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Gene: Nr1h3 (nuclear receptor subfamily 1, group H, member 3) Mus musculus
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Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to nuclear receptor activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including lipid homeostasis; negative regulation of secretion; and regulation of transcription by RNA polymerase II. Localizes to RNA polymerase II transcription regulator complex; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; nervous system; retina; and thymus. Used to study ovarian hyperstimulation syndrome. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3); PARTICIPATES IN bile acid signaling pathway; hepatitis C pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU018371; liver X receptor alpha; LXR; LXR alpha; nuclear receptor subfamily 1 group H member 3; oxysterols receptor LXR-alpha; RLD1; ubiquitously-expressed nuclear receptor 1; Unr1
Orthologs:
Homo sapiens (human) : NR1H3 (nuclear receptor subfamily 1 group H member 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nr1h3 (nuclear receptor subfamily 1, group H, member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h3 (nuclear receptor subfamily 1 group H member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Canis lupus familiaris (dog) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h3 (nuclear receptor subfamily 1 group H member 3)
Sus scrofa (pig) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Chlorocebus sabaeus (African green monkey) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Heterocephalus glaber (naked mole-rat) : Nr1h3 (nuclear receptor subfamily 1 group H member 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl291,184,061 - 91,202,834 (-)EnsemblGRCm38mm10GRCm38
GRCm38291,184,061 - 91,202,829 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37291,024,218 - 91,035,273 (-)NCBIGRCm37mm9NCBIm37
MGSCv36290,984,949 - 90,995,955 (-)NCBImm8
Celera292,568,901 - 92,580,220 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nr1h3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62202
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.