Spink1 (serine peptidase inhibitor, Kazal type 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Spink1 (serine peptidase inhibitor, Kazal type 1) Mus musculus
Analyze
Symbol: Spink1
Name: serine peptidase inhibitor, Kazal type 1
RGD ID: 1551337
MGI Page MGI
Description: Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of protein metabolic process; regulation of calcium ion transport; and sperm capacitation. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; liver; and yolk sac. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC107555; p1; p12; prostatic secretory glycoprotein; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1; serine protease inhibitor Kazal-type 3; serine protease inhibitor, Kazal type 3; Sp; Spink3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,861,134 - 43,870,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)EnsemblGRCm39 Ensembl
GRCm381843,728,069 - 43,737,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv371843,887,723 - 43,896,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361843,853,416 - 43,862,528 (-)NCBIMGSCv36mm8
Celera1845,096,166 - 45,111,565 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropropane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
bazedoxifene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
Evodiamine  (EXP)
fentin chloride  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
furosemide  (ISO)
glafenine  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
inulin  (EXP)
lasofoxifene  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The protective effects of long-acting recombinant human pancreatic secretory trypsin inhibitor (R44S-PSTI) in a rat model of cerulein-induced pancreatitis. Chen YZ, etal., J Int Med Res. 1996 Jan-Feb;24(1):59-68.
2. Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI-I, monitor peptide) during development of chronic pancreatitis in the WBN/Kob rat. Graf R, etal., Pancreatology. 2002;2(2):108-15.
3. Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer. Hotakainen K, etal., Int J Oncol. 2006 Jan;28(1):95-101.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Tumor markers CA 125, carcinoembryonic antigen and tumor-associated trypsin inhibitor in patients with cervical adenocarcinoma. Leminen A Gynecol Oncol. 1990 Dec;39(3):358-63.
6. Tumor-associated trypsin inhibitor in normal and malignant renal tissue and in serum of renal-cell carcinoma patients. Lukkonen A, etal., Int J Cancer. 1999 Nov 12;83(4):486-90.
7. Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. Medl M, etal., Br J Obstet Gynaecol. 1997 Jan;104(1):78-81.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Nathan JD, etal., Gastroenterology. 2005 Mar;128(3):717-27.
11. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Nathan JD, etal., Pancreas. 2010 Jan;39(1):e24-30. doi: 10.1097/MPA.0b013e3181bc45e9.
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum. Paju A, etal., Clin Cancer Res. 2004 Jul 15;10(14):4761-8.
15. Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. Paju A, etal., Eur Urol. 2007 Dec;52(6):1670-9. Epub 2007 Feb 5.
16. Tumor associated trypsin inhibitor as a prognostic factor in renal cell carcinoma. Paju A, etal., J Urol. 2001 Mar;165(3):959-62.
17. TATI (tumor associated trypsin inhibitor) and cancer antigen 125 (CA 125) in patients with early-stage endometrial cancer. Peters-Engl C, etal., Anticancer Res. 1998 Nov-Dec;18(6B):4635-9.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1beta in the pancreas. Romac JM, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G535-41. doi: 10.1152/ajpgi.00287.2011. Epub 2011 Dec 15.
22. Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder. Shariat SF, etal., Eur Urol. 2005 Sep;48(3):424-31.
23. Elevation of circulating monitor peptide/pancreatic secretory trypsin inhibitor-I (PSTI-61) after turpentine-induced inflammation in rats: hepatocytes produce it as an acute phase reactant. Uda K, etal., J Surg Res. 1994 Nov;57(5):563-8.
24. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
25. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Witt H, etal., Nat Genet. 2000 Jun;25(2):213-6.
Additional References at PubMed
PMID:1929395   PMID:2430282   PMID:3399394   PMID:3428272   PMID:9507200   PMID:9828198   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14659016   PMID:15097871  
PMID:15489334   PMID:16083722   PMID:16141072   PMID:16141073   PMID:17328885   PMID:17683524   PMID:18386042   PMID:18554416   PMID:18715980   PMID:20003319   PMID:20110462   PMID:20157294  
PMID:20623140   PMID:20660988   PMID:21267068   PMID:21677750   PMID:22008794   PMID:22042864   PMID:22228629   PMID:22260730   PMID:24521862   PMID:24607897   PMID:25063451   PMID:26682926  
PMID:28049832   PMID:29463648   PMID:30831323   PMID:30959855   PMID:31923181   PMID:32179912   PMID:32325033   PMID:34524424   PMID:37353485   PMID:37528140   PMID:37829188   PMID:38763786  


Genomics

Comparative Map Data
Spink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,861,134 - 43,870,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)EnsemblGRCm39 Ensembl
GRCm381843,728,069 - 43,737,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv371843,887,723 - 43,896,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361843,853,416 - 43,862,528 (-)NCBIMGSCv36mm8
Celera1845,096,166 - 45,111,565 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.47NCBI
SPINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385147,824,582 - 147,839,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5147,824,572 - 147,831,671 (-)EnsemblGRCh38hg38GRCh38
GRCh375147,204,145 - 147,218,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,184,339 - 147,191,453 (-)NCBINCBI36Build 36hg18NCBI36
Build 345147,184,338 - 147,191,453NCBI
Celera5143,286,018 - 143,293,135 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,351,294 - 142,358,402 (-)NCBIHuRef
CHM1_15146,636,518 - 146,643,635 (-)NCBICHM1_1
T2T-CHM13v2.05148,360,276 - 148,374,975 (-)NCBIT2T-CHM13v2.0
Spink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,121,626 - 36,133,596 (-)NCBIGRCr8
mRatBN7.21835,870,723 - 35,882,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,824,550 - 35,882,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1835,974,739 - 35,986,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,693,067 - 36,705,037 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,070,012 - 36,081,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01838,221,919 - 38,242,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1838,221,681 - 38,242,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01837,878,841 - 37,898,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,135,503 - 37,148,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
Spink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,371,059 - 6,378,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,328,672 - 6,378,611 (+)NCBIChiLan1.0ChiLan1.0
SPINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,077,196 - 143,091,804 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,216,747 - 141,231,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,273,137 - 143,287,745 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,282,828 - 149,297,469 (-)NCBIpanpan1.1PanPan1.1panPan2
SPINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,112,015 - 42,120,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,112,016 - 42,120,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,152,835 - 39,161,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,566,457 - 42,575,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,566,457 - 42,575,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,642,905 - 39,651,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,452,599 - 40,461,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,275,547 - 41,284,243 (-)NCBIUU_Cfam_GSD_1.0
Spink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,400,956 - 145,407,408 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365046,975,044 - 6,981,304 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365046,975,044 - 6,981,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,071,703 - 149,079,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,072,652 - 149,079,529 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,635,045 - 155,641,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12350,365,686 - 50,373,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2350,365,269 - 50,372,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603427,392,009 - 27,396,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247747,281,227 - 7,287,791 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247747,281,298 - 7,287,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink1
337 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSMUST00000025381
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
10412262Gre1_mGlucocorticoid receptor expression 1 (mouse)Not determined184354107846536999Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse

Markers in Region
Spink3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
cM Map18 UniSTS
Spink3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025381   ⟹   ENSMUSP00000025381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)Ensembl
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)Ensembl
RefSeq Acc Id: NM_009258   ⟹   NP_033284
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391843,861,134 - 43,870,302 (-)NCBI
GRCm381843,728,069 - 43,737,237 (-)ENTREZGENE
MGSCv371843,887,723 - 43,896,891 (-)RGD
Celera1845,096,166 - 45,111,565 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033284 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86887 (Get FASTA)   NCBI Sequence Viewer  
  BAB25298 (Get FASTA)   NCBI Sequence Viewer  
  BAB25389 (Get FASTA)   NCBI Sequence Viewer  
  CAA29648 (Get FASTA)   NCBI Sequence Viewer  
  EDL10012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025381
  ENSMUSP00000025381.3
GenBank Protein P09036 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033284   ⟸   NM_009258
- Peptide Label: precursor
- UniProtKB: Q5M9M3 (UniProtKB/Swiss-Prot),   P09036 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025381   ⟸   ENSMUST00000025381
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09036-F1-model_v2 AlphaFold P09036 1-80 view protein structure

Promoters
RGD ID:13677700
Promoter ID:EPDNEW_M22999
Type:initiation region
Name:Spink1_1
Description:Mus musculus serine peptidase inhibitor, Kazal type 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381843,737,194 - 43,737,254EPDNEW
RGD ID:6829551
Promoter ID:MM_KWN:25172
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_009258
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361843,896,681 - 43,897,181 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106202 AgrOrtholog
Ensembl Genes ENSMUSG00000024503 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025381 ENTREZGENE
  ENSMUST00000025381.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Prot_inh_Kazal-m UniProtKB/Swiss-Prot
KEGG Report mmu:20730 UniProtKB/Swiss-Prot
MGD MGI:106202 ENTREZGENE
NCBI Gene 20730 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 1 UniProtKB/Swiss-Prot
Pfam Kazal_1 UniProtKB/Swiss-Prot
PhenoGen Spink1 PhenoGen
PRINTS KAZALINHBTR UniProtKB/Swiss-Prot
PROSITE KAZAL_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
UniProt ISK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M9M3 ENTREZGENE
UniProt Secondary Q5M9M3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-02 Spink1  serine peptidase inhibitor, Kazal type 1  Spink3  serine peptidase inhibitor, Kazal type 3  Symbol and/or name change 5135510 APPROVED