Tgm2 (transglutaminase 2, C polypeptide) - Rat Genome Database

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Gene: Tgm2 (transglutaminase 2, C polypeptide) Mus musculus
Analyze
Symbol: Tgm2
Name: transglutaminase 2, C polypeptide
RGD ID: 732488
MGI Page MGI
Description: Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C polypeptide; G[a]; G[a]h; isopeptidase TGM2; protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; TG C; TG(C); TG2; TGas; TGase C; TGase II; TGase-2; TGase2; TGC; tissue transglutaminase; transglutaminase C; transglutaminase II; transglutaminase-2; tTG; tTGas
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,958,325 - 157,988,312 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,958,322 - 157,988,356 (-)EnsemblGRCm39 Ensembl
GRCm382158,116,405 - 158,146,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2158,116,402 - 158,146,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv372157,942,141 - 157,972,128 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,807,846 - 157,837,833 (-)NCBIMGSCv36mm8
Celera2164,061,515 - 164,091,498 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hexylbenzene-1,3-diol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bucladesine  (EXP)
budesonide  (EXP)
buspirone  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cystamine  (ISO)
daidzein  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
ferric oxide  (EXP)
finasteride  (ISO)
flunisolide  (EXP)
flusilazole  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
graphite  (ISO)
griseofulvin  (EXP)
GTP  (ISO)
hemin  (ISO)
heptachlor  (ISO)
hydrazine  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP)
isoxazoles  (EXP,ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP)
LY294002  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
microcystin-LR  (EXP)
mitomycin C  (ISO)
mometasone furoate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pinocembrin  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
putrescine  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
styrene  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiophenes  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
undecane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin D  (ISO)
vitamin K  (ISO)
warfarin  (EXP,ISO)
XL147  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease. Andringa G, etal., FASEB J. 2004 May;18(7):932-4. Epub 2004 Mar 4.
2. Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. Bernassola F, etal., FASEB J. 2002 Sep;16(11):1371-8.
3. Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease. Citron BA, etal., J Biol Chem. 2001 Feb 2;276(5):3295-301. Epub 2000 Sep 29.
4. Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease. Ehrmann J Jr, etal., Virchows Arch. 2003 May;442(5):453-61. Epub 2003 Apr 16.
5. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Kang SK, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):383-90.
6. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Kim SY, etal., Neurochem Res. 2005 Oct;30(10):1245-55.
7. Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia. Lee J, etal., J Biol Chem. 2004 Dec 17;279(51):53725-35. Epub 2004 Oct 7.
8. Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression. Li ZY, etal., Parasit Vectors. 2019 Jun 14;12(1):302. doi: 10.1186/s13071-019-3542-4.
9. Increase in extracellular cross-linking by tissue transglutaminase and reduction in expression of MMP-9 contribute differentially to focal segmental glomerulosclerosis in rats. Liu S, etal., Mol Cell Biochem. 2006 Mar;284(1-2):9-17. Epub 2006 Feb 14.
10. Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer. Mehta K, etal., Clin Cancer Res. 2004 Dec 1;10(23):8068-76.
11. Abnormal accumulation of tTGase products in muscle and erythrocytes of chorea-acanthocytosis patients. Melone MA, etal., J Neuropathol Exp Neurol. 2002 Oct;61(10):841-8.
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Increases in renal epsilon-(gamma-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: pathologic implications. Skill NJ, etal., Lab Invest. 2001 May;81(5):705-16.
20. COX-2-dependent cardiac failure in Gh/tTG transgenic mice. Zhang Z, etal., Circ Res 2003 May 30;92(10):1153-61. Epub 2003 Apr 17.
Additional References at PubMed
PMID:1670766   PMID:7911253   PMID:7945328   PMID:8626785   PMID:8828830   PMID:8858601   PMID:8873145   PMID:9448282   PMID:9511731   PMID:9771644   PMID:10200571   PMID:10334875  
PMID:10349636   PMID:10825574   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11113189   PMID:11217851   PMID:11274171   PMID:11390390   PMID:11723121   PMID:11867617   PMID:11869041  
PMID:11883932   PMID:12061780   PMID:12231209   PMID:12477932   PMID:12606540   PMID:12651621   PMID:12810961   PMID:12832399   PMID:12859959   PMID:12929572   PMID:14555966   PMID:14681479  
PMID:15381106   PMID:15541364   PMID:15584913   PMID:15606898   PMID:15740708   PMID:15800063   PMID:15849356   PMID:15857675   PMID:15905580   PMID:15909997   PMID:15970210   PMID:16108039  
PMID:16141072   PMID:16141073   PMID:16294209   PMID:16368540   PMID:16410462   PMID:16452636   PMID:16465267   PMID:16469487   PMID:16528383   PMID:16602821   PMID:16691213   PMID:16741156  
PMID:16757564   PMID:16763214   PMID:16979579   PMID:17009310   PMID:17064362   PMID:17116873   PMID:17341477   PMID:17408647   PMID:17478427   PMID:17612588   PMID:17707797   PMID:17711877  
PMID:17898543   PMID:18003922   PMID:18202319   PMID:18250473   PMID:18353867   PMID:18405667   PMID:18497756   PMID:18499669   PMID:18523305   PMID:18544639   PMID:18554416   PMID:18584285  
PMID:18594942   PMID:18594946   PMID:18632639   PMID:18688035   PMID:19013523   PMID:19146825   PMID:19201861   PMID:19208340   PMID:19239248   PMID:19398782   PMID:19643138   PMID:19644512  
PMID:19657147   PMID:19893320   PMID:19955852   PMID:19996413   PMID:20003977   PMID:20004474   PMID:20049854   PMID:20049897   PMID:20371597   PMID:20451610   PMID:20489165   PMID:20810110  
PMID:20864802   PMID:20876521   PMID:20929862   PMID:21094133   PMID:21156794   PMID:21187074   PMID:21196314   PMID:21267068   PMID:21277850   PMID:21355047   PMID:21420434   PMID:21479826  
PMID:21677750   PMID:21700912   PMID:21746810   PMID:21818782   PMID:21873635   PMID:21901120   PMID:21908620   PMID:21960143   PMID:21997537   PMID:22008794   PMID:22034513   PMID:22045386  
PMID:22142843   PMID:22159717   PMID:22183397   PMID:22183400   PMID:22194042   PMID:22198379   PMID:22203995   PMID:22220477   PMID:22258055   PMID:22319575   PMID:22322858   PMID:22330344  
PMID:22394545   PMID:22451718   PMID:22573678   PMID:22658978   PMID:22759359   PMID:22843703   PMID:22921425   PMID:23001131   PMID:23053022   PMID:23364326   PMID:23466867   PMID:23496815  
PMID:23524335   PMID:23704086   PMID:23717413   PMID:23824706   PMID:23873798   PMID:23896968   PMID:23966323   PMID:24002652   PMID:24036114   PMID:24045949   PMID:24052076   PMID:24152195  
PMID:24191290   PMID:24260489   PMID:24336287   PMID:24349085   PMID:24356421   PMID:24357671   PMID:24569994   PMID:24628083   PMID:24727157   PMID:24778599   PMID:24863408   PMID:24955833  
PMID:25057925   PMID:25060553   PMID:25131634   PMID:25202021   PMID:25301694   PMID:25612735   PMID:25680676   PMID:25889736   PMID:25924936   PMID:26025364   PMID:26175493   PMID:26209276  
PMID:26313919   PMID:26386840   PMID:26935419   PMID:27165830   PMID:27169926   PMID:27207524   PMID:27236567   PMID:27262403   PMID:27811936   PMID:27826792   PMID:27864691   PMID:28003361  
PMID:28071719   PMID:28371893   PMID:28387755   PMID:28522262   PMID:28684792   PMID:28700664   PMID:28774822   PMID:28878266   PMID:29072680   PMID:29222550   PMID:29449533   PMID:29481819  
PMID:29530978   PMID:29743665   PMID:29752334   PMID:29809138   PMID:29935061   PMID:29969654   PMID:30020832   PMID:30104731   PMID:30195017   PMID:30300608   PMID:30415489   PMID:30550785  
PMID:30590033   PMID:30647729   PMID:30683901   PMID:30943188   PMID:31107524   PMID:31165747   PMID:31189431   PMID:31462079   PMID:31666191   PMID:31727780   PMID:31786225   PMID:31874419  
PMID:31914588   PMID:32006666   PMID:32098917   PMID:32116663   PMID:32134139   PMID:32325033   PMID:32485850   PMID:32502569   PMID:32581705   PMID:32764573   PMID:32793209   PMID:33202201  
PMID:33253822   PMID:33672962   PMID:33674551   PMID:33806203   PMID:34099759   PMID:34264172   PMID:34326316   PMID:34607226   PMID:34731200   PMID:34818962   PMID:34831164   PMID:34831312  
PMID:34861212   PMID:34902478   PMID:35017645   PMID:35054938   PMID:35141929   PMID:35158413   PMID:35266881   PMID:35913916   PMID:35966081   PMID:36178196   PMID:36603588   PMID:36625326  
PMID:36753416   PMID:36831225   PMID:37037393   PMID:37047031   PMID:37088726   PMID:37511238   PMID:37643535   PMID:37681871   PMID:37839992   PMID:37951336  


Genomics

Comparative Map Data
Tgm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,958,325 - 157,988,312 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,958,322 - 157,988,356 (-)EnsemblGRCm39 Ensembl
GRCm382158,116,405 - 158,146,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2158,116,402 - 158,146,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv372157,942,141 - 157,972,128 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,807,846 - 157,837,833 (-)NCBIMGSCv36mm8
Celera2164,061,515 - 164,091,498 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.72NCBI
TGM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382038,127,385 - 38,168,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2038,127,385 - 38,166,578 (-)EnsemblGRCh38hg38GRCh38
GRCh372036,755,787 - 36,794,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,190,277 - 36,227,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 342036,199,764 - 36,227,114NCBI
Celera2033,465,637 - 33,502,475 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2033,493,671 - 33,530,533 (-)NCBIHuRef
CHM1_12036,660,115 - 36,696,950 (-)NCBICHM1_1
T2T-CHM13v2.02039,852,468 - 39,893,578 (-)NCBIT2T-CHM13v2.0
Tgm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,192,612 - 167,221,845 (-)NCBIGRCr8
mRatBN7.23146,772,684 - 146,801,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,772,687 - 146,801,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3150,598,013 - 150,627,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,097,613 - 159,126,553 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,839,077 - 156,868,039 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,597,165 - 154,627,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,597,168 - 154,627,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03160,977,905 - 161,007,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,832,866 - 148,862,385 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,738,777 - 148,768,294 (-)NCBI
Celera3145,473,663 - 145,503,117 (-)NCBICelera
Cytogenetic Map3q42NCBI
Tgm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544518,544,183 - 18,576,570 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544518,544,192 - 18,576,576 (+)NCBIChiLan1.0ChiLan1.0
TGM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22143,851,557 - 43,889,993 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12043,844,655 - 43,881,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02034,450,845 - 34,488,106 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12035,561,819 - 35,599,099 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2035,561,819 - 35,599,042 (-)Ensemblpanpan1.1panPan2
TGM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12426,631,339 - 26,662,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2426,628,009 - 26,663,840 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2426,277,181 - 26,308,444 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02427,327,862 - 27,359,126 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2427,295,164 - 27,359,267 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12426,602,350 - 26,633,607 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02426,710,189 - 26,741,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02427,198,294 - 27,229,594 (-)NCBIUU_Cfam_GSD_1.0
Tgm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640175,541,933 - 175,571,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,178,293 - 3,207,561 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,178,244 - 3,207,551 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1741,186,770 - 41,221,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11741,186,765 - 41,221,686 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21746,592,093 - 46,629,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,585,827 - 25,623,961 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,585,865 - 25,624,280 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605074,426,778 - 74,465,107 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248421,491,584 - 1,522,287 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248421,491,583 - 1,522,293 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgm2
1098 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1105
Count of miRNA genes:580
Interacting mature miRNAs:712
Transcripts:ENSMUST00000103122, ENSMUST00000140923, ENSMUST00000152690, ENSMUST00000174718
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
1301588Hrec_mhemotopoietic response to early cytokines (mouse)Not determined2154553217159428450Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse

Markers in Region
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372157,954,449 - 157,955,095UniSTSGRCm37
Celera2164,073,712 - 164,074,359UniSTS
Cytogenetic Map2H1UniSTS
cM Map289.0UniSTS
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382158,116,458 - 158,116,792UniSTSGRCm38
MGSCv372157,942,194 - 157,942,528UniSTSGRCm37
Cytogenetic Map2H1UniSTS
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
cM Map289.0UniSTS
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382158,124,178 - 158,124,245UniSTSGRCm38
MGSCv372157,949,914 - 157,949,981UniSTSGRCm37
Celera2164,069,185 - 164,069,252UniSTS
Cytogenetic Map2H1UniSTS
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382158,128,713 - 158,129,359UniSTSGRCm38
MGSCv372157,954,449 - 157,955,095UniSTSGRCm37
Celera2164,073,712 - 164,074,359UniSTS
Cytogenetic Map2H1UniSTS
cM Map289.0UniSTS
Tgm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS
cM Map289.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF076928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF114266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000103122   ⟹   ENSMUSP00000099411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,958,322 - 157,988,356 (-)Ensembl
GRCm38.p6 Ensembl2158,116,402 - 158,146,436 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140923
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,972,300 - 157,988,286 (-)Ensembl
GRCm38.p6 Ensembl2158,130,380 - 158,146,366 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,976,242 - 157,981,656 (-)Ensembl
GRCm38.p6 Ensembl2158,134,322 - 158,139,736 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174718   ⟹   ENSMUSP00000133662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2157,969,265 - 157,988,313 (-)Ensembl
GRCm38.p6 Ensembl2158,127,345 - 158,146,393 (-)Ensembl
RefSeq Acc Id: NM_009373   ⟹   NP_033399
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392157,958,325 - 157,988,312 (-)NCBI
GRCm382158,116,405 - 158,146,392 (-)ENTREZGENE
MGSCv372157,942,141 - 157,972,128 (-)RGD
Celera2164,061,515 - 164,091,498 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033399   ⟸   NM_009373
- UniProtKB: Q91VG9 (UniProtKB/Swiss-Prot),   Q8C217 (UniProtKB/Swiss-Prot),   Q3TLV2 (UniProtKB/Swiss-Prot),   O88901 (UniProtKB/Swiss-Prot),   Q9R1F7 (UniProtKB/Swiss-Prot),   P21981 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000133662   ⟸   ENSMUST00000174718
RefSeq Acc Id: ENSMUSP00000099411   ⟸   ENSMUST00000103122
Protein Domains
Transglutaminase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21981-F1-model_v2 AlphaFold P21981 1-686 view protein structure

Promoters
RGD ID:6832929
Promoter ID:MM_KWN:32720
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:ENSMUST00000047109,   OTTMUST00000037774
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362157,965,911 - 157,966,467 (-)MPROMDB
RGD ID:6832931
Promoter ID:MM_KWN:32721
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000037773,   UC008NPS.1,   UC008NPT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362157,971,736 - 157,972,236 (-)MPROMDB
RGD ID:6879486
Promoter ID:EPDNEW_M3194
Type:initiation region
Name:Tgm2_1
Description:Mus musculus transglutaminase 2, C polypeptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382158,146,365 - 158,146,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98731 AgrOrtholog
Ensembl Genes ENSMUSG00000037820 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103122 ENTREZGENE
  ENSMUST00000103122.10 UniProtKB/Swiss-Prot
  ENSMUST00000174718.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.260.10 UniProtKB/Swiss-Prot
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Transglutaminase-like UniProtKB/Swiss-Prot
  Transglutaminase-like_sf UniProtKB/Swiss-Prot
  Transglutaminase_animal UniProtKB/Swiss-Prot
  Transglutaminase_AS UniProtKB/Swiss-Prot
  Transglutaminase_C UniProtKB/Swiss-Prot
  Transglutaminase_C_sf UniProtKB/Swiss-Prot
  Transglutaminase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21817 UniProtKB/Swiss-Prot
MGD MGI:98731 ENTREZGENE
NCBI Gene 21817 ENTREZGENE
PANTHER PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transglut_C UniProtKB/Swiss-Prot
  Transglut_core UniProtKB/Swiss-Prot
  Transglut_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgm2 PhenoGen
PIRSF TGM_EBP42 UniProtKB/Swiss-Prot
PROSITE TRANSGLUTAMINASES UniProtKB/Swiss-Prot
SMART TGc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49309 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UXE8_MOUSE UniProtKB/TrEMBL
  O88901 ENTREZGENE
  P21981 ENTREZGENE
  Q3TLV2 ENTREZGENE
  Q8C217 ENTREZGENE
  Q91VG9 ENTREZGENE
  Q9R1F7 ENTREZGENE
  TGM2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O88901 UniProtKB/Swiss-Prot
  Q3TLV2 UniProtKB/Swiss-Prot
  Q8C217 UniProtKB/Swiss-Prot
  Q91VG9 UniProtKB/Swiss-Prot
  Q9R1F7 UniProtKB/Swiss-Prot