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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Elk4 | Mouse | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of ELK4 mRNA | CTD | PMID:28189721 and PMID:28960355 | Elk4 | Mouse | 17beta-estradiol | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of ELK4 mRNA | CTD | PMID:23019147 | Elk4 | Mouse | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | Dapsone analog inhibits the reaction [Metribolone results in increased expression of ELK4 mRNA] | CTD | PMID:21440447 | Elk4 | Mouse | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Metribolone results in increased expression of ELK4 mRNA | CTD | PMID:21440447 | Elk4 | Mouse | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of ELK4 mRNA | CTD | PMID:29581250 | Elk4 | Mouse | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Elk4 | Mouse | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Elk4 | Mouse | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | Elk4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ELK4 mRNA | CTD | PMID:24058054 | Elk4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ELK4 mRNA | CTD | PMID:33387578 | Elk4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ELK4 mRNA | CTD | PMID:34747641 | Elk4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ELK4 promoter] | CTD | PMID:19654925 | Elk4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ELK4 mRNA | CTD | PMID:19770486 | Elk4 | Mouse | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ELK4 mRNA | CTD | PMID:20188158 | Elk4 | Mouse | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Elk4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ELK4 mRNA | CTD | PMID:36041667 | Elk4 | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of ELK4 mRNA | CTD | PMID:30047161 | Elk4 | Mouse | all-trans-retinoic acid | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ELK4 mRNA | CTD | PMID:21934132 | Elk4 | Mouse | amitrole | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of ELK4 mRNA | CTD | PMID:30047161 | Elk4 | Mouse | antirheumatic drug | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ELK4 mRNA | CTD | PMID:24449571 | Elk4 | Mouse | aristolochic acid A | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ELK4 mRNA | CTD | PMID:33212167 | Elk4 | Mouse | arsane | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of ELK4 mRNA | CTD | PMID:35072517 | Elk4 | Mouse | arsenic atom | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of ELK4 mRNA | CTD | PMID:35072517 | Elk4 | Mouse | arsenous acid | decreases methylation | ISO | ELK4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased methylation of ELK4 promoter | CTD | PMID:26046465 | Elk4 | Mouse | benzo[a]pyrene | affects methylation | ISO | ELK4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ELK4 promoter | CTD | PMID:27901495 | Elk4 | Mouse | benzo[a]pyrene diol epoxide I | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | Elk4 | Mouse | bisphenol A | affects expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ELK4 mRNA | CTD | PMID:25181051 | Elk4 | Mouse | bisphenol A | multiple interactions | ISO | Elk4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ELK4 mRNA | CTD | PMID:36041667 | Elk4 | Mouse | bisphenol A | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of ELK4 gene | CTD | PMID:31601247 | Elk4 | Mouse | bisphenol A | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ELK4 mRNA | CTD | PMID:34947998 | Elk4 | Mouse | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ELK4 mRNA | CTD | PMID:33221593 | Elk4 | Mouse | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of ELK4 promoter | CTD | PMID:27334623 | Elk4 | Mouse | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of ELK4 mRNA | CTD | PMID:38685157 | Elk4 | Mouse | bisphenol F | multiple interactions | ISO | Elk4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ELK4 mRNA | CTD | PMID:36041667 | Elk4 | Mouse | cadmium atom | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ELK4 mRNA | CTD | PMID:35301059 | Elk4 | Mouse | cadmium dichloride | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | cadmium dichloride | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ELK4 mRNA | CTD | PMID:35301059 | Elk4 | Mouse | cadmium dichloride | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of ELK4 mRNA | CTD | PMID:38568856 | Elk4 | Mouse | CGP 52608 | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ELK4 gene] | CTD | PMID:28238834 | Elk4 | Mouse | chloroacetaldehyde | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | chloroacetaldehyde results in increased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | cidofovir anhydrous | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Cidofovir results in decreased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | cisplatin | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of ELK4 mRNA | CTD | PMID:25596134 and PMID:27594783 | Elk4 | Mouse | clodronic acid | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Clodronic Acid results in decreased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | copper atom | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of ELK4 mRNA | CTD | PMID:30911355 | Elk4 | Mouse | copper(0) | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of ELK4 mRNA | CTD | PMID:30911355 | Elk4 | Mouse | crocidolite asbestos | affects expression | EXP | | 6480464 | Asbestos and Crocidolite affects the expression of ELK4 mRNA | CTD | PMID:19446018 | Elk4 | Mouse | crotonaldehyde | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | 2-butenal results in decreased expression of ELK4 mRNA | CTD | PMID:20471460 | Elk4 | Mouse | cyclosporin A | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of ELK4 mRNA | CTD | PMID:25562108 | Elk4 | Mouse | dapsone | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | Dapsone analog inhibits the reaction [Metribolone results in increased expression of ELK4 mRNA] | CTD | PMID:21440447 | Elk4 | Mouse | diarsenic trioxide | decreases methylation | ISO | ELK4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased methylation of ELK4 promoter | CTD | PMID:26046465 | Elk4 | Mouse | dibutyl phthalate | increases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in increased expression of ELK4 mRNA | CTD | PMID:21266533 | Elk4 | Mouse | Diisodecyl phthalate | decreases expression | EXP | | 6480464 | diisodecyl phthalate results in decreased expression of ELK4 mRNA | CTD | PMID:25270620 | Elk4 | Mouse | dioxygen | affects expression | ISO | ELK4 (Homo sapiens) | 6480464 | Oxygen deficiency affects the expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | dorsomorphin | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Elk4 | Mouse | doxorubicin | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ELK4 mRNA | CTD | PMID:29803840 | Elk4 | Mouse | ethyl methanesulfonate | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of ELK4 mRNA | CTD | PMID:23649840 | Elk4 | Mouse | fenofibrate | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Fenofibrate results in increased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of ELK4 mRNA | CTD | PMID:25629700 | Elk4 | Mouse | folic acid | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of ELK4 mRNA | CTD | PMID:21867686 | Elk4 | Mouse | formaldehyde | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of ELK4 mRNA | CTD | PMID:23649840 | Elk4 | Mouse | fulvestrant | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of ELK4 gene | CTD | PMID:31601247 | Elk4 | Mouse | furan | increases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | furan results in increased expression of ELK4 mRNA | CTD | PMID:26194646 | Elk4 | Mouse | gentamycin | increases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of ELK4 mRNA | CTD | PMID:22061828 | Elk4 | Mouse | gentamycin | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of ELK4 mRNA | CTD | PMID:33387578 | Elk4 | Mouse | geraniol | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | geraniol results in increased expression of ELK4 mRNA | CTD | PMID:27683099 | Elk4 | Mouse | glyphosate | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of ELK4 mRNA | CTD | PMID:31295307 | Elk4 | Mouse | ibuprofen | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Ibuprofen results in increased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | ifosfamide | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Ifosfamide results in decreased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | iron dichloride | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of ELK4 mRNA | CTD | PMID:35984750 | Elk4 | Mouse | metformin | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Metformin results in increased expression of ELK4 mRNA | CTD | PMID:25596134 | Elk4 | Mouse | methapyrilene | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of ELK4 mRNA | CTD | PMID:30467583 | Elk4 | Mouse | methidathion | decreases expression | EXP | | 6480464 | methidathion results in decreased expression of ELK4 mRNA | CTD | PMID:34813904 | Elk4 | Mouse | methimazole | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of ELK4 mRNA | CTD | PMID:30047161 | Elk4 | Mouse | methyl methanesulfonate | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of ELK4 mRNA | CTD | PMID:23649840 | Elk4 | Mouse | methylmercury chloride | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of ELK4 mRNA | CTD | PMID:28001369 | Elk4 | Mouse | nickel atom | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Nickel results in increased expression of ELK4 mRNA | CTD | PMID:24768652 and PMID:25583101 | Elk4 | Mouse | nitrates | multiple interactions | EXP | | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of ELK4 mRNA | CTD | PMID:35964746 | Elk4 | Mouse | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ELK4 mRNA | CTD | PMID:34911549 | Elk4 | Mouse | paracetamol | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of ELK4 mRNA | CTD | PMID:33387578 | Elk4 | Mouse | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Elk4 | Mouse | phenylmercury acetate | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of ELK4 mRNA | CTD | PMID:26272509 | Elk4 | Mouse | phenylmercury acetate | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELK4 mRNA | CTD | PMID:27188386 | Elk4 | Mouse | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of ELK4 mRNA | CTD | PMID:20813756 | Elk4 | Mouse | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of ELK4 mRNA | CTD | PMID:30047161 | Elk4 | Mouse | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of ELK4 mRNA | CTD | PMID:21278054 | Elk4 | Mouse | quercetin | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Quercetin results in increased expression of ELK4 mRNA | CTD | PMID:21632981 | Elk4 | Mouse | SB 431542 | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Elk4 | Mouse | silicon dioxide | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of ELK4 mRNA | CTD | PMID:25351596 | Elk4 | Mouse | silver atom | decreases expression | EXP | | 6480464 | Silver results in decreased expression of ELK4 mRNA | CTD | PMID:27131904 | Elk4 | Mouse | silver(0) | decreases expression | EXP | | 6480464 | Silver results in decreased expression of ELK4 mRNA | CTD | PMID:27131904 | Elk4 | Mouse | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of ELK4 mRNA | CTD | PMID:16014739 | Elk4 | Mouse | sodium arsenite | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of ELK4 mRNA | CTD | PMID:35072517 | Elk4 | Mouse | Soman | decreases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | Soman results in decreased expression of ELK4 mRNA | CTD | PMID:19281266 | Elk4 | Mouse | sunitinib | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ELK4 mRNA | CTD | PMID:31533062 | Elk4 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of ELK4 gene | CTD | PMID:35295148 | Elk4 | Mouse | tributylstannane | increases expression | ISO | Elk4 (Rattus norvegicus) | 6480464 | tributyltin results in increased expression of ELK4 mRNA | CTD | PMID:31129395 | Elk4 | Mouse | trichostatin A | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ELK4 mRNA | CTD | PMID:24935251 | Elk4 | Mouse | triphenyl phosphate | affects expression | ISO | ELK4 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of ELK4 mRNA | CTD | PMID:37042841 | Elk4 | Mouse | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of ELK4 mRNA | CTD | PMID:28973697 | Elk4 | Mouse | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of ELK4 mRNA | CTD | PMID:30912803 | Elk4 | Mouse | urethane | increases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Urethane results in increased expression of ELK4 mRNA | CTD | PMID:28818685 | Elk4 | Mouse | valproic acid | decreases expression | ISO | ELK4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ELK4 mRNA | CTD | PMID:23179753 more ... | Elk4 | Mouse | valproic acid | multiple interactions | ISO | ELK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELK4 mRNA | CTD | PMID:27188386 | |