RGD Reference Report - Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.

General

Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.
Authors:	Jiang, Yan Liang, Zheng D Wu, Tsung T Cao, Liyu Zhang, Hongfu Xu, Xiao-Chun
Citation:	Jiang Y, etal., Int J Cancer. 2007 Jan 1;120(1):91-5. doi: 10.1002/ijc.22121.
RGD ID:	150340713
Pubmed:	PMID:17019709 (View Abstract at PubMed)
DOI:	DOI:10.1002/ijc.22121 (Journal Full-text)
Esophageal cancer is a substantial health problem because of its usually late stage at diagnosis and poor prognosis. Tobacco smoking and alcohol use are the most important risk factors in the development of esophageal squamous cell carcinoma (SCC). Our previous study demonstrated the binding of benzo[a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke and environmental pollution, to the ataxia-telangiectasia mutated (ATM) gene. To understand how this binding affects the alteration of ATM expression and to identify biomarkers for the detection of esophageal cancer, we analyzed ATM mRNA expression in tissue specimens from patients with esophageal SCC and premalignant lesions using in situ hybridization. We then performed in vitro experiments to verify and extend our ex vivo observations. We found that ATM expression was increased in esophageal SCC and its premalignant lesions when compared with normal tissues and that increased ATM expression was associated with tobacco smoke exposure and tumor de-differentiation. Moreover, BPDE induced ATM expression in esophageal SCC cell lines in a time-dependent manner. In summary, the BPDE in tobacco smoke may be responsible for increased ATM expression in premalignant and malignant esophageal tissues. Our findings suggest that the ATM gene should be further evaluated as a biomarker for the early detection of esophageal cancer and tobacco use in patients.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
esophagus squamous cell carcinoma	disease_progression	IEP		150340713	Smoke Inhalation Injury and mRNA:increased expression:esophagus (human)	RGD
esophagus squamous cell carcinoma	disease_progression	ISO	ATM (Homo sapiens)	150340713; 150340713	Smoke Inhalation Injury and mRNA:increased expression:esophagus (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Atm (ATM serine/threonine kinase)

Genes (Mus musculus)

Atm (ataxia telangiectasia mutated)

Genes (Homo sapiens)

ATM (ATM serine/threonine kinase)

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Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.