Pitx3 (paired-like homeodomain transcription factor 3) - Rat Genome Database

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Gene: Pitx3 (paired-like homeodomain transcription factor 3) Mus musculus
Analyze
Symbol: Pitx3
Name: paired-like homeodomain transcription factor 3
RGD ID: 736766
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in lens development in camera-type eye; nervous system development; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within locomotory behavior; neuron development; and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Used to study Parkinson's disease and anterior segment dysgenesis. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ak; aphakia; homeobox protein PITX3; pituitary homeobox 3; Pituitary homeobox 3 (Homeobox protein PITX3); Ptx; Ptx3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,123,720 - 46,136,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,124,124 - 46,136,765 (-)EnsemblGRCm39 Ensembl
GRCm381946,135,281 - 46,148,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,135,685 - 46,148,326 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,210,175 - 46,222,815 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,188,996 - 46,201,636 (-)NCBIMGSCv36mm8
Celera1946,899,486 - 46,912,129 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior eye segment morphology  (IAGP)
abnormal autophagy  (IAGP)
abnormal bone structure  (IEA)
abnormal breathing pattern  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eye morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal gait  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal iris pigmentation  (IAGP)
abnormal lens development  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal motor coordination/balance  (IEA)
abnormal motor learning  (IEA)
abnormal neurite morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal ocular fundus morphology  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal respiratory function  (IAGP)
abnormal retina morphology  (IAGP)
abnormal sleep behavior  (IEA)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
acoria  (IAGP)
alpha-synuclein inclusion body  (IAGP)
anophthalmia  (IEA)
aphakia  (IAGP)
astrocytosis  (IAGP)
decreased anxiety-related response  (IAGP)
decreased blood uric acid level  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased chemical nociceptive threshold  (IAGP)
decreased circulating amylase level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating iron level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased exploration in new environment  (IAGP)
decreased grip strength  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased substantia nigra size  (IAGP)
decreased thermal nociceptive threshold  (IAGP)
decreased tidal volume  (IAGP)
decreased total body fat amount  (IAGP)
decreased vertical activity  (IAGP)
disorganized retina layers  (IAGP)
enlarged lacrimal gland  (IAGP)
eyelids fail to open  (IAGP)
fused cornea and lens  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IEA)
hyperresponsive to tactile stimuli  (IAGP)
impaired coordination  (IAGP)
increased anxiety-related response  (IAGP)
increased blood uric acid level  (IAGP)
increased body temperature  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating phosphate level  (IAGP)
increased coping response  (IEA)
increased energy expenditure  (IAGP)
increased fasting circulating glucose level  (IEA)
increased granulocyte number  (IAGP)
increased grip strength  (IEA)
increased heart rate  (IEA)
increased lean body mass  (IAGP)
increased locomotor activity  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuron number  (IAGP)
increased pulmonary respiratory rate  (IAGP)
loss of dopaminergic neurons  (IAGP)
microgliosis  (IAGP)
microphthalmia  (IAGP)
neuron degeneration  (IAGP)
reduced fertility  (IAGP)
retina fold  (IAGP)
short stride length  (IAGP)
shortened ST segment  (IEA)
slow postnatal weight gain  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. Addison PK, etal., Br J Ophthalmol. 2005 Feb;89(2):138-41.
2. Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Ardayfio P, etal., Neurobiol Dis. 2008 Sep;31(3):406-12. doi: 10.1016/j.nbd.2008.05.017. Epub 2008 Jun 4.
3. Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Bidinost C, etal., Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1274-80.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Rieger DK, etal., Genomics. 2001 Feb 15;72(1):61-72.
14. A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Semina EV, etal., Nat Genet 1998 Jun;19(2):167-70.
15. A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Smidt MP, etal., Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13305-10.
16. Anterior segment mesenchymal dysgenesis in a large Australian family is associated with the recurrent 17 bp duplication in PITX3. Summers KM, etal., Mol Vis. 2008;14:2010-5. Epub 2008 Nov 5.
17. Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. Wada K, etal., PLoS One. 2014 Oct 27;9(10):e111432. doi: 10.1371/journal.pone.0111432. eCollection 2014.
18. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6. Zhang Q, etal., Nat Genet 2003 Feb;33(2):145-53.
Additional References at PubMed
PMID:1093912   PMID:1155804   PMID:3522797   PMID:4970465   PMID:6745489   PMID:8402911   PMID:9328475   PMID:9520484   PMID:9883582   PMID:9922405   PMID:9932285   PMID:10051411  
PMID:10087301   PMID:10473596   PMID:10627821   PMID:10725922   PMID:10861284   PMID:11287205   PMID:11299318   PMID:12477932   PMID:12498783   PMID:12655058   PMID:12702666   PMID:12764108  
PMID:12829322   PMID:14622207   PMID:14645517   PMID:14681479   PMID:14973278   PMID:15016072   PMID:15385555   PMID:15584907   PMID:15618518   PMID:15691706   PMID:15728853   PMID:15950611  
PMID:16140547   PMID:16198487   PMID:16243425   PMID:16269007   PMID:16339193   PMID:16396906   PMID:16410412   PMID:16414173   PMID:16477036   PMID:16571633   PMID:16602821   PMID:16641236  
PMID:16741229   PMID:16782087   PMID:16837663   PMID:16968817   PMID:17159989   PMID:17184956   PMID:17499513   PMID:17540357   PMID:17592014   PMID:17670789   PMID:17687036   PMID:17761882  
PMID:17848564   PMID:17919745   PMID:17949697   PMID:17965710   PMID:18215235   PMID:18224708   PMID:18231602   PMID:18287559   PMID:18327786   PMID:18351630   PMID:18388307   PMID:18424556  
PMID:18495356   PMID:18543300   PMID:18588871   PMID:18704092   PMID:18820178   PMID:18953410   PMID:19007884   PMID:19144721   PMID:19334279   PMID:19439492   PMID:19508691   PMID:19515692  
PMID:19592574   PMID:19607821   PMID:19619134   PMID:19681134   PMID:19780901   PMID:19795519   PMID:19796621   PMID:19842188   PMID:19850875   PMID:19951692   PMID:20016108   PMID:20026251  
PMID:20033184   PMID:20035737   PMID:20059953   PMID:20105280   PMID:20211142   PMID:21057506   PMID:21122108   PMID:21187382   PMID:21205797   PMID:21267068   PMID:21347250   PMID:21752929  
PMID:21798254   PMID:21873635   PMID:21880902   PMID:21900559   PMID:21917791   PMID:22019014   PMID:22069189   PMID:22278924   PMID:22363463   PMID:22537018   PMID:22639370   PMID:22748019  
PMID:22764233   PMID:22820144   PMID:22870339   PMID:22875923   PMID:22993445   PMID:23145024   PMID:23159831   PMID:23213462   PMID:23264561   PMID:23331067   PMID:23357114   PMID:23453598  
PMID:23489835   PMID:23863478   PMID:24066094   PMID:24146773   PMID:24194600   PMID:24307298   PMID:24496614   PMID:24680684   PMID:24749075   PMID:24865427   PMID:24871946   PMID:24952961  
PMID:25033181   PMID:25051958   PMID:25281315   PMID:25501001   PMID:25661301   PMID:25762221   PMID:25804738   PMID:25948263   PMID:26123485   PMID:26164566   PMID:26317866   PMID:26363812  
PMID:26424886   PMID:26490861   PMID:26490873   PMID:26542012   PMID:26755703   PMID:26879466   PMID:26912775   PMID:26985023   PMID:27171818   PMID:27210758   PMID:27468917   PMID:27514757  
PMID:27626380   PMID:27798131   PMID:27927785   PMID:28174244   PMID:28246328   PMID:28413000   PMID:28424350   PMID:28706191   PMID:28800615   PMID:28883785   PMID:29038581   PMID:29163030  
PMID:29321139   PMID:29483281   PMID:29577367   PMID:30057204   PMID:30106373   PMID:30271956   PMID:30352686   PMID:30566076   PMID:30705619   PMID:30718509   PMID:30837649   PMID:30890737  
PMID:30930745   PMID:30991053   PMID:31604921   PMID:31825844   PMID:31850343   PMID:31989652   PMID:32075770   PMID:32191871   PMID:32387338   PMID:32562661   PMID:33000527   PMID:33195246  
PMID:35636646   PMID:35700056  


Genomics

Comparative Map Data
Pitx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,123,720 - 46,136,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,124,124 - 46,136,765 (-)EnsemblGRCm39 Ensembl
GRCm381946,135,281 - 46,148,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,135,685 - 46,148,326 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,210,175 - 46,222,815 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,188,996 - 46,201,636 (-)NCBIMGSCv36mm8
Celera1946,899,486 - 46,912,129 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
PITX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,230,189 - 102,241,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10102,230,186 - 102,241,512 (-)EnsemblGRCh38hg38GRCh38
GRCh3710103,989,946 - 104,001,269 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,979,936 - 103,991,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410103,979,935 - 103,991,221NCBI
Celera1097,730,869 - 97,742,153 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,622,237 - 97,633,522 (-)NCBIHuRef
CHM1_110104,273,459 - 104,284,755 (-)NCBICHM1_1
T2T-CHM13v2.010103,115,176 - 103,126,499 (-)NCBIT2T-CHM13v2.0
Pitx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,001,106 - 245,013,881 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,001,164 - 245,013,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,122,834 - 253,135,529 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01259,817,740 - 259,830,442 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01252,469,560 - 252,482,261 (-)NCBIRnor_WKY
Rnor_6.01265,886,766 - 265,899,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,887,230 - 265,899,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,317,125 - 273,330,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,355,785 - 251,368,502 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,616,353 - 251,629,068 (-)NCBI
Celera1240,784,495 - 240,797,213 (-)NCBICelera
Cytogenetic Map1q54NCBI
Pitx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,130,244 - 8,140,292 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,130,244 - 8,140,292 (+)NCBIChiLan1.0ChiLan1.0
PITX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110102,301,528 - 102,302,943 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01098,833,330 - 98,846,292 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PITX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,760,741 - 14,775,584 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,761,094 - 14,762,716 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,932,709 - 14,949,677 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,234,082 - 15,251,065 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,234,605 - 15,248,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,779,199 - 14,796,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,818,353 - 14,829,717 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,951,115 - 14,968,074 (-)NCBIUU_Cfam_GSD_1.0
Pitx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,004,580 - 32,016,313 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,607,819 - 3,620,917 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366003,607,883 - 3,619,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,230,965 - 113,241,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,230,194 - 113,241,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,084,113 - 123,095,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PITX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,266,257 - 95,278,333 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,266,582 - 95,268,139 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604856,368,363 - 56,370,376 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,650,381 - 1,651,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,649,585 - 1,651,729 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir133bmmu-miR-133b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20056941

Predicted Target Of
Summary Value
Count of predictions:764
Count of miRNA genes:423
Interacting mature miRNAs:487
Transcripts:ENSMUST00000026259, ENSMUST00000172971, ENSMUST00000172980
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse

Markers in Region
AF005772  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,135,721 - 46,135,815UniSTSGRCm38
MGSCv371946,210,211 - 46,210,305UniSTSGRCm37
Celera1946,899,522 - 46,899,616UniSTS
Cytogenetic Map19C3UniSTS
cM Map1947.0UniSTS
cM Map1946.5UniSTS
Whitehead/MRC_RH19455.85UniSTS
RH142219  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,135,789 - 46,135,983UniSTSGRCm38
MGSCv371946,210,279 - 46,210,473UniSTSGRCm37
Celera1946,899,590 - 46,899,784UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
cM Map1947.0UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,136,859 - 46,136,970UniSTSGRCm38
MGSCv371946,211,349 - 46,211,460UniSTSGRCm37
Celera1946,900,660 - 46,900,771UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,137,162 - 46,137,403UniSTSGRCm38
MGSCv371946,211,652 - 46,211,893UniSTSGRCm37
Celera1946,900,963 - 46,901,204UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,136,394 - 46,136,631UniSTSGRCm38
MGSCv371946,210,884 - 46,211,121UniSTSGRCm37
Celera1946,900,195 - 46,900,432UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,136,348 - 46,137,041UniSTSGRCm38
MGSCv371946,210,838 - 46,211,531UniSTSGRCm37
Celera1946,900,149 - 46,900,842UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,136,394 - 46,136,605UniSTSGRCm38
MGSCv371946,210,884 - 46,211,095UniSTSGRCm37
Celera1946,900,195 - 46,900,406UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,136,394 - 46,136,604UniSTSGRCm38
MGSCv371946,210,884 - 46,211,094UniSTSGRCm37
Celera1946,900,195 - 46,900,405UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map3E3-F1UniSTS
cM Map1946.5UniSTS
D1Bda64  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,136,387 - 46,137,059UniSTSGRCm38
MGSCv371946,210,877 - 46,211,549UniSTSGRCm37
Celera1946,900,188 - 46,900,860UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS
Pitx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map1946.5UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026259   ⟹   ENSMUSP00000026259
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,124,124 - 46,136,765 (-)Ensembl
GRCm38.p6 Ensembl1946,135,685 - 46,148,326 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172971   ⟹   ENSMUSP00000134563
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,125,471 - 46,129,422 (-)Ensembl
GRCm38.p6 Ensembl1946,137,032 - 46,140,983 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172980
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,124,934 - 46,125,728 (-)Ensembl
GRCm38.p6 Ensembl1946,136,495 - 46,137,289 (-)Ensembl
RefSeq Acc Id: NM_008852   ⟹   NP_032878
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391946,124,124 - 46,136,764 (-)NCBI
GRCm381946,135,685 - 46,148,325 (-)NCBI
MGSCv371946,210,175 - 46,222,815 (-)RGD
Celera1946,899,486 - 46,912,129 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526764   ⟹   XP_006526827
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391946,123,720 - 46,129,652 (-)NCBI
GRCm381946,135,281 - 46,141,213 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032878   ⟸   NM_008852
- UniProtKB: Q0VB03 (UniProtKB/Swiss-Prot),   O35160 (UniProtKB/Swiss-Prot),   A0A8C6GYG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526827   ⟸   XM_006526764
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000026259   ⟸   ENSMUST00000026259
RefSeq Acc Id: ENSMUSP00000134563   ⟸   ENSMUST00000172971
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35160-F1-model_v2 AlphaFold O35160 1-302 view protein structure

Promoters
RGD ID:13679668
Promoter ID:EPDNEW_M23983
Type:multiple initiation site
Name:Pitx3_1
Description:Mus musculus paired-like homeodomain transcription factor 3 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381946,148,381 - 46,148,441EPDNEW
RGD ID:6830310
Promoter ID:MM_KWN:27221
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000050294
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361946,222,906 - 46,223,406 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100498 AgrOrtholog
Ensembl Genes ENSMUSG00000025229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026259 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134563.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026259 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000172971.2 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_Pitx/unc30 UniProtKB/Swiss-Prot
  OAR_dom UniProtKB/Swiss-Prot
KEGG Report mmu:18742 UniProtKB/Swiss-Prot
MGD MGI:1100498 ENTREZGENE
NCBI Gene 18742 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot
PhenoGen Pitx3 PhenoGen
PIRSF Homeobox_protein_Pitx/Unc30 UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C6GYG8 ENTREZGENE
  G3UZN3_MOUSE UniProtKB/TrEMBL
  O35160 ENTREZGENE, UniProtKB/Swiss-Prot
  Q0VB03 ENTREZGENE
UniProt Secondary Q0VB03 UniProtKB/Swiss-Prot