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Gene: Gpnmb (glycoprotein (transmembrane) nmb) Mus musculus
Symbol: Gpnmb
Name: glycoprotein (transmembrane) nmb
Description: Exhibits heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and regulation of tissue remodeling. Localizes to cytoplasmic vesicle and integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary cutaneous amyloidosis. Orthologous to human GPNMB (glycoprotein nmb); INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DC-HIL; Dchil; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; ipd; iris pigment dispersion; osteoactivin; transmembrane glycoprotein NMB
Homo sapiens (human) : GPNMB (glycoprotein nmb)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gpnmb (glycoprotein nmb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpnmb (glycoprotein nmb)
Pan paniscus (bonobo/pygmy chimpanzee) : GPNMB (glycoprotein nmb)
Canis lupus familiaris (dog) : GPNMB (glycoprotein nmb)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpnmb (glycoprotein nmb)
Sus scrofa (pig) : GPNMB (glycoprotein nmb)
Chlorocebus sabaeus (African green monkey) : GPNMB (glycoprotein nmb)
Heterocephalus glaber (naked mole-rat) : Gpnmb (glycoprotein nmb)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl649,036,546 - 49,070,929 (+)EnsemblGRCm38mm10GRCm38
GRCm38649,036,518 - 49,058,182 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37648,986,517 - 49,008,181 (+)NCBIGRCm37mm9NCBIm37
MGSCv36648,966,211 - 48,987,694 (+)NCBImm8
Celera649,546,153 - 49,567,869 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gpnmb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733525
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.