C1galt1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1) - Rat Genome Database

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Gene: C1galt1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1) Mus musculus
Analyze
Symbol: C1galt1
Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
RGD ID: 732030
MGI Page MGI
Description: Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Acts upstream of or within angiogenesis; intestinal epithelial cell development; and protein O-linked glycosylation. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1); PARTICIPATES IN O-linked glycan biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210410E06Rik; AV284120; core 1 beta1,3-galactosyltransferase 1; core 1 beta3-Gal-T; core 1 beta3-Gal-T1; core 1 O-glycan T-synthase; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; T-syn; T-synt; T-synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm11871  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,845,224 - 7,872,042 (+)NCBIGRCm39mm39
GRCm39 Ensembl67,844,842 - 7,875,687 (+)Ensembl
GRCm3867,845,224 - 7,872,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,844,842 - 7,875,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,795,224 - 7,822,042 (+)NCBIGRCm37mm9NCBIm37
MGSCv3667,795,333 - 7,822,047 (+)NCBImm8
Celera67,987,647 - 8,014,466 (+)NCBICelera
Cytogenetic Map6A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal capillary morphology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal duodenum crypts of Lieberkuhn morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal hormone level  (IAGP)
abnormal ileum morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian follicle number  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovarian secretion  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal platelet morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal thrombopoiesis  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal zona pellucida morphology  (IAGP)
albuminuria  (IAGP)
anemia  (IAGP)
decreased body weight  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased litter size  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased oocyte number  (IAGP)
decreased ovary weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
dilated capillary  (IAGP)
duodenal lesions  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
female infertility  (IAGP)
giant platelets  (IAGP)
glomerulonephritis  (IAGP)
hemorrhage  (IAGP)
increased bleeding time  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased duodenum adenocarcinoma incidence  (IAGP)
increased duodenum glandular epithelium tumor incidence  (IAGP)
increased mean platelet volume  (IAGP)
increased primary ovarian follicle number  (IAGP)
increased urine protein level  (IAGP)
intracranial hemorrhage  (IAGP)
kidney cortex atrophy  (IAGP)
kidney inflammation  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
polyovular ovarian follicle  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced female fertility  (IAGP)
renal cast  (IAGP)
small intestinal inflammation  (IAGP)
spinal hemorrhage  (IAGP)
thin zona pellucida  (IAGP)
thrombocytopenia  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11677243   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:14745002  
PMID:16141072   PMID:16141073   PMID:17062753   PMID:17113876   PMID:17374637   PMID:18773292   PMID:18799693   PMID:18924607   PMID:20439727   PMID:21220419   PMID:21239444   PMID:21267068  
PMID:21383503   PMID:21677750   PMID:21873635   PMID:22492969   PMID:22581805   PMID:22919046   PMID:23794065   PMID:24416370   PMID:25089569   PMID:25336627   PMID:25416550   PMID:25855670  
PMID:26124096   PMID:27229122   PMID:27581083   PMID:27874308   PMID:28716912   PMID:28842487   PMID:29698056   PMID:30086262   PMID:30550785   PMID:31645367   PMID:33093110  


Genomics

Comparative Map Data
C1galt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,845,224 - 7,872,042 (+)NCBIGRCm39mm39
GRCm39 Ensembl67,844,842 - 7,875,687 (+)Ensembl
GRCm3867,845,224 - 7,872,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,844,842 - 7,875,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,795,224 - 7,822,042 (+)NCBIGRCm37mm9NCBIm37
MGSCv3667,795,333 - 7,822,047 (+)NCBImm8
Celera67,987,647 - 8,014,466 (+)NCBICelera
Cytogenetic Map6A1NCBI
C1GALT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl77,156,934 - 7,248,616 (+)EnsemblGRCh38hg38GRCh38
GRCh3877,182,544 - 7,248,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3777,222,175 - 7,288,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3677,240,414 - 7,250,506 (+)NCBINCBI36hg18NCBI36
Build 3477,047,128 - 7,057,220NCBI
Celera77,191,989 - 7,253,724 (+)NCBI
Cytogenetic Map7p22.1-p21.3NCBI
HuRef77,070,739 - 7,136,784 (+)NCBIHuRef
CHM1_177,222,244 - 7,288,282 (+)NCBICHM1_1
CRA_TCAGchr7v277,269,406 - 7,335,444 (+)NCBI
C1galt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2435,930,743 - 35,966,102 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl435,928,104 - 35,961,831 (+)Ensembl
Rnor_6.0433,890,353 - 33,943,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,890,349 - 33,943,211 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,751,506 - 33,801,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,903,434 - 32,933,953 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1433,021,973 - 33,052,493 (+)NCBI
Celera431,436,062 - 31,466,434 (+)NCBICelera
Cytogenetic Map4q21NCBI
C1galt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543214,298,822 - 14,353,824 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543214,298,873 - 14,353,824 (+)NCBIChiLan1.0ChiLan1.0
C1GALT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.177,260,615 - 7,355,079 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl77,314,423 - 7,328,760 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v077,881,615 - 8,002,349 (+)NCBIMhudiblu_PPA_v0panPan3
C1GALT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,863,861 - 22,902,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,885,720 - 22,944,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,439,162 - 22,477,295 (+)NCBI
ROS_Cfam_1.01422,682,498 - 22,720,721 (+)NCBI
UMICH_Zoey_3.11422,835,602 - 22,873,767 (+)NCBI
UNSW_CanFamBas_1.01422,563,579 - 22,601,746 (+)NCBI
UU_Cfam_GSD_1.01422,825,564 - 22,863,772 (+)NCBI
C1galt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511836,181,136 - 36,212,418 (+)NCBI
SpeTri2.0NW_0049365852,650,868 - 2,682,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1GALT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1977,509,342 - 77,549,545 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2985,078,690 - 85,118,881 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C1GALT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12150,965,519 - 51,047,863 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604253,330,319 - 53,416,709 (+)NCBIVero_WHO_p1.0
C1galt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248134,795,542 - 4,832,056 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AV284120  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3867,871,248 - 7,871,339UniSTSGRCm38
MGSCv3767,821,248 - 7,821,339UniSTSGRCm37
Celera68,013,672 - 8,013,763UniSTS
Cytogenetic Map6A1UniSTS
Whitehead/MRC_RH676.14UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746985Manh59_mmandible shape 59 (mouse)6120847193Mouse
1357503Nhdlq5_mnon-HDL QTL 5 (mouse)Not determined6121465015Mouse
1301178Lith10_mlithogenic gene 10 (mouse)Not determined6121465015Mouse
10043884Bhr8_mbronchial hyperresponsiveness 8 (mouse)Not determined6121465015Mouse
10044000Mobq9_mmultigenetic obesity QTL 9 (mouse)Not determined6121465015Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144496Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144496Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144496Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633535476335Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920738249326Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751334Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345314181Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348726677Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348726677Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348726677Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:197
Interacting mature miRNAs:224
Transcripts:ENSMUST00000040159
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000040159   ⟹   ENSMUSP00000047931
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl67,844,842 - 7,875,687 (+)Ensembl
GRCm38.p6 Ensembl67,844,842 - 7,875,687 (+)Ensembl
RefSeq Acc Id: NM_052993   ⟹   NP_443719
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3967,845,224 - 7,872,042 (+)NCBI
GRCm3867,845,224 - 7,872,042 (+)ENTREZGENE
MGSCv3767,795,224 - 7,822,042 (+)RGD
Celera67,987,647 - 8,014,466 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_443719 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF81982 (Get FASTA)   NCBI Sequence Viewer  
  AAH25899 (Get FASTA)   NCBI Sequence Viewer  
  AAH64767 (Get FASTA)   NCBI Sequence Viewer  
  EDL13941 (Get FASTA)   NCBI Sequence Viewer  
  Q9JJ06 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_443719   ⟸   NM_052993
- UniProtKB: Q9JJ06 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000047931   ⟸   ENSMUST00000040159

Promoters
RGD ID:6839007
Promoter ID:MM_KWN:45133
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000055938
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3667,794,491 - 7,795,362 (+)MPROMDB
RGD ID:6888986
Promoter ID:EPDNEW_M7944
Type:initiation region
Name:C1galt1_1
Description:Mus musculus core 1 synthase, glycoprotein-N-acetylgalactosamine3-beta-galactosyltransferase, 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3867,845,263 - 7,845,323EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2151071 AgrOrtholog
Ensembl Genes ENSMUSG00000042460 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000047931 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040159 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro C1GALT1 UniProtKB/Swiss-Prot
  Fringe-like UniProtKB/Swiss-Prot
KEGG Report mmu:94192 UniProtKB/Swiss-Prot
MGD MGI:2151071 ENTREZGENE
NCBI Gene 94192 ENTREZGENE
PANTHER PTHR23033:SF13 UniProtKB/Swiss-Prot
Pfam Fringe UniProtKB/Swiss-Prot
PhenoGen C1galt1 PhenoGen
UniProt C1GLT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6P218 UniProtKB/Swiss-Prot
  Q8R0Z7 UniProtKB/Swiss-Prot