Bglap (bone gamma carboxyglutamate protein) - Rat Genome Database

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Gene: Bglap (bone gamma carboxyglutamate protein) Mus musculus
Analyze
Symbol: Bglap
Name: bone gamma carboxyglutamate protein
RGD ID: 1621634
MGI Page MGI
Description: Predicted to have calcium ion binding activity and hydroxyapatite binding activity. Predicted to be a structural constituent of bone. Involved in cellular response to BMP stimulus. Localizes to cytoplasm and extracellular region. Is expressed in several structures, including bone; forelimb; lower jaw; and rib. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Bgl; Bglap1; Bglap2; BGP; bone gamma carboxyglutamate protein 1; bone Gla protein; gamma-carboxyglutamic acid-containing protein; mOC; mOC-A; O; OC; OG; OG1; oste; osteocalcin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,290,802 - 88,291,773 (-)NCBIGRCm39mm39
GRCm39 Ensembl388,290,808 - 88,291,771 (-)Ensembl
GRCm38388,383,495 - 88,384,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,383,501 - 88,384,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,187,417 - 88,188,386 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,469,422 - 88,470,391 (-)NCBImm8
Celera388,423,135 - 88,424,104 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bisphospho-D-glyceric acid  (ISO)
2,3-bisphosphoglyceric acid  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-aminobenzamide  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (EXP)
allopurinol  (ISO)
alloxanthine  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (EXP)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
aucubin  (ISO)
azadirachtin A  (EXP)
bafilomycin A1  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
Bisphenol A diglycidyl ether  (EXP)
boron atom  (ISO)
budesonide  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caesium atom  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium carbonate  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
CHIR 99021  (EXP)
chitosan  (ISO)
chlormequat chloride  (ISO)
chloroquine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cycloheximide  (EXP)
daidzein  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental boron  (ISO)
enalapril  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
Falecalcitriol  (ISO)
fasudil hydrochloride  (EXP)
fentin hydroxide  (EXP)
flavonoids  (ISO)
fluticasone  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-Oryzanol (TN)  (ISO)
genistein  (EXP,ISO)
glycerol 2-phosphate  (EXP,ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
Goserelin  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
ifosfamide  (ISO)
ionomycin  (EXP)
iron dextran  (ISO)
isonicotinamide  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
levonorgestrel  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
magnesium atom  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
menaquinone  (ISO)
menaquinone-7  (EXP)
menatetrenone  (EXP)
methotrexate  (ISO)
methylparaben  (EXP)
montelukast  (EXP)
myricitrin  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
naringin  (EXP,ISO)
nebivolol  (ISO)
neoeriocitrin  (EXP)
nicotine  (ISO)
nitric acid  (ISO)
NMN zwitterion  (EXP,ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
ormeloxifene  (ISO)
oxaliplatin  (ISO)
pamidronate  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
Phenylamil  (ISO)
phosphatidic acid  (ISO)
phylloquinone  (EXP)
pioglitazone  (EXP)
poly(ethylene)  (ISO)
prallethrin  (EXP)
quercetin  (ISO)
quinoxyfen  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sciadopitysin  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium atom  (ISO)
topotecan  (ISO)
tributylstannane  (EXP,ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tungsten  (EXP)
uranium atom  (EXP,ISO)
valproic acid  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
vitamin K  (ISO)
vorinostat  (ISO)
warfarin  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone remodeling  (IAGP)
abnormal bone structure  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased energy expenditure  (IAGP)
decreased epididymis weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased Leydig cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased testis weight  (IAGP)
impaired glucose tolerance  (IAGP)
increased bone mass  (IAGP)
increased bone strength  (IAGP)
increased circulating estradiol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased compact bone thickness  (IAGP)
increased osteoclast cell number  (IAGP)
increased total body fat amount  (IAGP)
increased trabecular bone thickness  (IAGP)
insulin resistance  (IAGP)
oligozoospermia  (IAGP)
small pancreatic islets  (IAGP)
small testis  (IAGP)
References

References - curated
1. Achemlal L, etal., Clin Rheumatol. 2005 Sep;24(5):493-6. Epub 2005 Mar 4.
2. Arrabal-Polo MA, etal., Urology. 2012 Jan;79(1):48-54. doi: 10.1016/j.urology.2011.07.1382. Epub 2011 Sep 9.
3. Bruyere O, etal., Maturitas. 2003 Apr 25;44(4):259-65.
4. Christoforidis A, etal., J Bone Miner Metab. 2011 May;29(3):321-7. doi: 10.1007/s00774-010-0220-1. Epub 2010 Sep 16.
5. Gevers G, etal., Br J Rheumatol. 1986 Aug;25(3):260-2.
6. Horiuchi T, etal., J Bone Miner Metab. 2004;22(3):236-40.
7. Inukai T, etal., Diabetes Res Clin Pract. 1997 Oct;38(1):53-9.
8. Kalichman L and Kobyliansky E, Rheumatol Int. 2010 Jun;30(8):1131-5. Epub 2010 Feb 16.
9. Kanazawa I, etal., Calcif Tissue Int. 2009 Sep;85(3):228-34. doi: 10.1007/s00223-009-9272-4. Epub 2009 Jul 30.
10. Kang KY, etal., Rheumatol Int. 2012 Mar 25.
11. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
12. Li YL and Wang H, Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):653-6.
13. Maicas N, etal., Antioxid Redox Signal. 2011 Aug 15;15(4):889-901. Epub 2011 May 25.
14. Masse PG, etal., J Am Coll Nutr. 2010 Aug;29(4):419-29.
15. Miazgowski T and Czekalski S, Osteoporos Int. 1998;8(5):399-403.
16. Naito K, etal., Int J Mol Med. 2012 May;29(5):756-60. doi: 10.3892/ijmm.2012.897. Epub 2012 Jan 26.
17. Nakajima S, etal., Nutrition. 2011 Oct;27(10):1023-8. Epub 2011 Apr 9.
18. Nickolas TL, etal., J Am Soc Nephrol. 2011 Aug;22(8):1560-72. doi: 10.1681/ASN.2010121275. Epub 2011 Jul 22.
19. Nicolaidou P, etal., Eur J Pediatr. 2006 Aug;165(8):540-5. Epub 2006 Apr 19.
20. Okura T, etal., Kidney Blood Press Res. 2010;33(1):66-71. Epub 2010 Mar 2.
21. Oostlander AE, etal., J Cell Biochem. 2012 Jul;113(7):2424-2431. doi: 10.1002/jcb.24119.
22. Oste L, etal., Ren Fail. 2007;29(1):1-12.
23. Owen C, etal., J Cell Biochem. 2012 Jul;113(7):2432-41. doi: 10.1002/jcb.24115.
24. Petramala L, etal., Arch Dermatol Res. 2012 May;304(4):325-31. Epub 2011 Nov 27.
25. Pivonello R, etal., J Clin Endocrinol Metab. 1998 Jul;83(7):2275-80.
26. RGD automated import pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Salekzamani S, etal., Diabetes Metab Syndr Obes. 2011;4:205-12. Epub 2011 Jun 10.
30. Sato Y, etal., Mov Disord. 2005 Dec;20(12):1598-603.
31. Silva IV, etal., J Bone Miner Res. 2003 Apr;18(4):615-23.
32. Soontrapa S, etal., J Med Assoc Thai. 2005 Oct;88 Suppl 5:S29-32.
33. Takeuchi H, etal., Endocr J. 1993 Jun;40(3):351-62.
34. Thomas S, etal., Bone Miner. 1990 Jan;8(1):1-6.
35. Tural S, etal., Gene. 2013 Feb 15;515(1):167-72. doi: 10.1016/j.gene.2012.10.041. Epub 2012 Nov 5.
36. Wang CJ, etal., Arch Orthop Trauma Surg. 2011 Aug;131(8):1153-8. Epub 2011 Mar 9.
37. Weiler H, etal., Pediatr Nephrol. 2002 Oct;17(10):795-9. Epub 2002 Aug 10.
38. Wientroub S, etal., Calcif Tissue Int. 1987 Mar;40(3):166-72.
39. Wu HC, etal., Eur Urol. 2003 Feb;43(2):197-200.
40. Zeng GF, etal., J Ethnopharmacol. 2011 Jun 14;136(1):224-9. Epub 2011 Apr 28.
Additional References at PubMed
PMID:1774075   PMID:3019668   PMID:7575621   PMID:7598807   PMID:7626896   PMID:7891679   PMID:7915557   PMID:7958862   PMID:8043949   PMID:8055537   PMID:8075499   PMID:8089190  
PMID:8243336   PMID:8280378   PMID:8288580   PMID:8565822   PMID:8617498   PMID:8684484   PMID:8894143   PMID:8995235   PMID:8995767   PMID:9084638   PMID:9096102   PMID:9169155  
PMID:9182763   PMID:9225719   PMID:9241280   PMID:9259282   PMID:9328351   PMID:9333117   PMID:9457684   PMID:9457685   PMID:9556061   PMID:9737340   PMID:9832460   PMID:10433909  
PMID:10465785   PMID:10495271   PMID:10556287   PMID:10742104   PMID:10861287   PMID:10934642   PMID:11160153   PMID:11165481   PMID:11230154   PMID:11341333   PMID:11400162   PMID:11472836  
PMID:11518254   PMID:11545733   PMID:11606467   PMID:11713230   PMID:11792318   PMID:11804779   PMID:11934855   PMID:11937493   PMID:11937494   PMID:12000792   PMID:12369786   PMID:12414734  
PMID:12434152   PMID:12466851   PMID:12538525   PMID:12704187   PMID:12756187   PMID:12798773   PMID:14523025   PMID:14610273   PMID:14617570   PMID:14654219   PMID:14706625   PMID:15030764  
PMID:15131132   PMID:15132997   PMID:15177029   PMID:15207743   PMID:15389629   PMID:15456762   PMID:15509771   PMID:15576404   PMID:15579309   PMID:15660420   PMID:15689378   PMID:15866163  
PMID:15866164   PMID:15922673   PMID:15963767   PMID:15990875   PMID:16007336   PMID:16141072   PMID:16203988   PMID:16278811   PMID:16319118   PMID:16326388   PMID:16368934   PMID:16504022  
PMID:16730692   PMID:16751105   PMID:16815385   PMID:16857753   PMID:16936265   PMID:17050674   PMID:17141628   PMID:17142326   PMID:17289022   PMID:17336904   PMID:17488194   PMID:17544391  
PMID:17548469   PMID:17555517   PMID:17693256   PMID:17705049   PMID:17764670   PMID:17927973   PMID:17931618   PMID:18025304   PMID:18052755   PMID:18234177   PMID:18362359   PMID:18393307  
PMID:18446812   PMID:18487609   PMID:18514492   PMID:18582454   PMID:18821584   PMID:19073177   PMID:19103808   PMID:19121369   PMID:19144722   PMID:19162043   PMID:19197242   PMID:19224984  
PMID:19356224   PMID:19389359   PMID:19419310   PMID:19468303   PMID:19489959   PMID:19501582   PMID:19605502   PMID:19653325   PMID:19723774   PMID:19725955   PMID:19737917   PMID:19762422  
PMID:19906844   PMID:19954489   PMID:20010698   PMID:20025746   PMID:20038793   PMID:20142103   PMID:20200944   PMID:20628571   PMID:20655470   PMID:20816666   PMID:20838829   PMID:20847738  
PMID:20877012   PMID:20939017   PMID:21308778   PMID:21308779   PMID:21324897   PMID:21333348   PMID:21351141   PMID:21364421   PMID:21427224   PMID:21471200   PMID:21494559   PMID:21557453  
PMID:21571217   PMID:21703370   PMID:21757657   PMID:21762405   PMID:21788370   PMID:21852324   PMID:21873635   PMID:21924256   PMID:21934140   PMID:22022457   PMID:22028889   PMID:22093826  
PMID:22102412   PMID:22110141   PMID:22155508   PMID:22155527   PMID:22190639   PMID:22206865   PMID:22337375   PMID:22350212   PMID:22351931   PMID:22354840   PMID:22411303   PMID:22457635  
PMID:22459449   PMID:22547067   PMID:22564414   PMID:22632802   PMID:22676849   PMID:22843502   PMID:22886599   PMID:22936354   PMID:22936364   PMID:23042641   PMID:23092676   PMID:23123502  
PMID:23185634   PMID:23233153   PMID:23322385   PMID:23437377   PMID:23652029   PMID:23722907   PMID:23728177   PMID:24009262   PMID:24046454   PMID:24074871   PMID:24076664   PMID:24128197  
PMID:24389415   PMID:24391920   PMID:24491691   PMID:24497849   PMID:24554534   PMID:24642469   PMID:24680482   PMID:24823377   PMID:24896339   PMID:25183373   PMID:25201465   PMID:25209980  
PMID:25262822   PMID:25279792   PMID:25376646   PMID:25382630   PMID:25432534   PMID:25464126   PMID:25564625   PMID:25568170   PMID:25605327   PMID:25735975   PMID:25753038   PMID:26090674  
PMID:26091038   PMID:26244796   PMID:26859889   PMID:26890219   PMID:26924503   PMID:27052174   PMID:27117872   PMID:27188231   PMID:27221046   PMID:27304508   PMID:27664939   PMID:27689017  
PMID:27922003   PMID:27930311   PMID:28327634   PMID:28437476   PMID:28484278   PMID:28487368   PMID:28851741   PMID:28880886   PMID:28947535   PMID:28959031   PMID:28972540   PMID:29115005  
PMID:29157601   PMID:29174564   PMID:29184513   PMID:29352125   PMID:29437042   PMID:29561836   PMID:29718910   PMID:29884458   PMID:29975682   PMID:30111653   PMID:30268758   PMID:30355501  
PMID:30691926   PMID:30801848   PMID:31199918   PMID:31246957   PMID:31358536   PMID:31523009   PMID:32144802   PMID:32186512   PMID:32219165   PMID:32320893   PMID:32344102   PMID:32463812  
PMID:32463816  


Genomics

Comparative Map Data
Bglap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,290,802 - 88,291,773 (-)NCBIGRCm39mm39
GRCm39 Ensembl388,290,808 - 88,291,771 (-)Ensembl
GRCm38388,383,495 - 88,384,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,383,501 - 88,384,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,187,417 - 88,188,386 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,469,422 - 88,470,391 (-)NCBImm8
Celera388,423,135 - 88,424,104 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.82NCBI
BGLAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1156,242,184 - 156,243,317 (+)EnsemblGRCh38hg38GRCh38
GRCh381156,242,184 - 156,243,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,211,975 - 156,213,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,478,629 - 154,479,736 (+)NCBINCBI36hg18NCBI36
Build 341153,025,077 - 153,026,185NCBI
Celera1129,284,933 - 129,286,094 (+)NCBI
Cytogenetic Map1q22NCBI
HuRef1127,573,050 - 127,574,222 (+)NCBIHuRef
CHM1_11157,607,726 - 157,609,096 (+)NCBICHM1_1
Bglap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,838,518 - 173,839,495 (-)NCBI
Rnor_6.0 Ensembl2187,741,770 - 187,742,747 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02187,741,770 - 187,748,445 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02207,144,494 - 207,150,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,482,313 - 180,483,290 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,432,418 - 180,433,396 (-)NCBI
Celera2167,783,260 - 167,784,237 (-)NCBICelera
Cytogenetic Map2q34NCBI
Bglap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,381,156 - 2,381,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,381,091 - 2,382,114 (+)NCBIChiLan1.0ChiLan1.0
BGLAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,413,871 - 135,416,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,413,871 - 135,416,432 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,583,789 - 131,586,459 (+)NCBIMhudiblu_PPA_v0panPan3
BGLAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,630,092 - 41,630,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,630,098 - 41,665,791 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,117,871 - 41,118,763 (-)NCBI
ROS_Cfam_1.0741,494,521 - 41,495,418 (-)NCBI
UMICH_Zoey_3.1741,275,834 - 41,276,717 (-)NCBI
UNSW_CanFamBas_1.0741,329,023 - 41,329,894 (-)NCBI
UU_Cfam_GSD_1.0741,613,117 - 41,614,007 (-)NCBI
LOC101978603
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,449,368 - 26,451,906 (+)NCBI
SpeTri2.0NW_0049365805,480,023 - 5,482,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103223843
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,623,716 - 7,626,353 (-)NCBI
ChlSab1.1 Ensembl207,623,883 - 7,624,812 (-)Ensembl
Bglap
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,526,625 - 1,528,235 (+)NCBI

Position Markers
Bglap-rs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
cM Map342.6UniSTS
cM Map338.81UniSTS
Bglap1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
cM Map342.6UniSTS
PMC34669P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
cM Map342.6UniSTS
cM Map342.6UniSTS
cM Map342.6UniSTS
UniSTS:484830  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38388,383,503 - 88,384,433UniSTSGRCm38
MGSCv37388,187,425 - 88,188,355UniSTSGRCm37
Celera388,423,143 - 88,424,073UniSTS
Cytogenetic Map3F1UniSTS
cM Map342.6UniSTS
cM Map342.6UniSTS
Bglap1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38726314789232787Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:305
Interacting mature miRNAs:320
Transcripts:ENSMUST00000076048, ENSMUST00000128732
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000076048   ⟹   ENSMUSP00000075425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl388,383,501 - 88,384,433 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128732
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl388,383,827 - 88,384,464 (-)Ensembl
RefSeq Acc Id: NM_007541   ⟹   NP_031567
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,290,802 - 88,291,773 (-)NCBI
GRCm38388,383,495 - 88,384,466 (-)NCBI
MGSCv37388,187,417 - 88,188,386 (-)RGD
Celera388,423,135 - 88,424,106 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031567 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA39856 (Get FASTA)   NCBI Sequence Viewer  
  AAB40035 (Get FASTA)   NCBI Sequence Viewer  
  EDL15288 (Get FASTA)   NCBI Sequence Viewer  
  P86546 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031567   ⟸   NM_007541
- Peptide Label: preproprotein
- UniProtKB: P86546 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000075425   ⟸   ENSMUST00000076048
Protein Domains
Gla

Promoters
RGD ID:6881134
Promoter ID:EPDNEW_M4018
Type:multiple initiation site
Name:Bglap_1
Description:Mus musculus bone gamma carboxyglutamate protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38388,384,464 - 88,384,524EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88156 AgrOrtholog
Ensembl Genes ENSMUSG00000074483 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000075425 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000076048 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GLA-like_dom_SF UniProtKB/Swiss-Prot
  GLA_domain UniProtKB/Swiss-Prot
  Osteocalcin UniProtKB/Swiss-Prot
  Osteocalcin/MGP UniProtKB/Swiss-Prot
KEGG Report mmu:12096 UniProtKB/Swiss-Prot
MGD MGI:88156 ENTREZGENE
NCBI Gene 12096 ENTREZGENE
PANTHER PTHR14235 UniProtKB/Swiss-Prot
PharmGKB BGLAP RGD
PhenoGen Bglap PhenoGen
PRINTS GLABONE UniProtKB/Swiss-Prot
PROSITE GLA_1 UniProtKB/Swiss-Prot
  GLA_2 UniProtKB/Swiss-Prot
SMART GLA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57630 UniProtKB/Swiss-Prot
UniProt OSTCN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P04641 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Bglap  bone gamma carboxyglutamate protein  Bglap1  bone gamma carboxyglutamate protein 1  Symbol and/or name change 5135510 APPROVED