Shisa7 (shisa family member 7) - Rat Genome Database

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Gene: Shisa7 (shisa family member 7) Mus musculus
Analyze
Symbol: Shisa7
Name: shisa family member 7
RGD ID: 1622954
MGI Page MGI
Description: Enables GABA receptor binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; rib; and tail mesenchyme. Orthologous to human SHISA7 (shisa family member 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CKAMP; ckamp59; cysteine-knot AMPAR-modulating protein 59; cystine-knot AMPAR modulating protein of 59 kDa; D430041B17Rik; GABA(A) receptor auxiliary subunit Shisa7; protein shisa-6-like; protein shisa-7; shisa homolog 7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,828,551 - 4,847,788 (-)NCBIGRCm39mm39
GRCm39 Ensembl74,828,551 - 4,847,695 (-)Ensembl
GRCm3874,825,551 - 4,844,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,825,552 - 4,844,696 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,777,154 - 4,796,298 (-)NCBIGRCm37mm9NCBIm37
MGSCv3674,431,561 - 4,442,291 (-)NCBImm8
Celera74,563,009 - 4,582,132 (-)NCBICelera
Cytogenetic Map7A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:26623514  
PMID:28671696   PMID:28706196   PMID:29199957   PMID:31040226   PMID:31601770   PMID:33761345  


Genomics

Comparative Map Data
Shisa7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,828,551 - 4,847,788 (-)NCBIGRCm39mm39
GRCm39 Ensembl74,828,551 - 4,847,695 (-)Ensembl
GRCm3874,825,551 - 4,844,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,825,552 - 4,844,696 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,777,154 - 4,796,298 (-)NCBIGRCm37mm9NCBIm37
MGSCv3674,431,561 - 4,442,291 (-)NCBImm8
Celera74,563,009 - 4,582,132 (-)NCBICelera
Cytogenetic Map7A1NCBI
SHISA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,428,740 - 55,443,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1955,428,740 - 55,443,300 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,940,107 - 55,954,667 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,636,335 - 60,654,784 (-)NCBINCBI36hg18NCBI36
Celera1952,980,996 - 53,005,709 (-)NCBI
Cytogenetic Map19q13.42NCBI
HuRef1952,261,714 - 52,265,905 (-)NCBIHuRef
CHM1_11955,933,703 - 55,947,827 (-)NCBICHM1_1
T2T-CHM13v2.01958,524,194 - 58,538,751 (-)NCBI
Shisa7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2168,993,900 - 69,012,943 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl168,994,025 - 69,012,943 (+)Ensembl
Rnor_6.0172,545,413 - 72,564,513 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,545,596 - 72,564,513 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,971,937 - 75,990,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,710,526 - 67,729,443 (+)NCBIRGSC3.4rn4RGSC3.4
Celera168,111,510 - 68,130,334 (-)NCBICelera
Cytogenetic Map1q12NCBI
Shisa7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955567840,193 - 845,093 (+)NCBIChiLan1.0ChiLan1.0
SHISA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11961,165,673 - 61,175,020 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01952,475,852 - 52,496,819 (-)NCBIMhudiblu_PPA_v0panPan3
SHISA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,260,917 - 102,270,388 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,261,484 - 102,268,179 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,310,808 - 102,328,742 (+)NCBI
ROS_Cfam_1.01102,907,280 - 102,925,221 (+)NCBI
ROS_Cfam_1.0 Ensembl1102,905,126 - 102,925,247 (+)Ensembl
UMICH_Zoey_3.11102,544,484 - 102,562,438 (+)NCBI
UNSW_CanFamBas_1.01102,256,598 - 102,274,537 (+)NCBI
UU_Cfam_GSD_1.01103,019,825 - 103,037,770 (+)NCBI
Shisa7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,878,026 - 1,895,150 (+)NCBI
SpeTri2.0NW_004936886664,075 - 675,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHISA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,582,708 - 59,604,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,582,706 - 59,601,979 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SHISA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1648,028,539 - 48,049,478 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045677,739 - 697,961 (-)NCBIVero_WHO_p1.0
Shisa7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,900,580 - 1,909,125 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248321,898,049 - 1,909,155 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI553388  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3874,845,202 - 4,845,299UniSTSGRCm38
MGSCv3774,796,804 - 4,796,901UniSTSGRCm37
Celera74,582,638 - 4,582,735UniSTS
Cytogenetic Map7A1UniSTS
Whitehead/MRC_RH740.5UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25394570Skmw58_mskeletal muscle weight 58, TA (mouse)735524286281481Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25394569Skmw57_mskeletal muscle weight 57, gastroc (mouse)7458046916687861Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5856
Count of miRNA genes:778
Interacting mature miRNAs:992
Transcripts:ENSMUST00000066041, ENSMUST00000117452, ENSMUST00000119433, ENSMUST00000132806, ENSMUST00000157068, ENSMUST00000172377
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066041   ⟹   ENSMUSP00000064886
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl74,828,552 - 4,847,695 (-)Ensembl
GRCm38.p6 Ensembl74,825,553 - 4,844,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000117452   ⟹   ENSMUSP00000112405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl74,828,551 - 4,839,173 (-)Ensembl
GRCm38.p6 Ensembl74,825,552 - 4,836,174 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119433   ⟹   ENSMUSP00000112423
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl74,831,026 - 4,847,695 (-)Ensembl
GRCm38.p6 Ensembl74,828,027 - 4,844,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132806
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl74,834,390 - 4,837,514 (-)Ensembl
GRCm38.p6 Ensembl74,831,391 - 4,834,515 (-)Ensembl
RefSeq Acc Id: ENSMUST00000157068
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl74,833,176 - 4,834,126 (-)Ensembl
GRCm38.p6 Ensembl74,830,177 - 4,831,127 (-)Ensembl
RefSeq Acc Id: NM_001290291   ⟹   NP_001277220
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3974,828,551 - 4,847,695 (-)NCBI
GRCm3874,825,552 - 4,844,696 (-)NCBI
Celera74,563,009 - 4,582,132 (-)NCBI
Sequence:
RefSeq Acc Id: NM_172737   ⟹   NP_766325
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3974,828,551 - 4,847,695 (-)NCBI
GRCm3874,825,552 - 4,844,696 (-)NCBI
MGSCv3774,777,154 - 4,796,298 (-)RGD
Celera74,563,009 - 4,582,132 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539775   ⟹   XP_006539838
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3974,828,551 - 4,847,788 (-)NCBI
GRCm3874,825,552 - 4,844,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242416   ⟹   XP_030098276
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3974,828,551 - 4,847,788 (-)NCBI
GRCm3874,825,552 - 4,844,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242417   ⟹   XP_030098277
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3974,828,551 - 4,840,055 (-)NCBI
GRCm3874,825,552 - 4,837,108 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_766325   ⟸   NM_172737
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8C3Q5 (UniProtKB/Swiss-Prot),   A0A172Q418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539838   ⟸   XM_006539775
- Peptide Label: isoform X1
- UniProtKB: Q8C3Q5 (UniProtKB/Swiss-Prot),   A0A172Q418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277220   ⟸   NM_001290291
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8C3Q5 (UniProtKB/Swiss-Prot),   A0A172Q401 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030098276   ⟸   XM_030242416
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030098277   ⟸   XM_030242417
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000112423   ⟸   ENSMUST00000119433
RefSeq Acc Id: ENSMUSP00000064886   ⟸   ENSMUST00000066041
RefSeq Acc Id: ENSMUSP00000112405   ⟸   ENSMUST00000117452

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C3Q5-F1-model_v2 AlphaFold Q8C3Q5 1-558 view protein structure

Promoters
RGD ID:6842019
Promoter ID:MM_KWN:48482
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000117452,   ENSMUST00000119433
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3674,787,816 - 4,788,316 (-)MPROMDB
RGD ID:6840458
Promoter ID:MM_KWN:48483
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_172737,   OTTMUST00000056201
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3674,795,996 - 4,796,496 (-)MPROMDB
RGD ID:6891722
Promoter ID:EPDNEW_M9312
Type:initiation region
Name:Shisa7_1
Description:Mus musculus shisa family member 7 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3874,844,688 - 4,844,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3605641 AgrOrtholog
Ensembl Genes ENSMUSG00000053550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000064886 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112405 UniProtKB/TrEMBL
  ENSMUSP00000112423 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000066041 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000117452 UniProtKB/TrEMBL
  ENSMUST00000119433 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Shisa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232813 UniProtKB/Swiss-Prot
MGD MGI:3605641 ENTREZGENE
NCBI Gene 232813 ENTREZGENE
PANTHER PTHR31774 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Shisa UniProtKB/Swiss-Prot
PhenoGen Shisa7 PhenoGen
UniProt A0A172Q401 ENTREZGENE
  A0A172Q418 ENTREZGENE
  F6T9T6_MOUSE UniProtKB/TrEMBL
  Q8C3Q5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A172Q401 UniProtKB/Swiss-Prot
  A0A172Q418 UniProtKB/Swiss-Prot
  Q3UMB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-10-21 Shisa7  shisa family member 7    shisa homolog 7 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED