Agtr1a (angiotensin II receptor, type 1a) - Rat Genome Database

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Gene: Agtr1a (angiotensin II receptor, type 1a) Mus musculus
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
RGD ID: 737190
Description: Enables angiotensin type I receptor activity. Involved in gene expression; positive regulation of cytokine production; and regulation of blood pressure. Acts upstream of or within several processes, including circulatory system development; regulation of blood pressure; and regulation of smooth muscle cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; extraembryonic component; genitourinary system; and submandibular gland. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810074K20Rik; AG2S; Agt; Agt1ar; Agtr; Agtr-1a; Agtr1; AI551199; angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; Angt; Angtr-1a; AT; AT1; AT1 receptor A; AT1a; AT2R1; AT2R1A; MGC37610; type-1 angiotensin II receptor A; type-1A angiotensin II receptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)EnsemblGRCm39 Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBIMGSCv36mm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP,ISO)
aceruloplasminemia  (ISO)
AIDS-Associated Nephropathy  (IMP)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (IMP,ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
breast lobular carcinoma  (EXP)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (EXP,ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
cerebrovascular disease  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (IMP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (EXP)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (ISO)
Ductal Carcinoma  (EXP)
Endotoxemia  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (EXP,IMP)
Experimental Mammary Neoplasms  (EXP,ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (EXP,ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glomerulosclerosis  (ISO)
glucose intolerance  (EXP)
glycogen storage disease XV  (ISO)
Huntington's disease  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (IMP)
intermediate coronary syndrome  (ISO)
kidney disease  (EXP,ISO)
Left Ventricular Hypertrophy  (ISO)
limb ischemia  (IMP)
lung disease  (IEP)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
patent ductus arteriosus  (ISO)
Pituitary Neoplasms  (ISO)
placental insufficiency  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (IMP)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
sarcoidosis  (ISO)
Spontaneous Abortions  (ISO)
Vascular System Injuries  (EXP)
Ventricular Remodeling  (ISO)
vesicoureteral reflux  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
benazepril  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
capsaicin  (ISO)
captopril  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
cholesterol  (EXP)
chromium(6+)  (ISO)
cilazapril monohydrate  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
corticosterone  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
diisononyl phthalate  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
doxorubicin  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
esculetin  (ISO)
estriol  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
goralatide  (EXP)
Heptachlor epoxide  (EXP)
hexachlorobenzene  (ISO)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
irbesartan  (EXP,ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-ethionine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
mevinphos  (ISO)
mifepristone  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
Nandrolone decanoate  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitrendipine  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
olmesartan  (ISO)
omeprazole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenylarsine oxide  (ISO)
phosphane  (ISO)
picrotoxin  (ISO)
pioglitazone  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregabalin  (ISO)
propanal  (ISO)
Ptaquiloside  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
spironolactone  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
superoxide  (ISO)
telmisartan  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO)
aging  (ISO)
angiotensin-activated signaling pathway  (ISO)
blood vessel development  (IGI)
brain renin-angiotensin system  (IMP)
calcium-mediated signaling  (ISO)
cell chemotaxis  (ISO)
cellular response to dexamethasone stimulus  (ISO)
dopamine biosynthetic process  (ISO)
drinking behavior  (IGI,IMP,ISO)
G protein-coupled receptor signaling pathway  (IBA,IC,ISO)
gene expression  (IMP)
heart development  (IMP)
inflammatory response  (IBA,IGI)
kidney development  (IGI,IMP,ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of smooth muscle cell apoptotic process  (IMP)
neuron apoptotic process  (IMP)
obsolete positive regulation of cholesterol esterification  (ISO)
phospholipase C-activating angiotensin-activated signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood pressure  (IDA,IGI,IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of cytokine production  (IMP)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of phospholipase A2 activity  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of blood pressure  (IMP)
regulation of pH  (ISO)
regulation of renal output by angiotensin  (IMP)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (IGI)
regulation of vascular associated smooth muscle cell apoptotic process  (IGI)
regulation of vasoconstriction  (ISO)
renin secretion into blood stream  (IMP)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to activity  (ISO)
response to angiotensin  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to salt stress  (ISO)
Rho protein signal transduction  (ISO)
signal transduction  (IEA)
vascular associated smooth muscle cell proliferation  (IMP)
vasoconstriction  (ISO)
viral entry into host cell  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
angiotensin II signaling pathway  (ISO)
angiotensin II signaling pathway via AT1 receptor  (ISO,TAS)
angiotensin III signaling pathway  (ISO)
angiotensin III signaling pathway via AT1 receptor  (ISO)
atenolol pharmacodynamics pathway  (ISO)
benazepril pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
candesartan pharmacodynamics pathway  (ISO)
captopril pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
cilazapril pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
enalapril pharmacodynamics pathway  (ISO)
eprosartan pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forasartsn pharmacodynamics pathway  (ISO)
fosinopril pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
irbesartan pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lisinopril pharmacodynamics pathway  (ISO)
losartan pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
moexipril pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
olmesartan pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
perindopril pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinapril pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
ramipril pharmacodynamics pathway  (ISO)
renin-angiotensin cascade pathway  (IEA,TAS)
sotalol pharmacodynamics pathway  (ISO)
spirapril pharmacodynamics pathway  (ISO)
telmisartan pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
trandolapril pharmacodynamics pathway  (ISO)
valsartan pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue development  (IAGP)
abnormal amygdala morphology  (IAGP)
abnormal aorta elastic fiber morphology  (IAGP)
abnormal ascending aorta morphology  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal erythrocyte cell number  (IEA)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart rate  (IAGP)
abnormal hematocrit  (IEA)
abnormal hemoglobin content  (IEA)
abnormal juxtaglomerular apparatus morphology  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney interlobular artery morphology  (IAGP)
abnormal kidney interstitium morphology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal kidney papilla morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal mean corpuscular hemoglobin  (IEA)
abnormal physiological response to xenobiotic  (IAGP)
abnormal platelet cell number  (IEA)
abnormal red blood cell distribution width  (IEA)
abnormal renal water reabsorption  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spleen morphology  (IEA)
abnormal systemic arterial blood pressure  (IAGP)
abnormal thalamus morphology  (IAGP)
absent kidney pelvis  (IAGP)
cardiac fibrosis  (IAGP)
cardiac interstitial fibrosis  (IAGP)
decreased aorta wall thickness  (IAGP)
decreased body weight  (IAGP)
decreased circulating angiotensin II level  (IAGP)
decreased circulating renin level  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased kidney weight  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased renin activity  (IAGP)
decreased susceptibility to induced aneurysm formation  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine potassium level  (IAGP)
decreased white fat cell number  (IAGP)
dilated kidney calyx  (IAGP)
dilated renal tubule  (IAGP)
enlarged heart  (IEA)
enlarged spleen  (IEA)
high mean erythrocyte cell number  (IAGP)
hydronephrosis  (IAGP)
hypotension  (IAGP)
increased aorta wall thickness  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating renin level  (IAGP)
increased fluid intake  (IAGP)
increased glomerular capsule space  (IAGP)
increased heart weight  (IAGP)
increased hemoglobin content  (IAGP)
increased renin activity  (IAGP)
increased spleen weight  (IEA)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased urine osmolality  (IAGP)
increased white fat cell size  (IAGP)
juxtaglomerular cell hyperplasia  (IAGP)
kidney cyst  (IAGP)
kidney inflammation  (IAGP)
kidney papillary hypoplasia  (IAGP)
muscular ventricular septal defect  (IAGP)
oliguria  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
polycystic kidney  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
renal fibrosis  (IAGP)
renal glomerulus atrophy  (IAGP)
ventricular septal defect  (IAGP)

References - curated
# Reference Title Reference Citation
1. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Abdollahi MR, etal., Hum Mutat. 2007 Jan 8;28(4):365-373.
2. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. Ali MS, etal., J Biol Chem. 1997 Sep 12;272(37):23382-8.
3. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Araujo MA, etal., Int J Cardiol. 2005 Aug 3;103(1):27-32. Epub 2004 Dec 15.
4. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Differential responses to salt supplementation in adult male and female rat adrenal glands following intrauterine growth restriction. Bibeau K, etal., J Endocrinol. 2011 Apr;209(1):85-94. Epub 2011 Feb 8.
7. Gene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis. Biller H, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):139-46.
8. Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade. Bonnet F, etal., J Hypertens. 2002 Aug;20(8):1615-24.
9. Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. Bose KS and Sarma RH, Biochem Biophys Res Commun 1975 Oct 27;66(4):1173-9.
10. Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension. Boshra V, etal., Can J Physiol Pharmacol. 2011 Feb;89(2):103-7.
11. [Association of the renin-angiotensin system gene polymorphism with nephropathy in type II diabetes]. Buraczynska M, etal., Pol Arch Med Wewn. 2002 Aug;108(2):725-30.
12. Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. Cao Z, etal., J Am Soc Nephrol. 2002 Jul;13(7):1773-87.
13. Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. Chan LY, etal., J Am Soc Nephrol. 2005 Aug;16(8):2306-17. Epub 2005 Jun 1.
14. Upregulation of angiotensin II receptors in reflux nephropathy. Chertin B, etal., J Pediatr Surg. 2002 Feb;37(2):251-5.
15. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. Chung WK, etal., J Heart Lung Transplant. 2009 Apr;28(4):373-9.
16. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. Coll E, etal., J Nephrol. 2003 May-Jun;16(3):357-64.
17. Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation. Cong H, etal., J Thorac Cardiovasc Surg. 2010 Aug;140(2):298-304. Epub 2010 Jan 18.
18. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
19. International union of pharmacology. XXIII. The angiotensin II receptors. de Gasparo M, etal., Pharmacol Rev. 2000 Sep;52(3):415-72.
20. Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Dolley-Hitze T, etal., Br J Cancer. 2010 Nov 23;103(11):1698-705.
21. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. Esteban V, etal., J Am Soc Nephrol. 2004 Jun;15(6):1514-29.
22. Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
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Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)EnsemblGRCm39 Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBIMGSCv36mm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36Build 36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
T2T-CHM13v2.03151,448,936 - 151,494,033 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKY
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1388,934,868 - 88,983,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11541,957,826 - 42,002,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604114,800,710 - 14,845,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473025,964,811 - 26,006,463 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:242
Interacting mature miRNAs:276
Transcripts:ENSMUST00000066412, ENSMUST00000143181
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,381,393 - 30,381,596UniSTSGRCm38
MGSCv371330,473,262 - 30,473,465UniSTSGRCm37
Celera1330,595,807 - 30,596,010UniSTS
Cytogenetic Map13A3.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,382,536 - 30,382,661UniSTSGRCm38
MGSCv371330,474,405 - 30,474,530UniSTSGRCm37
Celera1330,596,950 - 30,597,075UniSTS
Cytogenetic Map13A3.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,381,326 - 30,381,395UniSTSGRCm38
GRCm38320,315,999 - 20,316,068UniSTSGRCm38
MGSCv37320,214,921 - 20,214,990UniSTSGRCm37
MGSCv371330,473,195 - 30,473,264UniSTSGRCm37
Celera1330,595,740 - 30,595,809UniSTS
Celera320,305,099 - 20,305,168UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map3A2UniSTS
cM Map1316.0UniSTS
cM Map1316.0UniSTS
cM Map37.6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38320,315,694 - 20,316,334UniSTSGRCm38
GRCm381330,381,060 - 30,381,700UniSTSGRCm38
MGSCv371330,472,929 - 30,473,569UniSTSGRCm37
MGSCv37320,214,616 - 20,215,256UniSTSGRCm37
Celera1330,595,474 - 30,596,114UniSTS
Celera320,304,794 - 20,305,434UniSTS
Cytogenetic Map3A2UniSTS
Cytogenetic Map13A3.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,381,060 - 30,381,750UniSTSGRCm38
MGSCv371330,472,929 - 30,473,619UniSTSGRCm37
Celera1330,595,474 - 30,596,164UniSTS
Cytogenetic Map13A3.2UniSTS
cM Map1316.0UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000066412   ⟹   ENSMUSP00000070958
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143181
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,529,893 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,345,910 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221743   ⟹   ENSMUSP00000152634
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,529,524 - 30,565,089 (+)Ensembl
GRCm38.p6 Ensembl1330,345,541 - 30,381,106 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222370   ⟹   ENSMUSP00000152133
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,565,116 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,381,133 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222503   ⟹   ENSMUSP00000152873
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,564,980 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,380,997 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223201   ⟹   ENSMUSP00000152265
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,427 - 30,564,997 (+)Ensembl
GRCm38.p6 Ensembl1330,336,444 - 30,381,014 (+)Ensembl
RefSeq Acc Id: NM_177322   ⟹   NP_796296
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391330,520,339 - 30,566,850 (+)NCBI
GRCm381330,336,356 - 30,382,867 (+)ENTREZGENE
MGSCv371330,428,225 - 30,474,736 (+)RGD
Celera1330,550,710 - 30,597,281 (+)RGD
RefSeq Acc Id: XM_006516534   ⟹   XP_006516597
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391330,520,352 - 30,566,850 (+)NCBI
GRCm381330,336,366 - 30,382,867 (+)NCBI
RefSeq Acc Id: XM_011244264   ⟹   XP_011242566
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391330,528,891 - 30,566,850 (+)NCBI
GRCm381330,344,899 - 30,382,867 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_796296   ⟸   NM_177322
- UniProtKB: P29754 (UniProtKB/Swiss-Prot),   A0A6P5QW60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516597   ⟸   XM_006516534
- Peptide Label: isoform X1
- UniProtKB: P29754 (UniProtKB/Swiss-Prot),   A0A6P5QW60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242566   ⟸   XM_011244264
- Peptide Label: isoform X1
- UniProtKB: P29754 (UniProtKB/Swiss-Prot),   A0A6P5QW60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000070958   ⟸   ENSMUST00000066412
RefSeq Acc Id: ENSMUSP00000152265   ⟸   ENSMUST00000223201
RefSeq Acc Id: ENSMUSP00000152133   ⟸   ENSMUST00000222370
RefSeq Acc Id: ENSMUSP00000152873   ⟸   ENSMUST00000222503
RefSeq Acc Id: ENSMUSP00000152634   ⟸   ENSMUST00000221743

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AT1a I-TASSER model P29754 1-359 view protein structure
AF-P29754-F1-model_v2 AlphaFold P29754 1-359 view protein structure

RGD ID:8679984
Promoter ID:EPDNEW_M18023
Type:multiple initiation site
Description:Mus musculus angiotensin II receptor, type 1a , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381330,336,441 - 30,336,501EPDNEW
RGD ID:6823635
Promoter ID:MM_KWN:13687
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_177322,   OTTMUST00000001294
Mouse AssemblyChrPosition (strand)Source
MGSCv361330,428,169 - 30,428,669 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87964 AgrOrtholog
Ensembl Genes ENSMUSG00000049115 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000070958 ENTREZGENE
  ENSMUSP00000070958.8 UniProtKB/Swiss-Prot
  ENSMUSP00000152133.2 UniProtKB/TrEMBL
  ENSMUSP00000152265.2 UniProtKB/TrEMBL
  ENSMUSP00000152634.2 UniProtKB/TrEMBL
  ENSMUSP00000152873.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066412 ENTREZGENE
  ENSMUST00000066412.8 UniProtKB/Swiss-Prot
  ENSMUST00000221743.2 UniProtKB/TrEMBL
  ENSMUST00000222370.2 UniProtKB/TrEMBL
  ENSMUST00000222503.2 UniProtKB/TrEMBL
  ENSMUST00000223201.2 UniProtKB/TrEMBL
Gene3D-CATH 6.20.400.20 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:11607 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Agtr1a PhenoGen
  ANGIOTENSN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL