Dclk3 (doublecortin-like kinase 3) - Rat Genome Database
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Gene: Dclk3 (doublecortin-like kinase 3) Mus musculus
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Symbol: Dclk3
Name: doublecortin-like kinase 3
RGD ID: 1618935
MGI Page MGI
Description: Exhibits protein kinase activity. Involved in negative regulation of protein localization to nucleus and peptidyl-serine phosphorylation. Localizes to cytoplasm and nucleus. Orthologous to human DCLK3 (doublecortin like kinase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BC056929; C730036H08; CLICK-I and II-related; Click-I, -II related; CLr; Dcamk; Dcamkl3; doublecortin and CaM kinase-like 3; doublecortin-like and CAM kinase-like 3; serine/threonine-protein kinase DCLK3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,268,149 - 111,318,679 (+)NCBIGRCm39mm39
GRCm389111,439,081 - 111,489,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,439,081 - 111,489,118 (+)EnsemblGRCm38mm10GRCm38
MGSCv379111,341,585 - 111,392,115 (+)NCBIGRCm37mm9NCBIm37
MGSCv369111,283,929 - 111,333,929 (+)NCBImm8
Celera9111,166,896 - 111,211,288 (+)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
nucleus  (IBA,IDA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16684769   PMID:16869982  
PMID:20236041   PMID:21677750   PMID:21873635   PMID:25556833   PMID:29534157  


Genomics

Comparative Map Data
Dclk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,268,149 - 111,318,679 (+)NCBIGRCm39mm39
GRCm389111,439,081 - 111,489,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,439,081 - 111,489,118 (+)EnsemblGRCm38mm10GRCm38
MGSCv379111,341,585 - 111,392,115 (+)NCBIGRCm37mm9NCBIm37
MGSCv369111,283,929 - 111,333,929 (+)NCBImm8
Celera9111,166,896 - 111,211,288 (+)NCBICelera
Cytogenetic Map9F3NCBI
DCLK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl336,712,422 - 36,764,349 (-)EnsemblGRCh38hg38GRCh38
GRCh38336,712,422 - 36,764,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37336,753,913 - 36,781,352 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36336,728,917 - 36,756,356 (-)NCBINCBI36hg18NCBI36
Celera336,696,656 - 36,724,088 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef336,694,656 - 36,722,087 (-)NCBIHuRef
CHM1_1336,704,133 - 36,731,552 (-)NCBICHM1_1
Dclk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08119,691,567 - 119,744,484 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,691,388 - 119,744,506 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08119,040,830 - 119,093,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,830,472 - 115,883,560 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,849,754 - 115,902,190 (+)NCBI
Celera8110,683,369 - 110,735,326 (+)NCBICelera
Cytogenetic Map8q32NCBI
Dclk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554213,590,455 - 3,636,801 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554213,593,328 - 3,618,427 (-)NCBIChiLan1.0ChiLan1.0
DCLK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1336,911,427 - 36,936,326 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl336,911,427 - 36,936,326 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0336,620,793 - 36,670,506 (-)NCBIMhudiblu_PPA_v0panPan3
DCLK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,631,052 - 6,662,949 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dclk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647326,300,195 - 26,320,953 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCLK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,040,828 - 22,095,474 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,040,518 - 22,095,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21323,860,743 - 23,989,814 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCLK3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl152,666,575 - 2,693,611 (+)Ensembl
ChlSab1.1152,641,036 - 2,690,573 (+)NCBI
Dclk3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478814,753,550 - 14,787,721 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:196
Interacting mature miRNAs:204
Transcripts:ENSMUST00000111879
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000111879   ⟹   ENSMUSP00000107510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9111,439,081 - 111,489,118 (+)Ensembl
RefSeq Acc Id: NM_172928   ⟹   NP_766516
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399111,268,149 - 111,318,679 (+)NCBI
GRCm389111,439,081 - 111,489,611 (+)ENTREZGENE
MGSCv379111,341,585 - 111,392,115 (+)RGD
Celera9111,166,896 - 111,211,288 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_766516 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH56929 (Get FASTA)   NCBI Sequence Viewer  
  ABB89470 (Get FASTA)   NCBI Sequence Viewer  
  BAC34182 (Get FASTA)   NCBI Sequence Viewer  
  Q8BWQ5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_766516   ⟸   NM_172928
- UniProtKB: Q8BWQ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107510   ⟸   ENSMUST00000111879
Protein Domains
Doublecortin   Protein kinase

Promoters
RGD ID:6844398
Promoter ID:MM_KWN:58967
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_172928
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369111,341,606 - 111,342,106 (+)MPROMDB
RGD ID:8671062
Promoter ID:EPDNEW_M13562
Type:initiation region
Name:Dclk3_1
Description:Mus musculus doublecortin-like kinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389111,439,108 - 111,439,168EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3039580 AgrOrtholog
Ensembl Genes ENSMUSG00000032500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000107510 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000111879 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.230 UniProtKB/Swiss-Prot
InterPro Doublecortin_dom UniProtKB/Swiss-Prot
  Doublecortin_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:245038 UniProtKB/Swiss-Prot
MGD MGI:3039580 ENTREZGENE
NCBI Gene 245038 ENTREZGENE
Pfam DCX UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Dclk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS50309 UniProtKB/Swiss-Prot
SMART DCX UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF89837 UniProtKB/Swiss-Prot
UniGene Mm.26361 ENTREZGENE
UniProt DCLK3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q1A748 UniProtKB/Swiss-Prot