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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614055
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3increases expressionISOCXCL1 (Homo sapiens)6480464CTDzoledronic acid results in increased expression of CXCL1 mRNAPMID:24714768
Cxcl3multiple interactionsISOCXCL1 (Homo sapiens)6480464CTD[zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNAPMID:19825521
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