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Gene: Cybb (cytochrome b-245, beta polypeptide) Mus musculus
Symbol: Cybb
Name: cytochrome b-245, beta polypeptide
Description: Exhibits superoxide-generating NADPH oxidase activity. Predicted to contribute to electron transfer activity. Involved in several processes, including hydrogen peroxide biosynthetic process; innate immune response; and superoxide metabolic process. Localizes to NADPH oxidase complex and phagocytic vesicle. Predicted to colocalize with perinuclear endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Used to study chronic granulomatous disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and primary immunodeficiency disease. Orthologous to human CYBB (cytochrome b-245 beta chain).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C88302; Cgd; CGD91-phox; Cyd; cytochrome b(558) subunit beta; cytochrome b-245 heavy chain; cytochrome b558 subunit beta; gp91-1; gp91-phox; gp91phox; heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; Nox2; p22 phagocyte B-cytochrome
Homo sapiens (human) : CYBB (cytochrome b-245 beta chain)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cybb (cytochrome b-245 beta chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012042 (cytochrome b-245 heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982531 (cytochrome b-245 heavy chain)
Canis lupus familiaris (dog) : CYBB (cytochrome b-245 beta chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966992 (cytochrome b-245 heavy chain)
Sus scrofa (pig) : GP91-PHOX (NADPH oxidase heavy chain subunit)
Chlorocebus sabaeus (African green monkey) : CYBB (cytochrome b-245 heavy chain)
Heterocephalus glaber (naked mole-rat) : LOC101709509 (cytochrome b-245 heavy chain)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX9,435,252 - 9,487,771 (-)EnsemblGRCm38mm10GRCm38
GRCm38X9,435,252 - 9,487,766 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X9,012,378 - 9,046,450 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X8,593,665 - 8,626,226 (-)NCBImm8
CeleraX7,154,874 - 7,188,991 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cybb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733265
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.