PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) - Rat Genome Database

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Gene: PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) Homo sapiens
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Symbol: PIK3CA
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RGD ID: 1352691
HGNC Page HGNC:8975
Description: Enables 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Involved in several processes, including negative regulation of anoikis; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within phosphorylation. Part of phosphatidylinositol 3-kinase complex, class IA. Implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Biomarker of esophageal cancer and stomach cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CCM4; CLAPO; CLOVE; CWS5; HMH; MCAP; MCM; MCMTC; MGC142161; MGC142163; mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; p110-alpha; p110alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; phosphoinositide 3-kinase alpha; phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase p110; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC100422375  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,148,126 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,148,114 - 179,240,093 (+)EnsemblGRCh38hg38GRCh38
GRCh373178,866,145 - 178,957,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,915,414 (+)NCBICHM1_1
T2T-CHM13v2.03181,951,917 - 182,043,930 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
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