Epm2aip1 (EPM2A (laforin) interacting protein 1) - Rat Genome Database

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Gene: Epm2aip1 (EPM2A (laforin) interacting protein 1) Mus musculus
Analyze
Symbol: Epm2aip1
Name: EPM2A (laforin) interacting protein 1
RGD ID: 1322183
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Acts upstream of or within positive regulation of glycogen (starch) synthase activity; positive regulation of glycogen biosynthetic process; and response to insulin. Located in cytoplasmic side of endoplasmic reticulum membrane and nucleus. Is expressed in embryo. Orthologous to human EPM2AIP1 (EPM2A interacting protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A930003G21Rik; EPM2A-interacting protein 1; laforin-interacting protein; mKIAA0766
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,100,913 - 111,108,161 (+)NCBIGRCm39mm39
GRCm39 Ensembl9111,100,997 - 111,108,161 (+)Ensembl
GRCm389111,271,845 - 111,279,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,271,929 - 111,279,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv379111,174,349 - 111,181,597 (+)NCBIGRCm37mm9NCBIm37
MGSCv369111,116,745 - 111,123,905 (+)NCBImm8
Celera9110,995,011 - 111,002,246 (+)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
aflatoxin B1  (EXP)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
imidacloprid  (ISO)
leflunomide  (ISO)
methylmercury chloride  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium fluoride  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thiabendazole  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12693553   PMID:15102711   PMID:15489334   PMID:16107646   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:18973680   PMID:21267068   PMID:21873635   PMID:22001906   PMID:24142699   PMID:28536304   PMID:28671696   PMID:32325033  


Genomics

Comparative Map Data
Epm2aip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,100,913 - 111,108,161 (+)NCBIGRCm39mm39
GRCm39 Ensembl9111,100,997 - 111,108,161 (+)Ensembl
GRCm389111,271,845 - 111,279,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,271,929 - 111,279,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv379111,174,349 - 111,181,597 (+)NCBIGRCm37mm9NCBIm37
MGSCv369111,116,745 - 111,123,905 (+)NCBImm8
Celera9110,995,011 - 111,002,246 (+)NCBICelera
Cytogenetic Map9F3NCBI
EPM2AIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38336,985,043 - 36,993,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl336,985,043 - 36,993,131 (-)EnsemblGRCh38hg38GRCh38
GRCh37337,026,534 - 37,034,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,004,233 - 37,009,799 (-)NCBINCBI36hg18NCBI36
Build 34337,004,232 - 37,009,799NCBI
Celera336,970,125 - 36,977,560 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef336,968,039 - 36,975,475 (-)NCBIHuRef
CHM1_1336,978,987 - 36,986,425 (-)NCBICHM1_1
T2T-CHM13v2.0336,986,417 - 36,994,504 (-)NCBI
Epm2aip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28111,233,871 - 111,241,219 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8111,233,826 - 111,241,871 (+)Ensembl
Rnor_6.08119,524,039 - 119,531,387 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,524,039 - 119,531,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,865,643 - 118,872,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,653,794 - 115,656,867 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,673,241 - 115,721,997 (+)NCBI
Celera8110,515,491 - 110,522,839 (+)NCBICelera
Cytogenetic Map8q32NCBI
Epm2aip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554213,888,007 - 3,889,833 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554213,882,486 - 3,889,851 (-)NCBIChiLan1.0ChiLan1.0
EPM2AIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1337,181,452 - 37,189,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl337,187,354 - 37,189,177 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0336,894,383 - 36,899,772 (-)NCBIMhudiblu_PPA_v0panPan3
EPM2AIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,880,996 - 6,888,863 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl236,886,885 - 6,888,711 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha236,920,696 - 6,929,083 (-)NCBI
ROS_Cfam_1.0237,166,293 - 7,174,683 (-)NCBI
ROS_Cfam_1.0 Ensembl237,172,187 - 7,174,013 (-)Ensembl
UMICH_Zoey_3.1236,986,257 - 6,994,111 (-)NCBI
UNSW_CanFamBas_1.0237,128,462 - 7,136,312 (-)NCBI
UU_Cfam_GSD_1.0237,118,608 - 7,126,995 (-)NCBI
Epm2aip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118193,410,275 - 193,417,791 (-)NCBI
SpeTri2.0NW_00493647326,548,847 - 26,556,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPM2AIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1321,878,146 - 21,879,972 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11321,877,863 - 21,886,210 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21323,777,539 - 23,782,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPM2AIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,418,518 - 2,422,637 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl152,418,630 - 2,420,453 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606311,155,386 - 11,162,525 (+)NCBIVero_WHO_p1.0
Epm2aip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478815,108,361 - 15,110,187 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478815,102,663 - 15,110,354 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2203
Count of miRNA genes:720
Interacting mature miRNAs:910
Transcripts:ENSMUST00000060711, ENSMUST00000135807
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060711   ⟹   ENSMUSP00000052904
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9111,101,013 - 111,108,161 (+)Ensembl
GRCm38.p6 Ensembl9111,271,945 - 111,279,093 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135807   ⟹   ENSMUSP00000120245
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9111,100,997 - 111,108,157 (+)Ensembl
GRCm38.p6 Ensembl9111,271,929 - 111,279,089 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200053
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9111,103,170 - 111,106,609 (+)Ensembl
GRCm38.p6 Ensembl9111,274,102 - 111,277,541 (+)Ensembl
RefSeq Acc Id: NM_175266   ⟹   NP_780475
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399111,100,913 - 111,108,161 (+)NCBI
GRCm389111,271,845 - 111,279,093 (+)ENTREZGENE
MGSCv379111,174,349 - 111,181,597 (+)RGD
Celera9110,995,011 - 111,002,246 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_780475   ⟸   NM_175266
- UniProtKB: Q8VEH5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000120245   ⟸   ENSMUST00000135807
RefSeq Acc Id: ENSMUSP00000052904   ⟸   ENSMUST00000060711

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VEH5-F1-model_v2 AlphaFold Q8VEH5 1-606 view protein structure

Promoters
RGD ID:6844801
Promoter ID:MM_KWN:58964
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026810,   NM_175266,   OTTMUST00000074949,   OTTMUST00000078765,   OTTMUST00000078766,   OTTMUST00000078768,   UC009RVQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369111,173,921 - 111,177,682 (-)MPROMDB
RGD ID:8671058
Promoter ID:EPDNEW_M13560
Type:initiation region
Name:Epm2aip1_1
Description:Mus musculus EPM2A interacting protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389111,271,874 - 111,271,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925031 AgrOrtholog
Ensembl Genes ENSMUSG00000046785 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000052904 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000120245 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060711 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000135807 UniProtKB/Swiss-Prot
InterPro EPM2A-int_1 UniProtKB/Swiss-Prot
  SPIN-DOC_Znf-C2H2 UniProtKB/Swiss-Prot
KEGG Report mmu:77781 UniProtKB/Swiss-Prot
MGD MGI:1925031 ENTREZGENE
NCBI Gene 77781 ENTREZGENE
PANTHER PTHR45913 UniProtKB/Swiss-Prot
Pfam zf-C2H2_12 UniProtKB/Swiss-Prot
PhenoGen Epm2aip1 PhenoGen
UniProt EPMIP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q80TS4 UniProtKB/Swiss-Prot