Spink1 (serine peptidase inhibitor, Kazal type 1) - Rat Genome Database

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Gene: Spink1 (serine peptidase inhibitor, Kazal type 1) Mus musculus
Analyze
Symbol: Spink1
Name: serine peptidase inhibitor, Kazal type 1
RGD ID: 1551337
MGI Page MGI
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of cellular protein metabolic process; negative regulation of nitric oxide mediated signal transduction; and regulation of calcium ion transport. Localizes to extracellular space. Is expressed in embryo ectoderm; embryo endoderm; genitourinary system; gut; and yolk sac. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC107555; p1; p12; prostatic secretory glycoprotein; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1; serine protease inhibitor Kazal-type 3; serine protease inhibitor, Kazal type 3; Sp; Spink3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,861,134 - 43,870,302 (-)NCBIGRCm39mm39
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)Ensembl
GRCm381843,728,069 - 43,737,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv371843,887,723 - 43,896,891 (-)NCBIGRCm37mm9NCBIm37
MGSCv361843,853,416 - 43,862,528 (-)NCBImm8
Celera1845,096,166 - 45,111,565 (-)NCBICelera
Cytogenetic Map18B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropropane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
bazedoxifene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
furosemide  (ISO)
glafenine  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
lasofoxifene  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

References

References - curated
1. Chen YZ, etal., J Int Med Res. 1996 Jan-Feb;24(1):59-68.
2. Graf R, etal., Pancreatology. 2002;2(2):108-15.
3. Hotakainen K, etal., Int J Oncol. 2006 Jan;28(1):95-101.
4. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Leminen A Gynecol Oncol. 1990 Dec;39(3):358-63.
6. Lukkonen A, etal., Int J Cancer. 1999 Nov 12;83(4):486-90.
7. Medl M, etal., Br J Obstet Gynaecol. 1997 Jan;104(1):78-81.
8. MGD data from the GO Consortium
9. MGD IEA
10. Nathan JD, etal., Gastroenterology. 2005 Mar;128(3):717-27.
11. Nathan JD, etal., Pancreas. 2010 Jan;39(1):e24-30. doi: 10.1097/MPA.0b013e3181bc45e9.
12. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline
14. Paju A, etal., Clin Cancer Res. 2004 Jul 15;10(14):4761-8.
15. Paju A, etal., Eur Urol. 2007 Dec;52(6):1670-9. Epub 2007 Feb 5.
16. Paju A, etal., J Urol. 2001 Mar;165(3):959-62.
17. Peters-Engl C, etal., Anticancer Res. 1998 Nov-Dec;18(6B):4635-9.
18. RGD automated import pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Romac JM, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G535-41. doi: 10.1152/ajpgi.00287.2011. Epub 2011 Dec 15.
22. Shariat SF, etal., Eur Urol. 2005 Sep;48(3):424-31.
23. Uda K, etal., J Surg Res. 1994 Nov;57(5):563-8.
24. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
25. Witt H, etal., Nat Genet. 2000 Jun;25(2):213-6.
Additional References at PubMed
PMID:1929395   PMID:2430282   PMID:3399394   PMID:3428272   PMID:9507200   PMID:9828198   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14659016   PMID:15097871  
PMID:15489334   PMID:16083722   PMID:16141072   PMID:16141073   PMID:17328885   PMID:17683524   PMID:18386042   PMID:18554416   PMID:18715980   PMID:20003319   PMID:20110462   PMID:20157294  
PMID:20623140   PMID:20660988   PMID:21267068   PMID:21677750   PMID:22008794   PMID:22042864   PMID:22228629   PMID:22260730   PMID:24521862   PMID:24607897   PMID:25063451   PMID:26682926  
PMID:28049832   PMID:29463648   PMID:30831323   PMID:31923181   PMID:32179912   PMID:32325033  


Genomics

Comparative Map Data
Spink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,861,134 - 43,870,302 (-)NCBIGRCm39mm39
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)Ensembl
GRCm381843,728,069 - 43,737,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv371843,887,723 - 43,896,891 (-)NCBIGRCm37mm9NCBIm37
MGSCv361843,853,416 - 43,862,528 (-)NCBImm8
Celera1845,096,166 - 45,111,565 (-)NCBICelera
Cytogenetic Map18B3NCBI
SPINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5147,824,572 - 147,831,671 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5147,824,568 - 147,831,786 (-)EnsemblGRCh38hg38GRCh38
GRCh385147,824,582 - 147,839,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375147,204,145 - 147,218,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,184,339 - 147,191,453 (-)NCBINCBI36hg18NCBI36
Build 345147,184,338 - 147,191,453NCBI
Celera5143,286,018 - 143,293,135 (-)NCBI
Cytogenetic Map5q32NCBI
HuRef5142,351,294 - 142,358,402 (-)NCBIHuRef
CHM1_15146,636,518 - 146,651,169 (-)NCBICHM1_1
Spink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21835,870,723 - 35,882,693 (-)NCBI
Rnor_6.0 Ensembl1838,221,681 - 38,242,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01838,221,919 - 38,242,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01837,878,841 - 37,898,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,135,503 - 37,148,282 (-)NCBIRGSC3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
Spink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,371,059 - 6,378,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,328,672 - 6,378,611 (+)NCBIChiLan1.0ChiLan1.0
SPINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15149,282,828 - 149,297,469 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v05143,273,137 - 143,287,745 (-)NCBIMhudiblu_PPA_v0panPan3
SPINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,112,015 - 42,120,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,112,016 - 42,120,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,152,835 - 39,161,514 (-)NCBI
ROS_Cfam_1.0242,566,457 - 42,575,135 (-)NCBI
UMICH_Zoey_3.1239,642,905 - 39,651,567 (-)NCBI
UNSW_CanFamBas_1.0240,452,599 - 40,461,319 (-)NCBI
UU_Cfam_GSD_1.0241,275,547 - 41,284,243 (-)NCBI
Spink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,400,956 - 145,407,408 (+)NCBI
SpeTri2.0NW_0049365046,975,044 - 6,981,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,071,703 - 149,079,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,072,652 - 149,079,529 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,635,045 - 155,641,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12350,365,686 - 50,373,300 (-)NCBI
ChlSab1.1 Ensembl2350,365,269 - 50,372,814 (-)Ensembl
Spink1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247747,281,298 - 7,287,735 (-)NCBI

Position Markers
Spink3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
cM Map18 UniSTS
Spink3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060800000Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961139571Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181350407347504073Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181606658750066723Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181800665152006806Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181888582152885939Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181888582152885939Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182082063757457636Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182108452755084674Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182248686156487074Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182248686156487074Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182248686156487074Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182248686156487074Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182248686156487074Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182398250757982677Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182592381059923810Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182710806258694005Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182710806258694005Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182710806258694005Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182797631361976451Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2799753761997672Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182953484763534993Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183010000064100000Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183185541365855562Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183295797666958154Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183552556069525779Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183605451444976451Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183615795070158108Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183807349772073497Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183807349772073497Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183807349772073497Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183807349772073497Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183897060572970721Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184317804877178271Mouse
10412262Gre1_mGlucocorticoid receptor expression 1 (mouse)Not determined184340801346403932Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSMUST00000025381
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025381   ⟹   ENSMUSP00000025381
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)Ensembl
RefSeq Acc Id: NM_009258   ⟹   NP_033284
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391843,861,134 - 43,870,302 (-)NCBI
GRCm381843,728,069 - 43,737,237 (-)ENTREZGENE
MGSCv371843,887,723 - 43,896,891 (-)RGD
Celera1845,096,166 - 45,111,565 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033284   ⟸   NM_009258
- Peptide Label: precursor
- UniProtKB: P09036 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025381   ⟸   ENSMUST00000025381
Protein Domains
Kazal-like

Promoters
RGD ID:13677700
Promoter ID:EPDNEW_M22999
Type:initiation region
Name:Spink1_1
Description:Mus musculus serine peptidase inhibitor, Kazal type 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381843,737,194 - 43,737,254EPDNEW
RGD ID:6829551
Promoter ID:MM_KWN:25172
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_009258
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361843,896,681 - 43,897,181 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106202 AgrOrtholog
Ensembl Genes ENSMUSG00000024503 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000025381 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025381 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Prot_inh_Kazal-m UniProtKB/Swiss-Prot
KEGG Report mmu:20730 UniProtKB/Swiss-Prot
MGD MGI:106202 ENTREZGENE
NCBI Gene 20730 ENTREZGENE
Pfam Kazal_1 UniProtKB/Swiss-Prot
PhenoGen Spink1 PhenoGen
PRINTS KAZALINHBTR UniProtKB/Swiss-Prot
PROSITE KAZAL_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
UniProt ISK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5M9M3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-02 Spink1  serine peptidase inhibitor, Kazal type 1  Spink3  serine peptidase inhibitor, Kazal type 3  Symbol and/or name change 5135510 APPROVED