,680,957 - 1,816,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,848,670 - 3,989,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,934,967 - 3,087,691 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,934,966 - 3,087,691 (+)NCBI
Celera123,053,590 - 3,185,991 (-)NCBICelera
Cytogenetic Map12p12NCBI
Insr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,867,400 - 2,009,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,867,400 - 2,011,845 (+)NCBIChiLan1.0ChiLan1.0
INSR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1197,255,444 - 7,411,916 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,260,246 - 7,414,889 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0196,393,407 - 6,578,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
INSR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,017,261 - 52,136,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,021,887 - 52,136,046 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,822,227 - 51,957,301 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,547,342 - 52,682,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,551,139 - 52,683,109 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12051,751,620 - 51,886,677 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,194,853 - 52,330,054 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,425,027 - 52,560,283 (-)NCBIUU_Cfam_GSD_1.0
Insr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,335,383 - 213,489,477 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,345,306 - 4,453,668 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365884,345,306 - 4,453,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,797,204 - 71,936,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,797,209 - 71,939,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,388,108 - 72,420,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q11-q21NCBI
INSR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,625,951 - 6,803,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,630,777 - 6,803,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,077,953 - 1,266,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828345,135 - 486,184 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828345,135 - 485,856 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1352
Count of miRNA genes:689
Interacting mature miRNAs:872
Transcripts:ENSMUST00000091291, ENSMUST00000139504
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse

Markers in Region
UniSTS:224303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3883,220,356 - 3,220,519UniSTSGRCm38
MGSCv3783,220,356 - 3,220,519UniSTSGRCm37
Celera83,445,606 - 3,445,769UniSTS
Cytogenetic Map8A1.1UniSTS
Insr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
cM Map81.0UniSTS
D12Wox28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3883,154,522 - 3,154,651UniSTSGRCm38
MGSCv3783,154,522 - 3,154,651UniSTSGRCm37
Celera83,378,921 - 3,379,050UniSTS
Cytogenetic Map8A1.1UniSTS
Igf1r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D1UniSTS
Cytogenetic Map8A1.1UniSTS
Insr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
cM Map81.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001330056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC168068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF030770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY733217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR517528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU346716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC356871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000091291   ⟹   ENSMUSP00000088837
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,200,922 - 3,329,617 (-)Ensembl
GRCm38.p6 Ensembl83,150,922 - 3,279,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139504
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,261,101 - 3,329,551 (-)Ensembl
GRCm38.p6 Ensembl83,211,101 - 3,279,551 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207100   ⟹   ENSMUSP00000146818
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,224,795 - 3,242,717 (-)Ensembl
GRCm38.p6 Ensembl83,174,795 - 3,192,717 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207295
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,227,833 - 3,231,851 (-)Ensembl
GRCm38.p6 Ensembl83,177,833 - 3,181,851 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208839   ⟹   ENSMUSP00000146651
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl83,172,061 - 3,209,555 (-)Ensembl
GRCm38.p6 Ensembl83,122,061 - 3,159,555 (-)Ensembl
RefSeq Acc Id: NM_001330056   ⟹   NP_001316985
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,617 (-)NCBI
GRCm3883,150,922 - 3,279,617 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010568   ⟹   NP_034698
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,617 (-)NCBI
GRCm3883,150,922 - 3,279,617 (-)NCBI
MGSCv3783,150,922 - 3,279,617 (-)RGD
Celera83,375,321 - 3,505,728 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508700   ⟹   XP_006508763
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,649 (-)NCBI
GRCm3883,150,922 - 3,279,649 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006508701   ⟹   XP_006508764
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,200,922 - 3,329,649 (-)NCBI
GRCm3883,150,922 - 3,279,649 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034698   ⟸   NM_010568
- Peptide Label: isoform A preproprotein
- UniProtKB: F8VPU4 (UniProtKB/Swiss-Prot),   P15208 (UniProtKB/Swiss-Prot),   Q3TPM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508764   ⟸   XM_006508701
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006508763   ⟸   XM_006508700
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001316985   ⟸   NM_001330056
- Peptide Label: isoform B preproprotein
- UniProtKB: M4TKR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000088837   ⟸   ENSMUST00000091291
RefSeq Acc Id: ENSMUSP00000146651   ⟸   ENSMUST00000208839
RefSeq Acc Id: ENSMUSP00000146818   ⟸   ENSMUST00000207100
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15208-F1-model_v2 AlphaFold P15208 1-1372 view protein structure

Promoters
RGD ID:8666309
Promoter ID:EPDNEW_M11186
Type:initiation region
Name:Insr_1
Description:Mus musculus insulin receptor , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3883,279,547 - 3,279,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96575 AgrOrtholog
Ensembl Genes ENSMUSG00000005534 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000088837 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000146651.2 UniProtKB/TrEMBL
  ENSMUSP00000146818.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000091291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000207100.2 UniProtKB/TrEMBL
  ENSMUST00000208839.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_insulin-like_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16337 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96575 ENTREZGENE
NCBI Gene 16337 ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Insr PhenoGen
PIRSF Insulin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LI30_MOUSE UniProtKB/TrEMBL
  B8Q3N4_MOUSE UniProtKB/TrEMBL
  F8VPU4 ENTREZGENE
  INSR_MOUSE UniProtKB/Swiss-Prot
  M4TKR7 ENTREZGENE, UniProtKB/TrEMBL
  O35466_MOUSE UniProtKB/TrEMBL
  P15208 ENTREZGENE
  Q3TPM5 ENTREZGENE, UniProtKB/TrEMBL
  Q3V2X8_MOUSE UniProtKB/TrEMBL
  Q3V313_MOUSE UniProtKB/TrEMBL
UniProt Secondary F8VPU4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Insr  insulin receptor  D630014A15Rik  RIKEN cDNA D630014A15 gene  Data Merged 737654 PROVISIONAL