Galr2 (galanin receptor 2) - Rat Genome Database

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Gene: Galr2 (galanin receptor 2) Mus musculus
Analyze
Symbol: Galr2
Name: galanin receptor 2
RGD ID: 736654
MGI Page MGI
Description: Predicted to enable galanin receptor activity; neuropeptide binding activity; and peptide hormone binding activity. Acts upstream of or within neuron projection development. Predicted to be located in cilium. Orthologous to human GALR2 (galanin receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ga; GAL2-R; galanin receptor type 2; GALR-2; mG; mGalR; MGC151357; MGC151359
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,170,520 - 116,174,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,171,765 - 116,174,764 (+)EnsemblGRCm39 Ensembl
GRCm3811116,280,106 - 116,283,950 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,280,939 - 116,283,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,142,253 - 116,145,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,097,029 - 116,100,005 (+)NCBIMGSCv36mm8
Celera11128,045,589 - 128,048,587 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (ISO)
membrane  (IEA)
plasma membrane  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9832121   PMID:9832122   PMID:10349636   PMID:10818207   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12381728   PMID:12477932   PMID:12533601   PMID:14610273  
PMID:15249737   PMID:15899880   PMID:15904718   PMID:16141072   PMID:16141073   PMID:16487144   PMID:16602821   PMID:17076662   PMID:17257664   PMID:17263796   PMID:17627995   PMID:18554714  
PMID:18799693   PMID:19127771   PMID:19717462   PMID:21496293   PMID:21672612   PMID:21677750   PMID:21873635   PMID:22723691   PMID:23387435   PMID:23639882   PMID:24726665   PMID:24952961  
PMID:26053317   PMID:26292267   PMID:28154160   PMID:28219675   PMID:29183756   PMID:30298565   PMID:31730796   PMID:31953035   PMID:32231393   PMID:33436730   PMID:33915732   PMID:35431947  
PMID:35681537  


Genomics

Comparative Map Data
Galr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,170,520 - 116,174,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,171,765 - 116,174,764 (+)EnsemblGRCm39 Ensembl
GRCm3811116,280,106 - 116,283,950 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,280,939 - 116,283,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,142,253 - 116,145,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,097,029 - 116,100,005 (+)NCBIMGSCv36mm8
Celera11128,045,589 - 128,048,587 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.1NCBI
GALR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,071,962 - 76,077,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,074,781 - 76,077,537 (+)EnsemblGRCh38hg38GRCh38
GRCh371774,070,862 - 74,073,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,582,487 - 71,585,168 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,582,486 - 71,585,168NCBI
Celera1770,664,718 - 70,667,399 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,499,823 - 69,502,494 (+)NCBIHuRef
CHM1_11774,135,817 - 74,138,498 (+)NCBICHM1_1
T2T-CHM13v2.01776,964,823 - 76,974,102 (+)NCBIT2T-CHM13v2.0
Galr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,012,086 - 102,016,057 (+)NCBIGRCr8
mRatBN7.210101,513,689 - 101,517,176 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,514,471 - 101,517,176 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,571,364 - 106,573,793 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,034,454 - 106,036,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,435,666 - 101,438,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,156,793 - 105,159,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,156,632 - 105,237,611 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,900,150 - 104,902,315 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,394,006 - 106,396,171 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,408,502 - 106,410,685 (+)NCBI
Celera10100,087,566 - 100,089,731 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Galr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555066,172,366 - 6,176,084 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555066,172,366 - 6,178,061 (-)NCBIChiLan1.0ChiLan1.0
GALR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,114,145 - 92,123,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,939,371 - 96,948,006 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,019,383 - 70,028,689 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,578,072 - 75,580,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,578,072 - 75,580,806 (+)Ensemblpanpan1.1panPan2
GALR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,559,710 - 4,562,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,560,067 - 4,562,463 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,240,420 - 5,242,990 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,230,227 - 5,232,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,230,403 - 5,232,798 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,270,157 - 5,272,724 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,379,443 - 5,382,005 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,440,143 - 5,442,711 (-)NCBIUU_Cfam_GSD_1.0
Galr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,172,746 - 5,175,859 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,236,061 - 1,239,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,236,281 - 1,239,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GALR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,359,582 - 5,363,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,360,232 - 5,364,396 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,262,826 - 5,267,911 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GALR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,599,934 - 45,603,207 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,600,038 - 45,602,561 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,346,223 - 16,349,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Galr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,983,254 - 5,985,596 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,982,870 - 5,987,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Galr2
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:141
Interacting mature miRNAs:163
Transcripts:ENSMUST00000055872, ENSMUST00000154277
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000055872   ⟹   ENSMUSP00000054062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,171,765 - 116,174,764 (+)Ensembl
GRCm38.p6 Ensembl11116,280,939 - 116,283,938 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11116,172,312 - 116,174,487 (+)Ensembl
GRCm38.p6 Ensembl11116,281,486 - 116,283,661 (+)Ensembl
RefSeq Acc Id: NM_010254   ⟹   NP_034384
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,171,765 - 116,174,764 (+)NCBI
GRCm3811116,280,939 - 116,283,938 (+)NCBI
MGSCv3711116,142,253 - 116,145,252 (+)RGD
Celera11128,045,589 - 128,048,587 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248727   ⟹   XP_011247029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911116,170,520 - 116,174,776 (+)NCBI
GRCm3811116,280,106 - 116,283,950 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034384   ⟸   NM_010254
- UniProtKB: Q14A53 (UniProtKB/Swiss-Prot),   Q9Z2B0 (UniProtKB/Swiss-Prot),   O88854 (UniProtKB/Swiss-Prot),   Q8BKB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011247029   ⟸   XM_011248727
- Peptide Label: isoform X1
- UniProtKB: Q8BKB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000054062   ⟸   ENSMUST00000055872
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88854-F1-model_v2 AlphaFold O88854 1-371 view protein structure

Promoters
RGD ID:6820918
Promoter ID:MM_KWN:10634
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000106424,   NM_010254,   OTTMUST00000008434
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611116,142,821 - 116,143,321 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1337018 AgrOrtholog
Ensembl Genes ENSMUSG00000020793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055872 ENTREZGENE
  ENSMUST00000055872.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAL2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galanin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14428 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1337018 ENTREZGENE
NCBI Gene 14428 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GALANIN RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Galr2 PhenoGen
PRINTS GALANIN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GALANINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GALR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q14A53 ENTREZGENE
  Q8BKB0 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2B0 ENTREZGENE
UniProt Secondary Q14A53 UniProtKB/Swiss-Prot
  Q9Z2B0 UniProtKB/Swiss-Prot