Cxcl3 (C-X-C motif chemokine ligand 3) - Rat Genome Database

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Gene: Cxcl3 (C-X-C motif chemokine ligand 3) Mus musculus
Analyze
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
RGD ID: 1614055
MGI Page MGI
Description: Enables chemokine activity. Involved in neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; and thymus. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-X-C motif chemokine 3; chemokine (C-X-C motif) ligand 3; Dci; Dcip1; dendritic cell inflammatory protein 1; gene model 1960, (ncbi); Gm1960
RGD Orthologs
Human
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,933,960 - 90,935,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,933,962 - 90,937,459 (+)EnsemblGRCm39 Ensembl
GRCm38590,786,101 - 90,788,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,215,129 - 91,217,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,861,303 - 91,863,290 (+)NCBIMGSCv36mm8
Celera588,937,720 - 88,939,708 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloroethane  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2''-galloylhyperin  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (EXP)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-Hydroxybenzophenone  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-fluorouracil  (EXP)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
aluminium sulfate (anhydrous)  (EXP)
AM-251  (EXP)
amitrole  (ISO)
amlexanox  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
antimycin A  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic acid  (EXP)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
asbestos  (EXP,ISO)
asperentin  (EXP)
astemizole  (ISO)
astressin 2B  (EXP)
atrazine  (ISO)
atropine  (EXP)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (EXP,ISO)
Botulinum toxin type A  (EXP)
Brevianamide A  (EXP)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
C.I. Natural Red 20  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
Calcimycin  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP,ISO)
capecitabine  (EXP)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carrageenan  (EXP)
carvacrol  (EXP)
ceruletide  (EXP)
cetirizine  (EXP)
chenodeoxycholic acid  (EXP)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
choline  (EXP)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
corosolic acid  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cyanuric chloride  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
Di-n-octyl phthalate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dicloxacillin  (EXP)
diethyl malate  (EXP)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP)
dimercaprol  (EXP)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
domperidone  (EXP)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental selenium  (ISO)
enniatin  (EXP)
epoxiconazole  (EXP)
Erionite  (EXP)
ethanol  (EXP)
eugenol  (EXP,ISO)
ferric oxide  (EXP,ISO)
flavonoids  (ISO)
flucloxacillin  (EXP)
fluoranthene  (EXP)
fluticasone  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (EXP)
fumonisin B1  (ISO)
gadolinium trichloride  (EXP)
gemcitabine  (ISO)
glucose  (EXP)
glutathione  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
gossypol  (ISO)
graphene oxide  (EXP)
halothane  (EXP)
heparan sulfate  (ISO)
hesperidin  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxychloroquine  (ISO)
imiquimod  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
isoflurane  (EXP)
isotretinoin  (ISO)
itraconazole  (EXP)
ketamine  (EXP)
L-methionine  (EXP)
leukotriene B4  (EXP)
leukotriene C4  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
maslinic acid  (EXP)
mesalamine  (ISO)
methamphetamine  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
methylparaben  (ISO)
metoclopramide  (EXP)
Microcystin la  (ISO)
microcystin-LR  (EXP)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
muramyl dipeptide  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (EXP)
neocuproine  (EXP)
neoechinulin A  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP)
nonivamide  (EXP)
o-anisidine  (ISO)
obeticholic acid  (EXP)
oleanolic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
PD 0325901  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phalloidin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
Phytolaccoside E  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
poly(I:C)  (EXP)
polymyxin B2  (EXP)
potassium bromate  (EXP)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Primycin  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propofol  (EXP)
propylparaben  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP)
resolvin D1  (EXP)
resolvin D2  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
ritonavir  (ISO)
rofecoxib  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (ISO)
SB-239063  (EXP)
selenium atom  (ISO)
serpentine asbestos  (EXP,ISO)
Shikonin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (EXP,ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
styrene  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
tauro-beta-muricholic acid  (EXP)
taurocholic acid  (EXP)
tebufenpyrad  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
toluene 2,4-diisocyanate  (EXP)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (EXP)
tungsten  (EXP)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vitamin D  (EXP)
XL147  (EXP)
zaragozic acid A  (EXP)
zileuton  (EXP)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc nitrate  (EXP)
zinc oxide  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
2. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
3. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
4. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
5. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
6. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Miura TA, etal., Virology. 2007 Dec 20;369(2):288-98. Epub 2007 Sep 5.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
9. Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Yao Z, etal., Aging (Albany NY). 2020 May 2;12(9):7639-7651. doi: 10.18632/aging.103101. Epub 2020 May 2.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14764687   PMID:16141072   PMID:16141073   PMID:17201934   PMID:21267068   PMID:21873635  
PMID:23115191   PMID:24194600   PMID:27193261   PMID:27512010   PMID:28018222   PMID:28928065   PMID:31712428   PMID:32296175   PMID:32948685   PMID:37073091   PMID:38218976   PMID:38355793  
PMID:38617547  


Genomics

Comparative Map Data
Cxcl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,933,960 - 90,935,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,933,962 - 90,937,459 (+)EnsemblGRCm39 Ensembl
GRCm38590,786,101 - 90,788,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,215,129 - 91,217,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,861,303 - 91,863,290 (+)NCBIMGSCv36mm8
Celera588,937,720 - 88,939,708 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
CXCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,869,393 - 73,871,308 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
Cxcl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,571,900 - 17,573,624 (-)NCBIGRCr8
mRatBN7.21417,287,727 - 17,289,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Celera1416,646,603 - 16,666,030 (-)NCBICelera
Cytogenetic Map14p22NCBI
LOC100976904
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,193,010 - 56,195,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,382,200 - 56,384,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,325,248 - 50,327,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,157,626 - 56,159,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,153,899 - 56,159,474 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in Cxcl3
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:117
Interacting mature miRNAs:119
Transcripts:ENSMUST00000031326
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
UniSTS:491958  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,786,146 - 90,787,474UniSTSGRCm38
MGSCv37591,215,172 - 91,216,500UniSTSGRCm37
Celera588,937,763 - 88,939,092UniSTS
Cytogenetic Map5E1UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000031326   ⟹   ENSMUSP00000031326
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,933,962 - 90,935,952 (+)Ensembl
GRCm38.p6 Ensembl590,786,103 - 90,788,093 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,933,962 - 90,937,459 (+)Ensembl
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)Ensembl
RefSeq Acc Id: NM_203320   ⟹   NP_976065
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39590,933,960 - 90,935,952 (+)NCBI
GRCm38590,786,101 - 90,788,093 (+)NCBI
MGSCv37591,215,129 - 91,217,116 (+)RGD
Celera588,937,718 - 88,939,711 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_976065   ⟸   NM_203320
- Peptide Label: precursor
- UniProtKB: Q3UNK9 (UniProtKB/Swiss-Prot),   Q6W5C0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031326   ⟸   ENSMUST00000031326

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6W5C0-F1-model_v2 AlphaFold Q6W5C0 1-100 view protein structure

Promoters
RGD ID:6887124
Promoter ID:EPDNEW_M7013
Type:multiple initiation site
Name:Cxcl3_1
Description:Mus musculus chemokine (C-X-C motif) ligand 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38590,786,103 - 90,786,163EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3037818 AgrOrtholog
Ensembl Genes ENSMUSG00000029379 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031326 ENTREZGENE
  ENSMUST00000031326.10 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:330122 UniProtKB/Swiss-Prot
MGD MGI:3037818 ENTREZGENE
NCBI Gene 330122 ENTREZGENE
PANTHER C-X-C MOTIF CHEMOKINE 3 UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Cxcl3 PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXCL3_MOUSE UniProtKB/Swiss-Prot
  Q3UNK9 ENTREZGENE
  Q6W5C0 ENTREZGENE
UniProt Secondary Q3UNK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Cxcl3  C-X-C motif chemokine ligand 3  Cxcl3  chemokine (C-X-C motif) ligand 3  Symbol and/or name change 5135510 APPROVED