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Gene: Casp8 (caspase 8) Mus musculus
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Symbol: Casp8
Name: caspase 8
Description: Exhibits cysteine-type endopeptidase activity involved in apoptotic process and protein heterodimerization activity. Involved in several processes, including hepatocyte apoptotic process; regulation of programmed cell death; and tube morphogenesis. Localizes to the Noc1p-Noc2p complex; cytoplasm; and plasma membrane. Used to study atopic dermatitis and autoimmune lymphoproliferative syndrome type 2B. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; hepatocellular carcinoma; pancreatic cancer; and primary immunodeficiency disease. Is expressed in several structures, including central nervous system; gonad; heart; hemolymphoid system; and limb ectoderm. Orthologous to human CASP8 (caspase 8).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CASP-8; caspase-8; Fas-linked ICE-like protease; FLICE; MACH; Mch5
Orthologs:
Homo sapiens (human) : CASP8 (caspase 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casp8 (caspase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp8 (caspase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP8 (caspase 8)
Canis lupus familiaris (dog) : CASP8 (caspase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp8 (caspase 8)
Sus scrofa (pig) : CASP8 (caspase 8)
more info ...
Related Pseudogenes: Gm20257  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38158,795,233 - 58,847,503 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37158,852,218 - 58,904,347 (+)NCBIGRCm37mm9NCBIm37
MGSCv36158,740,040 - 58,791,559 (+)NCBImm8
Celera159,314,392 - 59,366,511 (+)NCBICelera
Cytogenetic Map1 C1.3NCBI
cM Map129.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated