Cxcr2 (chemokine (C-X-C motif) receptor 2) - Rat Genome Database

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Gene: Cxcr2 (chemokine (C-X-C motif) receptor 2) Mus musculus
Symbol: Cxcr2
Name: chemokine (C-X-C motif) receptor 2
RGD ID: 735300
Description: Enables chemokine receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; epithelium; heart; and intraembryonic coelom. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C chemokine receptor type 2; CD128; CDw128; chemokine (C-X-C) receptor 2; Cmka; Cmkar2; CXC-R2; CXCR-2; Gpcr; Gpcr16; GRO/MGSA receptor; high affinity interleukin-8 receptor B; I; Il; IL-; IL-8 receptor alpha chain; IL-8R B; IL-8rb; IL-8Rh; IL8RA; Il8rb; interleukin 8 receptor, beta; interleukin-8 receptor type B; mIL-8RH
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39174,193,153 - 74,200,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,193,148 - 74,200,405 (+)EnsemblGRCm39 Ensembl
GRCm38174,153,994 - 74,161,246 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,153,989 - 74,161,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,200,568 - 74,207,820 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,087,201 - 74,094,453 (+)NCBIMGSCv36mm8
Celera174,715,354 - 74,722,423 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
asperentin  (EXP)
atrazine  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (EXP)
celecoxib  (EXP)
ceric oxide  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clodronic acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cytochalasin D  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dioxygen  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
excitatory amino acid agonist  (EXP)
fenvalerate  (ISO)
formaldehyde  (ISO)
furan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (EXP)
lipoarabinomannan  (ISO)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
mechlorethamine  (EXP)
methacholine chloride  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
nickel atom  (ISO)
Nicotinamide N-oxide  (ISO)
nicotine  (ISO)
oleandrin  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (EXP)
prednisolone  (ISO)
reparixin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
tungsten  (EXP)
vinclozolin  (ISO)
wortmannin  (ISO)
XL147  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal airway responsiveness  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal eosinophil physiology  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal interleukin level  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal myelination  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal respiratory mucosa goblet cell morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tumor morphology  (IAGP)
corneal vascularization  (IAGP)
decreased airway responsiveness  (IAGP)
decreased B cell number  (IEA)
decreased body size  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased circulating fructosamine level  (IEA)
decreased circulating serum albumin level  (IEA)
decreased circulating thyroxine level  (IEA)
decreased immature B cell number  (IEA)
decreased kidney weight  (IAGP)
decreased mature B cell number  (IEA)
decreased mean corpuscular hemoglobin  (IEA)
decreased metastatic potential  (IAGP)
decreased oligodendrocyte progenitor number  (IAGP)
decreased pre-B cell number  (IEA)
decreased pre-pro B cell number  (IEA)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased spleen weight  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to fungal infection  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased T cell number  (IEA)
decreased thymus weight  (IAGP)
decreased tumor growth/size  (IAGP)
delayed wound healing  (IAGP)
enlarged cervical lymph nodes  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
improved glucose tolerance  (IEA)
increased anti-nuclear antigen antibody level  (IEA)
increased B cell number  (IAGP)
increased CD103-positive CD11b-low dendritic cell number  (IEA)
increased CD4-positive, alpha-beta memory T cell number  (IEA)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased circulating calcium level  (IEA)
increased circulating creatinine level  (IEA)
increased circulating interleukin-6 level  (IAGP)
increased circulating magnesium level  (IEA)
increased circulating total protein level  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased effector memory T-helper cell number  (IEA)
increased eosinophil cell number  (IEA)
increased epididymis weight  (IAGP)
increased gamma-delta T cell number  (IEA)
increased granulocyte number  (IAGP)
increased IgE level  (IAGP)
increased kidney weight  (IAGP)
increased KLRG1+ CD4 alpha beta T cell number  (IEA)
increased KLRG1+ CD8 alpha beta T cell number  (IEA)
increased leukocyte cell number  (IAGP)
increased Ly6C high monocyte number  (IEA)
increased Ly6C low monocyte number  (IEA)
increased memory-marker CD4-positive NK T cell number  (IEA)
increased memory-marker gamma-delta T cell number  (IEA)
increased memory-marker NK cell number  (IEA)
increased monocyte cell number  (IEA)
increased neutrophil cell number  (IAGP)
increased red blood cell distribution width  (IEA)
increased seminal vesicle weight  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
lymph node medullary cord hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
small adrenal glands  (IAGP)
small liver  (IAGP)
thrombocytosis  (IEA)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Contrasting roles for CXCR2 during experimental colitis. Ajuebor MN, etal., Exp Mol Pathol. 2004 Feb;76(1):1-8.
2. Bladder cancer SNP panel predicts susceptibility and survival. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Bhatia M and Hegde A, Regul Pept. 2007 Jan 10;138(1):40-8. Epub 2006 Oct 2.
4. Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2. Brown CR, etal., J Immunol. 2003 Jul 15;171(2):893-901.
5. Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion. Cugini D, etal., Kidney Int. 2005 May;67(5):1753-61.
6. Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague. Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
7. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus. Eriksson C, etal., Lupus. 2003;12(10):766-74.
8. Suppression of liver regeneration affects hepatic graft survival in small-for-size liver transplantation in rats. Fu WY, etal., Hepatol Res. 2013 Mar;43(3):300-10. doi: 10.1111/j.1872-034X.2012.01071.x. Epub 2012 Aug 6.
9. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Hoth JJ, etal., Shock. 2011 Jun;35(6):604-9.
10. Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children. Javor J, etal., Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
11. Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration. Kang MK, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1060-9. doi: 10.1152/ajprenal.00106.2012. Epub 2012 Jul 11.
12. Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis. Kerstetter AE, etal., Exp Neurol. 2009 Nov;220(1):44-56. doi: 10.1016/j.expneurol.2009.07.010. Epub 2009 Jul 17.
13. ELR+-CXC chemokines and their receptors in early metanephric development. Levashova ZB, etal., J Am Soc Nephrol. 2007 Aug;18(8):2359-70. Epub 2007 Jul 18.
14. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. Li L, etal., J Clin Invest. 2010 Jan;120(1):331-42. doi: 10.1172/JCI38702. Epub 2009 Dec 14.
15. CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
16. Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
17. Interleukin-33 contributes to disease severity in Dengue virus infection in mice. Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
18. Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis. Martin-Manso G, etal., PLoS One. 2012;7(11):e48775. doi: 10.1371/journal.pone.0048775. Epub 2012 Nov 7.
19. The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma. Mestas J, etal., J Immunol. 2005 Oct 15;175(8):5351-7.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
23. CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection. Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Qiu Y, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75. Epub 2003 Jul 11.
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. A rat model of picornavirus-induced airway infection and inflammation. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
29. Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. Russo RC, etal., Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3.
30. Association of chemokine gene variants with end stage renal disease in North Indian population. Singh V, etal., Transpl Immunol. 2013 Jun;28(4):189-92. doi: 10.1016/j.trim.2013.04.004. Epub 2013 Apr 21.
31. Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Stevenson CS, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29.
32. Polymorphisms of CXCL8 and Its Receptor CXCR2 Contribute to the Development and Progression of Childhood IgA Nephropathy. Suh JS, etal., J Interferon Cytokine Res. 2011 Jan 8.
33. Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection. Svensson M, etal., Kidney Int. 2008 Jul;74(1):81-90. doi: 10.1038/ki.2008.105. Epub 2008 Apr 9.
34. Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice. Svensson M, etal., Kidney Int. 2011 Nov;80(10):1064-72. doi: 10.1038/ki.2011.257. Epub 2011 Aug 3.
35. Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
36. Expression of angiogenic factors in rat periapical lesions. Yamanaka Y, etal., J Endod. 2012 Mar;38(3):313-7. doi: 10.1016/j.joen.2011.11.009. Epub 2011 Dec 23.
37. Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. Yi M, etal., Am J Respir Crit Care Med. 2004 Dec 1;170(11):1188-96. Epub 2004 Sep 3.
38. Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXC chemokine receptor 2 in infiltration during nephrotoxic nephritis. Zernecke A, etal., J Immunol. 2001 May 1;166(9):5755-62.
Additional References at PubMed
PMID:7518426   PMID:7636264   PMID:7667641   PMID:7828830   PMID:7890604   PMID:7919662   PMID:7961909   PMID:8036519   PMID:8105477   PMID:8194768   PMID:8288218   PMID:8288247  
PMID:8631787   PMID:8751373   PMID:8920870   PMID:8955112   PMID:9435307   PMID:9507200   PMID:9510554   PMID:10021459   PMID:10349636   PMID:10411002   PMID:10415460   PMID:10479460  
PMID:10556837   PMID:10570306   PMID:10571666   PMID:10845602   PMID:10951241   PMID:10993918   PMID:11016460   PMID:11042159   PMID:11046063   PMID:11069247   PMID:11076861   PMID:11123307  
PMID:11171016   PMID:11217851   PMID:11238651   PMID:11444905   PMID:11698278   PMID:11714818   PMID:11801688   PMID:11983913   PMID:12028561   PMID:12176324   PMID:12464676   PMID:12466851  
PMID:12470609   PMID:12477932   PMID:12626595   PMID:12753603   PMID:14500678   PMID:14568904   PMID:14707102   PMID:14764687   PMID:14978086   PMID:15004193   PMID:15105284   PMID:15356099  
PMID:15361358   PMID:15364949   PMID:15385471   PMID:15466624   PMID:15489334   PMID:15509523   PMID:15610233   PMID:15688008   PMID:15705791   PMID:15723811   PMID:15998678   PMID:16084593  
PMID:16094689   PMID:16118408   PMID:16141072   PMID:16141073   PMID:16485040   PMID:16565511   PMID:16602821   PMID:16613762   PMID:16618742   PMID:16670325   PMID:16886211   PMID:16888100  
PMID:16920786   PMID:16941672   PMID:16963267   PMID:16988250   PMID:17028201   PMID:17035062   PMID:17138957   PMID:17197447   PMID:17202320   PMID:17255321   PMID:17436230   PMID:17488888  
PMID:17494633   PMID:17556491   PMID:17603159   PMID:17641048   PMID:17656654   PMID:17728444   PMID:17823985   PMID:17931107   PMID:17942909   PMID:17974994   PMID:18077323   PMID:18156186  
PMID:18199703   PMID:18319289   PMID:18347102   PMID:18347198   PMID:18391506   PMID:18442092   PMID:18505935   PMID:18519646   PMID:18555777   PMID:18556780   PMID:18628996   PMID:18641353  
PMID:18668539   PMID:18688883   PMID:19050234   PMID:19050294   PMID:19109198   PMID:19118017   PMID:19121387   PMID:19147552   PMID:19155217   PMID:19234125   PMID:19255141   PMID:19356715  
PMID:19435808   PMID:19494115   PMID:19642907   PMID:19675161   PMID:19752233   PMID:19785013   PMID:19805574   PMID:19887480   PMID:19893623   PMID:20042467   PMID:20044435   PMID:20082763  
PMID:20154684   PMID:20368349   PMID:20495072   PMID:20506316   PMID:20516641   PMID:20596532   PMID:20610741   PMID:20621186   PMID:20625428   PMID:20683965   PMID:20727790   PMID:20870046  
PMID:20889916   PMID:20947763   PMID:21084199   PMID:21170303   PMID:21191074   PMID:21224471   PMID:21254176   PMID:21383500   PMID:21441140   PMID:21521824   PMID:21677750   PMID:21704645  
PMID:21873635   PMID:21960549   PMID:21980263   PMID:21985298   PMID:22135382   PMID:22203670   PMID:22277947   PMID:22320712   PMID:22326959   PMID:22371491   PMID:22379036   PMID:22566565  
PMID:22634615   PMID:22686371   PMID:22791336   PMID:22865624   PMID:22869904   PMID:22893608   PMID:22922255   PMID:22961770   PMID:22976954   PMID:22996693   PMID:23391392   PMID:23550035  
PMID:23636057   PMID:23650205   PMID:23708969   PMID:23755134   PMID:23756451   PMID:23831863   PMID:23868943   PMID:23897983   PMID:23986515   PMID:24026079   PMID:24084739   PMID:24223177  
PMID:24229710   PMID:24321089   PMID:24321240   PMID:24338666   PMID:24442436   PMID:24442441   PMID:24446518   PMID:24493287   PMID:24509076   PMID:24510965   PMID:24651866   PMID:24663678  
PMID:24670684   PMID:24726646   PMID:24848257   PMID:24968718   PMID:24999035   PMID:25024172   PMID:25063073   PMID:25107538   PMID:25166912   PMID:25172501   PMID:25412626   PMID:25511644  
PMID:25622052   PMID:25756662   PMID:25757087   PMID:25765938   PMID:25806513   PMID:25950520   PMID:25990934   PMID:26015476   PMID:26138727   PMID:26169939   PMID:26282875   PMID:26297794  
PMID:26337969   PMID:26603204   PMID:26606969   PMID:26678340   PMID:26747783   PMID:26791948   PMID:26797460   PMID:26802238   PMID:26939934   PMID:27027573   PMID:27222476   PMID:27265504  
PMID:27375023   PMID:27438770   PMID:27454298   PMID:27543854   PMID:27551153   PMID:27551720   PMID:27624780   PMID:27697507   PMID:27737879   PMID:27820602   PMID:27995997   PMID:28294319  
PMID:28341702   PMID:28529998   PMID:28705496   PMID:28739876   PMID:28743719   PMID:28763485   PMID:28970523   PMID:29070568   PMID:29120053   PMID:29136508   PMID:29168180   PMID:29197248  
PMID:29398651   PMID:29445104   PMID:29445180   PMID:30068506   PMID:30218547   PMID:30362570   PMID:30458137   PMID:30517976   PMID:30617225   PMID:30630119   PMID:30709741   PMID:30726742  
PMID:30799265   PMID:31039135   PMID:31041783   PMID:31043491   PMID:31085833   PMID:31107242   PMID:31221018   PMID:31311916   PMID:31364370   PMID:31395859   PMID:31433989   PMID:31492743  
PMID:31562303   PMID:31573846   PMID:31699822   PMID:31932813   PMID:31981231   PMID:32019585   PMID:32041848   PMID:32289253   PMID:32398640   PMID:32453916   PMID:32639881   PMID:32881070  
PMID:32937134   PMID:32948685   PMID:33453178   PMID:33597297   PMID:33718269   PMID:33785307   PMID:33953162   PMID:34011393   PMID:34571976   PMID:34576061   PMID:34714950   PMID:34850744  
PMID:35493520   PMID:35708907   PMID:35981418   PMID:36311783  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39174,193,153 - 74,200,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,193,148 - 74,200,405 (+)EnsemblGRCm39 Ensembl
GRCm38174,153,994 - 74,161,246 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,153,989 - 74,161,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,200,568 - 74,207,820 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,087,201 - 74,094,453 (+)NCBIMGSCv36mm8
Celera174,715,354 - 74,722,423 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.41NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382218,125,294 - 218,137,251 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2218,125,289 - 218,137,251 (+)EnsemblGRCh38hg38GRCh38
GRCh372218,990,017 - 219,001,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,698,991 - 218,710,220 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,816,251 - 218,827,481NCBI
Celera2212,756,449 - 212,768,411 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2210,842,767 - 210,854,732 (+)NCBIHuRef
CHM1_12218,996,503 - 219,008,469 (+)NCBICHM1_1
T2T-CHM13v2.02218,610,987 - 218,622,946 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2975,729,493 - 75,735,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,729,115 - 75,739,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,182,990 - 84,189,368 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0989,311,908 - 89,318,286 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0987,698,116 - 87,704,494 (+)NCBIRnor_WKY
Rnor_6.0981,427,275 - 81,435,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,193,442 - 81,199,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,470,943 - 73,477,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1973,617,924 - 73,624,297 (+)NCBI
Celera973,306,852 - 73,313,224 (+)NCBICelera
Cytogenetic Map9q33NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12B223,987,556 - 223,999,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B223,997,066 - 223,998,148 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B105,387,198 - 105,400,533 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13724,831,351 - 24,846,387 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,843,171 - 24,844,247 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,659,341 - 25,664,768 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03724,847,511 - 24,862,398 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3724,855,136 - 24,860,563 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,760,631 - 24,766,058 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,694,995 - 24,700,420 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,714,358 - 24,719,785 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.115120,219,657 - 120,230,203 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,275,203 - 133,286,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110104,012,906 - 104,025,599 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,022,811 - 104,023,893 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604095,376,101 - 95,386,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:850
Count of miRNA genes:398
Interacting mature miRNAs:458
Transcripts:ENSMUST00000027372, ENSMUST00000106899
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7162467978183144Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17413915981777715Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,159,476 - 74,159,625UniSTSGRCm38
MGSCv37174,206,050 - 74,206,199UniSTSGRCm37
Celera174,720,846 - 74,720,995UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.0UniSTS
Whitehead_YAC1 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,159,465 - 74,159,559UniSTSGRCm38
MGSCv37174,206,039 - 74,206,133UniSTSGRCm37
Celera174,720,835 - 74,720,929UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,158,595 - 74,159,040UniSTSGRCm38
MGSCv37174,205,169 - 74,205,614UniSTSGRCm37
Celera174,719,965 - 74,720,410UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,159,430 - 74,159,624UniSTSGRCm38
MGSCv37174,206,004 - 74,206,198UniSTSGRCm37
Celera174,720,800 - 74,720,994UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,158,263 - 74,158,650UniSTSGRCm38
Celera174,719,633 - 74,720,020UniSTS
Cytogenetic Map1C3UniSTS
cM Map140.0UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000027372   ⟹   ENSMUSP00000027372
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,193,148 - 74,199,769 (+)Ensembl
GRCm38.p6 Ensembl174,153,989 - 74,160,610 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106899   ⟹   ENSMUSP00000102512
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,193,150 - 74,200,405 (+)Ensembl
GRCm38.p6 Ensembl174,153,991 - 74,161,246 (+)Ensembl
RefSeq Acc Id: NM_009909   ⟹   NP_034039
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39174,193,153 - 74,200,405 (+)NCBI
GRCm38174,153,994 - 74,161,246 (+)ENTREZGENE
MGSCv37174,200,568 - 74,207,820 (+)RGD
Celera174,715,354 - 74,722,423 (+)RGD
RefSeq Acc Id: XM_006495638   ⟹   XP_006495701
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,194,808 - 74,200,404 (+)NCBI
GRCm38174,155,648 - 74,161,245 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034039   ⟸   NM_009909
- UniProtKB: Q53X27 (UniProtKB/Swiss-Prot),   P35343 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006495701   ⟸   XM_006495638
- Peptide Label: isoform X1
- UniProtKB: Q53X27 (UniProtKB/Swiss-Prot),   P35343 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027372   ⟸   ENSMUST00000027372
RefSeq Acc Id: ENSMUSP00000102512   ⟸   ENSMUST00000106899

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35343-F1-model_v2 AlphaFold P35343 1-359 view protein structure

RGD ID:6874048
Promoter ID:EPDNEW_M475
Type:initiation region
Description:Mus musculus chemokine (C-X-C motif) receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38174,153,994 - 74,154,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105303 AgrOrtholog
Ensembl Genes ENSMUSG00000026180 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000027372 UniProtKB/Swiss-Prot
  ENSMUSP00000102512 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027372 UniProtKB/Swiss-Prot
  ENSMUST00000106899 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine_CXCR2 UniProtKB/Swiss-Prot
  Chemokine_CXCR_1/2 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:12765 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Cxcr2 PhenoGen
  INTRLEUKIN8R UniProtKB/Swiss-Prot
  INTRLEUKN8BR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt Secondary Q53X27 UniProtKB/Swiss-Prot