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Gene: CXCL2 (C-X-C motif chemokine ligand 2) Homo sapiens
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
RGD ID: 735621
Description: Predicted to have CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; and response to molecule of bacterial origin. Predicted to localize to extracellular space. Biomarker of COVID-19 and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-X-C motif chemokine 2; chemokine (C-X-C motif) ligand 2; CINC-2a; gro-beta; GRO2; GRO2 oncogene; GROb; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta; MGSA beta; MGSA-b; MIP-2a; MIP2; MIP2-alpha; MIP2A; SCYB2
Mus musculus (house mouse) : Cxcl2 (chemokine (C-X-C motif) ligand 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cxcl2 (C-X-C motif chemokine ligand 2)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CXCL2 (C-X-C motif chemokine ligand 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl474,097,040 - 74,099,196 (-)EnsemblGRCh38hg38GRCh38
GRCh38474,097,040 - 74,099,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37474,962,752 - 74,964,997 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,181,616 - 75,183,861 (-)NCBINCBI36hg18NCBI36
Build 34475,327,790 - 75,329,927NCBI
Celera472,322,837 - 72,325,084 (-)NCBI
Cytogenetic Map4q13.3NCBI
HuRef470,773,657 - 70,775,906 (-)NCBIHuRef
CHM1_1474,998,593 - 75,000,838 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CXCL2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735621
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.