Trib3 (tribbles pseudokinase 3) - Rat Genome Database

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Gene: Trib3 (tribbles pseudokinase 3) Mus musculus
Analyze
Symbol: Trib3
Name: tribbles pseudokinase 3
RGD ID: 732371
MGI Page MGI
Description: Enables enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of fat cell differentiation; and negative regulation of fatty acid biosynthetic process. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including bone; central nervous system; genitourinary system; heart; and retina. Orthologous to human TRIB3 (tribbles pseudokinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ifl; Ifld2; induced in fatty liver dystrophy 2; N; neuronal cell death-inducible putative kinase; Nipk; SINK; SK; SKIP3; Trb; TRB-3; Trb3; tribbles homolog 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,179,345 - 152,185,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,179,342 - 152,185,952 (-)EnsemblGRCm39 Ensembl
GRCm382152,337,425 - 152,344,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,337,422 - 152,344,032 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,163,161 - 152,169,796 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,028,863 - 152,035,473 (-)NCBIMGSCv36mm8
Celera2158,151,551 - 158,158,172 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(R)-lipoic acid  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-phenylbutylamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amino acid  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
antimycin A  (EXP,ISO)
Archazolid B  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
betulinic acid  (EXP,ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bortezomib  (EXP,ISO)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboxy-PTIO  (EXP,ISO)
cefaloridine  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
elesclomol  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
ferric oxide  (EXP)
flavokawain B  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fomepizole  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazines  (EXP)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
iron dichloride  (ISO)
isoniazide  (ISO)
ivermectin  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lamivudine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipoic acid  (EXP)
lithium chloride  (ISO)
manganese(II) chloride  (ISO)
menadione  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (EXP)
mitomycin C  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
nitroprusside  (EXP,ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
Octicizer  (EXP)
organoselenium compound  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
phorone  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
torin 1  (EXP)
tributyl phosphate  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10438476   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12749859   PMID:12791994   PMID:12904583   PMID:14610273  
PMID:15107844   PMID:15489334   PMID:15775988   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16794074   PMID:16887816   PMID:17170753   PMID:17207467   PMID:17303803  
PMID:17576771   PMID:17646392   PMID:18187772   PMID:18194653   PMID:18287559   PMID:18593568   PMID:18776938   PMID:19164449   PMID:19492410   PMID:19681769   PMID:19748123   PMID:19996382  
PMID:20059953   PMID:20360254   PMID:20410507   PMID:20421299   PMID:20592469   PMID:20660016   PMID:21203563   PMID:21267068   PMID:21275776   PMID:21435438   PMID:21606205   PMID:21873635  
PMID:22000581   PMID:22242143   PMID:22275087   PMID:22745161   PMID:22773666   PMID:22977230   PMID:23261831   PMID:23515163   PMID:23567453   PMID:23695665   PMID:24212932   PMID:24676635  
PMID:24691093   PMID:24732777   PMID:24740654   PMID:24746137   PMID:24824999   PMID:24834131   PMID:25108431   PMID:25133193   PMID:25168244   PMID:25204656   PMID:25503742   PMID:25601649  
PMID:25603829   PMID:26224857   PMID:26337904   PMID:26446156   PMID:26494538   PMID:26801556   PMID:27106802   PMID:27207527   PMID:27526673   PMID:27845424   PMID:28062363   PMID:28117339  
PMID:28393700   PMID:28486108   PMID:28962861   PMID:29079702   PMID:29180572   PMID:29213092   PMID:29378327   PMID:30031847   PMID:30071535   PMID:30681896   PMID:30720074   PMID:31125554  
PMID:31202927   PMID:31235507   PMID:31283965   PMID:31286822   PMID:31789450   PMID:31974597   PMID:32325033   PMID:32968282   PMID:33592376   PMID:33975909   PMID:34215725   PMID:34389433  
PMID:36048019   PMID:36154620   PMID:36539111   PMID:37172723   PMID:38240287   PMID:38445671  


Genomics

Comparative Map Data
Trib3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,179,345 - 152,185,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,179,342 - 152,185,952 (-)EnsemblGRCm39 Ensembl
GRCm382152,337,425 - 152,344,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,337,422 - 152,344,032 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,163,161 - 152,169,796 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,028,863 - 152,035,473 (-)NCBIMGSCv36mm8
Celera2158,151,551 - 158,158,172 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
TRIB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3820380,760 - 397,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl20362,835 - 397,559 (+)EnsemblGRCh38hg38GRCh38
GRCh3720361,404 - 378,203 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3620309,308 - 326,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 3420309,307 - 326,201NCBI
Celera20456,158 - 473,052 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef20312,732 - 329,628 (+)NCBIHuRef
CHM1_120361,309 - 361,866 (+)NCBICHM1_1
T2T-CHM13v2.020424,107 - 440,963 (+)NCBIT2T-CHM13v2.0
Trib3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,269,939 - 161,275,533 (-)NCBIGRCr8
mRatBN7.23140,809,634 - 140,815,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,809,043 - 140,814,497 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,714,722 - 144,720,327 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,298,562 - 153,304,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,038,803 - 151,044,379 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,814,056 - 147,819,650 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,813,473 - 147,819,571 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,162,197 - 154,167,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,664,641 - 142,670,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,569,627 - 142,575,693 (-)NCBI
Celera3139,561,433 - 139,567,041 (-)NCBICelera
Cytogenetic Map3q41NCBI
Trib3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955597260,790 - 265,326 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955597259,209 - 265,896 (+)NCBIChiLan1.0ChiLan1.0
TRIB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,469,634 - 1,485,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1201,466,483 - 1,482,488 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v020583,267 - 605,416 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.120359,470 - 375,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl20359,879 - 375,486 (+)Ensemblpanpan1.1panPan2
TRIB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,450,281 - 20,461,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,451,001 - 20,457,510 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,103,931 - 20,114,798 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,143,266 - 21,154,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,143,273 - 21,150,479 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,418,511 - 20,429,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,524,537 - 20,535,390 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,955,034 - 20,966,099 (-)NCBIUU_Cfam_GSD_1.0
Trib3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,645,481 - 169,660,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,077,850 - 18,083,553 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,077,850 - 18,082,817 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1734,807,582 - 34,816,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11734,808,273 - 34,819,592 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,595,609 - 39,602,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRIB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1235,512,911 - 35,530,856 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl235,512,861 - 35,530,966 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660787,686,687 - 7,704,641 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trib3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247411,484,863 - 1,494,829 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247411,486,223 - 1,494,005 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trib3
188 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:629
Count of miRNA genes:407
Interacting mature miRNAs:475
Transcripts:ENSMUST00000040312, ENSMUST00000123145, ENSMUST00000124995
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse

Markers in Region
C76863  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,337,708 - 152,337,819UniSTSGRCm38
MGSCv372152,163,444 - 152,163,555UniSTSGRCm37
Celera2158,151,834 - 158,151,945UniSTS
Cytogenetic Map2G3UniSTS
cM Map286.0UniSTS
Whitehead/MRC_RH21783.7UniSTS
Trib3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,337,504 - 152,337,719UniSTSGRCm38
MGSCv372152,163,240 - 152,163,455UniSTSGRCm37
Celera2158,151,630 - 158,151,845UniSTS
Cytogenetic Map2G3UniSTS
cM Map286.0UniSTS
UniSTS:235161  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382152,343,093 - 152,343,876UniSTSGRCm38
MGSCv372152,168,829 - 152,169,612UniSTSGRCm37
Celera2158,157,205 - 158,157,988UniSTS
Cytogenetic Map2G3UniSTS
cM Map286.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_175093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF358868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ514260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY010029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000040312   ⟹   ENSMUSP00000041747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2152,179,342 - 152,185,952 (-)Ensembl
GRCm38.p6 Ensembl2152,337,422 - 152,344,032 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2152,181,668 - 152,185,908 (-)Ensembl
GRCm38.p6 Ensembl2152,339,748 - 152,343,988 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2152,184,858 - 152,185,890 (-)Ensembl
GRCm38.p6 Ensembl2152,342,938 - 152,343,970 (-)Ensembl
RefSeq Acc Id: NM_175093   ⟹   NP_780302
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392152,179,345 - 152,185,980 (-)NCBI
GRCm382152,337,425 - 152,344,060 (-)ENTREZGENE
MGSCv372152,163,161 - 152,169,796 (-)RGD
Celera2158,151,551 - 158,158,172 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_780302   ⟸   NM_175093
- UniProtKB: Q3UMQ0 (UniProtKB/Swiss-Prot),   Q921E7 (UniProtKB/Swiss-Prot),   Q8K4K2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000041747   ⟸   ENSMUST00000040312
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4K2-F1-model_v2 AlphaFold Q8K4K2 1-354 view protein structure

Promoters
RGD ID:6832975
Promoter ID:MM_KWN:32354
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Brain,   ES_Cell,   Lung
Transcripts:ENSMUST00000099213
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362152,168,771 - 152,169,592 (-)MPROMDB
RGD ID:6832981
Promoter ID:MM_KWN:32355
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000037672,   OTTMUST00000037673,   OTTMUST00000037674
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362152,169,446 - 152,169,946 (-)MPROMDB
RGD ID:6879172
Promoter ID:EPDNEW_M3037
Type:initiation region
Name:Trib3_1
Description:Mus musculus tribbles pseudokinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382152,343,999 - 152,344,059EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1345675 AgrOrtholog
Ensembl Genes ENSMUSG00000032715 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040312 ENTREZGENE
  ENSMUST00000040312.7 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tribbles/Ser_Thr_kinase_40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:228775 UniProtKB/Swiss-Prot
MGD MGI:1345675 ENTREZGENE
NCBI Gene 228775 ENTREZGENE
PANTHER PTHR22961 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22961:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trib3 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3UJJ9_MOUSE UniProtKB/TrEMBL
  Q3UMQ0 ENTREZGENE
  Q8K4K2 ENTREZGENE
  Q921E7 ENTREZGENE
  TRIB3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3UMQ0 UniProtKB/Swiss-Prot
  Q921E7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 Trib3  tribbles pseudokinase 3    tribbles homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED