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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10199
Species: Mus musculus
RGD Object: Gene
Symbol: Atm
Name: ataxia telangiectasia mutated
Acc ID: CHEBI:40071
Term: 4-amino-1,8-naphthalimide
Definition: A benzoisoquinoline that has formula C12H8N2O2.
Chemical ID: MESH:C086538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmaffects response to substanceEXP 6480464CTDATM protein affects the susceptibility to 4-amino-1,8-naphthalimidePMID:16556909
Atmincreases phosphorylationEXP 6480464CTD4-amino-1,8-naphthalimide results in increased phosphorylation of ATM proteinPMID:16556909
Atmmultiple interactionsEXP 6480464CTDATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]PMID:16556909
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