CXCL2 (C-X-C motif chemokine ligand 2) - Rat Genome Database

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Gene: CXCL2 (C-X-C motif chemokine ligand 2) Homo sapiens
Analyze
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
RGD ID: 735621
HGNC Page HGNC:4603
Description: Predicted to enable chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and response to molecule of bacterial origin. Predicted to be located in extracellular space. Biomarker of COVID-19 and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-X-C motif chemokine 2; chemokine (C-X-C motif) ligand 2; CINC-2a; gro-beta; GRO2; GRO2 oncogene; GROb; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta; MGSA beta; MGSA-b; MIP-2a; MIP2; MIP2-alpha; MIP2A; SCYB2
RGD Orthologs
Mouse
Rat
Bonobo
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,097,040 - 74,099,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,097,040 - 74,099,196 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,962,757 - 74,964,912 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,181,616 - 75,183,861 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,327,790 - 75,329,927NCBI
Celera472,322,837 - 72,325,084 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,773,657 - 70,775,906 (-)NCBIHuRef
CHM1_1474,998,593 - 75,000,838 (-)NCBICHM1_1
T2T-CHM13v2.0477,440,641 - 77,442,796 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
CXCL2HumanAcute Lung Injury  ISOCxcl2 (Mus musculus)5135253associated with Sepsis and mRNA:increased expression:lungRGD 
CXCL2HumanAcute Lung Injury  ISOCxcl2 (Mus musculus)5135247mRNA and protein:increased expression:lungRGD 
CXCL2HumanAcute Lung Injury  ISOCxcl2 (Rattus norvegicus)5147925protein:increased expression:respiratory system fluid/secretionRGD 
CXCL2Humanacute necrotizing pancreatitis severityISOCxcl2 (Rattus norvegicus)2307010 RGD 
CXCL2HumanAlcoholic Liver Diseases  ISOCxcl2 (Rattus norvegicus)5135271mRNA:increased expression:liverRGD 
CXCL2HumanAnimal Hepatitis  ISOCxcl2 (Rattus norvegicus)2307010mRNA:increased expression:liverRGD 
CXCL2Humanaspiration pneumonia  ISOCxcl2 (Rattus norvegicus)4891456 RGD 
CXCL2Humanasthma  ISOCxcl2 (Mus musculus)5129686mRNA:increased expression:lungRGD 
CXCL2Humanbacterial pneumonia severityISOCxcl2 (Mus musculus)5135065 RGD 
CXCL2Humanbacterial pneumonia  ISOCxcl2 (Rattus norvegicus)5135234 RGD 
CXCL2Humanbacterial pneumonia  ISOCxcl2 (Mus musculus)5135062 RGD 
CXCL2HumanBordetella Infections  ISOCxcl2 (Mus musculus)5134984associated with InfluenzaRGD 
CXCL2Humanbrain edema  ISOCxcl2 (Rattus norvegicus)5135068associated with Cerebral Hemorrhage and protein:increased expression:cerebral cortexRGD 
CXCL2HumanBrain Injuries  ISOCxcl2 (Rattus norvegicus)2306999protein:increased expression:brain and neuronRGD 
CXCL2HumanBurns  ISOCxcl2 (Rattus norvegicus)5135231protein:increased expression:serumRGD 
CXCL2Humancholangitis treatmentISOCxcl2 (Rattus norvegicus)14995925 RGD 
CXCL2HumanCoronavirus infectious disease  ISOCxcl2 (Rattus norvegicus)5135236 RGD 
CXCL2HumanCOVID-19  HEP 30296672mRNA:increased expression:bronchoalveolar lavage (human)RGD 
CXCL2HumanCOVID-19  IEP 30296676protein:increased expression:serum:RGD 
CXCL2Humancystic fibrosis  IEP 5135034protein:increased expression:sputumRGD 
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Original Reference(s)
CXCL2HumanAcute Lung Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27525872
CXCL2Humanallergic contact dermatitis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23178550
CXCL2HumanArsenic Poisoning  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16835338
CXCL2Humanbone resorption disease  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:21507677
CXCL2HumanBreast Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16298037
CXCL2Humancholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21224055
CXCL2Humanchronic obstructive pulmonary disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23099361
CXCL2Humancongestive heart failure  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22352330
CXCL2HumanEsophageal Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21509778
CXCL2HumanHemorrhagic Shock  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21192278
CXCL2Humanhypertension  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22352330
CXCL2HumanInflammation  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23451061
CXCL2Humanmiddle cerebral artery infarction  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12374626
CXCL2HumanMyocardial Ischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
CXCL2Humanosteoarthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15292528
CXCL2Humanpulmonary fibrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16324872
CXCL2HumanReperfusion Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12468449
CXCL2Humanrheumatoid arthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15292528
CXCL2Humanskin disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16835338
CXCL2HumanWounds and Injuries  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21192278
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CXCL2Human(-)-epigallocatechin 3-gallate affects expressionISOCxcl2 (Mus musculus)6480464epigallocatechin gallate affects the expression of CXCL2CTDPMID:25955525
CXCL2Human(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid multiple interactionsISOCxcl2 (Mus musculus)6480464argatroban affects the reaction [Dietary Fats results in increased expression of CXCL2 mRNA]CTDPMID:22841818
CXCL2Human(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid multiple interactionsISOCxcl2 (Mus musculus)648046417-hydroxy-4 more ...CTDPMID:21724996 and PMID:34601004
CXCL2Human(E)-cinnamyl alcohol increases expressionISOCxcl2 (Mus musculus)6480464cinnamyl alcohol results in increased expression of CXCL2 proteinCTDPMID:23178550
CXCL2Human(R,R,R)-alpha-tocopherol multiple interactionsISOCxcl2 (Rattus norvegicus)6480464alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]CTDPMID:24333275
CXCL2Human(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of CXCL2 mRNACTDPMID:18247414
CXCL2Human1,2,4-trimethylbenzene increases expressionISOCxcl2 (Rattus norvegicus)6480464pseudocumene results in increased expression of CXCL2 proteinCTDPMID:17337753
CXCL2Human1,3-benzothiazole-2-thiol increases expressionISOCxcl2 (Mus musculus)6480464captax results in increased expression of CXCL2 proteinCTDPMID:23178550
CXCL2Human1,4-phenylenediamine increases expressionISOCxcl2 (Mus musculus)64804644-phenylenediamine results in increased expression of CXCL2 proteinCTDPMID:23178550
CXCL2Human1,7-dimethylxanthine multiple interactionsISOCxcl2 (Mus musculus)64804641 more ...CTDPMID:19962977
CXCL2Human1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of CXCL2 mRNACTDPMID:20146380
CXCL2Human1-chloro-2,4-dinitrobenzene increases expressionISOCxcl2 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of CXCL2 mRNA and Dinitrochlorobenzene results in increased expression of CXCL2 proteinCTDPMID:16675337 more ...
CXCL2Human1-naphthyl isothiocyanate multiple interactionsISOCxcl2 (Mus musculus)64804643-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1 more ...CTDPMID:21356363 more ...
CXCL2Human1-naphthyl isothiocyanate multiple interactionsISOCxcl2 (Rattus norvegicus)6480464Dexamethasone promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA] and Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]CTDPMID:18590720
CXCL2Human1-naphthyl isothiocyanate increases expressionISOCxcl2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA and 1-Naphthylisothiocyanate results in increased expression of CXCL2 proteinCTDPMID:15130876 more ...
CXCL2Human1-naphthyl isothiocyanate increases expressionISOCxcl2 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA and 1-Naphthylisothiocyanate results in increased expression of CXCL2 proteinCTDPMID:18364083 more ...
CXCL2Human1-nitropyrene increases expressionEXP 64804641-nitropyrene results in increased expression of CXCL2 mRNACTDPMID:19041380
CXCL2Human13,14-dihydro-15-ketoprostaglandin D2 increases expressionISOCxcl2 (Mus musculus)648046413 and 14-dihydro-15-ketoprostaglandin D2 results in increased expression of CXCL2 proteinCTDPMID:21094227
CXCL2Human13,14-dihydro-15-ketoprostaglandin D2 multiple interactionsISOCxcl2 (Mus musculus)648046413 and 14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of CXCL2 mRNA]CTDPMID:21735453
CXCL2Human15-acetyldeoxynivalenol increases expressionISOCxcl2 (Mus musculus)648046415-acetyldeoxynivalenol results in increased expression of CXCL2 mRNACTDPMID:24793808

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Biological Process
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Original Reference(s)
CXCL2Humanantimicrobial humoral immune response mediated by antimicrobial peptide involved_inIDA 150520179 PMID:12949249UniProtPMID:12949249
CXCL2Humancell chemotaxis involved_inIEAGO:0008009150520179 GOCGO_REF:0000108
CXCL2Humancellular response to interleukin-1  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:16239643 and REF_RGD_ID:5135237
CXCL2Humancellular response to lipopolysaccharide  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:16239643 and REF_RGD_ID:5135237
CXCL2Humanchemotaxis involved_inIEAUniProtKB-KW:KW-0145150520179 UniProtGO_REF:0000043
CXCL2Humanchemotaxis involved_inTAS 150520179 PMID:2643119PINCPMID:2643119
CXCL2Humanchemotaxis involved_inIEAInterPro:IPR033899150520179 InterProGO_REF:0000002
CXCL2Humandefense response involved_inIEAInterPro:IPR033899150520179 InterProGO_REF:0000002
CXCL2Humanimmune response involved_inIEAInterPro:IPR001089 more ...150520179 InterProGO_REF:0000002
CXCL2Humaninflammatory response involved_inIEAUniProtKB-KW:KW-0395150520179 UniProtGO_REF:0000043
CXCL2Humaninflammatory response involved_inTAS 150520179 PMID:2643119PINCPMID:2643119
CXCL2Humanleukocyte chemotaxis  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:11837784 and REF_RGD_ID:727566
CXCL2Humanneutrophil chemotaxis  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:12460233 and REF_RGD_ID:632969
CXCL2Humanpositive regulation of cytosolic calcium ion concentration  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:10975996 and REF_RGD_ID:5135014
CXCL2Humanresponse to amphetamine  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:19582783 and REF_RGD_ID:2314489
CXCL2Humanresponse to estradiol  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:20709317 and REF_RGD_ID:5134961
CXCL2Humanresponse to gamma radiation  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:20185578 and REF_RGD_ID:5134998
CXCL2Humanresponse to glucocorticoid  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:20728373 and REF_RGD_ID:5134959
CXCL2Humanresponse to molecule of bacterial origin involved_inIDA 150520179 PMID:19912257BHF-UCLPMID:19912257
CXCL2Humansignal transduction involved_inIEAGO:0005125150520179 GOCGO_REF:0000108
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Cellular Component

  
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Original Reference(s)
CXCL2Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
CXCL2Humanextracellular region located_inIEAARBA:ARBA00027128150520179 UniProtGO_REF:0000117
CXCL2Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
CXCL2Humanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-373813 more ...
CXCL2Humanextracellular region located_inIEAInterPro:IPR001089 more ...150520179 InterProGO_REF:0000002
CXCL2Humanextracellular space  ISOCxcl2 (Rattus norvegicus)9068941 RGDPMID:20724665 and REF_RGD_ID:5134960
CXCL2Humanextracellular space located_inTAS 150520179 PMID:9873037PINCPMID:9873037
CXCL2Humanextracellular space located_inIEAUniProtKB-KW:KW-0202150520179 UniProtGO_REF:0000043

Molecular Function

  

Imported Annotations - KEGG (archival)

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Original Reference(s)
CXCL2HumanNOD-like receptor signaling pathway  IEA 6907045 KEGGhsa:04621

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#
Reference Title
Reference Citation
1. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
2. Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. Bauer CM, etal., PLoS One. 2010 Oct 12;5(10):e13251.
3. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
4. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Chandrasekar B, etal., Circulation. 2001 May 8;103(18):2296-302.
5. Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Chiang CH, etal., Intensive Care Med. 2011 May 27.
6. Lung and liver injury following hepatic ischemia/reperfusion in the rat is increased by exogenous lipopolysaccharide which also increases hepatic TNF production in vivo and in vitro. Colletti LM and Green M, Shock. 2001 Oct;16(4):312-9.
7. The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. Colletti LM, etal., Hepatology. 2000 Feb;31(2):435-45.
8. [Role of early growth response factor-1 signal pathway in acute intrahepatic cholestatic hepatic injury in rats]. Ding Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2008 Mar;16(3):215-9.
9. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
10. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. Fujita T, etal., Biochem Pharmacol. 2010 May 15;79(10):1496-505. Epub 2010 Jan 22.
11. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
12. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
13. Differential host gene responses in mice infected with two highly pathogenic avian influenza viruses of subtype H5N1 isolated from wild birds in Thailand. Hayashi T, etal., Virology. 2011 Mar 30;412(1):9-18. Epub 2011 Jan 19.
14. Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. Hsu JT, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1825-31. Epub 2008 Apr 23.
15. Platonin mitigates acute lung injury induced by bilateral lower limb ischemia-reperfusion in rats. Hsu KY, etal., J Surg Res. 2011 May 15;167(2):e255-62. Epub 2010 Apr 24.
16. Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice. James ML, etal., Pediatr Res. 2010 Jun;67(6):591-7.
17. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Jeyaseelan S, etal., Infect Immun. 2004 Dec;72(12):7247-56.
18. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-delta (delta-PKC). Kilpatrick LE, etal., J Leukoc Biol. 2011 Jan;89(1):3-10. Epub 2010 Aug 19.
19. Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice. KuoLee R, etal., Microbes Infect. 2011 May;13(5):447-56. Epub 2011 Jan 26.
20. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
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PMID:1906501   PMID:2078213   PMID:2129556   PMID:2201751   PMID:2217207   PMID:2341726   PMID:2643119   PMID:2834384   PMID:7864661   PMID:8702798   PMID:9260277   PMID:9277410  
PMID:9843467   PMID:9873037   PMID:10600366   PMID:10725737   PMID:10928473   PMID:11134351   PMID:11559650   PMID:12419803   PMID:12477932   PMID:12508094   PMID:12556377   PMID:12892904  
PMID:12949249   PMID:15489334   PMID:15614130   PMID:16421598   PMID:16697212   PMID:17466952   PMID:17703412   PMID:17944017   PMID:17999991   PMID:18191274   PMID:18240029   PMID:18275857  
PMID:18322244   PMID:18577758   PMID:18624398   PMID:18835392   PMID:19258923   PMID:19369450   PMID:19435811   PMID:19912257   PMID:20056178   PMID:20162422   PMID:20185584   PMID:20237496  
PMID:21145461   PMID:21220697   PMID:21314817   PMID:21630055   PMID:21677836   PMID:21738478   PMID:21738479   PMID:21873635   PMID:21988832   PMID:22056994   PMID:22615136   PMID:22770218  
PMID:22771802   PMID:23021568   PMID:23128233   PMID:23225384   PMID:23372021   PMID:23554905   PMID:23867815   PMID:23904157   PMID:24098805   PMID:24667918   PMID:25085744   PMID:25682075  
PMID:25708728   PMID:25801245   PMID:25802102   PMID:26063953   PMID:26345899   PMID:26888013   PMID:27117207   PMID:27580404   PMID:27721403   PMID:28381538   PMID:28765918   PMID:28928065  
PMID:29520695   PMID:30259595   PMID:30293547   PMID:30564899   PMID:31292171   PMID:31451648   PMID:31617252   PMID:32267022   PMID:32439934   PMID:32452055   PMID:32643867   PMID:32988253  
PMID:33010041   PMID:33571109   PMID:33793061   PMID:33807899   PMID:33961781   PMID:34085699   PMID:34115261   PMID:34474677   PMID:34607953   PMID:35541899   PMID:36073801   PMID:36281171  
PMID:36398464   PMID:36577281   PMID:38010448  
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CXCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,097,040 - 74,099,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,097,040 - 74,099,196 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,962,757 - 74,964,912 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,181,616 - 75,183,861 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,327,790 - 75,329,927NCBI
Celera472,322,837 - 72,325,084 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,773,657 - 70,775,906 (-)NCBIHuRef
CHM1_1474,998,593 - 75,000,838 (-)NCBICHM1_1
T2T-CHM13v2.0477,440,641 - 77,442,796 (-)NCBIT2T-CHM13v2.0
Cxcl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,051,758 - 91,053,797 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,051,730 - 91,053,797 (+)EnsemblGRCm39 Ensembl
GRCm38590,903,899 - 90,905,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,903,871 - 90,905,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,332,925 - 91,334,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,979,099 - 91,981,138 (+)NCBIMGSCv36mm8
Celera589,048,217 - 89,050,256 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,465,210 - 17,467,255 (-)NCBIGRCr8
mRatBN7.21417,181,030 - 17,183,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,181,062 - 17,183,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,181,873 - 17,183,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,500,809 - 18,502,853 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,192,924 - 17,194,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,731,346 - 18,733,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,731,378 - 18,733,391 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,640,312 - 18,642,357 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,677,129 - 18,679,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,677,128 - 18,679,175 (-)NCBI
Celera1416,558,112 - 16,560,157 (-)NCBICelera
Cytogenetic Map14p22NCBI
LOC100974886
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,960,804 - 55,963,432 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,150,028 - 56,152,424 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,092,989 - 50,095,541 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,925,562 - 55,927,809 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,925,562 - 55,986,555 (+)Ensemblpanpan1.1panPan2
CXCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,157,214 - 70,159,138 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,157,253 - 70,159,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,310,094 - 74,311,988 (+)NCBISscrofa10.2Sscrofa10.2susScr3

.

.
Variants in CXCL2
11 total Variants

1 to 10 of 46 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 4q13.3-21.21(chr4:71128874-78099088)x3 copy number gain See cases [RCV000051774] Chr4:71128874..78099088 [GRCh38]
Chr4:71994591..79020242 [GRCh37]
Chr4:72213455..79239266 [NCBI36]
Chr4:4q13.3-21.21		 pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3		 pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23		 pathogenic
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
Chr4:4q13.3-21.22		 pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1		 pathogenic
GRCh38/hg38 4q13.3(chr4:74097483-75266770)x1 copy number loss See cases [RCV000136998] Chr4:74097483..75266770 [GRCh38]
Chr4:74963200..76191980 [GRCh37]
Chr4:75182064..76411004 [NCBI36]
Chr4:4q13.3		 uncertain significance
GRCh38/hg38 4q13.2-13.3(chr4:67799665-74240920)x1 copy number loss See cases [RCV000137622] Chr4:67799665..74240920 [GRCh38]
Chr4:68665383..75106637 [GRCh37]
Chr4:68347978..75325501 [NCBI36]
Chr4:4q13.2-13.3		 likely pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3		 pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
1 to 10 of 46 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR126hsa-miR-126-3pOncomiRDBexternal_infoNANA23449143
MIR126hsa-miR-126-5pOncomiRDBexternal_infoNANA23449143

Predicted Target Of
Summary Value
Count of predictions:469
Count of miRNA genes:367
Interacting mature miRNAs:383
Transcripts:ENST00000296031, ENST00000508487, ENST00000510048
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597238040GWAS1334114_Hneutrophil-to-lymphocyte ratio QTL GWAS1334114 (human)4e-36neutrophil-to-lymphocyte ratio47409733274097333Human
597610844GWAS1667704_Hneutrophil count QTL GWAS1667704 (human)3e-51neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)47409733274097333Human
597081307GWAS1177381_Hneutrophil count QTL GWAS1177381 (human)9e-325neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)47409733274097333Human
597598096GWAS1654956_Hlymphocyte count QTL GWAS1654956 (human)1e-26lymphocyte countblood lymphocyte count (CMO:0000031)47409733274097333Human
597104921GWAS1200995_Hneutrophil percentage of leukocytes QTL GWAS1200995 (human)4e-126neutrophil quantity (VT:0000222)blood neutrophil count to total leukocyte count ratio (CMO:0000370)47409733274097333Human
597597329GWAS1654189_Hlymphocyte count QTL GWAS1654189 (human)3e-46lymphocyte countblood lymphocyte count (CMO:0000031)47409733274097333Human
597610769GWAS1667629_Hneutrophil count QTL GWAS1667629 (human)2e-63neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)47409733274097333Human
597587281GWAS1644141_Hneutrophil count QTL GWAS1644141 (human)1e-69neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)47409733274097333Human
596955783GWAS1075302_Hlymphocyte measurement, neutrophil measurement QTL GWAS1075302 (human)1e-73lymphocyte measurement, neutrophil measurement47409733274097333Human
597587085GWAS1643945_Hneutrophil count QTL GWAS1643945 (human)1e-61neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)47409733274097333Human

1 to 10 of 29 rows
CXCL2_1876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,962,712 - 74,963,418UniSTSGRCh37
Build 36475,181,576 - 75,182,282RGDNCBI36
Celera472,322,797 - 72,323,505RGD
HuRef470,773,617 - 70,774,327UniSTS
D4S2819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,963,353 - 74,963,472UniSTSGRCh37
GRCh37474,736,254 - 74,736,373UniSTSGRCh37
Build 36474,955,118 - 74,955,237RGDNCBI36
Celera472,323,440 - 72,323,559UniSTS
Celera472,096,382 - 72,096,501RGD
Cytogenetic Map4q21UniSTS
HuRef470,547,393 - 70,547,512UniSTS
HuRef470,774,262 - 70,774,381UniSTS
GeneMap99-GB4 RH Map4424.58UniSTS
Whitehead-RH Map4479.8UniSTS
Whitehead-YAC Contig Map4 UniSTS
NCBI RH Map4875.8UniSTS
SHGC-67843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,962,823 - 74,962,959UniSTSGRCh37
Build 36475,181,687 - 75,181,823RGDNCBI36
Celera472,322,908 - 72,323,044RGD
Cytogenetic Map4q21UniSTS
HuRef470,773,728 - 70,773,864UniSTS
GeneMap99-GB4 RH Map4424.53UniSTS
D4S3343  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,963,176 - 74,963,425UniSTSGRCh37
Build 36475,182,040 - 75,182,289RGDNCBI36
Celera472,323,261 - 72,323,512RGD
Cytogenetic Map4q21UniSTS
HuRef470,774,081 - 70,774,334UniSTS
RH17698  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,962,938 - 74,963,091UniSTSGRCh37
GRCh37474,736,628 - 74,736,783UniSTSGRCh37
Build 36474,955,492 - 74,955,647RGDNCBI36
Celera472,323,023 - 72,323,176UniSTS
Celera472,096,756 - 72,096,911RGD
Cytogenetic Map4q21UniSTS
HuRef470,547,767 - 70,547,922UniSTS
HuRef470,773,843 - 70,773,996UniSTS
GeneMap99-GB4 RH Map4425.86UniSTS
RH69945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37474,964,546 - 74,964,668UniSTSGRCh37
Build 36475,183,410 - 75,183,532RGDNCBI36
Celera472,324,633 - 72,324,755RGD
Cytogenetic Map4q21UniSTS
HuRef470,775,455 - 70,775,577UniSTS
GeneMap99-GB4 RH Map4425.68UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2435 2787 2234 4944 1723 2327 5 622 1501 463 2257 6859 6035 42 3707 1 841 1731 1595 174 1


1 to 16 of 16 rows
RefSeq Transcripts NM_002089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF043340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX334969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENST00000296031
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,097,676 - 74,099,195 (-)Ensembl
Ensembl Acc Id: ENST00000508487   ⟹   ENSP00000427279
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,097,040 - 74,099,195 (-)Ensembl
Ensembl Acc Id: ENST00000510048
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl474,098,531 - 74,099,196 (-)Ensembl
RefSeq Acc Id: NM_002089   ⟹   NP_002080
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38474,097,040 - 74,099,195 (-)NCBI
GRCh37474,962,752 - 74,964,997 (-)ENTREZGENE
Build 36475,181,616 - 75,183,861 (-)NCBI Archive
HuRef470,773,657 - 70,775,906 (-)ENTREZGENE
CHM1_1474,998,593 - 75,000,838 (-)NCBI
T2T-CHM13v2.0477,440,641 - 77,442,796 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002080   ⟸   NM_002089
- Peptide Label: precursor
- UniProtKB: Q6FGD6 (UniProtKB/Swiss-Prot),   Q9UPB8 (UniProtKB/Swiss-Prot),   P19875 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000427279   ⟸   ENST00000508487

Name Modeler Protein Id AA Range Protein Structure
AF-P19875-F1-model_v2 AlphaFold P19875 1-107 view protein structure

RGD ID:6867722
Promoter ID:EPDNEW_H7026
Type:initiation region
Name:CXCL2_1
Description:C-X-C motif chemokine ligand 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7027  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38474,099,195 - 74,099,255EPDNEW
RGD ID:6867724
Promoter ID:EPDNEW_H7027
Type:initiation region
Name:CXCL2_2
Description:C-X-C motif chemokine ligand 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7026  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38474,099,324 - 74,099,384EPDNEW
RGD ID:6812495
Promoter ID:HG_ACW:59654
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:CXCL2.FAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36475,182,401 - 75,182,901 (-)MPROMDB
RGD ID:6802190
Promoter ID:HG_KWN:48480
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   NB4
Transcripts:ENST00000395761,   NM_002089
Position:
Human AssemblyChrPosition (strand)Source
Build 36475,183,766 - 75,184,266 (-)MPROMDB


1 to 31 of 31 rows
Database
Acc Id
Source(s)
COSMIC CXCL2 COSMIC
Ensembl Genes ENSG00000081041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000508487 ENTREZGENE
  ENST00000508487.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000081041 GTEx
HGNC ID HGNC:4603 ENTREZGENE
Human Proteome Map CXCL2 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2920 UniProtKB/Swiss-Prot
NCBI Gene 2920 ENTREZGENE
OMIM 139110 OMIM
PANTHER C-X-C MOTIF CHEMOKINE 2 UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35051 PharmGKB
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXCL2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FGD6 ENTREZGENE
  Q9UPB8 ENTREZGENE
UniProt Secondary Q6FGD6 UniProtKB/Swiss-Prot
  Q9UPB8 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CXCL2  C-X-C motif chemokine ligand 2    chemokine (C-X-C motif) ligand 2  Symbol and/or name change 5135510 APPROVED