CXCL1 (C-X-C motif chemokine ligand 1) - Rat Genome Database

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Gene: CXCL1 (C-X-C motif chemokine ligand 1) Homo sapiens
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Symbol: CXCL1
Name: C-X-C motif chemokine ligand 1
RGD ID: 1343759
HGNC Page HGNC:4602
Description: Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to be located in extracellular region; specific granule lumen; and tertiary granule lumen. Predicted to be active in extracellular space. Biomarker of asthma; chronic obstructive pulmonary disease; common cold; cystic fibrosis; and hyperhomocysteinemia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein; FSP; GRO-alpha(1-73); GRO1; GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); GROa; growth-regulated alpha protein; melanoma growth stimulating activity, alpha; melanoma growth stimulatory activity alpha; MGSA; MGSA alpha; MGSA-a; NAP-3; neutrophil-activating protein 3; SCYB1
RGD Orthologs
Mouse
Mouse
Rat
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CXCL1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,869,393 - 73,871,308 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
Alcoholic Fatty Liver  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (EXP)
Alveolar Bone Loss  (ISO)
Animal Hepatitis  (ISO)
aspiration pneumonia  (ISO)
asthma  (IEP)
autoimmune hepatitis  (EXP)
bacterial pneumonia  (ISO)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (EXP)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
chronic obstructive pulmonary disease  (EXP,IEP)
common cold  (IEP)
Coronavirus infectious disease  (ISO)
COVID-19  (HEP)
cystic fibrosis  (IEP,ISO)
dilated cardiomyopathy  (ISO)
Endotoxemia  (ISO)
Enteritis  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (EXP)
Femoral Fractures  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (EXP,ISO)
Human Influenza  (ISO)
hyperhomocysteinemia  (IEP)
Inflammation  (ISO)
interstitial cystitis  (ISO)
juvenile rheumatoid arthritis  (EXP)
Legionnaires' disease  (ISO)
Liver Neoplasms  (EXP)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (IEP)
plague  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (EXP,ISO)
prostatitis  (ISO)
pulmonary emphysema  (ISO)
Reperfusion Injury  (EXP,ISO)
respiratory allergy  (EXP)
respiratory syncytial virus infectious disease  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Ventricular Dysfunction, Right  (ISO)
viral pneumonia  (ISO)
Wounds and Injuries  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloroethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichlorobenzene  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2''-galloylhyperin  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (EXP)
22-Hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-Nitrofluoranthene  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
Actein  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
alpha-amanitin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-Zearalanol  (ISO)
aluminium sulfate (anhydrous)  (ISO)
AM-251  (ISO)
amitrole  (ISO)
amlexanox  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (EXP)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (EXP)
apigenin  (EXP)
apocynin  (EXP)
aripiprazole  (EXP)
arsane  (EXP)
arsenic acid  (ISO)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
asbestos  (EXP,ISO)
asperentin  (ISO)
astemizole  (ISO)
astressin 2B  (ISO)
atrazine  (EXP)
atropine  (ISO)
Bardoxolone methyl  (EXP)
Belnacasan  (ISO)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beryllium sulfate  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (EXP,ISO)
Botulinum toxin type A  (ISO)
Brevianamide A  (ISO)
budesonide  (ISO)
butanal  (EXP)
butane-2,3-dione  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
cannabidiol  (EXP,ISO)
capecitabine  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (EXP)
carrageenan  (ISO)
carvacrol  (ISO)
cefaloridine  (ISO)
ceruletide  (ISO)
cetirizine  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
choline  (ISO)
chondroitin sulfate  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
corosolic acid  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
curcumin  (EXP,ISO)
cyanuric chloride  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimercaprol  (ISO)
dinitrogen  (EXP)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
domperidone  (ISO)
doramapimod  (EXP)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental selenium  (EXP)
emodin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
ethanol  (ISO)
eugenol  (EXP,ISO)
famotidine  (ISO)
fentanyl  (ISO)
ferric oxide  (EXP,ISO)
flavonoids  (ISO)
flucloxacillin  (ISO)
fluoranthene  (ISO)
fluticasone  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
halothane  (ISO)
heparan sulfate  (EXP)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
Hexadimethrine bromide  (ISO)
hispidulin  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxychloroquine  (EXP)
idelalisib  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
isotretinoin  (EXP)
itraconazole  (ISO)
ketamine  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
manganese(II) chloride  (ISO)
maslinic acid  (ISO)
mesalamine  (EXP)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (ISO)
methylparaben  (EXP)
metoclopramide  (ISO)
metyrapone  (ISO)
Microcystin la  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
muramyl dipeptide  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nonivamide  (ISO)
o-anisidine  (EXP)
obeticholic acid  (ISO)
oleanolic acid  (ISO)
oroxylin A  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PD 0325901  (EXP)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
perfluorobutyric acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phalloidin  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
Phytolaccoside E  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium chromate  (EXP)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (EXP)
progesterone  (EXP,ISO)
propanal  (EXP)
propofol  (ISO)
propylparaben  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (ISO)
ranitidine  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (EXP)
rofecoxib  (EXP)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (EXP,ISO)
SB-239063  (ISO)
SCH-351591  (ISO)
SCH772984  (ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP,ISO)
Soman  (ISO)
spironolactone  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
styrene  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulfapyridine  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (EXP)
telmisartan  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetradecane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
Tiron  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
undecane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
vitamin D  (ISO)
wortmannin  (ISO)
XL147  (ISO)
zaragozic acid A  (ISO)
zileuton  (ISO)
zinc acetate  (EXP)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc nitrate  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Akhtar S, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G340-7. Epub 2009 Jun 4.
2. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
3. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
4. Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. Andres-Hernando A, etal., Am J Physiol Renal Physiol. 2011 Oct;301(4):F907-16. Epub 2011 Jun 15.
5. A kinetic study of the cytokine/chemokines levels and disruption of blood-brain barrier in infant rats after pneumococcal meningitis. Barichello T, etal., J Neuroimmunol. 2011 Apr;233(1-2):12-7. Epub 2010 Nov 24.
6. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
7. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Chandrasekar B, etal., Circulation. 2001 May 8;103(18):2296-302.
8. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
9. Interferon-beta attenuates lung inflammation following experimental subarachnoid hemorrhage. Cobelens PM, etal., Crit Care. 2010;14(4):R157. Epub 2010 Aug 23.
10. The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. Colletti LM, etal., Hepatology. 2000 Feb;31(2):435-45.
11. Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague. Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
12. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
13. The molecular phenotype of severe asthma in children. Fitzpatrick AM, etal., J Allergy Clin Immunol. 2010 Apr;125(4):851-857.e18.
14. Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response. Funk CJ, etal., J Gen Virol. 2009 Dec;90(Pt 12):2956-64. Epub 2009 Sep 9.
15. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
16. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
17. Folic acid treatment reduces chemokine release from peripheral blood mononuclear cells in hyperhomocysteinemic subjects. Holven KB, etal., Arterioscler Thromb Vasc Biol. 2002 Apr 1;22(4):699-703.
18. Pulmonary contusion primes systemic innate immunity responses. Hoth JJ, etal., J Trauma. 2009 Jul;67(1):14-21; discussion 21-2.
19. Increased expression of the chemokines CXCL1 and MIP-1alpha by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats. Johnson EA, etal., J Neuroinflammation. 2011 May 2;8:41.
20. Attenuation of warm ischemia-reperfusion injury in the liver by bucillamine through decreased neutrophil activation and Bax/Bcl-2 modulation. Junnarkar SP, etal., J Gastroenterol Hepatol. 2010 Dec;25(12):1891-9. doi: 10.1111/j.1440-1746.2010.06312.x.
21. Elucidation of the pathophysiology of interstitial cystitis/bladder pain syndrome via experimental autoimmune cystitis rat model. Kadekawa K, etal., Am J Physiol Regul Integr Comp Physiol. 2024 Aug 1;327(2):R250-R260. doi: 10.1152/ajpregu.00269.2023. Epub 2024 Jun 6.
22. Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis. Khadem F, etal., J Antimicrob Chemother. 2017 Feb;72(2):467-477. doi: 10.1093/jac/dkw448. Epub 2016 Dec 20.
23. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-delta (delta-PKC). Kilpatrick LE, etal., J Leukoc Biol. 2011 Jan;89(1):3-10. Epub 2010 Aug 19.
24. Stress-Responsive Gene FK506-Binding Protein 51 Mediates Alcohol-Induced Liver Injury Through the Hippo Pathway and Chemokine (C-X-C Motif) Ligand 1 Signaling. Kusumanchi P, etal., Hepatology. 2021 Sep;74(3):1234-1250. doi: 10.1002/hep.31800. Epub 2021 Aug 30.
25. Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy. Lin YC, etal., J Transl Med. 2010 Sep 26;8:88.
26. The migration of T cells in response to influenza virus is altered in neonatal mice. Lines JL, etal., J Immunol. 2010 Sep 1;185(5):2980-8. Epub 2010 Jul 23.
27. Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model. Liu FC, etal., Resuscitation. 2011 Mar;82(3):335-40. Epub 2010 Dec 18.
28. Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat. Mafra de Lima F, etal., J Photochem Photobiol B. 2010 Dec 2;101(3):271-8. Epub 2010 Jul 27.
29. CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
30. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. McTigue DM, etal., J Neurosci Res. 1998 Aug 1;53(3):368-76.
31. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Nanji AA, etal., Hepatology. 1999 Oct;30(4):934-43.
32. Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Neumann B, etal., Int Immunol. 1999 Feb;11(2):217-27.
33. Cyclooxygenase inhibition in ventilator-induced lung injury. Niitsu T, etal., Anesth Analg. 2011 Jan;112(1):143-9. Epub 2010 Nov 3.
34. Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis. Okayama T, etal., J Gastroenterol. 2009;44 Suppl 19:35-9. Epub 2009 Jan 16.
35. Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps. Payne SC, etal., Am J Rhinol. 2008 Nov-Dec;22(6):568-81.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. Raghavendran K, etal., J Surg Res. 2009 Aug;155(2):273-82. Epub 2008 Sep 16.
39. Preliminary investigation of a mice model of Klebsiella pneumoniae subsp. ozaenae induced pneumonia. Renois F, etal., Microbes Infect. 2011 Jun 30.
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. A rat model of picornavirus-induced airway infection and inflammation. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
42. The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia. Rovai LE, etal., J Leukoc Biol. 1998 Oct;64(4):494-502.
43. Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. Schmerbach K, etal., PLoS One. 2010 Nov 29;5(11):e15052.
44. Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. Schneider D, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):332-40. Epub 2010 Apr 15.
45. Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat model. Sears BW, etal., J Inflamm Res. 2010 Aug 1;2010(3):105-114.
46. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Sharma AK, etal., Respir Res. 2009 Jun 26;10:58.
47. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
48. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
49. Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Smith MW, etal., Comp Med. 2007 Feb;57(1):82-9.
50. The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis. Stolina M, etal., Biomarkers. 2008 Nov;13(7):692-712.
51. Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Stoner GD, etal., Pharm Res. 2010 Jun;27(6):1138-45. Epub 2010 Mar 16.
52. Effect of a phytotherapeutic agent, Eviprostat(R), on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis. Sugimoto M, etal., Prostate. 2011 Mar 1;71(4):438-44. doi: 10.1002/pros.21299. Epub 2010 Oct 28.
53. The role of the choroid plexus in neutrophil invasion after traumatic brain injury. Szmydynger-Chodobska J, etal., J Cereb Blood Flow Metab. 2009 Sep;29(9):1503-16. Epub 2009 May 27.
54. Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
55. Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia. Tellabati A, etal., Part Fibre Toxicol. 2010 Oct 19;7:30.
56. Dietary (n-3) polyunsaturated fatty acids affect the kinetics of pro- and antiinflammatory responses in mice with Pseudomonas aeruginosa lung infection. Tiesset H, etal., J Nutr. 2009 Jan;139(1):82-9. Epub 2008 Dec 3.
57. Respiratory syncytial virus (RSV) RNA loads in peripheral blood correlates with disease severity in mice. Torres JP, etal., Respir Res. 2010 Sep 15;11:125.
58. The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. Tsai JJ, etal., J Asthma. 2010 Nov;47(9):1040-4.
59. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Uchida Y, etal., Transplantation. 2010 May 15;89(9):1050-6.
60. Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. van den Berg E, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Jul 8.
61. [Anti-inflammatory effects of erythropoietin on hyperoxia-induced bronchopulmonary dysplasia in newborn rats]. Wang XL and Xue XD, Zhonghua Er Ke Za Zhi. 2009 Jun;47(6):446-51.
62. Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats. Watts JA, etal., J Cardiovasc Pharmacol. 2009 Sep;54(3):246-52.
63. [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats] Xu CF, etal., Zhonghua Yi Xue Za Zhi. 2008 Mar 11;88(10):711-5.
64. Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis. Yang SJ, etal., Injury. 2011 Jul;42(7):638-42. Epub 2010 Aug 14.
65. Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Yu HP, etal., Surgery. 2010 Jul;148(1):103-9. Epub 2010 Feb 1.
66. Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis. Yubero S, etal., Biochim Biophys Acta. 2009 Dec;1792(12):1205-11. Epub 2009 Oct 7.
67. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
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PMID:38724465  


Genomics

Comparative Map Data
CXCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,869,393 - 73,871,308 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
Cxcl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,933,960 - 90,935,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,933,962 - 90,937,459 (+)EnsemblGRCm39 Ensembl
GRCm38590,786,101 - 90,788,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,215,129 - 91,217,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,861,303 - 91,863,290 (+)NCBIMGSCv36mm8
Celera588,937,720 - 88,939,708 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,039,104 - 91,040,980 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,039,100 - 91,040,974 (+)EnsemblGRCm39 Ensembl
GRCm38590,891,245 - 90,893,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,891,241 - 90,893,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,320,271 - 91,322,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,966,510 - 91,968,315 (+)NCBIMGSCv36mm8
Celera589,035,565 - 89,037,441 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,477,542 - 17,479,321 (-)NCBIGRCr8
mRatBN7.21417,193,364 - 17,195,143 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,193,365 - 17,195,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,194,186 - 17,195,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,513,114 - 18,514,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,205,210 - 17,206,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,743,678 - 18,745,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,743,685 - 18,745,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,653,032 - 18,654,811 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,690,339 - 18,692,118 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,690,338 - 18,692,118 (-)NCBI
Celera1416,570,160 - 16,571,939 (-)NCBICelera
RH 3.4 Map14215.0RGD
Cytogenetic Map14p22NCBI
Cxcl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,571,900 - 17,573,624 (-)NCBIGRCr8
mRatBN7.21417,287,727 - 17,289,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Celera1416,646,603 - 16,666,030 (-)NCBICelera
Cytogenetic Map14p22NCBI
LOC100976904
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,193,010 - 56,195,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,382,200 - 56,384,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,325,248 - 50,327,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,157,626 - 56,159,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,153,899 - 56,159,474 (-)Ensemblpanpan1.1panPan2
CXCL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,327,041 - 22,329,405 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,569,355 - 22,569,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 Ensembl722,327,508 - 22,328,959 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084462,274 - 464,225 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CXCL1
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q13.3(chr4:73510905-73978175)x3 copy number gain See cases [RCV000051603] Chr4:73510905..73978175 [GRCh38]
Chr4:74376622..74843892 [GRCh37]
Chr4:74595486..75062756 [NCBI36]
Chr4:4q13.3		 uncertain significance
GRCh38/hg38 4q13.3-21.21(chr4:71128874-78099088)x3 copy number gain See cases [RCV000051774] Chr4:71128874..78099088 [GRCh38]
Chr4:71994591..79020242 [GRCh37]
Chr4:72213455..79239266 [NCBI36]
Chr4:4q13.3-21.21		 pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3		 pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23		 pathogenic
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
Chr4:4q13.3-21.22		 pathogenic
GRCh38/hg38 4q13.2-13.3(chr4:67799665-74240920)x1 copy number loss See cases [RCV000137622] Chr4:67799665..74240920 [GRCh38]
Chr4:68665383..75106637 [GRCh37]
Chr4:68347978..75325501 [NCBI36]
Chr4:4q13.2-13.3		 likely pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3		 pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q13.1-21.1(chr4:66017575-76772947)x1 copy number loss See cases [RCV000510445] Chr4:66017575..76772947 [GRCh37]
Chr4:4q13.1-21.1		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_001511.4(CXCL1):c.130C>G (p.Gln44Glu) single nucleotide variant not specified [RCV004305132] Chr4:73869698 [GRCh38]
Chr4:74735415 [GRCh37]
Chr4:4q13.3		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q13.3(chr4:73952783-75261407)x3 copy number gain not provided [RCV000682420] Chr4:73952783..75261407 [GRCh37]
Chr4:4q13.3		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_001511.4(CXCL1):c.209C>T (p.Ala70Val) single nucleotide variant not provided [RCV000965676] Chr4:73869777 [GRCh38]
Chr4:74735494 [GRCh37]
Chr4:4q13.3		 benign
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
Chr4:4q13.3-21.23		 pathogenic
GRCh37/hg19 4q13.2-21.21(chr4:68950363-79738598)x1 copy number loss not provided [RCV001005553] Chr4:68950363..79738598 [GRCh37]
Chr4:4q13.2-21.21		 pathogenic
GRCh37/hg19 4q13.3-21.1(chr4:71561780-78304341)x1 copy number loss not provided [RCV000846231] Chr4:71561780..78304341 [GRCh37]
Chr4:4q13.3-21.1		 pathogenic
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
Chr4:4q13.2-21.22		 pathogenic
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]
Chr4:4q13.3-21.3		 pathogenic
GRCh38/hg38 4q12-21.1(chr4:51891814-76009719)x1 copy number loss Piebaldism [RCV001420508] Chr4:51891814..76009719 [GRCh38]
Chr4:4q12-21.1		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q13.3-21.21(chr4:73055313-80083154) copy number loss not specified [RCV002053427] Chr4:73055313..80083154 [GRCh37]
Chr4:4q13.3-21.21		 pathogenic
NC_000004.12:g.67833055_82716065del deletion See cases [RCV003313802] Chr4:67833055..82716065 [GRCh38]
Chr4:4q13.2-21.22		 pathogenic
NM_001511.4(CXCL1):c.148C>A (p.Gln50Lys) single nucleotide variant not specified [RCV004228974] Chr4:73869716 [GRCh38]
Chr4:74735433 [GRCh37]
Chr4:4q13.3		 uncertain significance
NM_001511.4(CXCL1):c.28C>T (p.Pro10Ser) single nucleotide variant not specified [RCV004159803] Chr4:73869498 [GRCh38]
Chr4:74735215 [GRCh37]
Chr4:4q13.3		 uncertain significance
NM_001511.4(CXCL1):c.170T>C (p.Ile57Thr) single nucleotide variant not specified [RCV004181193] Chr4:73869738 [GRCh38]
Chr4:74735455 [GRCh37]
Chr4:4q13.3		 uncertain significance
NM_001511.4(CXCL1):c.183C>G (p.Asn61Lys) single nucleotide variant not specified [RCV004193261] Chr4:73869751 [GRCh38]
Chr4:74735468 [GRCh37]
Chr4:4q13.3		 likely benign
GRCh37/hg19 4q13.2-13.3(chr4:69146217-75500577)x1 copy number loss not provided [RCV003485422] Chr4:69146217..75500577 [GRCh37]
Chr4:4q13.2-13.3		 pathogenic
NM_001511.4(CXCL1):c.184G>A (p.Val62Met) single nucleotide variant not specified [RCV004367559] Chr4:73869752 [GRCh38]
Chr4:74735469 [GRCh37]
Chr4:4q13.3		 uncertain significance
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_001511.4(CXCL1):c.151G>A (p.Gly51Arg) single nucleotide variant not specified [RCV004616182] Chr4:73869719 [GRCh38]
Chr4:74735436 [GRCh37]
Chr4:4q13.3		 uncertain significance
NM_001511.4(CXCL1):c.296A>T (p.Lys99Met) single nucleotide variant not specified [RCV004616183] Chr4:73869977 [GRCh38]
Chr4:74735694 [GRCh37]
Chr4:4q13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:460
Count of miRNA genes:390
Interacting mature miRNAs:420
Transcripts:ENST00000395761, ENST00000509101
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-67281  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,736,669 - 74,736,909UniSTSGRCh37
Build 36474,955,533 - 74,955,773RGDNCBI36
Celera472,096,797 - 72,097,037RGD
Cytogenetic Map4q21UniSTS
HuRef470,547,808 - 70,548,048UniSTS
TNG Radiation Hybrid Map442521.0UniSTS
GeneMap99-GB4 RH Map4450.27UniSTS
SHGC4-1010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,735,849 - 74,736,058UniSTSGRCh37
Build 36474,954,713 - 74,954,922RGDNCBI36
Celera472,095,977 - 72,096,186RGD
Cytogenetic Map4q21UniSTS
HuRef470,546,988 - 70,547,197UniSTS
TNG Radiation Hybrid Map442555.0UniSTS
RH119675  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,903,748 - 74,904,020UniSTSGRCh37
GRCh37474,735,496 - 74,735,768UniSTSGRCh37
Build 36474,954,360 - 74,954,632RGDNCBI36
Celera472,263,838 - 72,264,110UniSTS
Celera472,095,624 - 72,095,896RGD
Cytogenetic Map4q21UniSTS
HuRef470,546,635 - 70,546,907UniSTS
HuRef470,714,658 - 70,714,930UniSTS
TNG Radiation Hybrid Map442489.0UniSTS
G33800  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,736,052 - 74,736,281UniSTSGRCh37
Build 36474,954,916 - 74,955,145RGDNCBI36
Celera472,096,180 - 72,096,409RGD
Cytogenetic Map4q21UniSTS
HuRef470,547,191 - 70,547,420UniSTS
D4S2819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,963,353 - 74,963,472UniSTSGRCh37
GRCh37474,736,254 - 74,736,373UniSTSGRCh37
Build 36474,955,118 - 74,955,237RGDNCBI36
Celera472,323,440 - 72,323,559UniSTS
Celera472,096,382 - 72,096,501RGD
Cytogenetic Map4q21UniSTS
HuRef470,547,393 - 70,547,512UniSTS
HuRef470,774,262 - 70,774,381UniSTS
GeneMap99-GB4 RH Map4424.58UniSTS
Whitehead-RH Map4479.8UniSTS
Whitehead-YAC Contig Map4 UniSTS
NCBI RH Map4875.8UniSTS
RH17698  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,962,938 - 74,963,091UniSTSGRCh37
GRCh37474,736,628 - 74,736,783UniSTSGRCh37
Build 36474,955,492 - 74,955,647RGDNCBI36
Celera472,323,023 - 72,323,176UniSTS
Celera472,096,756 - 72,096,911RGD
Cytogenetic Map4q21UniSTS
HuRef470,547,767 - 70,547,922UniSTS
HuRef470,773,843 - 70,773,996UniSTS
GeneMap99-GB4 RH Map4425.86UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_046035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG121608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM554448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM996663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ000742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB112830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI519534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA514411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000395761   ⟹   ENSP00000379110
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl473,869,393 - 73,871,308 (+)Ensembl
Ensembl Acc Id: ENST00000509101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl473,869,393 - 73,870,177 (+)Ensembl
RefSeq Acc Id: NM_001511   ⟹   NP_001502
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38473,869,393 - 73,871,308 (+)NCBI
GRCh37474,735,109 - 74,737,019 (+)NCBI
Build 36474,953,973 - 74,955,817 (+)NCBI Archive
HuRef470,546,248 - 70,548,158 (+)NCBI
CHM1_1474,771,032 - 74,772,942 (+)NCBI
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBI
Sequence:
RefSeq Acc Id: NR_046035
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38473,869,393 - 73,871,308 (+)NCBI
HuRef470,546,248 - 70,548,158 (+)NCBI
CHM1_1474,771,032 - 74,772,942 (+)NCBI
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001502   ⟸   NM_001511
- Peptide Label: precursor
- UniProtKB: Q9UCR7 (UniProtKB/Swiss-Prot),   P09341 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000379110   ⟸   ENST00000395761

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09341-F1-model_v2 AlphaFold P09341 1-107 view protein structure

Promoters
RGD ID:6867710
Promoter ID:EPDNEW_H7020
Type:initiation region
Name:CXCL1_1
Description:C-X-C motif chemokine ligand 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38473,869,393 - 73,869,453EPDNEW
RGD ID:6802145
Promoter ID:HG_KWN:48473
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000296031,   NM_001511
Position:
Human AssemblyChrPosition (strand)Source
Build 36474,953,641 - 74,954,141 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4602 AgrOrtholog
COSMIC CXCL1 COSMIC
Ensembl Genes ENSG00000163739 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000395761 ENTREZGENE
  ENST00000395761.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000163739 GTEx
HGNC ID HGNC:4602 ENTREZGENE
Human Proteome Map CXCL1 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2919 UniProtKB/Swiss-Prot
NCBI Gene 2919 ENTREZGENE
OMIM 155730 OMIM
PANTHER GROWTH-REGULATED ALPHA PROTEIN UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35050 PharmGKB
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt GROA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9UCR7 ENTREZGENE
UniProt Secondary Q9UCR7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 CXCL1  C-X-C motif chemokine ligand 1  FSP  fibroblast secretory protein  Data merged from RGD:1349045 737654 PROVISIONAL
2016-03-07 CXCL1  C-X-C motif chemokine ligand 1  CXCL1  chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)  Symbol and/or name change 5135510 APPROVED