Agtr1a (angiotensin II receptor, type 1a) - Rat Genome Database

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Gene: Agtr1a (angiotensin II receptor, type 1a) Mus musculus
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Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
RGD ID: 737190
MGI Page MGI
Description: Enables angiotensin type I receptor activity. Involved in gene expression; positive regulation of cytokine production; and regulation of blood pressure. Acts upstream of or within several processes, including circulatory system development; regulation of blood pressure; and regulation of smooth muscle cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; extraembryonic component; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810074K20Rik; AG2S; Agt; Agt1ar; Agtr; Agtr-1a; Agtr1; AI551199; angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; Angt; Angtr-1a; AT; AT1; AT1 receptor A; AT1a; AT2R1; AT2R1A; MGC37610; type-1 angiotensin II receptor A; type-1A angiotensin II receptor
RGD Orthologs
Human
Rat
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)EnsemblGRCm39 Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBIMGSCv36mm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP,ISO)
AIDS-Associated Nephropathy  (IMP)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (IMP,ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
breast lobular carcinoma  (EXP)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (EXP,ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
cerebrovascular disease  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (IMP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (EXP)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (ISO)
Ductal Carcinoma  (EXP)
Endotoxemia  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (EXP,IMP)
Experimental Mammary Neoplasms  (EXP,ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (EXP,ISO)
focal segmental glomerulosclerosis  (ISO)
Friedreich ataxia  (ISO)
genetic disease  (ISO)
glomerulosclerosis  (ISO)
glucose intolerance  (EXP)
glycogen storage disease XV  (ISO)
Huntington's disease  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (IMP)
intermediate coronary syndrome  (ISO)
kidney disease  (EXP,ISO)
Left Ventricular Hypertrophy  (ISO)
limb ischemia  (IMP)
lung disease  (IEP)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
patent ductus arteriosus  (ISO)
Pituitary Neoplasms  (ISO)
placental insufficiency  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (IMP)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
sarcoidosis  (ISO)
Spontaneous Abortions  (ISO)
Vascular System Injuries  (EXP)
Ventricular Remodeling  (ISO)
vesicoureteral reflux  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-dihydroxybenzoic acid  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amlodipine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
ATP  (ISO)
benazepril  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
capsaicin  (ISO)
captopril  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
cholesterol  (EXP)
chromium(6+)  (ISO)
cilazapril monohydrate  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
corticosterone  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
diisononyl phthalate  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
esculetin  (ISO)
estriol  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glyoxylic acid  (ISO)
goralatide  (EXP)
Heptachlor epoxide  (EXP)
hexachlorobenzene  (ISO)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
irbesartan  (EXP,ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-ethionine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
mevinphos  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
Nandrolone decanoate  (ISO)
nerolidol  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nitrendipine  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
olmesartan  (ISO)
omeprazole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenylarsine oxide  (ISO)
phosphane  (ISO)
picrotoxin  (ISO)
pioglitazone  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregabalin  (ISO)
propanal  (ISO)
Ptaquiloside  (EXP)
quercetin  (EXP,ISO)
ramipril  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
spironolactone  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
superoxide  (ISO)
telmisartan  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
troglitazone  (EXP)
tryptophan  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
warfarin  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO)
angiotensin-activated signaling pathway  (ISO)
blood vessel development  (IGI)
brain renin-angiotensin system  (IMP)
calcium-mediated signaling  (ISO)
cell chemotaxis  (ISO)
cellular response to dexamethasone stimulus  (ISO)
dopamine biosynthetic process  (ISO)
drinking behavior  (IGI,IMP,ISO)
G protein-coupled receptor signaling pathway  (IBA,IC,ISO)
gene expression  (IMP)
heart development  (IMP)
inflammatory response  (IBA,IGI)
kidney development  (IGI,IMP,ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of smooth muscle cell apoptotic process  (IMP)
neuron apoptotic process  (IMP)
phospholipase C-activating angiotensin-activated signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood pressure  (IDA,IGI,IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (IMP)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of blood pressure  (IMP)
regulation of pH  (ISO)
regulation of renal output by angiotensin  (IMP)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (IGI)
regulation of vascular associated smooth muscle cell apoptotic process  (IGI)
regulation of vasoconstriction  (ISO)
renin secretion into blood stream  (IMP)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to activity  (ISO)
response to angiotensin  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to salt stress  (ISO)
Rho protein signal transduction  (ISO)
signal transduction  (IEA)
symbiont entry into host cell  (ISO)
vascular associated smooth muscle cell proliferation  (IMP)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway   (ISO)
angiotensin II signaling pathway   (ISO)
angiotensin II signaling pathway via AT1 receptor  (ISO,TAS)
angiotensin III signaling pathway  (ISO)
angiotensin III signaling pathway via AT1 receptor  (ISO)
atenolol pharmacodynamics pathway  (ISO)
benazepril pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
candesartan pharmacodynamics pathway  (ISO)
captopril pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
cilazapril pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
enalapril pharmacodynamics pathway  (ISO)
eprosartan pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forasartsn pharmacodynamics pathway  (ISO)
fosinopril pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
irbesartan pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lisinopril pharmacodynamics pathway   (ISO)
losartan pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
moexipril pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
olmesartan pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
perindopril pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinapril pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
ramipril pharmacodynamics pathway   (ISO)
renin-angiotensin cascade pathway  (IEA,TAS)
sotalol pharmacodynamics pathway  (ISO)
spirapril pharmacodynamics pathway  (ISO)
telmisartan pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
trandolapril pharmacodynamics pathway  (ISO)
valsartan pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue development  (IAGP)
abnormal amygdala morphology  (IAGP)
abnormal aorta elastic fiber morphology  (IAGP)
abnormal ascending aorta morphology  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal erythrocyte cell number  (IEA)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart rate  (IAGP)
abnormal hematocrit  (IEA)
abnormal hemoglobin content  (IEA)
abnormal juxtaglomerular apparatus morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney interlobular artery morphology  (IAGP)
abnormal kidney interstitium morphology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal kidney papilla morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal kidney vasculature morphology  (IAGP)
abnormal mean corpuscular hemoglobin  (IEA)
abnormal physiological response to xenobiotic  (IAGP)
abnormal platelet cell number  (IEA)
abnormal red blood cell distribution width  (IEA)
abnormal renal water reabsorption  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spleen morphology  (IEA)
abnormal systemic arterial blood pressure  (IAGP)
abnormal thalamus morphology  (IAGP)
absent kidney pelvis  (IAGP)
cardiac fibrosis  (IAGP)
cardiac interstitial fibrosis  (IAGP)
decreased aorta wall thickness  (IAGP)
decreased body weight  (IAGP)
decreased circulating angiotensin II level  (IAGP)
decreased circulating renin level  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased kidney weight  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased renin activity  (IAGP)
decreased susceptibility to induced aneurysm formation  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine potassium level  (IAGP)
decreased white fat cell number  (IAGP)
dilated kidney calyx  (IAGP)
dilated renal tubule  (IAGP)
enlarged heart  (IEA)
enlarged spleen  (IEA)
high mean erythrocyte cell number  (IAGP)
hydronephrosis  (IAGP)
hypotension  (IAGP)
increased aorta wall thickness  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating renin level  (IAGP)
increased fluid intake  (IAGP)
increased glomerular capsule space  (IAGP)
increased heart weight  (IAGP)
increased hemoglobin content  (IAGP)
increased renin activity  (IAGP)
increased spleen weight  (IEA)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased urine osmolality  (IAGP)
increased white fat cell size  (IAGP)
juxtaglomerular cell hyperplasia  (IAGP)
kidney cyst  (IAGP)
kidney inflammation  (IAGP)
kidney papillary hypoplasia  (IAGP)
muscular ventricular septal defect  (IAGP)
oliguria  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
polycystic kidney  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
renal fibrosis  (IAGP)
renal glomerulus atrophy  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Abdollahi MR, etal., Hum Mutat. 2007 Jan 8;28(4):365-373.
2. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. Ali MS, etal., J Biol Chem. 1997 Sep 12;272(37):23382-8.
3. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Araujo MA, etal., Int J Cardiol. 2005 Aug 3;103(1):27-32. Epub 2004 Dec 15.
4. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Differential responses to salt supplementation in adult male and female rat adrenal glands following intrauterine growth restriction. Bibeau K, etal., J Endocrinol. 2011 Apr;209(1):85-94. Epub 2011 Feb 8.
7. Gene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis. Biller H, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):139-46.
8. Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade. Bonnet F, etal., J Hypertens. 2002 Aug;20(8):1615-24.
9. Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. Bose KS and Sarma RH, Biochem Biophys Res Commun 1975 Oct 27;66(4):1173-9.
10. Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension. Boshra V, etal., Can J Physiol Pharmacol. 2011 Feb;89(2):103-7.
11. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
12. [Association of the renin-angiotensin system gene polymorphism with nephropathy in type II diabetes]. Buraczynska M, etal., Pol Arch Med Wewn. 2002 Aug;108(2):725-30.
13. Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. Cao Z, etal., J Am Soc Nephrol. 2002 Jul;13(7):1773-87.
14. Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. Chan LY, etal., J Am Soc Nephrol. 2005 Aug;16(8):2306-17. Epub 2005 Jun 1.
15. Upregulation of angiotensin II receptors in reflux nephropathy. Chertin B, etal., J Pediatr Surg. 2002 Feb;37(2):251-5.
16. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. Chung WK, etal., J Heart Lung Transplant. 2009 Apr;28(4):373-9.
17. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
18. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. Coll E, etal., J Nephrol. 2003 May-Jun;16(3):357-64.
19. Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation. Cong H, etal., J Thorac Cardiovasc Surg. 2010 Aug;140(2):298-304. Epub 2010 Jan 18.
20. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
21. International union of pharmacology. XXIII. The angiotensin II receptors. de Gasparo M, etal., Pharmacol Rev. 2000 Sep;52(3):415-72.
22. Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Dolley-Hitze T, etal., Br J Cancer. 2010 Nov 23;103(11):1698-705.
23. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. Esteban V, etal., J Am Soc Nephrol. 2004 Jun;15(6):1514-29.
24. Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
25. Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases. Gardemann A, etal., Eur Heart J. 1998 Nov;19(11):1657-65.
26. Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders. Ge J and Barnes NM, Eur J Pharmacol. 1996 Feb 22;297(3):299-306.
27. The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Ghosh S, etal., Am J Med Sci. 2002 Dec;324(6):296-304.
28. Angiotensin II AT-1A receptor immunolabeling in rat medial nucleus tractus solitarius neurons: subcellular targeting and relationships with catecholamines. Glass MJ, etal., Neuroscience. 2005;130(3):713-23.
29. Placental gene expression in a rat 'model' of placental insufficiency. Goyal R, etal., Placenta. 2010 Jul;31(7):568-75. Epub 2010 Jun 8.
30. Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Granzow M, etal., Hepatology. 2014 Jul;60(1):334-48. doi: 10.1002/hep.27117. Epub 2014 May 6.
31. Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Guo DF, etal., Biochem Biophys Res Commun. 2003 Oct 31;310(4):1254-65.
32. Renin and angiotensin II receptor gene expression in kidneys of renal hypertensive rats. Haefliger JA, etal., Hypertension. 1995 Nov;26(5):733-7.
33. Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Henriques T, etal., Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1251-6. Epub 2008 May 1.
34. Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Henskens LH, etal., Stroke. 2005 Sep;36(9):1869-73. Epub 2005 Aug 18.
35. Radionuclide imaging of angiotensin II type 1 receptor upregulation after myocardial ischemia-reperfusion injury. Higuchi T, etal., J Nucl Med. 2010 Dec;51(12):1956-61. Epub 2010 Nov 15.
36. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor? Hsu CN, etal., Int J Mol Sci. 2018 Aug 20;19(8):2459. doi: 10.3390/ijms19082459.
37. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
38. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
39. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
40. Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. Iijima K, etal., Jpn Circ J. 1998 Jun;62(6):449-54.
41. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
42. Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats. Iwai J, etal., Eur J Pharmacol. 1993 Dec 1;248(4):341-4.
43. Application of angiotensin II to healthy rat sciatic nerve can produce neuropathy without associated vasculopathy. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
44. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
45. A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Kelly M, etal., J Mol Cell Cardiol. 2011 Nov;51(5):848-54. doi: 10.1016/j.yjmcc.2011.07.001. Epub 2011 Jul 12.
46. Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
47. Angiotensin II receptor type 1 1166 A/C and angiotensin converting enzyme I/D gene polymorphisms in a Dutch sarcoidosis cohort. Kruit A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(2):147-52.
48. Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer's disease. Kume K, etal., Geriatr Gerontol Int. 2012 Apr;12(2):207-14. doi: 10.1111/j.1447-0594.2011.00746.x. Epub 2011 Sep 19.
49. Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts. Li L, etal., Cardiovasc Res. 2011 Mar 2.
50. [Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy]. Li YQ, etal., Sheng Li Xue Bao. 1998 Jun;50(3):303-8.
51. Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. Li Z, etal., Biochem Biophys Res Commun. 2014 Jun 20;449(1):74-80. doi: 10.1016/j.bbrc.2014.04.153. Epub 2014 May 9.
52. [ACE and AGTR1 genes polymorphisms in left ventricular hypertrophy pathogenesis in humans]. Makeeva OA, etal., Mol Biol (Mosk). 2004 Nov-Dec;38(6):990-6.
53. Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. Meng J, etal., Emerg Microbes Infect. 2020 Dec;9(1):757-760. doi: 10.1080/22221751.2020.1746200.
54. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
55. MGDs mouse GO annotations MGD data from the GO Consortium
56. MGD IEA MGD IEA
57. A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists. Michel MC, etal., Pharmacol Rev. 2013 Mar 13;65(2):809-48. doi: 10.1124/pr.112.007278. Print 2013 Apr.
58. TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor. Miura S, etal., J Biol Chem 2003 Feb 7;278(6):3720-5.
59. Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathy. Moulder JE, etal., Radiat Res. 2004 Mar;161(3):312-7.
60. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Naito T, etal., Am J Physiol Renal Physiol. 2010 Mar;298(3):F683-91. Epub 2009 Dec 30.
61. Activation of cardiac renin-angiotensin system in unstable angina. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
62. The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma. Ohwada K, etal., Clin Exp Allergy. 2007 Nov;37(11):1720-7. Epub 2007 Sep 17.
63. Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A. Ohyama K, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):362-7.
64. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
65. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
66. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Paradis P, etal., Proc Natl Acad Sci U S A 2000 Jan 18;97(2):931-6.
67. Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
68. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
69. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
70. Renin-angiotensin polymorphisms and QTc interval prolongation in end-stage renal disease. Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
71. Mouse MP Annotation Import Pipeline RGD automated import pipeline
72. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
73. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
74. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
75. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Samuelsson AM, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H787-96. Epub 2006 Mar 24.
76. Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis. Sasaki K, etal., J Clin Invest 2002 Mar;109(5):603-11.
77. [Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)]. Schrader J, etal., Med Klin (Munich). 2008 Jul 15;103(7):491-9. doi: 10.1007/s00063-008-1073-4.
78. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
79. Angiotensin II type 1 receptor blockade prevents up-regulation of angiotensin II type 1A receptors in rat injured artery. Tazawa S, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):898-904.
80. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
81. Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure. Uhlenius N, etal., Kidney Blood Press Res. 2002;25(2):71-9.
82. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
83. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
84. Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. Wagner C and Kurtz A, Pflugers Arch. 1998 Aug;436(3):323-8.
85. [Role of angiotensin II type 1 receptor in activation of nuclear factor-kappaB and activator protein-1 in lung of mice with acute lung injury]. Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6.
86. Effect of valsartan on the expression of angiotensin II receptors in the lung of chronic antigen exposure rats. Wang T, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2312-9.
87. Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice. Waseda Y, etal., Respir Res. 2008 May 23;9:43.
88. [The relationship between angiotensin II type 1 receptor gene and coronary heart disease, hypertension and diabetes mellitus in Chinese] Xiang K, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Feb 10;15(1):9-12.
89. Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Xu X, etal., Cardiovasc Res. 2008 Jun 1;78(3):523-32. doi: 10.1093/cvr/cvn028. Epub 2008 Feb 5.
90. Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat. Yamaguchi N, etal., Peptides. 2006 Sep;27(9):2258-70. Epub 2006 May 24.
91. Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis. Ye S, etal., Heart. 2003 Oct;89(10):1195-9.
92. Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension Zhang JQ, etal., Zhonghua Yi Xue Za Zhi. 2006 Apr 25;86(16):1138-43.
93. Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis. Zhu S and Meng QH, Clin Chem Lab Med. 2006;44(3):282-4.
94. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:1497638   PMID:1599461   PMID:7642517   PMID:7724593   PMID:7731139   PMID:8074205   PMID:8878439   PMID:9096120   PMID:9140053   PMID:9177228   PMID:9245700   PMID:9310306  
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PMID:11790405   PMID:11818364   PMID:11999647   PMID:12167595   PMID:12270869   PMID:12358147   PMID:12370342   PMID:12388241   PMID:12411470   PMID:12429556   PMID:12468582   PMID:12477932  
PMID:12486173   PMID:12591117   PMID:12657564   PMID:12680593   PMID:12691672   PMID:12697907   PMID:12707382   PMID:12890498   PMID:12907424   PMID:12909574   PMID:12963678   PMID:14551224  
PMID:14563714   PMID:14592959   PMID:14599720   PMID:14633624   PMID:14688210   PMID:14699015   PMID:14718357   PMID:14718562   PMID:14962948   PMID:14963002   PMID:15001561   PMID:15007032  
PMID:15016612   PMID:15059935   PMID:15087458   PMID:15123520   PMID:15129016   PMID:15146194   PMID:15277329   PMID:15306694   PMID:15331365   PMID:15489334   PMID:15498586   PMID:15498966  
PMID:15499027   PMID:15576667   PMID:15596561   PMID:15637093   PMID:15699451   PMID:15757644   PMID:15764682   PMID:15808846   PMID:15835378   PMID:15841186   PMID:15851599   PMID:15928210  
PMID:15944203   PMID:15998710   PMID:16001071   PMID:16023638   PMID:16094317   PMID:16104380   PMID:16126915   PMID:16141072   PMID:16141073   PMID:16214839   PMID:16223784   PMID:16254200  
PMID:16332932   PMID:16380537   PMID:16469824   PMID:16495379   PMID:16500763   PMID:16514431   PMID:16543233   PMID:16582578   PMID:16585392   PMID:16602821   PMID:16643970   PMID:16738017  
PMID:16888236   PMID:16902180   PMID:17028164   PMID:17043228   PMID:17060617   PMID:17090678   PMID:17148616   PMID:17158350   PMID:17213477   PMID:17220190   PMID:17224157   PMID:17318197  
PMID:17350036   PMID:17409281   PMID:17429342   PMID:17449556   PMID:17460297   PMID:17493931   PMID:17537986   PMID:17607364   PMID:17633135   PMID:17761193   PMID:17875676   PMID:17929248  
PMID:17962627   PMID:17982475   PMID:18033753   PMID:18037754   PMID:18045833   PMID:18049031   PMID:18094367   PMID:18180383   PMID:18188158   PMID:18192335   PMID:18258202   PMID:18258853  
PMID:18259044   PMID:18274671   PMID:18287559   PMID:18288458   PMID:18310259   PMID:18326554   PMID:18464932   PMID:18479832   PMID:18483625   PMID:18487452   PMID:18490898   PMID:18497303  
PMID:18551014   PMID:18579707   PMID:18650792   PMID:18753266   PMID:18945827   PMID:18971539   PMID:18971558   PMID:18974301   PMID:18989682   PMID:19017652   PMID:19023134   PMID:19047580  
PMID:19074984   PMID:19106212   PMID:19124678   PMID:19197138   PMID:19262461   PMID:19287096   PMID:19387470   PMID:19389828   PMID:19395110   PMID:19395552   PMID:19404405   PMID:19407821  
PMID:19464844   PMID:19508861   PMID:19604148   PMID:19628784   PMID:19628967   PMID:19666663   PMID:19696070   PMID:19706421   PMID:19706425   PMID:19710239   PMID:19759335   PMID:19762686  
PMID:19782130   PMID:19834109   PMID:19884564   PMID:19914088   PMID:19940029   PMID:19996062   PMID:20019328   PMID:20056745   PMID:20065159   PMID:20071356   PMID:20079903   PMID:20142565  
PMID:20205562   PMID:20413721   PMID:20516139   PMID:20530803   PMID:20554912   PMID:20580688   PMID:20628203   PMID:20807774   PMID:20843830   PMID:20964730   PMID:20970951   PMID:20975035  
PMID:21187267   PMID:21235392   PMID:21242463   PMID:21252156   PMID:21267068   PMID:21367915   PMID:21415394   PMID:21459331   PMID:21525005   PMID:21641389   PMID:21651842   PMID:21677750  
PMID:21751211   PMID:21753145   PMID:21774352   PMID:21822148   PMID:21825227   PMID:21849491   PMID:21852574   PMID:21873635   PMID:21887703   PMID:21921024   PMID:21979434   PMID:22052052  
PMID:22234465   PMID:22237799   PMID:22249006   PMID:22286690   PMID:22291447   PMID:22308361   PMID:22323719   PMID:22357914   PMID:22435601   PMID:22460554   PMID:22474255   PMID:22531728  
PMID:22534490   PMID:22539767   PMID:22610169   PMID:22665126   PMID:22673782   PMID:22739536   PMID:22837003   PMID:22844079   PMID:22869618   PMID:22919058   PMID:22954336   PMID:22986786  
PMID:23034941   PMID:23090770   PMID:23119030   PMID:23204186   PMID:23219751   PMID:23236507   PMID:23266541   PMID:23333075   PMID:23374104   PMID:23398821   PMID:23427083   PMID:23486953  
PMID:23580147   PMID:23585396   PMID:23592774   PMID:23636094   PMID:23831688   PMID:23937445   PMID:24001896   PMID:24014678   PMID:24096831   PMID:24154952   PMID:24166718   PMID:24177423  
PMID:24206662   PMID:24215514   PMID:24218433   PMID:24400170   PMID:24431207   PMID:24529758   PMID:24531548   PMID:24566994   PMID:24586922   PMID:24588264   PMID:24664319   PMID:24740791  
PMID:24743144   PMID:24799612   PMID:24834011   PMID:24838176   PMID:24952961   PMID:25143378   PMID:25171374   PMID:25217656   PMID:25241776   PMID:25249154   PMID:25391767   PMID:25395620  
PMID:25512346   PMID:25527780   PMID:25556973   PMID:25565204   PMID:25574809   PMID:25830096   PMID:25855778   PMID:25980014   PMID:26025227   PMID:26092119   PMID:26107632   PMID:26154270  
PMID:26160957   PMID:26209257   PMID:26227882   PMID:26257395   PMID:26445208   PMID:26531127   PMID:26637556   PMID:26667412   PMID:26727887   PMID:26744488   PMID:26773730   PMID:26864937  
PMID:26876143   PMID:26930476   PMID:27045029   PMID:27141055   PMID:27279487   PMID:27330080   PMID:27413199   PMID:27447725   PMID:27509058   PMID:27643439   PMID:27663860   PMID:27763643  
PMID:27782175   PMID:27841763   PMID:27911784   PMID:27917469   PMID:27955986   PMID:27991901   PMID:27992452   PMID:28181498   PMID:28219987   PMID:28254489   PMID:28263184   PMID:28329706  
PMID:28405625   PMID:28434702   PMID:28461455   PMID:28512108   PMID:28566500   PMID:28646220   PMID:28660748   PMID:28665931   PMID:28760942   PMID:28877878   PMID:29133788   PMID:29211853  
PMID:29268095   PMID:29269324   PMID:29296021   PMID:29364700   PMID:29371244   PMID:29412691   PMID:29433732   PMID:29464572   PMID:29470987   PMID:29505736   PMID:29541380   PMID:29574718  
PMID:29661841   PMID:29710550   PMID:29879378   PMID:29897266   PMID:29929188   PMID:29976627   PMID:29990483   PMID:29993275   PMID:30181481   PMID:30385711   PMID:30776402   PMID:30903169  
PMID:30969804   PMID:30971441   PMID:31339777   PMID:31420088   PMID:31479491   PMID:31665900   PMID:31886721   PMID:32372285   PMID:32856035   PMID:33328294   PMID:33380422   PMID:33390039  
PMID:33441837   PMID:33480126   PMID:33576779   PMID:33641366   PMID:33708117   PMID:33781840   PMID:33858944   PMID:33972750   PMID:34069164   PMID:34282828   PMID:34344365   PMID:34407634  
PMID:34576047   PMID:34884653   PMID:34905510   PMID:35044462   PMID:35105870   PMID:36259376   PMID:36555438   PMID:36627369   PMID:36801399   PMID:37296613   PMID:37540598   PMID:37909221  
PMID:38025786  


Genomics

Comparative Map Data
Agtr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)EnsemblGRCm39 Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBIMGSCv36mm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
AGTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36Build 36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
T2T-CHM13v2.03151,448,936 - 151,494,033 (+)NCBIT2T-CHM13v2.0
Agtr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,383,397 - 34,435,523 (-)NCBIGRCr8
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
AGTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1388,934,868 - 88,983,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,957,826 - 42,002,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604114,800,710 - 14,845,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agtr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473025,964,811 - 26,006,463 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agtr1a
1738 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:242
Interacting mature miRNAs:276
Transcripts:ENSMUST00000066412, ENSMUST00000143181
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse

Markers in Region
PMC162282P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,381,393 - 30,381,596UniSTSGRCm38
MGSCv371330,473,262 - 30,473,465UniSTSGRCm37
Celera1330,595,807 - 30,596,010UniSTS
Cytogenetic Map13A3.2UniSTS
AI551199  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,382,536 - 30,382,661UniSTSGRCm38
MGSCv371330,474,405 - 30,474,530UniSTSGRCm37
Celera1330,596,950 - 30,597,075UniSTS
Cytogenetic Map13A3.2UniSTS
Whitehead/MRC_RH13329.52UniSTS
Agtr1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,381,326 - 30,381,395UniSTSGRCm38
GRCm38320,315,999 - 20,316,068UniSTSGRCm38
MGSCv37320,214,921 - 20,214,990UniSTSGRCm37
MGSCv371330,473,195 - 30,473,264UniSTSGRCm37
Celera1330,595,740 - 30,595,809UniSTS
Celera320,305,099 - 20,305,168UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map3A2UniSTS
cM Map1316.0UniSTS
cM Map1316.0UniSTS
cM Map37.6UniSTS
Agtr1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38320,315,694 - 20,316,334UniSTSGRCm38
GRCm381330,381,060 - 30,381,700UniSTSGRCm38
MGSCv371330,472,929 - 30,473,569UniSTSGRCm37
MGSCv37320,214,616 - 20,215,256UniSTSGRCm37
Celera1330,595,474 - 30,596,114UniSTS
Celera320,304,794 - 20,305,434UniSTS
Cytogenetic Map3A2UniSTS
Cytogenetic Map13A3.2UniSTS
Agtr1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381330,381,060 - 30,381,750UniSTSGRCm38
MGSCv371330,472,929 - 30,473,619UniSTSGRCm37
Celera1330,595,474 - 30,596,164UniSTS
Cytogenetic Map13A3.2UniSTS
cM Map1316.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066412   ⟹   ENSMUSP00000070958
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143181
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,529,893 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,345,910 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221743   ⟹   ENSMUSP00000152634
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,529,524 - 30,565,089 (+)Ensembl
GRCm38.p6 Ensembl1330,345,541 - 30,381,106 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222370   ⟹   ENSMUSP00000152133
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,565,116 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,381,133 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222503   ⟹   ENSMUSP00000152873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,424 - 30,564,980 (+)Ensembl
GRCm38.p6 Ensembl1330,336,441 - 30,380,997 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223201   ⟹   ENSMUSP00000152265
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1330,520,427 - 30,564,997 (+)Ensembl
GRCm38.p6 Ensembl1330,336,444 - 30,381,014 (+)Ensembl
RefSeq Acc Id: NM_177322   ⟹   NP_796296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391330,520,339 - 30,566,850 (+)NCBI
GRCm381330,336,356 - 30,382,867 (+)ENTREZGENE
MGSCv371330,428,225 - 30,474,736 (+)RGD
Celera1330,550,710 - 30,597,281 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516534   ⟹   XP_006516597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391330,520,352 - 30,566,850 (+)NCBI
GRCm381330,336,366 - 30,382,867 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244264   ⟹   XP_011242566
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391330,528,891 - 30,566,850 (+)NCBI
GRCm381330,344,899 - 30,382,867 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_796296   ⟸   NM_177322
- UniProtKB: P29754 (UniProtKB/Swiss-Prot),   Q32MF7 (UniProtKB/TrEMBL),   Q8BU69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516597   ⟸   XM_006516534
- Peptide Label: isoform X1
- UniProtKB: P29754 (UniProtKB/Swiss-Prot),   Q32MF7 (UniProtKB/TrEMBL),   Q8BU69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242566   ⟸   XM_011244264
- Peptide Label: isoform X1
- UniProtKB: P29754 (UniProtKB/Swiss-Prot),   Q32MF7 (UniProtKB/TrEMBL),   Q8BU69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000070958   ⟸   ENSMUST00000066412
RefSeq Acc Id: ENSMUSP00000152265   ⟸   ENSMUST00000223201
RefSeq Acc Id: ENSMUSP00000152133   ⟸   ENSMUST00000222370
RefSeq Acc Id: ENSMUSP00000152873   ⟸   ENSMUST00000222503
RefSeq Acc Id: ENSMUSP00000152634   ⟸   ENSMUST00000221743

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AT1a I-TASSER model P29754 1-359 view protein structure
AF-P29754-F1-model_v2 AlphaFold P29754 1-359 view protein structure

Promoters
RGD ID:8679984
Promoter ID:EPDNEW_M18023
Type:multiple initiation site
Name:Agtr1a_1
Description:Mus musculus angiotensin II receptor, type 1a , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381330,336,441 - 30,336,501EPDNEW
RGD ID:6823635
Promoter ID:MM_KWN:13687
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_177322,   OTTMUST00000001294
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361330,428,169 - 30,428,669 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87964 AgrOrtholog
Ensembl Genes ENSMUSG00000049115 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066412 ENTREZGENE
  ENSMUST00000066412.8 UniProtKB/Swiss-Prot
  ENSMUST00000221743.2 UniProtKB/TrEMBL
  ENSMUST00000222370.2 UniProtKB/TrEMBL
  ENSMUST00000222503.2 UniProtKB/TrEMBL
  ENSMUST00000223201.2 UniProtKB/TrEMBL
Gene3D-CATH 6.20.400.20 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:11607 UniProtKB/Swiss-Prot
MGD MGI:87964 ENTREZGENE
NCBI Gene 11607 ENTREZGENE
PANTHER APELIN RECEPTOR UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB AGTR1 RGD
PhenoGen Agtr1a PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot
  ANGIOTENSN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VIT7_MOUSE UniProtKB/TrEMBL
  A0A1Y7VJY2_MOUSE UniProtKB/TrEMBL
  A0A1Y7VL16_MOUSE UniProtKB/TrEMBL
  A0A1Y7VMR7_MOUSE UniProtKB/TrEMBL
  AGTRA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q32MF7 ENTREZGENE
  Q8BU69 ENTREZGENE