Hrh3 (histamine receptor H3) - Rat Genome Database

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Gene: Hrh3 (histamine receptor H3) Mus musculus
Analyze
Symbol: Hrh3
Name: histamine receptor H3
RGD ID: 732357
MGI Page MGI
Description: Predicted to enable G protein-coupled amine receptor activity; amine binding activity; and heterocyclic compound binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion. Predicted to act upstream of or within signal transduction. Predicted to be located in myelin sheath; neuron projection; and plasma membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in brain. Orthologous to human HRH3 (histamine receptor H3).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW049250; Eae; Eae8; experimental allergic encephalomyelitis susceptibility 8; H3R; HH3R; histamine H3 receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392179,741,258 - 179,746,293 (-)NCBIGRCm39mm39
GRCm39 Ensembl2179,741,258 - 179,746,281 (-)Ensembl
GRCm382180,099,465 - 180,104,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,099,465 - 180,104,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372179,834,178 - 179,838,927 (-)NCBIGRCm37mm9NCBIm37
MGSCv362180,028,881 - 180,033,632 (-)NCBImm8
Celera2184,181,575 - 184,186,324 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2102.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:7561115   PMID:8757345   PMID:8889548   PMID:9712054   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12130692   PMID:12477932   PMID:12488429   PMID:12527809  
PMID:12626656   PMID:12706455   PMID:12810089   PMID:15078574   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16738217   PMID:16887177   PMID:17288995   PMID:17548817   PMID:18037404  
PMID:18845911   PMID:19446035   PMID:19547708   PMID:19549072   PMID:19563635   PMID:19589346   PMID:19783867   PMID:20864504   PMID:21173143   PMID:21239440   PMID:21267068   PMID:21654737  
PMID:21677750   PMID:21710252   PMID:21873635   PMID:22678907   PMID:22870296   PMID:23303066   PMID:23772030   PMID:23894272   PMID:24117016   PMID:24566390   PMID:24599455   PMID:24952961  
PMID:25680462   PMID:25746421   PMID:26660098   PMID:26945087   PMID:27510032   PMID:28117842   PMID:30278251   PMID:30714121   PMID:31857598  


Genomics

Comparative Map Data
Hrh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392179,741,258 - 179,746,293 (-)NCBIGRCm39mm39
GRCm39 Ensembl2179,741,258 - 179,746,281 (-)Ensembl
GRCm382180,099,465 - 180,104,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,099,465 - 180,104,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372179,834,178 - 179,838,927 (-)NCBIGRCm37mm9NCBIm37
MGSCv362180,028,881 - 180,033,632 (-)NCBImm8
Celera2184,181,575 - 184,186,324 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2102.62NCBI
HRH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2062,214,960 - 62,220,278 (-)EnsemblGRCh38hg38GRCh38
GRCh382062,213,845 - 62,220,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372060,790,016 - 60,795,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362060,223,421 - 60,228,718 (-)NCBINCBI36hg18NCBI36
Build 342060,223,421 - 60,228,707NCBI
Celera2057,525,154 - 57,530,460 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2057,566,507 - 57,570,202 (-)NCBIHuRef
CHM1_12060,690,583 - 60,695,889 (-)NCBICHM1_1
Hrh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,191,551 - 167,196,642 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3167,191,558 - 167,196,642 (-)Ensembl
Rnor_6.03175,474,310 - 175,479,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,473,078 - 175,479,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,639,287 - 181,644,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,154,980 - 169,160,064 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13169,061,015 - 169,066,100 (-)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBICelera
Cytogenetic Map3q43NCBI
Hrh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555281,819,247 - 1,826,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555281,819,247 - 1,826,707 (+)NCBIChiLan1.0ChiLan1.0
HRH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12059,900,919 - 59,905,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2059,901,327 - 59,909,901 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02058,581,228 - 58,586,585 (-)NCBIMhudiblu_PPA_v0panPan3
HRH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,239,883 - 46,243,123 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2445,476,507 - 45,480,947 (-)NCBI
ROS_Cfam_1.02447,095,982 - 47,100,422 (-)NCBI
ROS_Cfam_1.0 Ensembl2447,096,070 - 47,100,764 (-)Ensembl
UMICH_Zoey_3.12446,197,405 - 46,201,844 (-)NCBI
UNSW_CanFamBas_1.02446,320,612 - 46,325,047 (-)NCBI
UU_Cfam_GSD_1.02447,074,908 - 47,079,348 (-)NCBI
Hrh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640194,408,461 - 194,412,309 (-)NCBI
SpeTri2.0NW_0049365149,862,104 - 9,865,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,622,703 - 61,627,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,622,865 - 61,627,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.122,019,878 - 2,025,218 (+)NCBIChlSab1.1chlSab2
ChlSab1.122,019,878 - 2,025,218 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl22,020,286 - 2,025,202 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605049,967,430 - 49,972,751 (+)NCBIVero_WHO_p1.0
Hrh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474128,080,957 - 28,086,312 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AW049250  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382180,099,545 - 180,099,694UniSTSGRCm38
MGSCv372179,834,250 - 179,834,399UniSTSGRCm37
Celera2184,181,647 - 184,181,796UniSTS
Cytogenetic Map2H4UniSTS
Whitehead/MRC_RH22007.37UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163844614182113224Mouse
1558748Vacq1_mvoluntary alcohol consumption QTL 1 (mouse)Not determined2178800545181873487Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162791700182113224Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155982127182113224Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156354671182113224Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164873361182113224Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163844614182113224Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150370301182113224Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152487900182113224Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2700
Count of miRNA genes:698
Interacting mature miRNAs:887
Transcripts:ENSMUST00000056480, ENSMUST00000163215, ENSMUST00000164442, ENSMUST00000165248, ENSMUST00000165762, ENSMUST00000166392, ENSMUST00000166724, ENSMUST00000171736
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB445008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB445009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB445010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW049250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY044153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY142145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000056480   ⟹   ENSMUSP00000049963
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,741,258 - 179,746,281 (-)Ensembl
GRCm38.p6 Ensembl2180,099,465 - 180,104,488 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163215   ⟹   ENSMUSP00000127053
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,741,444 - 179,745,944 (-)Ensembl
GRCm38.p6 Ensembl2180,099,651 - 180,104,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164442   ⟹   ENSMUSP00000130553
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,742,289 - 179,745,944 (-)Ensembl
GRCm38.p6 Ensembl2180,100,496 - 180,104,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165248   ⟹   ENSMUSP00000130181
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,741,671 - 179,745,944 (-)Ensembl
GRCm38.p6 Ensembl2180,099,878 - 180,104,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165762   ⟹   ENSMUSP00000132203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,741,671 - 179,745,944 (-)Ensembl
GRCm38.p6 Ensembl2180,099,878 - 180,104,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166392
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,742,777 - 179,745,128 (-)Ensembl
GRCm38.p6 Ensembl2180,100,984 - 180,103,335 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166724   ⟹   ENSMUSP00000126336
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,742,072 - 179,745,967 (-)Ensembl
GRCm38.p6 Ensembl2180,100,279 - 180,104,174 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171736   ⟹   ENSMUSP00000127085
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2179,742,289 - 179,745,944 (-)Ensembl
GRCm38.p6 Ensembl2180,100,496 - 180,104,151 (-)Ensembl
RefSeq Acc Id: NM_133849   ⟹   NP_598610
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392179,741,258 - 179,746,200 (-)NCBI
GRCm382180,099,465 - 180,104,407 (-)NCBI
MGSCv372179,834,178 - 179,838,927 (-)RGD
Celera2184,181,567 - 184,186,330 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_102309
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392179,741,258 - 179,746,200 (-)NCBI
GRCm382180,099,465 - 180,104,407 (-)NCBI
Celera2184,181,567 - 184,186,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319357   ⟹   XP_017174846
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392179,741,258 - 179,745,788 (-)NCBI
GRCm382180,099,465 - 180,104,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162761   ⟹   XP_036018654
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392179,741,258 - 179,746,293 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598610   ⟸   NM_133849
- UniProtKB: P58406 (UniProtKB/Swiss-Prot),   Q3USH0 (UniProtKB/TrEMBL),   Q540P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017174846   ⟸   XM_017319357
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000130553   ⟸   ENSMUST00000164442
RefSeq Acc Id: ENSMUSP00000127053   ⟸   ENSMUST00000163215
RefSeq Acc Id: ENSMUSP00000126336   ⟸   ENSMUST00000166724
RefSeq Acc Id: ENSMUSP00000127085   ⟸   ENSMUST00000171736
RefSeq Acc Id: ENSMUSP00000132203   ⟸   ENSMUST00000165762
RefSeq Acc Id: ENSMUSP00000130181   ⟸   ENSMUST00000165248
RefSeq Acc Id: ENSMUSP00000049963   ⟸   ENSMUST00000056480
RefSeq Acc Id: XP_036018654   ⟸   XM_036162761
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6880042
Promoter ID:EPDNEW_M3472
Type:initiation region
Name:Hrh3_1
Description:Mus musculus histamine receptor H3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382180,104,471 - 180,104,531EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2139279 AgrOrtholog
Ensembl Genes ENSMUSG00000039059 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000049963 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126336 UniProtKB/TrEMBL
  ENSMUSP00000127053 UniProtKB/TrEMBL
  ENSMUSP00000127085 UniProtKB/TrEMBL
  ENSMUSP00000130181 UniProtKB/TrEMBL
  ENSMUSP00000130553 UniProtKB/TrEMBL
  ENSMUSP00000132203 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000056480 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000163215 UniProtKB/TrEMBL
  ENSMUST00000164442 UniProtKB/TrEMBL
  ENSMUST00000165248 UniProtKB/TrEMBL
  ENSMUST00000165762 UniProtKB/TrEMBL
  ENSMUST00000166724 UniProtKB/TrEMBL
  ENSMUST00000171736 UniProtKB/TrEMBL
InterPro 7tmA_HRH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histamine_H3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:99296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2139279 ENTREZGENE
NCBI Gene 99296 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hrh3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINEH3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3Y5Z8_MOUSE UniProtKB/TrEMBL
  E9PZM9_MOUSE UniProtKB/TrEMBL
  E9Q292_MOUSE UniProtKB/TrEMBL
  E9Q522_MOUSE UniProtKB/TrEMBL
  E9Q540_MOUSE UniProtKB/TrEMBL
  E9Q5S3_MOUSE UniProtKB/TrEMBL
  E9Q7T5_MOUSE UniProtKB/TrEMBL
  HRH3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U1A2_MOUSE UniProtKB/TrEMBL
  Q3USH0 ENTREZGENE, UniProtKB/TrEMBL
  Q540P3 ENTREZGENE, UniProtKB/TrEMBL
  Q8K116_MOUSE UniProtKB/TrEMBL