Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614055
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3increases expressionEXP 6480464CTDCisplatin results in increased expression of CXCL1 proteinPMID:20844023 PMID:26546572
Cxcl3multiple interactionsEXP 6480464CTD4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of CXCL1 protein]; [Cisplatin co-treated with TNF protein] results in increased expression of CXCL1 mRNA; [Cisplatin co-treated with TNF protein] results in increased expression of CXCL3 mRNAPMID:23103562 PMID:26546572
Cxcl3multiple interactionsISOCXCL1 (Homo sapiens)6480464CTD[Cisplatin co-treated with IL33] results in increased expression of CXCL1; CD4 mutant form inhibits the reaction [[Cisplatin co-treated with IL33] results in increased expression of CXCL1]PMID:21949094
Go Back to source page   Continue to Ontology report