Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) - Rat Genome Database

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Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) Mus musculus
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Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RGD ID: 1551142
MGI Page MGI
Description: Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to hydrostatic pressure; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a negative effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to glucose stimulus; negative regulation of apoptotic process; and regulation of macromolecule metabolic process. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330412C24Rik; caP; caPI3K; MGC161268; p110; p110alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)EnsemblGRCm39 Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBIMGSCv36mm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 33 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Pik3caMouseautosomal recessive polycystic kidney disease  ISORGD:62091610040950protein:increased expression:cholangiocyteRGD 
Pik3caMousebreast angiosarcoma  ISORGD:1352691151665102DNA:mutation:multiple (human)RGD 
Pik3caMouseBreast Neoplasms  ISORGD:13526912290476 RGD 
Pik3caMouseBreast Neoplasms  ISORGD:13526912313763 RGD 
Pik3caMouseCLOVES syndrome  ISORGD:135269113207409DNA: missense mutations: exon :p.H1047R, p.H1047LRGD 
Pik3caMousecolon adenocarcinoma  ISORGD:13526915685670DNA:mutationRGD 
Pik3caMousecolorectal carcinoma severityISORGD:135269114402406DNA:mutations:exons:RGD 
Pik3caMousecutaneous Paget's disease severityISORGD:135269114402410DNA:mutations:multiple:RGD 
Pik3caMouseDiabetic Cardiomyopathies amelioratesIEP 156430337 RGD 
Pik3caMouseEndometrial Neoplasms  ISORGD:13526914143515 RGD 
Pik3caMouseesophageal cancer  ISORGD:1352691152995510protein:increased expression:esophagus (human)RGD 
Pik3caMouseestrogen-receptor positive breast cancer treatmentISORGD:135269114402408DNA:mutations:plasma:RGD 
Pik3caMouseGastrointestinal Neoplasms  ISORGD:13526912290476 RGD 
Pik3caMousehepatocellular carcinoma  ISORGD:13526912290476 RGD 
Pik3caMousehepatocellular carcinoma treatmentISORGD:620916152177911 RGD 
Pik3caMousehepatocellular carcinoma susceptibilityISORGD:135269111556371DNA:SNPs: :rs17849071,rs17849079(human)RGD 
Pik3caMousehepatocellular carcinoma no_associationISORGD:135269114402405DNA:mutation:exon:RGD 
Pik3caMousehepatocellular carcinoma severityISORGD:135269114402404DNA:mutations:exons:RGD 
Pik3caMousehigh grade glioma  ISORGD:13526912290476 RGD 
Pik3caMouseHyperplasia  IMP 13207413 RGD 
1 to 20 of 33 rows
1 to 20 of 115 rows
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3caMouseAgenesis of Corpus Callosum  ISORGD:13526918554872ClinVar Annotator: match by term: Corpus callosum, agenesis ofClinVarPMID:25741868|PMID:28492532
Pik3caMousearteriovenous malformation  ISORGD:13526918554872ClinVar Annotator: match by term: Arteriovenous malformationClinVar 
Pik3caMouseBannayan-Riley-Ruvalcaba syndrome  ISORGD:13526918554872ClinVar Annotator: match by term: Cowden syndrome 1ClinVarPMID:15520168|PMID:22658544|PMID:22729222|PMID:23100325|PMID:23946963|PMID:25599672|PMID:25681199|PMID:25741868|PMID:26627007|PMID:27631024|PMID:28492532|PMID:29446767|PMID:34496175|PMID:34568242|PMID:34606700|PMID:37667289
Pik3caMouseBrain Neoplasms  ISORGD:85994879068941ClinVar Annotator: match by term: Brain NeoplasmsClinVarPMID:15016963|PMID:15254419|PMID:15520168|PMID:15647370|PMID:15805248|PMID:17673550|PMID:18676830|PMID:18725974|PMID:19366826|PMID:19903786|PMID:20453058|PMID:20619739|PMID:22162582|PMID:22162589|PMID:24265155|PMID:25157968|PMID:26619011
Pik3caMouseBrain Neoplasms  ISORGD:128343839068941ClinVar Annotator: match by term: Neoplasm of brainClinVarPMID:15016963|PMID:15254419|PMID:15647370|PMID:15805248|PMID:18676830|PMID:18725974|PMID:19366826|PMID:19903786|PMID:20453058|PMID:20619739|PMID:22162582|PMID:22162589|PMID:25741868|PMID:26619011
Pik3caMouseBrain Neoplasms  ISORGD:128343819068941ClinVar Annotator: match by term: Neoplasm of brainClinVarPMID:22209294|PMID:25741868|PMID:26619011|PMID:27631024
Pik3caMousebreast adenocarcinoma  ISORGD:13526918554872ClinVar Annotator: match by term: Breast adenocarcinoma | ClinVar Annotator: match by term: Breast adenocarcinoma, more ...ClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:15930273|PMID:17673550|PMID:20593314|PMID:21078999|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24782230|PMID:25599672|PMID:25681199|PMID:25741868|PMID:25880439|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26637981|PMID:26822237|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:29446767|PMID:29661094|PMID:29988677|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175|PMID:34568242|PMID:34606700|PMID:37667289|PMID:37712948|PMID:39825153
Pik3caMousebreast cancer  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, somaticClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:15930273|PMID:17673550|PMID:20593314|PMID:21078999|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24782230|PMID:25599672|PMID:25681199|PMID:25741868|PMID:25880439|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26637981|PMID:26822237|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:29446767|PMID:29661094|PMID:29988677|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175|PMID:34568242|PMID:34606700|PMID:37667289|PMID:37712948|PMID:39825153
Pik3caMousebreast cancer  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, somaticClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:15930273|PMID:17673550|PMID:20593314|PMID:21078999|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24782230|PMID:25599672|PMID:25681199|PMID:25741868|PMID:25880439|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26637981|PMID:26822237|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:29446767|PMID:29661094|PMID:29988677|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175|PMID:34568242|PMID:34606700|PMID:37667289|PMID:37712948
Pik3caMousebreast cancer  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, somatic | ClinVar Annotator: match by term: Malignant more ...ClinVarPMID:15016963|PMID:15254419|PMID:15520168|PMID:15608678|PMID:15647370|PMID:15805248|PMID:15930273|PMID:16906227|PMID:16930767|PMID:17673550|PMID:18676830|PMID:18725974|PMID:19029981|PMID:19223544|PMID:19366826|PMID:19513541|PMID:19903786|PMID:20453058|PMID:20593314|PMID:20619739|PMID:21078999|PMID:21430269|PMID:21558396|PMID:22162582|PMID:22162589|PMID:22271473|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23888070|PMID:23946963|PMID:24782230|PMID:25157968|PMID:25599672|PMID:25741868|PMID:25880439|PMID:26266975|PMID:26266985|PMID:26619011|PMID:26627007|PMID:26637981|PMID:26822237|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:29446767|PMID:29661094|PMID:29988677|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175|PMID:37712948
Pik3caMousebreast cancer  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, somaticClinVarPMID:15016963|PMID:15254419|PMID:15520168|PMID:15608678|PMID:15647370|PMID:15805248|PMID:15930273|PMID:16906227|PMID:16930767|PMID:17673550|PMID:18676830|PMID:18725974|PMID:19029981|PMID:19223544|PMID:19366826|PMID:19513541|PMID:19903786|PMID:20453058|PMID:20593314|PMID:20619739|PMID:21078999|PMID:21430269|PMID:21558396|PMID:22162582|PMID:22162589|PMID:22271473|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23888070|PMID:23946963|PMID:24782230|PMID:25157968|PMID:25599672|PMID:25741868|PMID:25880439|PMID:26266975|PMID:26266985|PMID:26619011|PMID:26627007|PMID:26637981|PMID:26822237|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:29661094|PMID:29988677|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175
Pik3caMousebreast cancer  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, somaticClinVarPMID:15016963|PMID:15254419|PMID:15520168|PMID:15608678|PMID:15647370|PMID:15805248|PMID:15930273|PMID:16906227|PMID:16930767|PMID:17673550|PMID:18676830|PMID:18725974|PMID:19029981|PMID:19223544|PMID:19366826|PMID:19513541|PMID:19903786|PMID:20453058|PMID:20619739|PMID:21078999|PMID:21430269|PMID:21558396|PMID:22162582|PMID:22162589|PMID:22271473|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23888070|PMID:24782230|PMID:25157968|PMID:25599672|PMID:25741868|PMID:25880439|PMID:26266975|PMID:26266985|PMID:26619011|PMID:26627007|PMID:26637981|PMID:26822237|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:29661094|PMID:29988677|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175
Pik3caMouseBreast Cancer, Familial  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, familial | ClinVar Annotator: match by term: Familial more ...ClinVarPMID:15016963|PMID:15254419|PMID:15520168|PMID:15608678|PMID:15647370|PMID:15805248|PMID:16906227|PMID:16930767|PMID:17376864|PMID:17673550|PMID:18676830|PMID:18725974|PMID:19029981|PMID:19223544|PMID:19366826|PMID:19513541|PMID:19903786|PMID:20453058|PMID:20593314|PMID:20619739|PMID:21430269|PMID:21558396|PMID:21824802|PMID:22162582|PMID:22162589|PMID:22271473|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729224|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24033266|PMID:24782230|PMID:25157968|PMID:25741868|PMID:26266975|PMID:26266985|PMID:26619011|PMID:26627007|PMID:26822237|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28492532|PMID:29988677|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175
Pik3caMouseBreast Cancer, Familial  ISORGD:13526918554872ClinVar Annotator: match by term: Breast cancer, familial | ClinVar Annotator: match by term: Familial more ...ClinVarPMID:17376864|PMID:22729222|PMID:22729224|PMID:24033266|PMID:25741868|PMID:27631024|PMID:28492532|PMID:33054853|PMID:35483878|PMID:37667289|PMID:37712948
Pik3caMousebreast carcinoma  ISORGD:13526918554872ClinVar Annotator: match by term: Carcinoma of breastClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:17673550|PMID:20593314|PMID:22370636|PMID:22658544|PMID:22729222|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24782230|PMID:25741868|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26822237|PMID:27126994|PMID:27626068|PMID:29988677|PMID:31536475|PMID:31775759|PMID:34008892|PMID:34496175|PMID:39825153
Pik3caMouseCapillary Malformation-Arteriovenous Malformation 1  ISORGD:13526918554872ClinVar Annotator: match by term: Capillary malformation-arteriovenous malformation 1ClinVar 
Pik3caMouseCardiovascular Abnormalities  ISORGD:13526918554872ClinVar Annotator: match by term: Abnormality of cardiovascular system morphologyClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:15930273|PMID:16353168|PMID:17376864|PMID:17673550|PMID:18074223|PMID:18371219|PMID:19671852|PMID:20177704|PMID:20593314|PMID:21078999|PMID:22120714|PMID:22228622|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:22949682|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24033266|PMID:24782230|PMID:25326635|PMID:25326637|PMID:25599672|PMID:25741868|PMID:25880439|PMID:25915946|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26637981|PMID:26822237|PMID:26851524|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:28492532|PMID:28502725|PMID:29446767|PMID:29661094|PMID:29758562|PMID:29988677|PMID:30063105|PMID:30231930|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:32595695|PMID:33077954|PMID:34008892|PMID:34496175|PMID:36474027|PMID:37712948|PMID:39825153
Pik3caMouseCerebral Cavernous Malformation 4  ISORGD:13526918554872ClinVar Annotator: match by term: Cerebral cavernous malformation 4 | ClinVar Annotator: match by term: more ...ClinVarPMID:25741868|PMID:28492532
Pik3caMouseCLAPO Syndrome  ISORGD:13526918554872ClinVar Annotator: match by term: CLAPO syndrome | ClinVar Annotator: match by term: Capillary malformation more ...ClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:15930273|PMID:17376864|PMID:17673550|PMID:18074223|PMID:20593314|PMID:22120714|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729224|PMID:22949682|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24033266|PMID:24782230|PMID:25599672|PMID:25681199|PMID:25741868|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26822237|PMID:26851524|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28492532|PMID:29446767|PMID:29988677|PMID:31536475|PMID:31775759|PMID:33054853|PMID:34008892|PMID:34496175|PMID:34568242|PMID:34606700|PMID:35483878|PMID:37667289|PMID:37712948|PMID:39825153
Pik3caMouseCLOVES syndrome  ISORGD:13526918554872ClinVar Annotator: match by term: CLOVE SYNDROME | ClinVar Annotator: match by term: CLOVES syndrome more ...ClinVarPMID:15016963|PMID:15520168|PMID:15608678|PMID:15930273|PMID:17376864|PMID:17673550|PMID:18074223|PMID:20593314|PMID:21078999|PMID:22120714|PMID:22228622|PMID:22370636|PMID:22658544|PMID:22729222|PMID:22729223|PMID:22729224|PMID:22949682|PMID:23066039|PMID:23100325|PMID:23946963|PMID:24033266|PMID:24782230|PMID:25326635|PMID:25326637|PMID:25599672|PMID:25681199|PMID:25741868|PMID:25880439|PMID:25915946|PMID:26266975|PMID:26266985|PMID:26627007|PMID:26637981|PMID:26822237|PMID:26851524|PMID:27126994|PMID:27626068|PMID:27631024|PMID:28151489|PMID:28425981|PMID:28492532|PMID:28502725|PMID:28941273|PMID:29296277|PMID:29446767|PMID:29661094|PMID:29758562|PMID:29988677|PMID:30063105|PMID:30231930|PMID:30376034|PMID:30543347|PMID:31536475|PMID:31775759|PMID:32595695|PMID:32778138|PMID:33054853|PMID:33077954|PMID:34008892|PMID:34496175|PMID:34568242|PMID:34606700|PMID:35483878|PMID:36474027|PMID:37667289|PMID:37712948|PMID:39825153
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3caMouseadenocarcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:22484628
Pik3caMouseadenoid cystic carcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:23685749
Pik3caMousebasal cell carcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:26950094
Pik3caMouseBreast Neoplasms  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:19196980|PMID:19685490|PMID:20479250|PMID:21633166|PMID:22370636|PMID:25267515|PMID:25358515|PMID:26587011
Pik3caMouseCLOVES syndrome  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTD 
Pik3caMouseColorectal Neoplasms  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTD 
Pik3caMousecomplex cortical dysplasia with other brain malformations  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:22729223
Pik3caMousediffuse large B-cell lymphoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:21173233
Pik3caMouseDisease Progression  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:29106415
Pik3caMouseepidermal nevus  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTD 
Pik3caMouseesophagus adenocarcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:23525077
Pik3caMouseGrowth Disorders  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:22729222
Pik3caMousehead and neck squamous cell carcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:23873848
Pik3caMousehepatocellular carcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTD 
Pik3caMouseHyperplasia  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:22729222
Pik3caMouselung adenocarcinoma  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:22135231
Pik3caMouseLung Neoplasms  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTD 
Pik3caMouseMegalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:22729224
Pik3caMouseMouth Neoplasms  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:24224046
Pik3caMouseNeoplasm Metastasis  ISORGD:135269111554173CTD Direct Evidence: marker/mechanismCTDPMID:29106415
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Object Symbol
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Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3caMousebreast cancer  IAGP 13592920OMIM:114480MouseDO 
Pik3caMouseCLOVES syndrome  IAGP 13592920OMIM:612918MouseDO 
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3caMousebreast cancer  ISORGD:13526917240710 OMIM 
Pik3caMouseCerebral Cavernous Malformation 4  ISORGD:13526917240710 OMIM 
Pik3caMouseCLAPO Syndrome  ISORGD:13526917240710 OMIM 
Pik3caMouseCLOVES syndrome  ISORGD:13526917240710 OMIM 
Pik3caMousecolorectal cancer  ISORGD:13526917240710 OMIM 
Pik3caMouseCowden syndrome 5  ISORGD:13526917240710 OMIM 
Pik3caMouseepidermal nevus  ISORGD:13526917240710 OMIM 
Pik3caMouseHemifacial Myohyperplasia  ISORGD:13526917240710 OMIM 
Pik3caMousehepatocellular carcinoma  ISORGD:13526917240710 OMIM 
Pik3caMouselung cancer  ISORGD:13526917240710 OMIM 
Pik3caMouseMegalencephaly - Cutis Marmorata Telangiectatica Congenita  ISORGD:13526917240710 OMIM 
Pik3caMouseMegalodactyly  ISORGD:13526917240710 OMIM 
Pik3caMouseovarian cancer  ISORGD:13526917240710 OMIM 
Pik3caMouseseborrheic keratosis  ISORGD:13526917240710 OMIM 
Pik3caMousestomach cancer  ISORGD:13526917240710 OMIM 
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1 to 20 of 217 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3caMouse(+)-taxifolin multiple interactionsISORGD:6209166480464taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in more ...CTDPMID:32828744
Pik3caMouse(S)-nicotine increases expressionISORGD:13526916480464Nicotine results in increased expression of PIK3CA mRNACTDPMID:16949557
Pik3caMouse1,2-dimethylhydrazine increases expressionEXP 64804641,2-Dimethylhydrazine results in increased expression of PIK3CA mRNACTDPMID:22206623
Pik3caMouse1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionISORGD:6209166480464Citalopram results in increased expression of PIK3CA mRNACTDPMID:28467792
Pik3caMouse17beta-estradiol increases expressionISORGD:13526916480464Estradiol results in increased expression of PIK3CA mRNACTDPMID:16029874|PMID:29783106
Pik3caMouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PIK3CA mRNACTDPMID:22467019
Pik3caMouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:62091664804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PIK3CA mRNACTDPMID:21394737
Pik3caMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PIK3CA mRNACTDPMID:19770486
Pik3caMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:6209166480464Tetrachlorodibenzodioxin results in increased expression of PIK3CA mRNACTDPMID:34747641
Pik3caMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PIK3CA mRNACTDPMID:21570461
Pik3caMouse2,5-hexanedione decreases expressionEXP 64804642,5-hexanedione results in decreased expression of PIK3CA mRNACTDPMID:33197454
Pik3caMouse4,4'-diaminodiphenylmethane increases expressionEXP 64804644,4'-diaminodiphenylmethane results in increased expression of PIK3CA mRNACTDPMID:18648102
Pik3caMouse4,4'-sulfonyldiphenol increases phosphorylationISORGD:13526916480464bisphenol S results in increased phosphorylation of PIK3CA proteinCTDPMID:39032682
Pik3caMouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of PIK3CA mRNACTDPMID:39298647
Pik3caMouse5-fluorouracil decreases expressionISORGD:13526916480464Fluorouracil results in decreased expression of PIK3CA mRNA mutant formCTDPMID:38423379
Pik3caMouse6-propyl-2-thiouracil multiple interactionsISORGD:6209166480464xiaoluowan inhibits the reaction [Propylthiouracil results in increased expression of PIK3CA protein]CTDPMID:35101570
Pik3caMouse6-propyl-2-thiouracil decreases expressionISORGD:6209166480464Propylthiouracil results in decreased expression of PIK3CA mRNACTDPMID:30047161
Pik3caMouse6-propyl-2-thiouracil increases expressionISORGD:6209166480464Propylthiouracil results in increased expression of PIK3CA proteinCTDPMID:35101570
Pik3caMouseacrylamide decreases expressionISORGD:6209166480464Acrylamide results in decreased expression of PIK3CA mRNACTDPMID:31644924
Pik3caMouseacrylamide increases expressionISORGD:13526916480464Acrylamide results in increased expression of PIK3CA mRNACTDPMID:32763439

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Biological Process
1 to 20 of 61 rows

  
Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3caMouseactin cytoskeleton organization involved_inIMP 2290270 PMID:30568254BHF-UCLPMID:30568254
Pik3caMouseadipose tissue development acts_upstream_of_or_withinIMPMGI:48458562290270 PMID:24691033MGIPMID:24691033
Pik3caMouseangiogenesis involved_inIEAUniProtKB-KW:KW-00372290270 UniProtGO_REF:0000043
Pik3caMouseautosome genomic imprinting acts_upstream_of_negative_effectIDA 2290270 PMID:21047779BHF-UCLPMID:21047779
Pik3caMousecardiac muscle cell contraction involved_inIMP 2290270 PMID:30568254BHF-UCLPMID:30568254
Pik3caMousecell migration involved_inIBAPANTHER:PTN000005674|FB:FBgn0015279|UniProtKB:O42391|UniProtKB:A0A8M9Q5U72290270 GO_CentralGO_REF:0000033
Pik3caMousecellular response to glucose stimulus acts_upstream_of_or_withinIMPMGI:48458562290270 PMID:24691033MGIPMID:24691033
Pik3caMousecellular response to hydrostatic pressure involved_inIMP 2290270 PMID:30568254BHF-UCLPMID:30568254
Pik3caMousecellular response to insulin stimulus involved_inISOUniProtKB:P423362290270 GO_CentralGO_REF:0000119
Pik3caMouseenergy homeostasis acts_upstream_of_or_withinIMPMGI:48458562290270 PMID:24691033MGIPMID:24691033
Pik3caMouseglucose metabolic process acts_upstream_of_or_withinIMPMGI:36288052290270 PMID:16625210MGIPMID:16625210
Pik3caMouseinsulin receptor signaling pathway involved_inIMPMGI:36914862290270 PMID:20197055MGIPMID:20197055
Pik3caMouseinsulin-like growth factor receptor signaling pathway involved_inIDA 2290270 PMID:11784871MGIPMID:11784871
Pik3caMouseinsulin-like growth factor receptor signaling pathway involved_inIMP 2290270 PMID:26872540MGIPMID:26872540
Pik3caMouseliver development acts_upstream_of_or_withinIMPMGI:48458562290270 PMID:24691033MGIPMID:24691033
Pik3caMousenegative regulation of actin filament depolymerization involved_inIMP 2290270 PMID:30568254BHF-UCLPMID:30568254
Pik3caMousenegative regulation of anoikis involved_inISOUniProtKB:P423362290270 GO_CentralGO_REF:0000119
Pik3caMousenegative regulation of anoikis involved_inIEAUniProtKB:P42336|ensembl:ENSP000002639672290270 EnsemblGO_REF:0000107
Pik3caMousenegative regulation of fibroblast apoptotic process acts_upstream_of_or_withinIDA 2290270 PMID:15192701MGIPMID:15192701
Pik3caMousenegative regulation of gene expression involved_inISORGD:6209162290270 GO_CentralGO_REF:0000096
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Cellular Component
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Object Symbol
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Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3caMousecytoplasm is_active_inIBAPANTHER:PTN000005673|SGD:S000004230|RGD:621213|UniProtKB:P48736|UniProtKB:O00750|SGD:S000005211|dictyBase:DDB_G0291093|UniProtKB:P42356|MGI:2445019|UniProtKB:P42338|UniProtKB:Q8I3V5|UniProtKB:O00443|WB:WBGene00009552|UniProtKB:P32871|WB:WBGene00006932|PomBase:SPAC22E12.16c|UniProtKB:Q9UBF8|FB:FBgn0015278|FB:FBgn0015277|dictyBase:DDB_G0283081|FB:FBgn0004373|UniProtKB:Q8NEB9|MGI:2685045|TAIR:locus:2010202|UniProtKB:Q57WD8|WB:WBGene00000090|TAIR:locus:21644012290270 GO_CentralGO_REF:0000033
Pik3caMousecytosol located_inTAS 2290270 ReactomeReactome:R-MMU-9027268|Reactome:R-MMU-9031553|Reactome:R-MMU-9680646|Reactome:R-MMU-9682158|Reactome:R-MMU-9682182|Reactome:R-MMU-9860560|Reactome:R-MMU-9860569|Reactome:R-MMU-9863577|Reactome:R-NUL-9031077|Reactome:R-NUL-9603412|Reactome:R-NUL-9616944
Pik3caMouseintercalated disc located_inIDA 2290270 PMID:30568254BHF-UCLPMID:30568254
Pik3caMouselamellipodium located_inIDA 2290270 PMID:14657280MGIPMID:14657280
Pik3caMousephosphatidylinositol 3-kinase complex  ISORGD:6209169068941 RGDPMID:12882977|REF_RGD_ID:4144086
Pik3caMousephosphatidylinositol 3-kinase complex part_ofISORGD:6209162290270 GO_CentralGO_REF:0000096
Pik3caMousephosphatidylinositol 3-kinase complex part_ofIPIPR:Q641432290270 PMID:7542745MGIPMID:7542745
Pik3caMousephosphatidylinositol 3-kinase complex, class IA part_ofIEAUniProtKB:P42336|ensembl:ENSP000002639672290270 EnsemblGO_REF:0000107
Pik3caMousephosphatidylinositol 3-kinase complex, class IA part_ofISOUniProtKB:P423362290270 GO_CentralGO_REF:0000119
Pik3caMousephosphatidylinositol 3-kinase complex, class IA part_ofIBAPANTHER:PTN000799659|UniProtKB:P48736|UniProtKB:P423362290270 GO_CentralGO_REF:0000033
Pik3caMousephosphatidylinositol 3-kinase complex, class IB part_ofIBAPANTHER:PTN000799659|UniProtKB:P487362290270 GO_CentralGO_REF:0000033
Pik3caMouseplasma membrane is_active_inIBAPANTHER:PTN000005674|UniProtKB:O00750|dictyBase:DDB_G0283081|dictyBase:DDB_G0278727|UniProtKB:P48736|UniProtKB:O00443|RGD:6209172290270 GO_CentralGO_REF:0000033
1 to 12 of 12 rows

Molecular Function
1 to 20 of 40 rows

  
Object Symbol
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Term
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Reference
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Source
Original Reference(s)
Pik3caMouse1-phosphatidylinositol-3-kinase activity enablesISOUniProtKB:P423362290270 GO_CentralGO_REF:0000119
Pik3caMouse1-phosphatidylinositol-3-kinase activity enablesIMP 2290270 PMID:26872540MGIPMID:26872540
Pik3caMouse1-phosphatidylinositol-3-kinase activity enablesIMPMGI:36914862290270 PMID:20197055MGIPMID:20197055
Pik3caMouse1-phosphatidylinositol-3-kinase activity enablesIDA 2290270 PMID:11784871, PMID:14657280MGIPMID:11784871|PMID:14657280
Pik3caMouse1-phosphatidylinositol-3-kinase activity enablesISORGD:6209162290270 GO_CentralGO_REF:0000096
Pik3caMouse1-phosphatidylinositol-3-kinase activity enablesIBAPANTHER:PTN000005674|RGD:1306468|RGD:620231|UniProtKB:P32871|FB:FBgn0015279|RGD:620917|MGI:1353576|UniProtKB:O00443|MGI:1206581|RGD:620916|UniProtKB:P42336|MGI:1922019|UniProtKB:O00750|MGI:1203729|MGI:1203730|UniProtKB:P48736|FB:FBgn00152782290270 GO_CentralGO_REF:0000033
Pik3caMouse1-phosphatidylinositol-3-kinase activity  ISORGD:6209169068941 RGDPMID:12882977|REF_RGD_ID:4144086
Pik3caMouse1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity enablesTAS 2290270 ReactomeReactome:R-NUL-9616944
Pik3caMouse1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity enablesISOUniProtKB:P423362290270 GO_CentralGO_REF:0000119
Pik3caMouse1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity enablesIBAPANTHER:PTN000799659|UniProtKB:O42391|UniProtKB:P48736|UniProtKB:P423362290270 GO_CentralGO_REF:0000033
Pik3caMouse1-phosphatidylinositol-4-phosphate 3-kinase activity enablesIBAPANTHER:PTN000005674|RGD:620231|UniProtKB:O00750|MGI:1203730|UniProtKB:P48736|UniProtKB:O00443|FB:FBgn0015278|FB:FBgn00152792290270 GO_CentralGO_REF:0000033
Pik3caMouse3-phosphoinositide-dependent protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMouseAMP-activated protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMouseATP binding enablesIEAUniProtKB-KW:KW-00672290270 UniProtGO_REF:0000043
Pik3caMouseDNA-dependent protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMouseeukaryotic translation initiation factor 2alpha kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMousehistone H2AS1 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMousehistone H2AS121 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMousehistone H2AT120 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Pik3caMousehistone H2AXS139 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
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RGD Manual Annotations

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1 to 11 of 11 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3caMouseadenosine signaling pathway  ISORGD:135269110402751 SMPDBSMP:00320
Pik3caMouseadenosine signaling pathway  ISORGD:135269110402751 SMPDBSMP:00321
Pik3caMouseFc epsilon receptor mediated signaling pathway  ISORGD:135269110402751 SMPDBSMP:00358
Pik3caMouseinositol metabolic pathway  ISORGD:135269110402751 SMPDBSMP:00011
Pik3caMousephosphoinositide metabolic pathway  ISORGD:135269110402751 SMPDBSMP:00463

Imported Annotations - KEGG (archival)

1 to 20 of 32 rows
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3caMouseacute myeloid leukemia pathway  IEA 6907045 KEGGmmu:05221
Pik3caMousealdosterone signaling pathway   IEA 6907045 KEGGmmu:04960
Pik3caMouseapoptotic cell death pathway  IEA 6907045 KEGGmmu:04210
Pik3caMouseB cell receptor signaling pathway  IEA 6907045 KEGGmmu:04662
Pik3caMouseceramide signaling pathway  IEA 6907045 KEGGmmu:05212
Pik3caMouseChagas disease pathway  IEA 6907045 KEGGmmu:05142
Pik3caMousechronic myeloid leukemia pathway  IEA 6907045 KEGGmmu:05220
Pik3caMousecolorectal cancer pathway   IEA 6907045 KEGGmmu:05210
Pik3caMouseendometrial cancer pathway   IEA 6907045 KEGGmmu:05213
Pik3caMouseEntamoebiasis pathway  IEA 6907045 KEGGmmu:05146
Pik3caMouseepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGmmu:04012
Pik3caMouseglioma pathway  IEA 6907045 KEGGmmu:05214
Pik3caMousehepatitis C pathway  IEA 6907045 KEGGmmu:05160
Pik3caMouseinfluenza A pathway  IEA 6907045 KEGGmmu:05164
Pik3caMouseinositol phosphate metabolic pathway  IEA 6907045 KEGGmmu:00562
Pik3caMouseinsulin signaling pathway   IEA 6907045 KEGGmmu:04910
Pik3caMouseJak-Stat signaling pathway   IEA 6907045 KEGGmmu:04630
Pik3caMousemeasles pathway  IEA 6907045 KEGGmmu:05162
Pik3caMousemelanoma pathway  IEA 6907045 KEGGmmu:05218
Pik3caMousemTOR signaling pathway   IEA 6907045 KEGGmmu:04150
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Imported Annotations - PID (archival)

1 to 20 of 28 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3caMouseE-cadherin signaling pathway  ISORGD:13526916484113 PIDPID:200124
Pik3caMouseE-cadherin signaling pathway  ISORGD:13526916484113 PIDPID:200147
Pik3caMouseephrin - ephrin receptor bidirectional signaling axis  ISORGD:13526916484113 PIDPID:200204
Pik3caMouseephrin - ephrin receptor bidirectional signaling axis  ISORGD:13526916484113 PIDPID:200052
Pik3caMouseephrin - ephrin receptor bidirectional signaling axis  ISORGD:13526916484113 PIDPID:200216
Pik3caMouseepidermal growth factor/neuregulin signaling pathway   ISORGD:13526916484113 PIDPID:200101
Pik3caMouseFasL mediated signaling pathway   ISORGD:13526916484113 PIDPID:200080
Pik3caMousefibroblast growth factor signaling pathway  ISORGD:13526916484113 PIDPID:200220
Pik3caMousegranulocyte-macrophage colony-stimulating factor signaling pathway  ISORGD:13526916484113 PIDPID:200019
Pik3caMouseHedgehog signaling pathway   ISORGD:13526916484113 PIDPID:200168
Pik3caMouseinsulin signaling pathway   ISORGD:13526916484113 PIDPID:200014
Pik3caMouseinsulin-like growth factor signaling pathway  ISORGD:13526916484113 PIDPID:200100
Pik3caMouseinterleukin-1 signaling pathway   ISORGD:13526916484113 PIDPID:200089
Pik3caMouseinterleukin-2 signaling pathway  ISORGD:13526916484113 PIDPID:200098
Pik3caMouseinterleukin-23 signaling pathway  ISORGD:13526916484113 PIDPID:200154
Pik3caMouseinterleukin-3 signaling pathway  ISORGD:13526916484113 PIDPID:200145
Pik3caMouseinterleukin-4 signaling pathway  ISORGD:13526916484113 PIDPID:200022
Pik3caMouseinterleukin-5 signaling pathway  ISORGD:13526916484113 PIDPID:200107
Pik3caMouseinterleukin-6 signaling pathway   ISORGD:13526916484113 PIDPID:200146
Pik3caMouseN-cadherin signaling pathway  ISORGD:13526916484113 PIDPID:200209
1 to 20 of 28 rows
1 to 20 of 106 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3caMouseabnormal angiogenesis  IAGP 5509061 MGIPMID:18449193
Pik3caMouseabnormal anogenital distance  IAGP 5509061 MGIPMID:28357399
Pik3caMouseabnormal anterior cardinal vein morphology  IAGP 5509061 MGIPMID:15687236
Pik3caMouseabnormal brain vasculature morphology  IAGP 5509061 MGIPMID:15687236
Pik3caMouseabnormal branching of the mammary ductal tree  IAGP 5509061 MGIPMID:22666336
Pik3caMouseabnormal branching of the mammary ductal tree  IAGP 5509061 MGIPMID:22370636
Pik3caMouseabnormal cell physiology  IAGP 5509061 MGIPMID:17060635
Pik3caMouseabnormal cell physiology  IAGP 5509061 MGIPMID:18594509
Pik3caMouseabnormal circulating androgen level  IAGP 5509061 MGIPMID:28357399
Pik3caMouseabnormal diaphragm morphology  IAGP 5509061 MGIPMID:22214849
Pik3caMouseabnormal dorsal aorta morphology  IAGP 5509061 MGIPMID:18449193
Pik3caMouseabnormal endocardium morphology  IAGP 5509061 MGIPMID:15687236
Pik3caMouseabnormal hormone level  IAGP 5509061 MGIPMID:28357399
Pik3caMouseabnormal intersomitic vessel morphology  IAGP 5509061 MGIPMID:18449193
Pik3caMouseabnormal lymphangiogenesis  IAGP 5509061 MGIPMID:17540175
Pik3caMouseabnormal lymphatic vessel morphology  IAGP 5509061 MGIPMID:17540175
Pik3caMouseabnormal mammary duct terminal end bud morphology  IAGP 5509061 MGIPMID:22666336
Pik3caMouseabnormal mammary gland duct morphology  IAGP 5509061 MGIPMID:22666336
Pik3caMouseabnormal mammary gland epithelium morphology  IAGP 5509061 MGIPMID:22666336
Pik3caMouseabnormal mammary gland myoepithelium morphology  IAGP 5509061 MGIPMID:22666336
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Reference Title
Reference Citation
1. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
2. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
3. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
4. Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma. Dong M, etal., Hum Pathol. 2016 Jul;53:25-34. doi: 10.1016/j.humpath.2016.02.007. Epub 2016 Mar 4.
5. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
6. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
7. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Guo XN, etal., Cancer Res. 2007 Jun 15;67(12):5851-8.
8. Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Hare LM, etal., Dev Biol. 2015 Aug 1;404(1):14-26. doi: 10.1016/j.ydbio.2015.04.022. Epub 2015 May 7.
9. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
10. Correlation of DLC1 gene methylation with oncogenic PIK3CA mutations in extramammary Paget's disease. Kang Z, etal., Mod Pathol. 2012 Aug;25(8):1160-8. doi: 10.1038/modpathol.2012.65. Epub 2012 Apr 20.
11. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. Kim DC, etal., APMIS. 2014 Oct;122(10):1001-6. doi: 10.1111/apm.12245. Epub 2014 Mar 28.
13. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. Kinross KM, etal., J Clin Invest. 2012 Feb;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3.
14. PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma. Li HG, etal., Int J Clin Exp Pathol. 2015 Nov 1;8(11):15255-9. eCollection 2015.
15. [A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis]. Liang L, etal., Zhonghua Wai Ke Za Zhi. 2012 Nov;50(11):1007-10.
16. Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. Lindhurst MJ, etal., Nat Genet. 2012 Jun 24;44(8):928-33. doi: 10.1038/ng.2332.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. Mutations of the PIK3CA gene in hereditary colorectal cancers. Miyaki M, etal., Int J Cancer. 2007 Oct 1;121(7):1627-30. doi: 10.1002/ijc.22829.
20. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
1 to 20 of 41 rows
1 to 10 of 31 rows
PMID:7534285   PMID:7542745   PMID:8139567   PMID:8889548   PMID:8947469   PMID:9235916   PMID:9671713   PMID:9852579   PMID:9927325   PMID:10094829   PMID:10196176   PMID:10349636  
PMID:10462494   PMID:10835352   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11784871   PMID:11902114   PMID:11903815   PMID:11919689   PMID:12086468   PMID:12162464   PMID:12477932  
PMID:12486171   PMID:12704201   PMID:14507992   PMID:14597618   PMID:14610273   PMID:14657280   PMID:14681479   PMID:15102471   PMID:15192701   PMID:15197263   PMID:15249583   PMID:15377662  
PMID:15496927   PMID:15687236   PMID:15713620   PMID:15829307   PMID:16005454   PMID:16039615   PMID:16141072   PMID:16141073   PMID:16467569   PMID:16514418   PMID:16625210   PMID:16647110  
PMID:17060635   PMID:17202264   PMID:17475835   PMID:17540175   PMID:17579043   PMID:17596516   PMID:17682062   PMID:17846664   PMID:17908814   PMID:17920279   PMID:18070887   PMID:18187452  
PMID:18239469   PMID:18285463   PMID:18287559   PMID:18367611   PMID:18449193   PMID:18590694   PMID:18594509   PMID:18653476   PMID:18668519   PMID:18799693   PMID:18932194   PMID:18988856  
PMID:19033389   PMID:19047141   PMID:19047410   PMID:19126672   PMID:19172191   PMID:19196980   PMID:19505983   PMID:19509054   PMID:19597047   PMID:19604150   PMID:19679877   PMID:19815551  
PMID:19819947   PMID:19822807   PMID:19834495   PMID:19883613   PMID:20167228   PMID:20167866   PMID:20197055   PMID:20237330   PMID:20505078   PMID:20534549   PMID:20620998   PMID:20665729  
PMID:20699475   PMID:20847309   PMID:20953381   PMID:21037083   PMID:21047779   PMID:21059846   PMID:21188463   PMID:21219477   PMID:21246652   PMID:21267068   PMID:21367821   PMID:21454528  
PMID:21464441   PMID:21540297   PMID:21593423   PMID:21677750   PMID:21703185   PMID:21731673   PMID:21757757   PMID:21780115   PMID:21872252   PMID:21873635   PMID:21912691   PMID:21917798  
1 to 10 of 31 rows



Pik3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)EnsemblGRCm39 Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBIMGSCv36mm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
PIK3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,148,126 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,148,114 - 179,240,093 (+)EnsemblGRCh38hg38GRCh38
GRCh373178,866,145 - 178,957,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,915,414 (+)NCBICHM1_1
T2T-CHM13v2.03181,951,917 - 182,043,930 (+)NCBIT2T-CHM13v2.0
Pik3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,103,643 - 117,177,411 (+)NCBIGRCr8
mRatBN7.22115,175,275 - 115,249,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,174,984 - 115,249,032 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,832,703 - 121,862,791 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02119,945,342 - 119,975,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,646,275 - 114,676,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
Pik3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,356,353 - 8,427,024 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,355,415 - 8,427,024 (+)NCBIChiLan1.0ChiLan1.0
PIK3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,018,967 - 177,103,829 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,023,686 - 177,108,546 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,355,789 - 184,441,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensemblpanpan1.1panPan2
PIK3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,600,140 - 12,681,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,600,233 - 12,675,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,743,641 - 16,822,678 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,496,918 - 12,576,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,497,011 - 12,573,751 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,551,928 - 12,630,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,531,843 - 12,610,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,771,120 - 12,850,124 (+)NCBIUU_Cfam_GSD_1.0
Pik3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,269,676 - 109,296,792 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,923,934 - 3,951,073 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,924,013 - 3,951,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,180,544 - 117,274,587 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,193,935 - 117,282,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213126,401,142 - 126,461,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,218,034 - 10,304,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,218,805 - 10,294,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606319,096,074 - 19,187,036 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473056,938,215 - 56,966,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473056,895,065 - 56,970,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Pik3ca
3178 total Variants

Predicted Target Of
Summary Value
Count of predictions:2871
Count of miRNA genes:717
Interacting mature miRNAs:886
Transcripts:ENSMUST00000029201, ENSMUST00000108242, ENSMUST00000108243
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse

1 to 10 of 18 rows
RH126565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,464,113 - 32,464,339UniSTSGRCm38
MGSCv37332,363,035 - 32,363,261UniSTSGRCm37
Celera332,374,044 - 32,374,270UniSTS
Cytogenetic Map3BUniSTS
cM Map312.4UniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,432,971 - 32,433,224UniSTSGRCm38
MGSCv37332,331,893 - 32,332,146UniSTSGRCm37
Celera332,342,902 - 32,343,155UniSTS
Cytogenetic Map3BUniSTS
cM Map312.4UniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3BUniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38332,436,281 - 32,436,539UniSTSGRCm38
MGSCv37332,335,203 - 32,335,461UniSTSGRCm37
Celera332,346,212 - 32,346,470UniSTS
Cytogenetic Map3BUniSTS
Pik3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3BUniSTS






1 to 17 of 17 rows
RefSeq Transcripts NM_008839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC006868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSMUST00000029201   ⟹   ENSMUSP00000029201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,490,300 - 32,522,635 (+)Ensembl
GRCm38.p6 Ensembl332,436,151 - 32,468,486 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108242   ⟹   ENSMUSP00000103877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,490,525 - 32,520,256 (+)Ensembl
GRCm38.p6 Ensembl332,436,376 - 32,466,107 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108243   ⟹   ENSMUSP00000103878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,451,820 - 32,520,256 (+)Ensembl
GRCm38.p6 Ensembl332,397,671 - 32,466,107 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,515,826 - 32,516,977 (+)Ensembl
GRCm38.p6 Ensembl332,461,677 - 32,462,828 (+)Ensembl
RefSeq Acc Id: NM_008839   ⟹   NP_032865
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,451,214 - 32,520,256 (+)NCBI
GRCm38332,397,065 - 32,466,107 (+)NCBI
MGSCv37332,335,073 - 32,367,408 (+)RGD
Celera332,346,082 - 32,378,426 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004941295
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,451,203 - 32,517,929 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_032865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18334 (Get FASTA)   NCBI Sequence Viewer  
  AAH89038 (Get FASTA)   NCBI Sequence Viewer  
  AAI30229 (Get FASTA)   NCBI Sequence Viewer  
  CDL93484 (Get FASTA)   NCBI Sequence Viewer  
  EDL34989 (Get FASTA)   NCBI Sequence Viewer  
  EDL34990 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000029201.8
  ENSMUSP00000103878
  ENSMUSP00000103878.2
GenBank Protein P42337 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_032865   ⟸   NM_008839
- UniProtKB: Q0VGQ5 (UniProtKB/Swiss-Prot),   P42337 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000103878   ⟸   ENSMUST00000108243
Ensembl Acc Id: ENSMUSP00000103877   ⟸   ENSMUST00000108242
Ensembl Acc Id: ENSMUSP00000029201   ⟸   ENSMUST00000029201
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Name Modeler Protein Id AA Range Protein Structure
AF-P42337-F1-model_v2 AlphaFold P42337 1-1068 view protein structure



1 to 40 of 55 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000027665 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029201.14 UniProtKB/Swiss-Prot
  ENSMUST00000108243 ENTREZGENE
  ENSMUST00000108243.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot
  PI3Kalpha_dom UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report mmu:18706 UniProtKB/Swiss-Prot
MGD MGI:1206581 ENTREZGENE
NCBI Gene 18706 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM UniProtKB/Swiss-Prot
  PTHR10048 UniProtKB/Swiss-Prot
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
PharmGKB PIK3CA RGD
PhenoGen Pik3ca PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PI3K_ABD UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
1 to 40 of 55 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3ca  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide  Symbol and/or name change 5135510 APPROVED