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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614055
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CXCL1 mRNA; Tetrachlorodibenzodioxin affects the expression of CXCL3 mRNAPMID:21570461
Cxcl3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CXCL1 mRNAPMID:23238561
Cxcl3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA; Tetrachlorodibenzodioxin results in increased expression of CXCL3 mRNAPMID:16054899 PMID:17320037 PMID:17407152 PMID:17942748 PMID:19770486 PMID:23999131 PMID:26862745 PMID:29673856 PMID:30790002
Cxcl3multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CXCL1 mRNA]; [Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CXCL1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CXCL1 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]; AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL3 mRNA]; parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CXCL1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CXCL1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CXCL1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of CXCL3 mRNA]PMID:15667827 PMID:16054899 PMID:17320037 PMID:17942748 PMID:21858153 PMID:23999131 PMID:26862745 PMID:30790002
Cxcl3affects expressionISOCxcl3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of CXCL3 mRNAPMID:22298810
Cxcl3increases expressionISOCXCL1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CXCL1 mRNAPMID:28351761
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