CXCL3 (C-X-C motif chemokine ligand 3) - Rat Genome Database

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Gene: CXCL3 (C-X-C motif chemokine ligand 3) Homo sapiens
Analyze
Symbol: CXCL3
Name: C-X-C motif chemokine ligand 3
RGD ID: 1348459
HGNC Page HGNC:4604
Description: Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Located in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-X-C motif chemokine 3; chemokine (C-X-C motif) ligand 3; CINC-2b; GRO-gamma; GRO-gamma(1-73); GRO3; GRO3 oncogene; GROg; growth-regulated protein gamma; macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma; MGSA gamma; MIP-2b; MIP2-beta; MIP2B; SCYB3
RGD Orthologs
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,036,589 - 74,038,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,036,589 - 74,038,807 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,902,306 - 74,904,406 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,121,170 - 75,123,354 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,267,348 - 75,269,525NCBI
Celera472,262,394 - 72,264,580 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,713,214 - 70,715,400 (-)NCBIHuRef
CHM1_1474,938,145 - 74,940,329 (-)NCBICHM1_1
T2T-CHM13v2.0477,380,195 - 77,382,297 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-nitropyrene  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-Nitrofluoranthene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-aminobenzhydrazide  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6alpha-methylprednisolone  (EXP)
aflatoxin M1  (EXP)
aldehydo-D-glucose  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
aripiprazole  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
beryllium sulfate  (EXP)
beta-lapachone  (EXP)
beta-naphthoflavone  (EXP)
bicalutamide  (EXP)
bisphenol A  (EXP)
bisphenol F  (EXP)
butanal  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
cannabidiol  (EXP)
captopril  (EXP)
carbon nanotube  (EXP)
CGP 52608  (EXP)
chondroitin sulfate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
dimethylarsinous acid  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP)
fulvestrant  (EXP)
gemcitabine  (EXP)
glucose  (EXP)
hexadecanoic acid  (EXP)
indometacin  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
lead diacetate  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methylparaben  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
oleic acid  (EXP)
ozone  (EXP)
paracetamol  (EXP)
pentanal  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
piroxicam  (EXP)
prednisolone  (EXP)
Primycin  (EXP)
propanal  (EXP)
pterostilbene  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
tamoxifen  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
triphenyl phosphate  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP)
vanadyl sulfate  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
2. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
3. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Miura TA, etal., Virology. 2007 Dec 20;369(2):288-98. Epub 2007 Sep 5.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
Additional References at PubMed
PMID:1906501   PMID:2129556   PMID:2201751   PMID:2217207   PMID:2834384   PMID:8166297   PMID:8344798   PMID:8702798   PMID:9277410   PMID:9322516   PMID:9873037   PMID:10095777  
PMID:12477932   PMID:12734364   PMID:12949249   PMID:15340161   PMID:15489334   PMID:16341674   PMID:16356540   PMID:17389786   PMID:17466952   PMID:17703412   PMID:18240029   PMID:18577758  
PMID:19258923   PMID:19369450   PMID:19448742   PMID:19741597   PMID:20056178   PMID:20162422   PMID:20237496   PMID:20503287   PMID:20628624   PMID:21873635   PMID:23023221   PMID:23128233  
PMID:23225384   PMID:23383108   PMID:23589610   PMID:23904157   PMID:24605943   PMID:26837773   PMID:27255419   PMID:28018222   PMID:28381538   PMID:28928065   PMID:29524043   PMID:29884302  
PMID:30528777   PMID:31545503   PMID:31667838   PMID:31709538   PMID:31931644   PMID:32416070   PMID:33191645   PMID:33568427   PMID:33961781   PMID:34269159   PMID:34392586   PMID:34870709  
PMID:35188401   PMID:35664357   PMID:35789398   PMID:36343679   PMID:36398464   PMID:38031087   PMID:38489741   PMID:39238192  


Genomics

Comparative Map Data
CXCL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,036,589 - 74,038,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,036,589 - 74,038,807 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,902,306 - 74,904,406 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,121,170 - 75,123,354 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,267,348 - 75,269,525NCBI
Celera472,262,394 - 72,264,580 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,713,214 - 70,715,400 (-)NCBIHuRef
CHM1_1474,938,145 - 74,940,329 (-)NCBICHM1_1
T2T-CHM13v2.0477,380,195 - 77,382,297 (-)NCBIT2T-CHM13v2.0
CXCL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,020,748 - 56,022,861 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,209,888 - 56,212,001 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,152,730 - 50,154,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,985,197 - 55,987,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,925,562 - 55,986,555 (+)Ensemblpanpan1.1panPan2
LOC103235798
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,575,728 - 22,635,261 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037912,379 - 914,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CXCL3
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q13.3-21.21(chr4:71128874-78099088)x3 copy number gain See cases [RCV000051774] Chr4:71128874..78099088 [GRCh38]
Chr4:71994591..79020242 [GRCh37]
Chr4:72213455..79239266 [NCBI36]
Chr4:4q13.3-21.21
pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3
pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23
pathogenic
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
Chr4:4q13.3-21.22
pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1
pathogenic
GRCh38/hg38 4q13.2-13.3(chr4:67799665-74240920)x1 copy number loss See cases [RCV000137622] Chr4:67799665..74240920 [GRCh38]
Chr4:68665383..75106637 [GRCh37]
Chr4:68347978..75325501 [NCBI36]
Chr4:4q13.2-13.3
likely pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3
pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.3(chr4:74846849-74964907)x3 copy number gain See cases [RCV000448541] Chr4:74846849..74964907 [GRCh37]
Chr4:4q13.3
likely benign
GRCh37/hg19 4q13.1-21.1(chr4:66017575-76772947)x1 copy number loss See cases [RCV000510445] Chr4:66017575..76772947 [GRCh37]
Chr4:4q13.1-21.1
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.3(chr4:73952783-75261407)x3 copy number gain not provided [RCV000682420] Chr4:73952783..75261407 [GRCh37]
Chr4:4q13.3
uncertain significance
GRCh37/hg19 4q13.3-21.1(chr4:74890695-77318961)x1 copy number loss not provided [RCV000682421] Chr4:74890695..77318961 [GRCh37]
Chr4:4q13.3-21.1
uncertain significance
GRCh37/hg19 4q13.3(chr4:74774372-75110540)x3 copy number gain not provided [RCV000743704] Chr4:74774372..75110540 [GRCh37]
Chr4:4q13.3
benign
GRCh37/hg19 4q13.3(chr4:74785503-74987870)x3 copy number gain not provided [RCV000743705] Chr4:74785503..74987870 [GRCh37]
Chr4:4q13.3
benign
GRCh37/hg19 4q13.3(chr4:74811802-75110540)x3 copy number gain not provided [RCV000743706] Chr4:74811802..75110540 [GRCh37]
Chr4:4q13.3
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.2-21.21(chr4:68950363-79738598)x1 copy number loss not provided [RCV001005553] Chr4:68950363..79738598 [GRCh37]
Chr4:4q13.2-21.21
pathogenic
GRCh37/hg19 4q13.3-21.1(chr4:71561780-78304341)x1 copy number loss not provided [RCV000846231] Chr4:71561780..78304341 [GRCh37]
Chr4:4q13.3-21.1
pathogenic
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
Chr4:4q13.2-21.22
pathogenic
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
Chr4:4q13.3-21.23
pathogenic
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]
Chr4:4q13.3-21.3
pathogenic
GRCh38/hg38 4q12-21.1(chr4:51891814-76009719)x1 copy number loss Piebaldism [RCV001420508] Chr4:51891814..76009719 [GRCh38]
Chr4:4q12-21.1
pathogenic
GRCh37/hg19 4q13.3-21.21(chr4:73055313-80083154) copy number loss not specified [RCV002053427] Chr4:73055313..80083154 [GRCh37]
Chr4:4q13.3-21.21
pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
NC_000004.12:g.67833055_82716065del deletion See cases [RCV003313802] Chr4:67833055..82716065 [GRCh38]
Chr4:4q13.2-21.22
pathogenic
NM_002090.3(CXCL3):c.5C>G (p.Ala2Gly) single nucleotide variant not specified [RCV004156276] Chr4:74038607 [GRCh38]
Chr4:74904324 [GRCh37]
Chr4:4q13.3
uncertain significance
NM_002090.3(CXCL3):c.11C>G (p.Ala4Gly) single nucleotide variant not specified [RCV004130101] Chr4:74038601 [GRCh38]
Chr4:74904318 [GRCh37]
Chr4:4q13.3
uncertain significance
NM_002090.3(CXCL3):c.94G>T (p.Ala32Ser) single nucleotide variant not specified [RCV004254549] Chr4:74038518 [GRCh38]
Chr4:74904235 [GRCh37]
Chr4:4q13.3
uncertain significance
NM_002090.3(CXCL3):c.95C>T (p.Ala32Val) single nucleotide variant not specified [RCV004254550] Chr4:74038517 [GRCh38]
Chr4:74904234 [GRCh37]
Chr4:4q13.3
uncertain significance
NM_002090.3(CXCL3):c.188G>A (p.Arg63Lys) single nucleotide variant not specified [RCV004341463] Chr4:74038326 [GRCh38]
Chr4:74904043 [GRCh37]
Chr4:4q13.3
likely benign
GRCh37/hg19 4q13.2-13.3(chr4:69146217-75500577)x1 copy number loss not provided [RCV003485422] Chr4:69146217..75500577 [GRCh37]
Chr4:4q13.2-13.3
pathogenic
GRCh37/hg19 4q13.3-21.21(chr4:74822261-79345650)x1 copy number loss not specified [RCV003986507] Chr4:74822261..79345650 [GRCh37]
Chr4:4q13.3-21.21
uncertain significance
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2
pathogenic
NM_002090.3(CXCL3):c.173A>G (p.Gln58Arg) single nucleotide variant not specified [RCV004367574] Chr4:74038341 [GRCh38]
Chr4:74904058 [GRCh37]
Chr4:4q13.3
uncertain significance
NM_002090.3(CXCL3):c.125G>A (p.Arg42His) single nucleotide variant not specified [RCV004616191] Chr4:74038389 [GRCh38]
Chr4:74904106 [GRCh37]
Chr4:4q13.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:285
Interacting mature miRNAs:291
Transcripts:ENST00000296026, ENST00000502974, ENST00000510390, ENST00000511669
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH119675  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,903,748 - 74,904,020UniSTSGRCh37
GRCh37474,735,496 - 74,735,768UniSTSGRCh37
Build 36474,954,360 - 74,954,632RGDNCBI36
Celera472,263,838 - 72,264,110UniSTS
Celera472,095,624 - 72,095,896RGD
Cytogenetic Map4q21UniSTS
HuRef470,546,635 - 70,546,907UniSTS
HuRef470,714,658 - 70,714,930UniSTS
TNG Radiation Hybrid Map442489.0UniSTS
CXCL3_1819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,902,204 - 74,902,983UniSTSGRCh37
Build 36475,121,068 - 75,121,847RGDNCBI36
Celera472,262,292 - 72,263,071RGD
HuRef470,713,112 - 70,713,891UniSTS
SHGC-67271  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,902,853 - 74,902,957UniSTSGRCh37
Build 36475,121,717 - 75,121,821RGDNCBI36
Celera472,262,941 - 72,263,045RGD
Cytogenetic Map4q21UniSTS
HuRef470,713,761 - 70,713,865UniSTS
GeneMap99-GB4 RH Map4450.06UniSTS
SHGC-35359  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,902,711 - 74,902,929UniSTSGRCh37
Build 36475,121,575 - 75,121,793RGDNCBI36
Celera472,262,799 - 72,263,017RGD
Cytogenetic Map4q21UniSTS
HuRef470,713,619 - 70,713,837UniSTS
TNG Radiation Hybrid Map442361.0UniSTS
Stanford-G3 RH Map44161.0UniSTS
GeneMap99-GB4 RH Map4450.06UniSTS
Whitehead-RH Map4482.1UniSTS
NCBI RH Map4868.4UniSTS
GeneMap99-G3 RH Map44145.0UniSTS
STS-M36821  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,902,639 - 74,902,846UniSTSGRCh37
Build 36475,121,503 - 75,121,710RGDNCBI36
Celera472,262,727 - 72,262,934RGD
Cytogenetic Map4q21UniSTS
HuRef470,713,547 - 70,713,754UniSTS
GeneMap99-GB4 RH Map4450.01UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2426 2754 2225 4840 1706 2315 2 614 1506 456 2241 6795 6015 43 3617 1 813 1717 1590 172 1

Sequence


Ensembl Acc Id: ENST00000296026   ⟹   ENSP00000296026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,036,589 - 74,038,689 (-)Ensembl
Ensembl Acc Id: ENST00000502974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,037,132 - 74,038,689 (-)Ensembl
Ensembl Acc Id: ENST00000510390
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,037,656 - 74,038,650 (-)Ensembl
Ensembl Acc Id: ENST00000511669
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,037,069 - 74,038,807 (-)Ensembl
RefSeq Acc Id: NM_002090   ⟹   NP_002081
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38474,036,589 - 74,038,689 (-)NCBI
GRCh37474,902,306 - 74,904,490 (-)ENTREZGENE
Build 36475,121,170 - 75,123,354 (-)NCBI Archive
HuRef470,713,214 - 70,715,400 (-)ENTREZGENE
CHM1_1474,938,145 - 74,940,329 (-)NCBI
T2T-CHM13v2.0477,380,195 - 77,382,297 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002081   ⟸   NM_002090
- Peptide Label: precursor
- UniProtKB: P19876 (UniProtKB/Swiss-Prot),   Q4W5H9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000296026   ⟸   ENST00000296026

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19876-F1-model_v2 AlphaFold P19876 1-107 view protein structure

Promoters
RGD ID:6867718
Promoter ID:EPDNEW_H7024
Type:initiation region
Name:CXCL3_1
Description:C-X-C motif chemokine ligand 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7025  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38474,038,689 - 74,038,749EPDNEW
RGD ID:6867720
Promoter ID:EPDNEW_H7025
Type:initiation region
Name:CXCL3_2
Description:C-X-C motif chemokine ligand 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7024  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38474,038,798 - 74,038,858EPDNEW
RGD ID:6802147
Promoter ID:HG_KWN:48479
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   NB4
Transcripts:NM_002090
Position:
Human AssemblyChrPosition (strand)Source
Build 36475,123,186 - 75,123,686 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4604 AgrOrtholog
COSMIC CXCL3 COSMIC
Ensembl Genes ENSG00000163734 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000296026 ENTREZGENE
  ENST00000296026.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000163734 GTEx
HGNC ID HGNC:4604 ENTREZGENE
Human Proteome Map CXCL3 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2921 UniProtKB/Swiss-Prot
NCBI Gene 2921 ENTREZGENE
OMIM 139111 OMIM
PANTHER C-X-C MOTIF CHEMOKINE 3 UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35052 PharmGKB
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXCL3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4W5H9 ENTREZGENE
UniProt Secondary Q4W5H9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CXCL3  C-X-C motif chemokine ligand 3    chemokine (C-X-C motif) ligand 3  Symbol and/or name change 5135510 APPROVED