Pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) - Rat Genome Database

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Gene: Pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) Mus musculus
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Symbol: Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
RGD ID: 1315104
MGI Page MGI
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including G protein-coupled receptor signaling pathway; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of Rac protein signal transduction. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and protein phosphorylation. Predicted to be located in cytosol and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in future spinal cord; hemolymphoid system; and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5830428L06Rik; p110ga; p110gamma; p120-PI3K; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI(3)Kg; PI3-kinase subunit gamma; PI3K-gamma; PI3K
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,223,128 - 32,258,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1232,223,472 - 32,258,658 (-)EnsemblGRCm39 Ensembl
GRCm381232,173,397 - 32,208,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,173,473 - 32,208,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,858,262 - 32,893,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361232,760,883 - 32,793,717 (-)NCBIMGSCv36mm8
Celera1233,627,107 - 33,665,676 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetohydrazide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-Zearalanol  (ISO)
amosite asbestos  (EXP)
amphetamine  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium silicate  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
cycloheximide  (ISO)
cyhalothrin  (ISO)
deoxynivalenol  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
ethanol  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (EXP)
hexadecanoic acid  (EXP)
hydrazine  (EXP)
IC-87114  (EXP)
idelalisib  (EXP)
isoprenaline  (EXP)
kaempferol  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP,ISO)
metformin  (ISO)
methylmercury(1+)  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
PCB138  (EXP)
pioglitazone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
tamibarotene  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (EXP)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
behavioral response to pain  (ISO)
cell migration  (IBA)
cellular response to cAMP  (IMP)
chemotaxis  (IEA)
chromatin remodeling  (IEA)
endocytosis  (IEA)
G protein-coupled receptor signaling pathway  (ISO)
hepatocyte apoptotic process  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IEA)
lipid metabolic process  (IEA)
negative regulation of fibroblast apoptotic process  (IDA)
negative regulation of triglyceride catabolic process  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IMP,ISO)
phosphatidylinositol phosphate biosynthetic process  (ISO)
phosphatidylinositol-3-phosphate biosynthetic process  (IBA,IEA)
phosphatidylinositol-mediated signaling  (IBA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (EXP)
phosphorylation  (IEA,ISO)
positive regulation of acute inflammatory response  (IEA,ISO)
positive regulation of catalytic activity  (IMP)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of endothelial cell migration  (IMP,ISO)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of Rac protein signal transduction  (IMP,ISO)
protein phosphorylation  (IDA)
regulation of angiogenesis  (IEA,ISO)
regulation of calcium ion transmembrane transport  (IMP)
regulation of protein phosphorylation  (IMP)
secretory granule localization  (IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IMP,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiac muscle relaxation  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK cell differentiation  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal response to infection  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thymus lobule morphology  (IAGP)
atherosclerotic lesions  (IAGP)
cardiac hypertrophy  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating alanine transaminase level  (IEA)
decreased circulating cholesterol level  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased platelet calcium level  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced thrombosis  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
enlarged heart  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased eosinophil cell number  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to Poxviridae infection  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
skin lesions  (IAGP)
small thymus  (IAGP)
spleen hypoplasia  (IAGP)
thymus hypoplasia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. Barber DF, etal., J Immunol. 2006 Jan 1;176(1):589-93.
2. PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Becattini B, etal., Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. Epub 2011 Sep 26.
3. PI3Kgamma controls leukocyte recruitment, tissue injury, and lethality in a model of graft-versus-host disease in mice. Castor MG, etal., J Leukoc Biol. 2011 Jun;89(6):955-64. Epub 2011 Mar 14.
4. Improvement of the resistance against early Mycobacterium tuberculosis-infection in the absence of PI3Kγ enzyme is associated with increase of CD4+IL-17+ cells and neutrophils. Cavalcanti-Neto MP, etal., Tuberculosis (Edinb). 2018 Dec;113:1-9. doi: 10.1016/j.tube.2018.08.009. Epub 2018 Aug 23.
5. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
6. Inhibitor of PI3Kgamma ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells. Dutra RC, etal., Br J Pharmacol. 2011 May;163(2):358-74. doi: 10.1111/j.1476-5381.2011.01226.x.
7. Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. Edling CE, etal., Clin Cancer Res. 2010 Oct 15;16(20):4928-37. doi: 10.1158/1078-0432.CCR-10-1210. Epub 2010 Sep 28.
8. Phosphoinositide 3-Kinase {gamma} Inhibition Plays a Crucial Role in Early Steps of Inflammation by Blocking Neutrophil Recruitment. Ferrandi C, etal., J Pharmacol Exp Ther. 2007 Sep;322(3):923-30. Epub 2007 May 25.
9. Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients. Garcia CC, etal., Front Immunol. 2018 May 15;9:975. doi: 10.3389/fimmu.2018.00975. eCollection 2018.
10. Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. Gonzalez-Garcia A, etal., Gastroenterology. 2010 Apr;138(4):1374-83. Epub 2009 Dec 11.
11. Loss of phosphoinositide 3-kinase gamma decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis. Gruen M, etal., BMC Musculoskelet Disord. 2010 Apr 7;11:63.
12. Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats. Guan X, etal., J Neurochem. 2015 Aug;134(3):590-600. doi: 10.1111/jnc.13139. Epub 2015 Jun 4.
13. PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. Haubner BJ, etal., PLoS One. 2010 Feb 22;5(2):e9350.
14. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
15. Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Jin R, etal., Stroke. 2011 Jul;42(7):2033-44. Epub 2011 May 5.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. PI3K-gamma inhibition ameliorates acute lung injury through regulation of IkappaBalpha/NF-kappaB pathway and innate immune responses. Kim DI, etal., J Clin Immunol. 2012 Apr;32(2):340-51. Epub 2011 Dec 24.
18. Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina. Kobayashi T and Puro DG, Invest Ophthalmol Vis Sci. 2007 May;48(5):2350-5.
19. Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria. Lacerda-Queiroz N, etal., PLoS One. 2015 Mar 16;10(3):e0119633. doi: 10.1371/journal.pone.0119633. eCollection 2015.
20. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
21. Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. Lionetti V, etal., Crit Care Med. 2006 Jan;34(1):134-41.
22. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Lu JM, etal., Exp Eye Res. 2020 Jan;190:107886. doi: 10.1016/j.exer.2019.107886. Epub 2019 Nov 21.
23. PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Martin D, etal., Cancer Cell. 2011 Jun 14;19(6):805-13. doi: 10.1016/j.ccr.2011.05.005.
24. Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. Martin EL, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73. Epub 2010 May 27.
25. Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. Maus UA, etal., Am J Respir Crit Care Med. 2007 May 1;175(9):958-66. doi: 10.1164/rccm.200610-1533OC. Epub 2007 Feb 22.
26. MGDs mouse GO annotations MGD data from the GO Consortium
27. MGD IEA MGD IEA
28. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
29. Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Passos GF, etal., Brain Behav Immun. 2010 Mar;24(3):493-501. Epub 2009 Dec 16.
30. Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. Perrino C, etal., J Am Coll Cardiol. 2005 Jun 7;45(11):1862-70.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
34. Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis. Rodrigues DH, etal., J Neuroimmunol. 2010 May;222(1-2):90-4. Epub 2010 Mar 19.
39. Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. Schneider C, etal., J Leukoc Biol. 2017 Feb;101(2):367-376. doi: 10.1189/jlb.4HI0316-157R. Epub 2016 Jul 28.
40. Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. Serajee FJ, etal., J Med Genet. 2003 Nov;40(11):e119.
41. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Silva MC, etal., Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.
42. Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. Siragusa M, etal., Circ Res. 2010 Mar 5;106(4):757-68. Epub 2010 Jan 7.
43. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Song LF, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):471-4.
44. Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice. Sun X, etal., J Immunol. 2013 Jan 1;190(1):357-65. doi: 10.4049/jimmunol.1201825. Epub 2012 Nov 23.
45. Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation. Thomas M, etal., Immunology. 2009 Mar;126(3):413-22. Epub 2008 Aug 27.
46. Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves phosphatidylinositol-3-OH kinase-Akt and a mitochondrial permeability transition pore during early reperfusion. Tosaka S, etal., J Anesth. 2007;21(2):176-80. Epub 2007 May 30.
47. The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. van Dop WA, etal., Immunol Lett. 2010 Jun 15;131(1):33-9. doi: 10.1016/j.imlet.2010.03.008. Epub 2010 Mar 27.
48. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. Xu H, etal., J Immunol. 2010 Feb 1;184(3):1492-8. doi: 10.4049/jimmunol.0902660. Epub 2009 Dec 18.
49. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. Yuan G, etal., Endocrinology. 2007 May;148(5):2016-26. Epub 2007 Feb 1.
50. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. Yum HK, etal., J Immunol. 2001 Dec 1;167(11):6601-8. doi: 10.4049/jimmunol.167.11.6601.
Additional References at PubMed
PMID:9115297   PMID:9852579   PMID:10349636   PMID:10669416   PMID:10669418   PMID:10972292   PMID:11042159   PMID:11054537   PMID:11076861   PMID:11511514   PMID:11677595   PMID:11756681  
PMID:11884408   PMID:11904423   PMID:11911828   PMID:12297047   PMID:12435753   PMID:12477932   PMID:12616480   PMID:12707323   PMID:12794110   PMID:12796499   PMID:14516793   PMID:14523044  
PMID:14681479   PMID:14762792   PMID:15046613   PMID:15100319   PMID:15102471   PMID:15192701   PMID:15231713   PMID:15271649   PMID:15292195   PMID:15294162   PMID:15294934   PMID:15318168  
PMID:15357953   PMID:15494014   PMID:15579443   PMID:15620702   PMID:15705797   PMID:15739165   PMID:15741161   PMID:15769890   PMID:15797027   PMID:15824082   PMID:15834429   PMID:15860757  
PMID:15860799   PMID:15878979   PMID:16107612   PMID:16110482   PMID:16116162   PMID:16141072   PMID:16141073   PMID:16183669   PMID:16186103   PMID:16304053   PMID:16430866   PMID:16467569  
PMID:16507763   PMID:16514418   PMID:16527821   PMID:16574789   PMID:16627784   PMID:16699071   PMID:16840732   PMID:16871217   PMID:16997858   PMID:17041586   PMID:17170126   PMID:17173040  
PMID:17173042   PMID:17277164   PMID:17284578   PMID:17325199   PMID:17488877   PMID:17499227   PMID:17579043   PMID:17615371   PMID:17626838   PMID:17644738   PMID:17673465   PMID:17675482  
PMID:17720808   PMID:17723215   PMID:17908814   PMID:17920279   PMID:17928414   PMID:17962628   PMID:17975110   PMID:17998387   PMID:18006698   PMID:18025236   PMID:18046317   PMID:18187452  
PMID:18201277   PMID:18250410   PMID:18250413   PMID:18250464   PMID:18268153   PMID:18323525   PMID:18367611   PMID:18523230   PMID:18536720   PMID:18542100   PMID:18544649   PMID:18558630  
PMID:18590694   PMID:18632611   PMID:18658026   PMID:18688045   PMID:18755982   PMID:18786920   PMID:18813358   PMID:18923161   PMID:19028980   PMID:19047410   PMID:19164702   PMID:19232703  
PMID:19232731   PMID:19291697   PMID:19297623   PMID:19339694   PMID:19451552   PMID:19494508   PMID:19509406   PMID:19515725   PMID:19549714   PMID:19604150   PMID:19732748   PMID:19734303  
PMID:19794963   PMID:19906996   PMID:19907415   PMID:19924283   PMID:19940148   PMID:20007453   PMID:20019838   PMID:20038597   PMID:20107187   PMID:20124452   PMID:20167705   PMID:20200404  
PMID:20299514   PMID:20392263   PMID:20451587   PMID:20501633   PMID:20505137   PMID:20534549   PMID:20616072   PMID:20637203   PMID:20665729   PMID:20678469   PMID:20847309   PMID:21048214  
PMID:21099282   PMID:21242482   PMID:21257963   PMID:21267068   PMID:21285350   PMID:21287545   PMID:21419339   PMID:21436039   PMID:21469095   PMID:21474070   PMID:21480213   PMID:21487106  
PMID:21538508   PMID:21665146   PMID:21677750   PMID:21698257   PMID:21873635   PMID:21921034   PMID:21930962   PMID:21996737   PMID:22019731   PMID:22053215   PMID:22058424   PMID:22084313  
PMID:22106345   PMID:22168443   PMID:22172670   PMID:22232690   PMID:22251152   PMID:22275805   PMID:22291096   PMID:22316281   PMID:22422878   PMID:22534961   PMID:22543031   PMID:22728827  
PMID:22930133   PMID:22972933   PMID:23008439   PMID:23024273   PMID:23028778   PMID:23029326   PMID:23142539   PMID:23143475   PMID:23216754   PMID:23236288   PMID:23276671   PMID:23282580  
PMID:23354687   PMID:23433113   PMID:23447687   PMID:23529017   PMID:23565202   PMID:23683463   PMID:23824069   PMID:23991137   PMID:24008870   PMID:24012746   PMID:24030559   PMID:24357053  
PMID:24654606   PMID:24659802   PMID:24676276   PMID:25033932   PMID:25073791   PMID:25103499   PMID:25173404   PMID:25288806   PMID:25327288   PMID:25373491   PMID:25406378   PMID:25451171  
PMID:25605974   PMID:25644171   PMID:25749189   PMID:25882071   PMID:25960397   PMID:26053836   PMID:26185363   PMID:26334033   PMID:26410627   PMID:26431158   PMID:26452362   PMID:26453378  
PMID:26596865   PMID:26839042   PMID:27030971   PMID:27050483   PMID:27179037   PMID:27306493   PMID:27442134   PMID:27531651   PMID:27642729   PMID:28003307   PMID:28081180   PMID:28130450  
PMID:28408298   PMID:28458167   PMID:28607113   PMID:28720716   PMID:28904022   PMID:28963139   PMID:29038423   PMID:29348263   PMID:29467755   PMID:30030497   PMID:30176533   PMID:30651001  
PMID:30720883   PMID:30973865   PMID:31106375   PMID:31187475   PMID:31216371   PMID:31266893   PMID:31392775   PMID:31554793   PMID:31691624   PMID:31719171   PMID:31781091   PMID:31836766  
PMID:32245826   PMID:32414808   PMID:32482794   PMID:32574650   PMID:32753644   PMID:32805234   PMID:33028343   PMID:33144519   PMID:33159421   PMID:33199895   PMID:33539876   PMID:33806610  
PMID:34236047   PMID:34566971   PMID:34685514   PMID:35269396   PMID:35353541   PMID:36245399   PMID:36779349   PMID:37379367   PMID:37676465   PMID:38271660   PMID:38355793   PMID:38959328  


Genomics

Comparative Map Data
Pik3cg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,223,128 - 32,258,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1232,223,472 - 32,258,658 (-)EnsemblGRCm39 Ensembl
GRCm381232,173,397 - 32,208,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,173,473 - 32,208,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,858,262 - 32,893,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361232,760,883 - 32,793,717 (-)NCBIMGSCv36mm8
Celera1233,627,107 - 33,665,676 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.74NCBI
PIK3CG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,865,282 - 106,908,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7106,865,278 - 106,908,980 (+)EnsemblGRCh38hg38GRCh38
GRCh377106,505,727 - 106,549,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,293,160 - 106,334,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 347106,099,874 - 106,141,543NCBI
Celera7101,311,222 - 101,352,879 (+)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef7100,864,687 - 100,906,376 (+)NCBIHuRef
CHM1_17106,439,450 - 106,481,120 (+)NCBICHM1_1
T2T-CHM13v2.07108,181,318 - 108,225,014 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27105,867,019 - 105,908,676 (+)NCBI
Pik3cg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8654,494,247 - 54,529,563 (-)NCBIGRCr8
mRatBN7.2648,766,778 - 48,802,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx649,076,821 - 49,111,984 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0649,391,750 - 49,426,907 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0648,836,049 - 48,871,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0651,465,696 - 51,501,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,106,730 - 61,142,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,441,892 - 50,476,931 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1650,447,918 - 50,480,237 (-)NCBI
Celera647,971,127 - 48,004,061 (-)NCBICelera
Cytogenetic Map6q16NCBI
Pik3cg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,402,520 - 11,437,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,402,476 - 11,433,335 (+)NCBIChiLan1.0ChiLan1.0
PIK3CG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26143,705,405 - 143,748,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17191,975,373 - 192,018,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0798,841,974 - 98,885,446 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17111,569,947 - 111,611,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7111,570,148 - 111,611,614 (+)Ensemblpanpan1.1panPan2
PIK3CG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,576,966 - 13,611,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,570,999 - 13,611,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,224,877 - 13,259,686 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01813,848,210 - 13,882,893 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,882,854 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11813,664,384 - 13,696,319 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01813,582,574 - 13,617,381 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01813,862,587 - 13,897,681 (-)NCBIUU_Cfam_GSD_1.0
Pik3cg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,959,678 - 55,990,585 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647917,084,920 - 17,112,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647917,084,006 - 17,112,264 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,698,207 - 106,745,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,698,200 - 106,748,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29117,537,774 - 117,572,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,781,812 - 75,823,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,784,648 - 75,825,496 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604228,038,017 - 28,081,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3cg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,737,270 - 22,772,589 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473922,737,376 - 22,772,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3cg
1500 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1504
Count of miRNA genes:565
Interacting mature miRNAs:660
Transcripts:ENSMUST00000053215, ENSMUST00000085469, ENSMUST00000126814, ENSMUST00000156904
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse

Markers in Region
BB283666  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381232,174,249 - 32,174,367UniSTSGRCm38
MGSCv371232,859,114 - 32,859,232UniSTSGRCm37
Celera1233,627,960 - 33,628,078UniSTS
Cytogenetic Map12BUniSTS
Whitehead/MRC_RH12301.61UniSTS
D12Mit106  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381232,187,399 - 32,187,534UniSTSGRCm38
MGSCv371232,872,264 - 32,872,399UniSTSGRCm37
Celera1233,641,116 - 33,641,241UniSTS
Cytogenetic Map12BUniSTS
cM Map1212.0UniSTS
Whitehead Genetic128.7UniSTS
Whitehead/MRC_RH12257.78UniSTS
Whitehead_YAC12 UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF208345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY831679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY194814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000053215   ⟹   ENSMUSP00000062864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,224,169 - 32,258,658 (-)Ensembl
GRCm38.p6 Ensembl1232,174,170 - 32,208,659 (-)Ensembl
Ensembl Acc Id: ENSMUST00000085469   ⟹   ENSMUSP00000082596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,225,623 - 32,258,469 (-)Ensembl
GRCm38.p6 Ensembl1232,175,624 - 32,208,470 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,250,550 - 32,251,008 (-)Ensembl
GRCm38.p6 Ensembl1232,200,551 - 32,201,009 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156904   ⟹   ENSMUSP00000123539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,223,472 - 32,258,610 (-)Ensembl
GRCm38.p6 Ensembl1232,173,473 - 32,208,611 (-)Ensembl
Ensembl Acc Id: ENSMUST00000217915   ⟹   ENSMUSP00000152007
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,226,577 - 32,255,985 (-)Ensembl
GRCm38.p6 Ensembl1232,176,578 - 32,205,986 (-)Ensembl
Ensembl Acc Id: ENSMUST00000218848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,225,651 - 32,228,453 (-)Ensembl
GRCm38.p6 Ensembl1232,175,652 - 32,178,454 (-)Ensembl
Ensembl Acc Id: ENSMUST00000220366   ⟹   ENSMUSP00000151400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1232,225,426 - 32,258,337 (-)Ensembl
GRCm38.p6 Ensembl1232,175,427 - 32,208,338 (-)Ensembl
RefSeq Acc Id: NM_001146200   ⟹   NP_001139672
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,223,396 - 32,258,658 (-)NCBI
GRCm381232,173,397 - 32,208,659 (-)NCBI
MGSCv371232,858,262 - 32,893,514 (-)RGD
Celera1233,627,107 - 33,665,676 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001146201   ⟹   NP_001139673
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,223,396 - 32,258,469 (-)NCBI
GRCm381232,173,397 - 32,208,470 (-)NCBI
MGSCv371232,858,262 - 32,893,514 (-)RGD
Celera1233,627,107 - 33,665,676 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_020272   ⟹   NP_064668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,223,396 - 32,258,469 (-)NCBI
GRCm381232,173,397 - 32,208,470 (-)NCBI
MGSCv371232,858,262 - 32,893,514 (-)RGD
Celera1233,627,107 - 33,665,676 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157094
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,223,396 - 32,258,658 (-)NCBI
GRCm381232,173,397 - 32,208,659 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006515112   ⟹   XP_006515175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,224,151 - 32,258,675 (-)NCBI
GRCm381232,174,152 - 32,208,677 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157468   ⟹   XP_036013361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,236,216 - 32,258,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157469   ⟹   XP_036013362
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,235,378 - 32,258,495 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004937505
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391232,223,128 - 32,258,495 (-)NCBI
Sequence:
RefSeq Acc Id: NP_064668   ⟸   NM_020272
- UniProtKB: Q80V09 (UniProtKB/Swiss-Prot),   Q9JHG7 (UniProtKB/Swiss-Prot),   Q3UVA4 (UniProtKB/TrEMBL),   Q3V1C0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139672   ⟸   NM_001146200
- UniProtKB: Q80V09 (UniProtKB/Swiss-Prot),   Q9JHG7 (UniProtKB/Swiss-Prot),   Q3UVA4 (UniProtKB/TrEMBL),   Q3V1C0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139673   ⟸   NM_001146201
- UniProtKB: Q80V09 (UniProtKB/Swiss-Prot),   Q9JHG7 (UniProtKB/Swiss-Prot),   Q3UVA4 (UniProtKB/TrEMBL),   Q3V1C0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515175   ⟸   XM_006515112
- Peptide Label: isoform X1
- UniProtKB: Q80V09 (UniProtKB/Swiss-Prot),   Q9JHG7 (UniProtKB/Swiss-Prot),   Q3UVA4 (UniProtKB/TrEMBL),   Q3V1C0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000082596   ⟸   ENSMUST00000085469
Ensembl Acc Id: ENSMUSP00000152007   ⟸   ENSMUST00000217915
Ensembl Acc Id: ENSMUSP00000062864   ⟸   ENSMUST00000053215
Ensembl Acc Id: ENSMUSP00000123539   ⟸   ENSMUST00000156904
Ensembl Acc Id: ENSMUSP00000151400   ⟸   ENSMUST00000220366
RefSeq Acc Id: XP_036013362   ⟸   XM_036157469
- Peptide Label: isoform X3
- UniProtKB: A0A1W2P8F6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013361   ⟸   XM_036157468
- Peptide Label: isoform X2
- UniProtKB: A0A1W2P8F6 (UniProtKB/TrEMBL)
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHG7-F1-model_v2 AlphaFold Q9JHG7 1-1102 view protein structure

Promoters
RGD ID:8678104
Promoter ID:EPDNEW_M17083
Type:initiation region
Name:Pik3cg_1
Description:Mus musculus phosphatidylinositol-4,5-bisphosphate 3-kinase catalyticsubunit gamma , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381232,208,567 - 32,208,627EPDNEW
RGD ID:6823265
Promoter ID:MM_KWN:11450
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:OTTMUST00000082639
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361232,885,451 - 32,886,307 (-)MPROMDB
RGD ID:6846994
Promoter ID:MM_ACW:10371
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:PIK3CG.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361232,890,556 - 32,891,056 (-)MPROMDB
RGD ID:6823261
Promoter ID:MM_KWN:11451
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:ENSMUST00000020890,   NM_001146201,   NM_020272,   OTTMUST00000082636,   UC007NIA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361232,893,256 - 32,893,807 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353576 AgrOrtholog
Ensembl Genes ENSMUSG00000020573 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000053215 ENTREZGENE
  ENSMUST00000053215.14 UniProtKB/Swiss-Prot
  ENSMUST00000085469 ENTREZGENE
  ENSMUST00000085469.6 UniProtKB/Swiss-Prot
  ENSMUST00000156904.8 UniProtKB/Swiss-Prot
  ENSMUST00000217915 ENTREZGENE
  ENSMUST00000217915.2 UniProtKB/TrEMBL
  ENSMUST00000220366 ENTREZGENE
  ENSMUST00000220366.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.20.770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:30955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1353576 ENTREZGENE
NCBI Gene 30955 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3cg PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P8F6 ENTREZGENE, UniProtKB/TrEMBL
  PK3CG_MOUSE UniProtKB/Swiss-Prot
  Q24LN5_MOUSE UniProtKB/TrEMBL
  Q3UPS4_MOUSE UniProtKB/TrEMBL
  Q3UVA4 ENTREZGENE, UniProtKB/TrEMBL
  Q3V1C0 ENTREZGENE, UniProtKB/TrEMBL
  Q80V09 ENTREZGENE
  Q8C5Q7_MOUSE UniProtKB/TrEMBL
  Q9EQL1_MOUSE UniProtKB/TrEMBL
  Q9JHG7 ENTREZGENE
UniProt Secondary Q80V09 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3cg  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma    phosphoinositide-3-kinase, catalytic, gamma polypeptide  Symbol and/or name change 5135510 APPROVED