Atm (ataxia telangiectasia mutated) - Rat Genome Database

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Gene: Atm (ataxia telangiectasia mutated) Mus musculus
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Symbol: Atm
Name: ataxia telangiectasia mutated
RGD ID: 10199
MGI Page MGI
Description: Enables histone H2AXS139 kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including immune system development; intracellular signal transduction; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-T mutated homolog; AI256621; ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated homolog; C030026E19Rik; serine-protein kinase ATM
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,348,422 - 53,448,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,350,449 - 53,448,040 (-)EnsemblGRCm39 Ensembl
GRCm38953,437,122 - 53,536,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,439,149 - 53,536,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,245,227 - 53,344,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,201,763 - 53,298,968 (-)NCBIMGSCv36mm8
Celera950,696,862 - 50,796,451 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (IEP,ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alzheimer's disease  (ISO)
Arenaviridae infectious disease  (IMP)
arteriosclerosis  (IMP)
astroblastoma, MN1-altered  (ISO)
ataxia telangiectasia  (IAGP,IMP,ISO)
Ataxia-Telangiectasia Variant  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta-ketothiolase deficiency  (ISO)
bilateral breast cancer  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cerebellar ataxia  (ISO)
chromosome 11 partial duplication syndrome  (ISO)
clear cell renal cell carcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial serous adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Colitis  (IMP)
Familial Pancreatic Carcinoma  (ISO)
Familial Prostate Cancer  (ISO)
female breast cancer  (ISO)
Fibrosis  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes simplex virus keratitis  (IMP)
Herpesviridae Infections  (IMP)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (IMP)
IDH-mutant anaplastic astrocytoma  (ISO)
infertility  (ISO)
influenza A  (IMP)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
Kidney Reperfusion Injury  (ISO)
leukemia  (ISO)
liver cancer  (IMP)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
Lynch syndrome 1  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (IDA)
microcephaly  (ISO)
multiple endocrine neoplasia type 1  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (IMP,ISO)
nasopharynx carcinoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (IMP)
Otorhinolaryngologic Neoplasms  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papillary thyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
peripheral T-cell lymphoma  (ISO)
Pneumococcal Meningitis  (IMP)
polycythemia vera  (ISO)
pre-malignant neoplasm  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retroviridae Infections  (IMP)
Rhabdoviridae Infections  (IMP)
senile cataract  (ISO)
Sepsis  (IMP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (IMP)
T-cell prolymphocytic leukemia  (ISO)
thyroid cancer  (ISO)
urinary bladder cancer  (ISO)
uterine corpus cancer  (ISO)
Ventricular Dysfunction, Left  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1S)-bornane-2,3-dione  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-methylcholine  (ISO)
3-aminobenzamide  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (EXP)
4-hydroxynon-2-enal  (EXP)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
amsacrine  (ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
aphidicolin  (EXP)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
busulfan  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
carteolol  (ISO)
casticin  (ISO)
CCCP  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
cobalt atom  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
daunorubicin  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diepoxybutane  (EXP,ISO)
diethyl maleate  (ISO)
dihydroxyacetone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
Ethyl maltol  (ISO)
etoposide  (EXP,ISO)
fenhexamid  (ISO)
fenthion  (EXP)
flavanones  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
furosemide  (ISO)
gadodiamide hydrate  (ISO)
gallic acid  (ISO)
geneticin  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
ginsenoside Rg1  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hellebrigenin  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
isocyanates  (EXP,ISO)
isoflavones  (ISO)
kaempferol  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
Licochalcone B  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
metformin  (ISO)
methidathion  (EXP)
methotrexate  (EXP)
methoxsalen  (ISO)
methylparaben  (ISO)
mitoxantrone  (ISO)
monocrotaline  (EXP,ISO)
motexafin gadolinium  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
nitenpyram  (ISO)
nitrates  (ISO)
nocodazole  (ISO)
O-methyleugenol  (ISO)
octamethylcyclotetrasiloxane  (ISO)
ouabain  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paromomycin  (ISO)
PCB138  (EXP)
pectolinarigenin  (ISO)
pentamidine  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
phosphoramide mustard  (ISO)
pifithrin-?  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
prochloraz  (ISO)
promethazine  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
remdesivir  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-nitrosoglutathione  (ISO)
selinexor  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP,ISO)
sodium fluoride  (ISO)
sterigmatocystin  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tungsten  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
yttrium chloride  (ISO)
zearalenone  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (IGI)
cellular response to gamma radiation  (IEA,ISO)
cellular response to ionizing radiation  (ISO)
cellular response to nitrosative stress  (IEA,ISO)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to retinoic acid  (IMP)
cellular response to stress  (ISO)
cellular response to X-ray  (IEA,ISO)
chromatin remodeling  (IEA)
chromosome organization involved in meiotic cell cycle  (IMP)
determination of adult lifespan  (IGI)
DNA damage checkpoint signaling  (IBA,IMP,ISO)
DNA damage response  (IGI,ISO,TAS)
DNA double-strand break processing  (IEA,ISO)
DNA repair  (IDA,IMP)
double-strand break repair  (IBA,ISO,ISS)
double-strand break repair via homologous recombination  (IMP,ISO)
establishment of protein-containing complex localization to telomere  (IEA,ISO)
establishment of RNA localization to telomere  (IEA,ISO)
female gamete generation  (IMP)
female gonad development  (IMP)
female meiotic nuclear division  (IMP)
heart development  (IGI)
histone mRNA catabolic process  (ISO,ISS)
immune system process  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IGI,IMP)
lipoprotein catabolic process  (IGI)
male meiotic nuclear division  (IMP)
meiotic telomere clustering  (IMP)
mitotic G2 DNA damage checkpoint signaling  (ISO)
mitotic spindle assembly checkpoint signaling  (ISO,ISS)
multicellular organism growth  (IMP)
negative regulation of B cell proliferation  (IEA,ISO)
negative regulation of telomere capping  (IEA,ISO)
negative regulation of TORC1 signaling  (IBA,IMP,ISO)
neuron apoptotic process  (IGI)
oocyte development  (IMP)
ovarian follicle development  (IMP)
peptidyl-serine autophosphorylation  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
pexophagy  (ISO,ISS)
phosphatidylinositol-3-phosphate biosynthetic process  (IEA)
phosphorylation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of cell adhesion  (IMP)
positive regulation of cell migration  (IEA,ISO)
positive regulation of DNA catabolic process  (IEA,ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neuron apoptotic process  (IGI,ISO)
positive regulation of telomerase catalytic core complex assembly  (IEA,ISO)
positive regulation of telomere maintenance via telomerase  (IMP)
positive regulation of telomere maintenance via telomere lengthening  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
post-embryonic development  (IMP)
pre-B cell allelic exclusion  (IMP)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (IDA,ISO)
regulation of autophagy  (IMP,ISO)
regulation of cell cycle  (ISO)
regulation of microglial cell activation  (IEA,ISO)
regulation of telomere maintenance via telomerase  (ISO)
replicative senescence  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to ionizing radiation  (IGI,ISO,ISS)
signal transduction in response to DNA damage  (ISO,ISS)
somitogenesis  (IGI)
telomere maintenance  (IBA)
thymus development  (IMP)
V(D)J recombination  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal CD4-positive helper T cell morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal DNA repair  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal female meiosis  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal lymphocyte morphology  (IEA)
abnormal lysosome morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal motor learning  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal oogenesis  (IAGP)
abnormal pluripotent precursor cell morphology  (IAGP)
abnormal Purkinje cell axon morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal synaptic physiology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal testis development  (IAGP)
abnormal testis morphology  (IAGP)
abnormal testis size  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal uterus morphology  (IAGP)
absent estrous cycle  (IAGP)
absent estrus  (IAGP)
absent oocytes  (IAGP)
absent ovarian follicles  (IAGP)
anemia  (IAGP)
arrest of male meiosis  (IAGP)
arrest of spermatogenesis  (IAGP)
ataxia  (IAGP)
azoospermia  (IAGP)
cerebellum atrophy  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
decreased activated T cell number  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased cell proliferation  (IAGP)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased IgG level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased immature B cell number  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased macrophage cell number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased pre-B cell number  (IAGP)
decreased response to antigen  (IEA)
decreased sensitivity to induced cell death  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased splenocyte number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased vertical activity  (IAGP)
ectopic Purkinje cell  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
female infertility  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
impaired humoral immune response  (IEA)
impaired macrophage phagocytosis  (IEA)
impaired neuron physiology  (IAGP)
impaired righting response  (IAGP)
increased adenoma incidence  (IAGP)
increased B cell number  (IAGP)
increased B-1 B cell number  (IEA)
increased B-1a cell number  (IEA)
increased brain apoptosis  (IAGP)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cell death  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased excitatory postsynaptic current frequency  (IAGP)
increased food intake  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased IgM level  (IEA)
increased leukemia incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IEA)
increased mortality induced by gamma-irradiation  (IAGP)
increased neuron apoptosis  (IAGP)
increased ovary tumor incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased single-positive T cell number  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased thymoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
intracranial hemorrhage  (IAGP)
lethality, incomplete penetrance  (IAGP)
male infertility  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
ovary degeneration  (IAGP)
oxidative stress  (IAGP)
perinatal lethality  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
Purkinje cell degeneration  (IAGP)
seminiferous tubule degeneration  (IAGP)
short stride length  (IAGP)
slow postnatal weight gain  (IAGP)
small lymph nodes  (IAGP)
small ovary  (IAGP)
small spleen  (IAGP)
small testis  (IAGP)
small thymus  (IAGP)
spontaneous chromosome breakage  (IAGP)
thin cerebellar molecular layer  (IAGP)
thin cerebral cortex  (IAGP)
thymus cortex hypoplasia  (IAGP)
References

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PMID:22346761   PMID:22466704   PMID:22475743   PMID:22509320   PMID:22510377   PMID:22522401   PMID:22544329   PMID:22555459   PMID:22560297   PMID:22575700   PMID:22578416   PMID:22588298  
PMID:22624716   PMID:22670056   PMID:22709691   PMID:22730535   PMID:22768840   PMID:22797809   PMID:22802532   PMID:22869595   PMID:22869596   PMID:22922362   PMID:22940690   PMID:22972376  
PMID:23100326   PMID:23173799   PMID:23197859   PMID:23219553   PMID:23297361   PMID:23318439   PMID:23349395   PMID:23355489   PMID:23382544   PMID:23435430   PMID:23470523   PMID:23470994  
PMID:23509290   PMID:23563309   PMID:23626787   PMID:23754744   PMID:23759310   PMID:23772033   PMID:23776597   PMID:23824539   PMID:23836881   PMID:23852118   PMID:23858098   PMID:23860718  
PMID:23878245   PMID:23900276   PMID:23900513   PMID:23912341   PMID:23935957   PMID:23975433   PMID:24040138   PMID:24097111   PMID:24135283   PMID:24162653   PMID:24217620   PMID:24238855  
PMID:24238962   PMID:24248351   PMID:24307734   PMID:24342190   PMID:24465754   PMID:24474198   PMID:24482479   PMID:24532689   PMID:24550317   PMID:24572510   PMID:24637776   PMID:24657168  
PMID:24672010   PMID:24709420   PMID:24729610   PMID:24777530   PMID:24793032   PMID:24794298   PMID:24899707   PMID:24913718   PMID:24966912   PMID:24982162   PMID:25010009   PMID:25036710  
PMID:25079327   PMID:25092319   PMID:25127855   PMID:25210801   PMID:25264618   PMID:25331887   PMID:25391321   PMID:25486566   PMID:25489053   PMID:25520329   PMID:25540325   PMID:25605334  
PMID:25646414   PMID:25659036   PMID:25676421   PMID:25683718   PMID:25721125   PMID:25768017   PMID:25818648   PMID:25936915   PMID:26001649   PMID:26023099   PMID:26096928   PMID:26158450  
PMID:26209650   PMID:26220524   PMID:26234156   PMID:26280532   PMID:26290337   PMID:26303202   PMID:26308889   PMID:26310626   PMID:26388201   PMID:26400962   PMID:26465009   PMID:26469940  
PMID:26502796   PMID:26510954   PMID:26538284   PMID:26544571   PMID:26586427   PMID:26611459   PMID:26623722   PMID:26657054   PMID:26745185   PMID:26752140   PMID:26822034   PMID:26833222  
PMID:26862121   PMID:26887372   PMID:26921311   PMID:26941064   PMID:26984279   PMID:27022623   PMID:27073218   PMID:27073845   PMID:27075534   PMID:27160905   PMID:27166172   PMID:27171262  
PMID:27288435   PMID:27304073   PMID:27318254   PMID:27320916   PMID:27424808   PMID:27477910   PMID:27625305   PMID:27677594   PMID:27694478   PMID:27732836   PMID:27738310   PMID:27745971  
PMID:27758128   PMID:27791036   PMID:27793024   PMID:27798842   PMID:27806302   PMID:27857169   PMID:27869164   PMID:27876863   PMID:27918549   PMID:27958289   PMID:27974220   PMID:28057860  
PMID:28123024   PMID:28137874   PMID:28186538   PMID:28199840   PMID:28303890   PMID:28339687   PMID:28362262   PMID:28363999   PMID:28436431   PMID:28487983   PMID:28489848   PMID:28495793  
PMID:28535250   PMID:28617799   PMID:28620865   PMID:28659469   PMID:28686579   PMID:28724653   PMID:28732227   PMID:28751718   PMID:28790064   PMID:28849346   PMID:28851706   PMID:28885618  
PMID:28894253   PMID:28930658   PMID:29279380   PMID:29282803   PMID:29311308   PMID:29437857   PMID:29531308   PMID:29652546   PMID:29717979   PMID:29955025   PMID:29976923   PMID:30012604  
PMID:30095186   PMID:30150306   PMID:30194346   PMID:30209244   PMID:30219864   PMID:30345028   PMID:30348496   PMID:30622252   PMID:30642892   PMID:30700723   PMID:30712845   PMID:30745336  
PMID:30995416   PMID:31028119   PMID:31074776   PMID:31101667   PMID:31189575   PMID:31285322   PMID:31315051   PMID:31381155   PMID:31435664   PMID:31565865   PMID:31577952   PMID:31664505  
PMID:31680852   PMID:31690822   PMID:31748650   PMID:31845528   PMID:31849966   PMID:31990056   PMID:32029507   PMID:32051414   PMID:32060145   PMID:32060399   PMID:32123907   PMID:32223892  
PMID:32321712   PMID:32325033   PMID:32554809   PMID:32567210   PMID:32757690   PMID:32990677   PMID:33239428   PMID:33290271   PMID:33444287   PMID:33536256   PMID:33608602   PMID:33734555  
PMID:33802342   PMID:33826883   PMID:33929897   PMID:34267759   PMID:34292326   PMID:34519267   PMID:34593604   PMID:34723800   PMID:34746147   PMID:34793701   PMID:34851661   PMID:35176943  
PMID:35196880   PMID:35764636   PMID:35920200   PMID:36293397   PMID:36434396   PMID:36470401   PMID:36526012   PMID:36640339   PMID:36752571   PMID:37048108   PMID:37236596   PMID:37787989  
PMID:37989727   PMID:38697554   PMID:38858601   PMID:39083600  


Genomics

Comparative Map Data
Atm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,348,422 - 53,448,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,350,449 - 53,448,040 (-)EnsemblGRCm39 Ensembl
GRCm38953,437,122 - 53,536,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,439,149 - 53,536,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,245,227 - 53,344,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,201,763 - 53,298,968 (-)NCBIMGSCv36mm8
Celera950,696,862 - 50,796,451 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
ATM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811108,223,067 - 108,369,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11108,222,804 - 108,369,102 (+)EnsemblGRCh38hg38GRCh38
GRCh3711108,093,794 - 108,239,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,598,769 - 107,745,036 (+)NCBINCBI36Build 36hg18NCBI36
Celera11105,248,510 - 105,394,764 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11104,019,183 - 104,165,444 (+)NCBIHuRef
CHM1_111107,976,660 - 108,122,959 (+)NCBICHM1_1
T2T-CHM13v2.011108,230,362 - 108,376,596 (+)NCBIT2T-CHM13v2.0
Atm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,724,939 - 62,829,040 (-)NCBIGRCr8
mRatBN7.2853,828,741 - 53,932,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,356,470 - 59,457,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,635,498 - 57,736,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,499,734 - 55,601,064 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,015,938 - 58,119,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,598,503 - 56,703,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4856,894,746 - 56,996,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera853,321,802 - 53,423,212 (-)NCBICelera
Cytogenetic Map8q24NCBI
Atm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,426,135 - 10,530,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,422,753 - 10,531,406 (+)NCBIChiLan1.0ChiLan1.0
ATM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29108,968,082 - 109,114,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111110,061,127 - 110,207,606 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011103,109,979 - 103,256,405 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111106,584,228 - 106,728,457 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,584,228 - 106,727,041 (+)Ensemblpanpan1.1panPan2
ATM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,180,129 - 24,297,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,182,135 - 24,297,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,107,778 - 24,222,696 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,211,375 - 24,326,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,211,375 - 24,326,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,258,890 - 24,373,424 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,160,300 - 24,274,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,218,488 - 24,333,125 (-)NCBIUU_Cfam_GSD_1.0
Atm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494791,001,856 - 91,178,286 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551359,362 - 532,211 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936551359,134 - 534,672 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,620,658 - 36,759,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,620,656 - 36,759,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,746,630 - 40,837,766 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2940,926,043 - 40,945,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,653,208 - 99,786,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,653,139 - 99,791,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,170,879 - 26,305,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247842,937,499 - 3,078,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247842,933,172 - 3,080,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atm
3538 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:966
Count of miRNA genes:552
Interacting mature miRNAs:652
Transcripts:ENSMUST00000118282, ENSMUST00000126598, ENSMUST00000132249, ENSMUST00000132403, ENSMUST00000150244
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
13515057Adip20b_madiposity 20b (mouse)94870090853791702Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse

Markers in Region
AW557183  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,439,726 - 53,439,822UniSTSGRCm38
MGSCv37953,247,831 - 53,247,927UniSTSGRCm37
Celera950,699,481 - 50,699,577UniSTS
Cytogenetic Map9C-DUniSTS
Whitehead/MRC_RH9533.36UniSTS
RH136054  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
Atm  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
cM Map930.0UniSTS
U43678  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,439,423 - 53,439,579UniSTSGRCm38
MGSCv37953,247,528 - 53,247,684UniSTSGRCm37
Celera950,699,178 - 50,699,334UniSTS
Cytogenetic Map9C-DUniSTS
Whitehead/MRC_RH9533.36UniSTS
Whitehead/MRC_RH9533.36UniSTS
Whitehead_YAC9 UniSTS
PMC316723P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,479,592 - 53,479,754UniSTSGRCm38
MGSCv37953,287,697 - 53,287,859UniSTSGRCm37
Celera950,739,346 - 50,739,508UniSTS
Cytogenetic Map9C-DUniSTS
PMC316723P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,479,592 - 53,479,749UniSTSGRCm38
MGSCv37953,287,697 - 53,287,854UniSTSGRCm37
Celera950,739,346 - 50,739,503UniSTS
Cytogenetic Map9C-DUniSTS
PMC316856P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,479,586 - 53,479,732UniSTSGRCm38
MGSCv37953,287,691 - 53,287,837UniSTSGRCm37
Celera950,739,340 - 50,739,486UniSTS
Cytogenetic Map9C-DUniSTS
U43678  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,439,500 - 53,439,579UniSTSGRCm38
MGSCv37953,247,605 - 53,247,684UniSTSGRCm37
Celera950,699,255 - 50,699,334UniSTS
Cytogenetic Map9C-DUniSTS
Whitehead/MRC_RH9533.36UniSTS
Atm  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
cM Map930.0UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000118282   ⟹   ENSMUSP00000113388
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,350,449 - 53,445,266 (-)Ensembl
GRCm38.p6 Ensembl953,439,149 - 53,533,966 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126598
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,351,405 - 53,353,860 (-)Ensembl
GRCm38.p6 Ensembl953,440,105 - 53,442,560 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132249   ⟹   ENSMUSP00000118199
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,356,675 - 53,364,917 (-)Ensembl
GRCm38.p6 Ensembl953,445,375 - 53,453,617 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,433,147 - 53,447,973 (-)Ensembl
GRCm38.p6 Ensembl953,521,847 - 53,536,673 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150244   ⟹   ENSMUSP00000115394
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,438,494 - 53,447,908 (-)Ensembl
GRCm38.p6 Ensembl953,527,194 - 53,536,608 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232179   ⟹   ENSMUSP00000156344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,350,668 - 53,448,040 (-)Ensembl
GRCm38.p6 Ensembl953,439,368 - 53,536,740 (-)Ensembl
RefSeq Acc Id: NM_007499   ⟹   NP_031525
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,348,422 - 53,447,971 (-)NCBI
GRCm38953,437,122 - 53,536,671 (-)NCBI
MGSCv37953,245,227 - 53,344,776 (-)RGD
Celera950,696,862 - 50,796,451 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242385   ⟹   XP_011240687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,348,432 - 53,448,115 (-)NCBI
GRCm38953,437,132 - 53,536,817 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154574   ⟹   XP_036010467
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,372,317 - 53,448,125 (-)NCBI
Sequence:
RefSeq Acc Id: XR_870525
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,348,432 - 53,448,122 (-)NCBI
GRCm38953,437,132 - 53,536,824 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031525   ⟸   NM_007499
- UniProtKB: Q62388 (UniProtKB/Swiss-Prot),   E9QNY7 (UniProtKB/Swiss-Prot),   B9EHX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240687   ⟸   XM_011242385
- Peptide Label: isoform X1
- UniProtKB: Q62388 (UniProtKB/Swiss-Prot),   E9QNY7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000115394   ⟸   ENSMUST00000150244
Ensembl Acc Id: ENSMUSP00000113388   ⟸   ENSMUST00000118282
Ensembl Acc Id: ENSMUSP00000118199   ⟸   ENSMUST00000132249
Ensembl Acc Id: ENSMUSP00000156344   ⟸   ENSMUST00000232179
RefSeq Acc Id: XP_036010467   ⟸   XM_036154574
- Peptide Label: isoform X2
Protein Domains
FAT   FATC   PI3K/PI4K catalytic   Telomere-length maintenance and DNA damage repair

Promoters
RGD ID:6844199
Promoter ID:MM_KWN:57364
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000118282,   NM_001081152,   OTTMUST00000078539,   OTTMUST00000078547
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36953,343,691 - 53,345,227 (-)MPROMDB
RGD ID:8669612
Promoter ID:EPDNEW_M12837
Type:initiation region
Name:Atm_1
Description:Mus musculus ataxia telangiectasia mutated , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38953,536,642 - 53,536,702EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107202 AgrOrtholog
Ensembl Genes ENSMUSG00000034218 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000118282 ENTREZGENE
  ENSMUST00000118282.9 UniProtKB/TrEMBL
  ENSMUST00000132249.2 UniProtKB/TrEMBL
  ENSMUST00000150244.2 UniProtKB/TrEMBL
  ENSMUST00000232179.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATM_plant UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKKc_ATM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107202 ENTREZGENE
NCBI Gene 11920 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/TrEMBL
Pfam FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atm PhenoGen
PROSITE FAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATM_MOUSE UniProtKB/Swiss-Prot
  B9EHX4 ENTREZGENE, UniProtKB/TrEMBL
  D3Z0Q2_MOUSE UniProtKB/TrEMBL
  E9QNY7 ENTREZGENE
  F6UXV2_MOUSE UniProtKB/TrEMBL
  Q3UT15_MOUSE UniProtKB/TrEMBL
  Q62388 ENTREZGENE
  Q6NX74_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QNY7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-24 Atm  ataxia telangiectasia mutated    ataxia telangiectasia mutated homolog (human)  Symbol and/or name change 5135510 APPROVED