Atm (ataxia telangiectasia mutated) - Rat Genome Database

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Gene: Atm (ataxia telangiectasia mutated) Mus musculus
Symbol: Atm
Name: ataxia telangiectasia mutated
RGD ID: 10199
Description: Enables protein kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; positive regulation of macromolecule biosynthetic process; and pre-B cell allelic exclusion. Acts upstream of or within several processes, including DNA recombination; intracellular signal transduction; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-T mutated homolog; AI256621; ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated homolog; C030026E19Rik; serine-protein kinase ATM
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39953,348,422 - 53,448,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,350,449 - 53,448,040 (-)EnsemblGRCm39 Ensembl
GRCm38953,437,122 - 53,536,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,439,149 - 53,536,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,245,227 - 53,344,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,201,763 - 53,298,968 (-)NCBIMGSCv36mm8
Celera950,696,862 - 50,796,451 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (IEP,ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alzheimer's disease  (ISO)
Arenaviridae infectious disease  (IMP)
arteriosclerosis  (IMP)
ataxia telangiectasia  (IAGP,IMP,ISO)
Ataxia-Telangiectasia Variant  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta-ketothiolase deficiency  (ISO)
bilateral breast cancer  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cerebellar ataxia  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
clear cell renal cell carcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism, Low-Birth-Weight Type, with Unresponsiveness to Growth Hormone  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial serous adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Colitis  (IMP)
Familial Pancreatic Carcinoma  (ISO)
Familial Prostate Cancer  (ISO)
female breast cancer  (ISO)
Fibrosis  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes simplex virus keratitis  (IMP)
Herpesviridae Infections  (IMP)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (IMP)
infertility  (ISO)
influenza A  (IMP)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
Kidney Reperfusion Injury  (ISO)
leukemia  (ISO)
liver cancer  (IMP)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
Lynch syndrome 1  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (IDA)
microcephaly  (ISO)
multiple myeloma  (ISO)
Multiple Polyps and Recurrent Inflammatory Fibroid, Gastrointestinal  (ISO)
myocardial infarction  (IMP,ISO)
nasopharynx carcinoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (IMP)
Otorhinolaryngologic Neoplasms  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
Parkinson's disease  (ISO)
peripheral T-cell lymphoma  (ISO)
Pneumococcal Meningitis  (IMP)
polycythemia vera  (ISO)
pre-malignant neoplasm  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retroviridae Infections  (IMP)
Rhabdoviridae Infections  (IMP)
senile cataract  (ISO)
Sepsis  (IMP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (IMP)
T-cell prolymphocytic leukemia  (ISO)
thyroid gland cancer  (ISO)
thyroid gland papillary carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine corpus cancer  (ISO)
Ventricular Dysfunction, Left  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1S)-bornane-2,3-dione  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-methylcholine  (ISO)
3-aminobenzamide  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (EXP)
4-hydroxynon-2-enal  (EXP)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
aphidicolin  (EXP)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
busulfan  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
cobalt atom  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
daunorubicin  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diepoxybutane  (EXP,ISO)
diethyl maleate  (ISO)
dihydroxyacetone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
Ethyl maltol  (ISO)
etoposide  (EXP,ISO)
fenhexamid  (ISO)
fenthion  (EXP)
flavanones  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
furosemide  (ISO)
gadodiamide hydrate  (ISO)
gallic acid  (ISO)
geneticin  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
ginsenoside Rg1  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hellebrigenin  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
isocyanates  (EXP,ISO)
isoflavones  (ISO)
kaempferol  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
Licochalcone B  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
metformin  (ISO)
methidathion  (EXP)
methotrexate  (EXP)
methoxsalen  (ISO)
methylparaben  (ISO)
mitoxantrone  (ISO)
monocrotaline  (EXP,ISO)
motexafin gadolinium  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
nitenpyram  (ISO)
nitrates  (ISO)
nocodazole  (ISO)
O-methyleugenol  (ISO)
octamethylcyclotetrasiloxane  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paromomycin  (ISO)
PCB138  (EXP)
pentamidine  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
phosphoramide mustard  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
prochloraz  (ISO)
promethazine  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (EXP,ISO)
remdesivir  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-nitrosoglutathione  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP,ISO)
sodium fluoride  (ISO)
sterigmatocystin  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
tributylstannane  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tungsten  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
yttrium chloride  (ISO)
zearalenone  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (IGI)
cellular response to gamma radiation  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to nitrosative stress  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to retinoic acid  (IMP)
cellular response to X-ray  (ISO)
chromosome organization involved in meiotic cell cycle  (IMP)
determination of adult lifespan  (IGI)
DNA damage checkpoint signaling  (IBA,IMP,ISO)
DNA damage response  (IGI,ISO,TAS)
DNA repair  (IDA,IMP)
double-strand break repair via homologous recombination  (IMP)
establishment of protein-containing complex localization to telomere  (ISO)
establishment of RNA localization to telomere  (ISO)
female gamete generation  (IMP)
female gonad development  (IMP)
female meiotic nuclear division  (IMP)
heart development  (IGI)
histone mRNA catabolic process  (ISO)
immune system process  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IGI,IMP)
lipoprotein catabolic process  (IGI)
male meiotic nuclear division  (IMP)
meiotic telomere clustering  (IMP)
mitotic G2 DNA damage checkpoint signaling  (ISO)
mitotic spindle assembly checkpoint signaling  (ISO)
multicellular organism growth  (IMP)
negative regulation of B cell proliferation  (ISO)
negative regulation of telomere capping  (ISO)
negative regulation of TORC1 signaling  (IBA,IMP,ISO)
neuron apoptotic process  (IGI)
oocyte development  (IMP)
ovarian follicle development  (IMP)
peptidyl-serine autophosphorylation  (ISO)
peptidyl-serine phosphorylation  (ISO)
pexophagy  (ISO)
phosphorylation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of cell adhesion  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of DNA catabolic process  (ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron apoptotic process  (IGI,ISO)
positive regulation of neuron death  (ISO)
positive regulation of telomerase catalytic core complex assembly  (ISO)
positive regulation of telomere maintenance via telomerase  (IMP)
positive regulation of telomere maintenance via telomere lengthening  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
post-embryonic development  (IMP)
pre-B cell allelic exclusion  (IMP)
protein autophosphorylation  (ISO)
protein phosphorylation  (IBA,IDA,ISO)
regulation of autophagy  (IMP,ISO)
regulation of cell cycle  (ISO)
regulation of microglial cell activation  (ISO)
regulation of telomerase activity  (ISO)
regulation of telomere maintenance via telomerase  (ISO)
replicative senescence  (ISO)
response to hypoxia  (ISO)
response to ionizing radiation  (IGI,ISO)
signal transduction in response to DNA damage  (ISO)
somitogenesis  (IGI)
telomere maintenance  (IBA)
thymus development  (IMP)
V(D)J recombination  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal CD4-positive helper T cell morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal DNA repair  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal female meiosis  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal lymphocyte morphology  (IEA)
abnormal lysosome morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal motor learning  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal oogenesis  (IAGP)
abnormal pluripotent precursor cell morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal synaptic physiology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal testis development  (IAGP)
abnormal testis morphology  (IAGP)
abnormal testis size  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal uterus morphology  (IAGP)
absent estrous cycle  (IAGP)
absent estrus  (IAGP)
absent oocytes  (IAGP)
absent ovarian follicles  (IAGP)
anemia  (IAGP)
arrest of male meiosis  (IAGP)
arrest of spermatogenesis  (IAGP)
ataxia  (IAGP)
azoospermia  (IAGP)
cerebellum atrophy  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
decreased activated T cell number  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased cell proliferation  (IAGP)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased IgG level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased immature B cell number  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased macrophage cell number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased pre-B cell number  (IAGP)
decreased response to antigen  (IEA)
decreased sensitivity to induced cell death  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased splenocyte number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased vertical activity  (IAGP)
ectopic Purkinje cell  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
female infertility  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
impaired humoral immune response  (IEA)
impaired macrophage phagocytosis  (IEA)
impaired neuron physiology  (IAGP)
impaired righting response  (IAGP)
increased adenoma incidence  (IAGP)
increased B cell number  (IAGP)
increased B-1 B cell number  (IEA)
increased B-1a cell number  (IEA)
increased brain apoptosis  (IAGP)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cell death  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased food intake  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased IgM level  (IEA)
increased leukemia incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IEA)
increased mortality induced by gamma-irradiation  (IAGP)
increased neuron apoptosis  (IAGP)
increased ovary tumor incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased single-positive T cell number  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased thymoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
intracranial hemorrhage  (IAGP)
lethality, incomplete penetrance  (IAGP)
male infertility  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
ovary degeneration  (IAGP)
oxidative stress  (IAGP)
perinatal lethality  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
Purkinje cell degeneration  (IAGP)
seminiferous tubule degeneration  (IAGP)
short stride length  (IAGP)
slow postnatal weight gain  (IAGP)
small lymph nodes  (IAGP)
small ovary  (IAGP)
small spleen  (IAGP)
small testis  (IAGP)
small thymus  (IAGP)
spontaneous chromosome breakage  (IAGP)
thin cerebellar molecular layer  (IAGP)
thin cerebral cortex  (IAGP)
thymus cortex hypoplasia  (IAGP)

References - curated
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51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:26280532   PMID:26290337   PMID:26303202   PMID:26308889   PMID:26310626   PMID:26388201   PMID:26400962   PMID:26465009   PMID:26469940   PMID:26502796   PMID:26510954   PMID:26538284  
PMID:26544571   PMID:26586427   PMID:26611459   PMID:26623722   PMID:26657054   PMID:26745185   PMID:26752140   PMID:26822034   PMID:26833222   PMID:26862121   PMID:26887372   PMID:26921311  
PMID:26941064   PMID:26984279   PMID:27022623   PMID:27073218   PMID:27073845   PMID:27160905   PMID:27166172   PMID:27171262   PMID:27288435   PMID:27304073   PMID:27318254   PMID:27320916  
PMID:27424808   PMID:27477910   PMID:27625305   PMID:27677594   PMID:27694478   PMID:27732836   PMID:27738310   PMID:27745971   PMID:27758128   PMID:27791036   PMID:27793024   PMID:27798842  
PMID:27806302   PMID:27857169   PMID:27869164   PMID:27876863   PMID:27918549   PMID:27958289   PMID:27974220   PMID:28057860   PMID:28123024   PMID:28137874   PMID:28186538   PMID:28199840  
PMID:28303890   PMID:28339687   PMID:28362262   PMID:28363999   PMID:28436431   PMID:28487983   PMID:28489848   PMID:28495793   PMID:28535250   PMID:28617799   PMID:28620865   PMID:28659469  
PMID:28686579   PMID:28724653   PMID:28732227   PMID:28751718   PMID:28790064   PMID:28849346   PMID:28851706   PMID:28885618   PMID:28894253   PMID:29279380   PMID:29282803   PMID:29311308  
PMID:29437857   PMID:29531308   PMID:29652546   PMID:29717979   PMID:29955025   PMID:29976923   PMID:30012604   PMID:30095186   PMID:30150306   PMID:30194346   PMID:30209244   PMID:30219864  
PMID:30345028   PMID:30348496   PMID:30622252   PMID:30642892   PMID:30700723   PMID:30712845   PMID:30745336   PMID:30995416   PMID:31028119   PMID:31101667   PMID:31189575   PMID:31285322  
PMID:31315051   PMID:31381155   PMID:31435664   PMID:31565865   PMID:31664505   PMID:31680852   PMID:31690822   PMID:31748650   PMID:31845528   PMID:31849966   PMID:31990056   PMID:32029507  
PMID:32051414   PMID:32060145   PMID:32060399   PMID:32123907   PMID:32223892   PMID:32321712   PMID:32325033   PMID:32554809   PMID:32567210   PMID:32757690   PMID:32990677   PMID:33239428  
PMID:33290271   PMID:33444287   PMID:33536256   PMID:33608602   PMID:33734555   PMID:33802342   PMID:33826883   PMID:33929897   PMID:34267759   PMID:34292326   PMID:34519267   PMID:34593604  
PMID:34723800   PMID:34746147   PMID:34793701   PMID:34851661   PMID:35176943   PMID:35764636   PMID:35920200   PMID:36434396   PMID:36470401   PMID:36526012   PMID:36640339  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39953,348,422 - 53,448,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,350,449 - 53,448,040 (-)EnsemblGRCm39 Ensembl
GRCm38953,437,122 - 53,536,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,439,149 - 53,536,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,245,227 - 53,344,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,201,763 - 53,298,968 (-)NCBIMGSCv36mm8
Celera950,696,862 - 50,796,451 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811108,223,067 - 108,369,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11108,223,044 - 108,369,102 (+)EnsemblGRCh38hg38GRCh38
GRCh3711108,093,794 - 108,239,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,598,769 - 107,745,036 (+)NCBINCBI36Build 36hg18NCBI36
Celera11105,248,510 - 105,394,764 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11104,019,183 - 104,165,444 (+)NCBIHuRef
CHM1_111107,976,660 - 108,122,959 (+)NCBICHM1_1
T2T-CHM13v2.011108,230,362 - 108,376,596 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2853,828,741 - 53,932,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,356,470 - 59,457,803 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0857,635,498 - 57,736,825 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0855,499,734 - 55,601,064 (-)NCBIRnor_WKY
Rnor_6.0858,015,938 - 58,119,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,598,503 - 56,703,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4856,894,746 - 56,996,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera853,321,802 - 53,423,212 (-)NCBICelera
Cytogenetic Map8q24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541210,426,135 - 10,530,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,422,753 - 10,531,406 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan111110,061,434 - 110,207,606 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011103,109,979 - 103,256,405 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111106,584,228 - 106,728,457 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,584,228 - 106,727,041 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1524,180,129 - 24,297,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,182,135 - 24,297,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,107,778 - 24,222,696 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,211,375 - 24,326,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,211,375 - 24,326,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,258,890 - 24,373,424 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,160,300 - 24,274,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,218,488 - 24,333,125 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494791,001,856 - 91,178,286 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551359,362 - 532,211 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936551359,134 - 534,672 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl936,620,658 - 36,759,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,620,656 - 36,759,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,746,630 - 40,837,766 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2940,926,043 - 40,945,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1199,653,208 - 99,786,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,653,139 - 99,791,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,170,879 - 26,305,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247842,937,499 - 3,078,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247842,933,172 - 3,080,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Atm
3538 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:966
Count of miRNA genes:552
Interacting mature miRNAs:652
Transcripts:ENSMUST00000118282, ENSMUST00000126598, ENSMUST00000132249, ENSMUST00000132403, ENSMUST00000150244
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
13515057Adip20b_madiposity 20b (mouse)94870090853791702Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,439,726 - 53,439,822UniSTSGRCm38
MGSCv37953,247,831 - 53,247,927UniSTSGRCm37
Celera950,699,481 - 50,699,577UniSTS
Cytogenetic Map9C-DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
cM Map930.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,439,423 - 53,439,579UniSTSGRCm38
MGSCv37953,247,528 - 53,247,684UniSTSGRCm37
Celera950,699,178 - 50,699,334UniSTS
Cytogenetic Map9C-DUniSTS
Whitehead_YAC9 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,479,592 - 53,479,754UniSTSGRCm38
MGSCv37953,287,697 - 53,287,859UniSTSGRCm37
Celera950,739,346 - 50,739,508UniSTS
Cytogenetic Map9C-DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,479,592 - 53,479,749UniSTSGRCm38
MGSCv37953,287,697 - 53,287,854UniSTSGRCm37
Celera950,739,346 - 50,739,503UniSTS
Cytogenetic Map9C-DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,479,586 - 53,479,732UniSTSGRCm38
MGSCv37953,287,691 - 53,287,837UniSTSGRCm37
Celera950,739,340 - 50,739,486UniSTS
Cytogenetic Map9C-DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,439,500 - 53,439,579UniSTSGRCm38
MGSCv37953,247,605 - 53,247,684UniSTSGRCm37
Celera950,699,255 - 50,699,334UniSTS
Cytogenetic Map9C-DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
cM Map930.0UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000118282   ⟹   ENSMUSP00000113388
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,350,449 - 53,445,266 (-)Ensembl
GRCm38.p6 Ensembl953,439,149 - 53,533,966 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126598
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,351,405 - 53,353,860 (-)Ensembl
GRCm38.p6 Ensembl953,440,105 - 53,442,560 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132249   ⟹   ENSMUSP00000118199
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,356,675 - 53,364,917 (-)Ensembl
GRCm38.p6 Ensembl953,445,375 - 53,453,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132403
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,433,147 - 53,447,973 (-)Ensembl
GRCm38.p6 Ensembl953,521,847 - 53,536,673 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150244   ⟹   ENSMUSP00000115394
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,438,494 - 53,447,908 (-)Ensembl
GRCm38.p6 Ensembl953,527,194 - 53,536,608 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232179   ⟹   ENSMUSP00000156344
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,350,668 - 53,448,040 (-)Ensembl
GRCm38.p6 Ensembl953,439,368 - 53,536,740 (-)Ensembl
RefSeq Acc Id: NM_007499   ⟹   NP_031525
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39953,348,422 - 53,447,971 (-)NCBI
GRCm38953,437,122 - 53,536,671 (-)NCBI
MGSCv37953,245,227 - 53,344,776 (-)RGD
Celera950,696,862 - 50,796,451 (-)RGD
RefSeq Acc Id: XM_011242385   ⟹   XP_011240687
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,348,432 - 53,448,115 (-)NCBI
GRCm38953,437,132 - 53,536,817 (-)NCBI
RefSeq Acc Id: XM_036154574   ⟹   XP_036010467
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,372,317 - 53,448,125 (-)NCBI