Strc (stereocilin) - Rat Genome Database

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Gene: Strc (stereocilin) Mus musculus
Analyze
Symbol: Strc
Name: stereocilin
RGD ID: 1623848
MGI Page MGI
Description: Involved in auditory receptor cell stereocilium organization. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor cell stereocilium organization; and protein localization. Located in kinocilium and stereocilium tip. Is expressed in cochlea; inner ear; semicircular duct ampulla; tectorial membrane; and utricle epithelium. Used to study autosomal recessive nonsyndromic deafness 16. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 16 and sensorineural hearing loss. Orthologous to several human genes including STRC (stereocilin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DFNB1; DFNB16
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,193,729 - 121,211,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,194,209 - 121,217,649 (-)EnsemblGRCm39 Ensembl
GRCm382121,363,248 - 121,381,370 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,363,728 - 121,387,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv372121,189,463 - 121,206,676 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,055,168 - 121,072,381 (-)NCBIMGSCv36mm8
Celera2122,514,641 - 122,531,929 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IBA,IEA)
kinocilium  (IBA,IDA)
stereocilium tip  (IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11687802   PMID:12466851   PMID:16141072   PMID:16141073   PMID:18849963   PMID:20856818   PMID:21165971   PMID:21267068  
PMID:21873635   PMID:24920589   PMID:30801007   PMID:31448880   PMID:31776257   PMID:34910522   PMID:38346162   PMID:38355793  


Genomics

Comparative Map Data
Strc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,193,729 - 121,211,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,194,209 - 121,217,649 (-)EnsemblGRCm39 Ensembl
GRCm382121,363,248 - 121,381,370 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,363,728 - 121,387,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv372121,189,463 - 121,206,676 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,055,168 - 121,072,381 (-)NCBIMGSCv36mm8
Celera2122,514,641 - 122,531,929 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.37NCBI
STRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381543,599,563 - 43,618,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1543,599,563 - 43,618,800 (-)EnsemblGRCh38hg38GRCh38
GRCh371543,891,761 - 43,910,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,679,053 - 41,698,290 (-)NCBINCBI36Build 36hg18NCBI36
Build 341541,679,052 - 41,698,290NCBI
Celera1520,720,867 - 20,723,140 (+)NCBICelera
Celera1520,841,352 - 20,846,505 (-)NCBICelera
Cytogenetic Map15q15.3NCBI
HuRef1520,721,598 - 20,740,111 (-)NCBIHuRef
CHM1_11544,009,808 - 44,029,087 (-)NCBICHM1_1
T2T-CHM13v2.01541,406,922 - 41,426,159 (-)NCBIT2T-CHM13v2.0
Strc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,785,817 - 128,811,773 (-)NCBIGRCr8
mRatBN7.23108,335,920 - 108,355,114 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,335,747 - 108,354,134 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03113,324,403 - 113,343,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,324,698 - 113,342,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,863,952 - 119,882,260 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,164,129 - 108,182,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3107,237,716 - 107,256,326 (-)NCBICelera
Cytogenetic Map3q35NCBI
Strc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541610,139,420 - 10,141,906 (-)NCBIChiLan1.0ChiLan1.0
LOC103785466
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21632,952,613 - 32,977,519 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11537,114,439 - 37,139,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,660,952 - 22,706,416 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,740,196 - 40,771,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,740,387 - 40,757,999 (-)Ensemblpanpan1.1panPan2
STRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,444,726 - 10,459,058 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,444,793 - 10,460,785 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,503,116 - 10,517,450 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03010,581,219 - 10,595,553 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,581,288 - 10,597,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,490,359 - 10,505,838 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,612,124 - 10,626,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,732,015 - 10,746,349 (-)NCBIUU_Cfam_GSD_1.0
Strc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864088,912,019 - 88,929,362 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,760,294 - 6,777,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,760,289 - 6,777,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1127,835,622 - 127,852,339 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11127,830,759 - 127,852,392 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,660,378 - 142,682,006 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103245735
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12639,376,441 - 39,397,613 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2639,378,318 - 39,401,072 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366618275,632 - 121,228 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Strc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248382,896,147 - 2,910,268 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248382,894,945 - 2,913,030 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:823
Count of miRNA genes:470
Interacting mature miRNAs:566
Transcripts:ENSMUST00000038389, ENSMUST00000129136, ENSMUST00000134443, ENSMUST00000149219, ENSMUST00000150332
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
12904007Cfq7_mconditioned fear QTL 7 (mouse)2118356772125048872Mouse
13506762Tbvq2_mtrabecular bone volume QTL 2 (mouse)2115430481124741920Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558825Aabpr_maberrant activation of B cell proliferation (mouse)Not determined2116033229122207534Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse

Markers in Region
Z13968  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382121,363,626 - 121,363,714UniSTSGRCm38
MGSCv372121,189,362 - 121,189,450UniSTSGRCm37
Celera2122,514,540 - 122,514,628UniSTS
Cytogenetic Map2F1-F3UniSTS
Cytogenetic Map2E5UniSTS
Whitehead/MRC_RH21535.05UniSTS
D2Mit134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382121,363,292 - 121,363,495UniSTSGRCm38
MGSCv372121,189,028 - 121,189,231UniSTSGRCm37
Celera2122,514,210 - 122,514,409UniSTS
Cytogenetic Map2F1-F3UniSTS
Cytogenetic Map2E5UniSTS
cM Map267.6UniSTS
Whitehead Genetic256.8UniSTS
ECD01483  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382121,364,839 - 121,365,878UniSTSGRCm38
MGSCv372121,190,575 - 121,191,614UniSTSGRCm37
Celera2122,515,752 - 122,516,810UniSTS
Cytogenetic Map2E5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000038389   ⟹   ENSMUSP00000039378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2121,194,209 - 121,211,421 (-)Ensembl
GRCm38.p6 Ensembl2121,363,728 - 121,380,940 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129136   ⟹   ENSMUSP00000118211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2121,198,884 - 121,205,512 (-)Ensembl
GRCm38.p6 Ensembl2121,368,403 - 121,375,031 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2121,203,367 - 121,205,496 (-)Ensembl
GRCm38.p6 Ensembl2121,372,886 - 121,375,015 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149219
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2121,206,825 - 121,217,649 (-)Ensembl
GRCm38.p6 Ensembl2121,376,344 - 121,387,168 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150332
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2121,203,446 - 121,205,270 (-)Ensembl
GRCm38.p6 Ensembl2121,372,965 - 121,374,789 (-)Ensembl
RefSeq Acc Id: NM_080459   ⟹   NP_536707
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392121,194,208 - 121,211,421 (-)NCBI
GRCm382121,363,727 - 121,380,940 (-)NCBI
MGSCv372121,189,463 - 121,206,676 (-)RGD
Celera2122,514,641 - 122,531,929 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498734   ⟹   XP_006498797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392121,194,209 - 121,211,851 (-)NCBI
GRCm382121,363,728 - 121,381,370 (-)NCBI
Sequence:
RefSeq Acc Id: XR_374401
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392121,193,729 - 121,211,689 (-)NCBI
GRCm382121,363,248 - 121,381,208 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_536707 (Get FASTA)   NCBI Sequence Viewer  
  XP_006498797 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL35321 (Get FASTA)   NCBI Sequence Viewer  
  BAE26168 (Get FASTA)   NCBI Sequence Viewer  
  EDL28053 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000039378
  ENSMUSP00000039378.9
  ENSMUSP00000118211.2
GenBank Protein Q8VIM6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_536707   ⟸   NM_080459
- Peptide Label: precursor
- UniProtKB: A2ARP7 (UniProtKB/Swiss-Prot),   Q8VIM6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498797   ⟸   XM_006498734
- Peptide Label: isoform X1
- UniProtKB: A2ARP7 (UniProtKB/Swiss-Prot),   Q8VIM6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000118211   ⟸   ENSMUST00000129136
Ensembl Acc Id: ENSMUSP00000039378   ⟸   ENSMUST00000038389
Protein Domains
Stereocilin LRR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIM6-F1-model_v2 AlphaFold Q8VIM6 1-1809 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2153816 AgrOrtholog
Ensembl Genes ENSMUSG00000033498 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038389 ENTREZGENE
  ENSMUST00000038389.15 UniProtKB/Swiss-Prot
  ENSMUST00000129136.8 UniProtKB/TrEMBL
InterPro Stereocilin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Stereocilin_LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:140476 UniProtKB/Swiss-Prot
MGD MGI:2153816 ENTREZGENE
NCBI Gene 140476 ENTREZGENE
PANTHER PTHR23412 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23412:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Stereocilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Strc PhenoGen
UniProt A2ARP7 ENTREZGENE
  F6UNX5_MOUSE UniProtKB/TrEMBL
  Q3UMD0_MOUSE UniProtKB/TrEMBL
  Q8VIM6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2ARP7 UniProtKB/Swiss-Prot