Slc26a5 (solute carrier family 26, member 5) - Rat Genome Database

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Gene: Slc26a5 (solute carrier family 26, member 5) Mus musculus
Analyze
Symbol: Slc26a5
Name: solute carrier family 26, member 5
RGD ID: 1621439
MGI Page MGI
Description: Enables spectrin binding activity. Acts upstream of or within regulation of membrane potential. Located in basolateral plasma membrane; lateral plasma membrane; and lateral wall of outer hair cell. Is expressed in brain; cochlea; embryo; and organ of Corti. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; acrylamide (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC124328; MGC124329; outer hair cell motor protein; P; pr; Pres; prestin; prestin (motor protein); solute carrier family 26 member 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,013,999 - 22,070,602 (-)NCBIGRCm39mm39
GRCm39 Ensembl522,015,653 - 22,070,602 (-)Ensembl
GRCm38521,809,001 - 21,865,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,810,655 - 21,865,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,316,473 - 21,371,422 (-)NCBIGRCm37mm9NCBIm37
MGSCv36521,322,479 - 21,377,428 (-)NCBImm8
Celera518,781,281 - 18,837,517 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:7607678   PMID:12239568   PMID:12466851   PMID:12477932   PMID:12584604   PMID:12865130   PMID:14553901   PMID:14610273   PMID:15207913   PMID:15478431   PMID:15925207   PMID:16141072  
PMID:16166160   PMID:16682411   PMID:16709400   PMID:16873410   PMID:17004922   PMID:17364360   PMID:17415610   PMID:17640919   PMID:17664869   PMID:17933870   PMID:18221877   PMID:18234980  
PMID:18397741   PMID:18466744   PMID:18506528   PMID:18796539   PMID:19320974   PMID:19339464   PMID:19521566   PMID:19776286   PMID:20138822   PMID:20142329   PMID:20169529   PMID:20359505  
PMID:20505086   PMID:20631244   PMID:21071769   PMID:21267068   PMID:21364896   PMID:21677750   PMID:21773053   PMID:21873635   PMID:21954035   PMID:21959151   PMID:22526732   PMID:23029017  
PMID:23212912   PMID:23542924   PMID:24303013   PMID:24453323   PMID:24496619   PMID:25467981   PMID:25486270   PMID:25748314   PMID:26352669   PMID:26682723   PMID:26854618   PMID:26903308  
PMID:27232762   PMID:27534441   PMID:27559308   PMID:28089576   PMID:29706463   PMID:30079013   PMID:30108230   PMID:30275816   PMID:30297983   PMID:30305733   PMID:30336149   PMID:30464345  
PMID:30753104   PMID:30833597   PMID:30938680   PMID:31053797   PMID:31297132   PMID:33964205  


Genomics

Comparative Map Data
Slc26a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,013,999 - 22,070,602 (-)NCBIGRCm39mm39
GRCm39 Ensembl522,015,653 - 22,070,602 (-)Ensembl
GRCm38521,809,001 - 21,865,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,810,655 - 21,865,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,316,473 - 21,371,422 (-)NCBIGRCm37mm9NCBIm37
MGSCv36521,322,479 - 21,377,428 (-)NCBImm8
Celera518,781,281 - 18,837,517 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
SLC26A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7103,352,730 - 103,446,207 (-)EnsemblGRCh38hg38GRCh38
GRCh387103,352,598 - 103,446,207 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377102,993,177 - 103,086,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,780,413 - 102,873,834 (-)NCBINCBI36hg18NCBI36
Celera797,800,386 - 97,892,942 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef797,355,533 - 97,447,053 (-)NCBIHuRef
CHM1_17102,926,169 - 103,019,937 (-)NCBICHM1_1
CRA_TCAGchr7v27102,353,543 - 102,447,443 (-)NCBI
Slc26a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2413,210,260 - 13,249,289 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
Rnor_6.049,795,811 - 9,860,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,822,682 - 9,861,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,657,314 - 8,697,539 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.148,657,313 - 8,697,539 (+)NCBI
Celera48,801,513 - 8,840,481 (+)NCBICelera
Cytogenetic Map4q11NCBI
Slc26a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,358,786 - 8,414,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,358,780 - 8,414,145 (-)NCBIChiLan1.0ChiLan1.0
SLC26A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17108,088,197 - 108,178,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,088,197 - 108,178,578 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0795,363,028 - 95,437,527 (-)NCBIMhudiblu_PPA_v0panPan3
SLC26A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,783,795 - 16,841,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,788,759 - 16,839,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1816,426,732 - 16,484,887 (+)NCBI
ROS_Cfam_1.01817,074,350 - 17,132,490 (+)NCBI
UMICH_Zoey_3.11816,839,580 - 16,897,324 (+)NCBI
UNSW_CanFamBas_1.01816,777,413 - 16,835,901 (+)NCBI
UU_Cfam_GSD_1.01817,046,210 - 17,104,115 (+)NCBI
Slc26a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511858,980,819 - 59,021,086 (+)NCBI
SpeTri2.0NW_00493647920,104,625 - 20,145,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC26A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,378,776 - 103,453,730 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,382,558 - 103,420,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,990,590 - 114,062,746 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC26A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,347,276 - 72,418,311 (-)NCBI
ChlSab1.1 Ensembl2172,347,792 - 72,393,765 (-)Ensembl
Vero_WHO_p1.0NW_02366604231,608,735 - 31,657,804 (+)NCBI
Slc26a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473925,925,835 - 25,998,410 (+)NCBI

Position Markers
D5Mit61  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38521,862,445 - 21,862,543UniSTSGRCm38
MGSCv37521,368,263 - 21,368,361UniSTSGRCm37
Celera518,834,366 - 18,834,456UniSTS
Cytogenetic Map5A3UniSTS
cM Map58.0UniSTS
Whitehead Genetic55.5UniSTS
D5Buc45  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38521,862,952 - 21,863,225UniSTSGRCm38
MGSCv37521,368,770 - 21,369,043UniSTSGRCm37
Celera518,834,865 - 18,835,138UniSTS
Cytogenetic Map5A3UniSTS
cM Map5 UniSTS
Slc26a5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38521,810,953 - 21,811,044UniSTSGRCm38
Celera518,781,579 - 18,781,670UniSTS
Cytogenetic Map5A3UniSTS
cM Map59.97UniSTS
Slc26a5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301468Eye1_meye weight 1 (mouse)Not determined5121879650Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123556323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129371157Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined561814634618282Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5517952239179654Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5791911941919241Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5879767233318293Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5886594940372526Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51340580847405808Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51547674049476846Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52052964954529790Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52150995255510060Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:560
Count of miRNA genes:329
Interacting mature miRNAs:365
Transcripts:ENSMUST00000030878, ENSMUST00000115176, ENSMUST00000127975, ENSMUST00000142888, ENSMUST00000150012
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000030878   ⟹   ENSMUSP00000030878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl522,015,653 - 22,070,602 (-)Ensembl
GRCm38.p6 Ensembl521,810,655 - 21,865,604 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115176   ⟹   ENSMUSP00000110830
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl522,015,653 - 22,066,996 (-)Ensembl
GRCm38.p6 Ensembl521,810,655 - 21,861,998 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127975   ⟹   ENSMUSP00000118029
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl522,016,147 - 22,052,330 (-)Ensembl
GRCm38.p6 Ensembl521,811,149 - 21,847,332 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142888   ⟹   ENSMUSP00000118263
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl522,016,016 - 22,052,378 (-)Ensembl
GRCm38.p6 Ensembl521,811,018 - 21,847,380 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150012
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl522,020,748 - 22,025,515 (-)Ensembl
GRCm38.p6 Ensembl521,815,750 - 21,820,517 (-)Ensembl
RefSeq Acc Id: NM_001289787   ⟹   NP_001276716
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39522,013,999 - 22,067,004 (-)NCBI
GRCm38521,809,001 - 21,862,006 (-)NCBI
Celera518,779,612 - 18,837,517 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289788   ⟹   NP_001276717
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39522,013,999 - 22,067,004 (-)NCBI
GRCm38521,809,001 - 21,862,006 (-)NCBI
Celera518,779,612 - 18,837,517 (-)NCBI
Sequence:
RefSeq Acc Id: NM_030727   ⟹   NP_109652
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39522,013,999 - 22,070,602 (-)NCBI
GRCm38521,809,001 - 21,865,604 (-)NCBI
MGSCv37521,316,473 - 21,371,422 (-)RGD
Celera518,779,612 - 18,837,517 (-)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006535818   ⟹   XP_006535881
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39522,014,072 - 22,052,077 (-)NCBI
GRCm38521,809,074 - 21,847,079 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_109652   ⟸   NM_030727
- Peptide Label: isoform 1
- UniProtKB: Q99NH7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006535881   ⟸   XM_006535818
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001276717   ⟸   NM_001289788
- Peptide Label: isoform 3
- UniProtKB: Q99NH7 (UniProtKB/Swiss-Prot),   Q32MT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276716   ⟸   NM_001289787
- Peptide Label: isoform 2
- UniProtKB: Q99NH7 (UniProtKB/Swiss-Prot),   Q32MT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000118029   ⟸   ENSMUST00000127975
RefSeq Acc Id: ENSMUSP00000110830   ⟸   ENSMUST00000115176
RefSeq Acc Id: ENSMUSP00000030878   ⟸   ENSMUST00000030878
RefSeq Acc Id: ENSMUSP00000118263   ⟸   ENSMUST00000142888
Protein Domains
STAS   Sulfate_transp

Promoters
RGD ID:6838361
Promoter ID:MM_KWN:41512
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000057767
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36521,325,796 - 21,326,296 (-)MPROMDB
RGD ID:6886082
Promoter ID:EPDNEW_M6492
Type:single initiation site
Name:Slc26a5_1
Description:Mus musculus solute carrier family 26, member 5 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38521,865,579 - 21,865,639EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933154 AgrOrtholog
Ensembl Genes ENSMUSG00000029015 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000030878 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000110830 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000118029 UniProtKB/TrEMBL
  ENSMUSP00000118263 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030878 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000115176 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000127975 UniProtKB/TrEMBL
  ENSMUST00000142888 UniProtKB/TrEMBL
InterPro Prestin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S04_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC26A/SulP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC26A/SulP_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:80979 UniProtKB/Swiss-Prot
MGD MGI:1933154 ENTREZGENE
NCBI Gene 80979 ENTREZGENE
PANTHER PTHR11814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11814:SF32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam STAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfate_transp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc26a5 PhenoGen
PROSITE SLC26A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs sulP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z013_MOUSE UniProtKB/TrEMBL
  D6RIK0_MOUSE UniProtKB/TrEMBL
  Q32MT6 ENTREZGENE, UniProtKB/TrEMBL
  Q32MT7 ENTREZGENE, UniProtKB/TrEMBL
  Q99NH7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q80ZB1 UniProtKB/Swiss-Prot