PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) - Rat Genome Database

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Gene: PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) Pan paniscus
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Symbol: PIK3CA
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RGD ID: 11714942
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adipose tissue development (ortholog); cardiac muscle cell contraction (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); adrenal carcinoma (ortholog); FOUND IN intercalated disc (ortholog); lamellipodium (ortholog); phosphatidylinositol 3-kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC103786683; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; uncharacterized LOC103786683
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13184,355,789 - 184,441,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenal carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
adult hepatocellular carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
basal cell carcinoma  (ISO)
bladder urothelial carcinoma  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
Cardiovascular Abnormalities  (ISO)
CLAPO Syndrome  (ISO)
CLOVES syndrome  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congenital heart disease  (ISO)
Cowden syndrome  (ISO)
Cowden Syndrome 5  (ISO)
Cowden-Like Syndrome  (ISO)
Currarino syndrome  (ISO)
cutaneous Paget's disease  (ISO)
diaphragmatic eventration  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
estrogen-receptor positive breast cancer  (ISO)
Facial Asymmetry  (ISO)
gallbladder carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glycogen storage disease II  (ISO)
Growth Disorders  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemimegalencephaly  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
Hypertelorism  (ISO)
liver cancer  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
medulloblastoma  (ISO)
Megalencephaly - Cutis Marmorata Telangiectatica Congenita  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome  (ISO)
Megalodactyly  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
non-Hodgkin lymphoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
ovary epithelial cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Penile Neoplasms  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
polycystic kidney disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
sarcoma  (ISO)
seborrheic keratosis  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
E-cadherin signaling pathway  (ISO)
endometrial cancer pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (ISO)
fibroblast growth factor signaling pathway  (ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (ISO)
inositol metabolic pathway  (ISO)
insulin signaling pathway  (ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway  (ISO)
interleukin-6 signaling pathway  (ISO)
N-cadherin signaling pathway  (ISO)
non-small cell lung carcinoma pathway  (ISO)
nuclear factor kappa B signaling pathway  (ISO)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway  (ISO)
prostate cancer pathway  (ISO)
Reelin signaling pathway  (ISO)
Trail mediated signaling pathway  (ISO)
type II interferon signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

References

Genomics

Comparative Map Data
PIK3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13184,355,789 - 184,441,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBIMhudiblu_PPA_v0panPan3
PIK3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3179,148,114 - 179,240,093 (+)EnsemblGRCh38hg38GRCh38
GRCh383179,148,114 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373178,866,145 - 178,957,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBI
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,920,795 (+)NCBICHM1_1
Pik3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBImm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
Pik3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22115,175,275 - 115,249,034 (+)NCBI
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
Pik3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,356,353 - 8,427,024 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,355,415 - 8,427,024 (+)NCBIChiLan1.0ChiLan1.0
PIK3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,600,140 - 12,681,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,600,233 - 12,675,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,743,641 - 16,822,678 (+)NCBI
ROS_Cfam_1.03412,496,918 - 12,576,076 (+)NCBI
UMICH_Zoey_3.13412,551,928 - 12,630,858 (+)NCBI
UNSW_CanFamBas_1.03412,531,843 - 12,610,836 (+)NCBI
UU_Cfam_GSD_1.03412,771,120 - 12,850,124 (+)NCBI
Pik3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,269,676 - 109,296,792 (+)NCBI
SpeTri2.0NW_0049365663,924,013 - 3,951,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,180,544 - 117,277,232 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,193,935 - 117,282,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213126,401,142 - 126,461,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,218,034 - 10,304,874 (-)NCBI
ChlSab1.1 Ensembl1510,218,805 - 10,294,316 (-)Ensembl
Pik3ca
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473056,895,065 - 56,970,563 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032787   ⟹   ENSPPAP00000010140
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensembl
RefSeq Acc Id: XM_034957744   ⟹   XP_034813635
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBI
RefSeq Acc Id: XM_034957745   ⟹   XP_034813636
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v03176,201,226 - 176,272,024 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034813635 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813636 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034813635   ⟸   XM_034957744
RefSeq Acc Id: XP_034813636   ⟸   XM_034957745
RefSeq Acc Id: ENSPPAP00000010140   ⟸   ENSPPAT00000032787
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K   PIK helical


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028292 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000010140 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032787 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/TrEMBL
  PI3Kalpha_dom UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene PIK3CA ENTREZGENE
PANTHER PTHR10048 UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9A4C9_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 PIK3CA  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  LOC103786683  uncharacterized LOC103786683  Data Merged 737654 PROVISIONAL