RGD Reference Report - Anthracyclines induce DNA damage response-mediated protection against severe sepsis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

Authors: Figueiredo, Nuno  Chora, Angelo  Raquel, Helena  Pejanovic, Nadja  Pereira, Pedro  Hartleben, Björn  Neves-Costa, Ana  Moita, Catarina  Pedroso, Dora  Pinto, Andreia  Marques, Sofia  Faridi, Hafeez  Costa, Paulo  Gozzelino, Raffaella  Zhao, Jimmy L  Soares, Miguel P  Gama-Carvalho, Margarida  Martinez, Jennifer  Zhang, Qingshuo  Döring, Gerd  Grompe, Markus  Simas, J Pedro  Huber, Tobias B  Baltimore, David  Gupta, Vineet  Green, Douglas R  Ferreira, João A  Moita, Luis F 
Citation: Figueiredo N, etal., Immunity. 2013 Nov 14;39(5):874-84. doi: 10.1016/j.immuni.2013.08.039. Epub 2013 Oct 31.
RGD ID: 126781746
Pubmed: PMID:24184056   (View Abstract at PubMed)
PMCID: PMC3968948   (View Article at PubMed Central)
DOI: DOI:10.1016/j.immuni.2013.08.039   (Journal Full-text)

Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage response and autophagy pathways in the lung, as demonstrated by deletion of the ataxia telangiectasia mutated (Atm) or the autophagy-related protein 7 (Atg7) specifically in this organ. The protective effect of anthracyclines occurs irrespectively of pathogen burden, conferring disease tolerance to severe sepsis. These findings demonstrate that DNA damage responses, including the ATM and Fanconi Anemia pathways, are important modulators of immune responses and might be exploited to confer protection to inflammation-driven conditions, including severe sepsis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATMHumanSepsis treatmentISOAtm (Mus musculus) RGD 
AtmMouseSepsis treatmentIMP  RGD 
AtmRatSepsis treatmentISOAtm (Mus musculus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atm  (ATM serine/threonine kinase)

Genes (Mus musculus)
Atm  (ataxia telangiectasia mutated)

Genes (Homo sapiens)
ATM  (ATM serine/threonine kinase)


Additional Information