RGD Reference Report - The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.

Authors: Bose, Shikha  Yap, Lee-Fah  Fung, Matthew  Starzcynski, Jane  Saleh, Amyza  Morgan, Susan  Dawson, Christopher  Chukwuma, Marilyn B  Maina, Esther  Buettner, Maike  Wei, Wenbin  Arrand, John  Lim, Paul V H  Young, Lawrence S  Teo, Soo Hwang  Stankovic, Tatjana  Woodman, Ciaran B J  Murray, Paul G 
Citation: Bose S, etal., J Pathol. 2009 Feb;217(3):345-52. doi: 10.1002/path.2487.
RGD ID: 126790562
Pubmed: PMID:19142888   (View Abstract at PubMed)
DOI: DOI:10.1002/path.2487   (Journal Full-text)

A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ATMHumannasopharynx carcinoma  IEP associated with Epstein-Barr Virus Infections and mRNA:decreased expression:nasopharyngeal tissue (human)RGD 
AtmMousenasopharynx carcinoma  ISOATM (Homo sapiens)associated with Epstein-Barr Virus Infections and mRNA:decreased expression:nasopharyngeal tissue (human)RGD 
AtmRatnasopharynx carcinoma  ISOATM (Homo sapiens)associated with Epstein-Barr Virus Infections and mRNA:decreased expression:nasopharyngeal tissue (human)RGD 


Genes (Rattus norvegicus)
Atm  (ATM serine/threonine kinase)

Genes (Mus musculus)
Atm  (ataxia telangiectasia mutated)

Genes (Homo sapiens)
ATM  (ATM serine/threonine kinase)