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Gene: Mme (membrane metallo endopeptidase) Mus musculus
Symbol: Mme
Name: membrane metallo endopeptidase
Description: Exhibits peptidase activity. Involved in several processes, including amyloid-beta clearance; amyloid-beta metabolic process; and positive regulation of long-term synaptic potentiation. Localizes to several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; Alzheimer's disease pathway; INTERACTS WITH 1,2-dichloroethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6030454K05Rik; atriopeptidase; C85356; CALLA; CD10; common acute lymphoblastic leukemia antigen; enkephalinase; NEP; neprilysin; neutral endopeptidase 24.11; SFE; skin fibroblast elastase
Homo sapiens (human) : MME (membrane metalloendopeptidase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mme (membrane metallo-endopeptidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mme (membrane metalloendopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : MME (membrane metalloendopeptidase)
Canis lupus familiaris (dog) : MME (membrane metalloendopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mme (membrane metalloendopeptidase)
Sus scrofa (pig) : MME (membrane metalloendopeptidase)
Chlorocebus sabaeus (African green monkey) : MME (membrane metalloendopeptidase)
Heterocephalus glaber (naked mole-rat) : Mme (membrane metalloendopeptidase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl363,241,537 - 63,386,030 (+)EnsemblGRCm38mm10GRCm38
GRCm38363,295,211 - 63,383,713 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37363,099,794 - 63,186,153 (+)NCBIGRCm37mm9NCBIm37
MGSCv36363,383,801 - 63,470,160 (+)NCBImm8
Celera362,969,256 - 63,055,608 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Protein Structures

Additional Information

External Database Links
More on Mme
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734285
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.