Slc25a33 (solute carrier family 25, member 33) - Rat Genome Database

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Gene: Slc25a33 (solute carrier family 25, member 33) Mus musculus
Analyze
Symbol: Slc25a33
Name: solute carrier family 25, member 33
RGD ID: 1318057
MGI Page MGI
Description: Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Involved in mitochondria-nucleus signaling pathway; positive regulation of cell growth; and pyrimidine nucleotide import into mitochondrion. Located in mitochondrial membrane. Is expressed in brainstem; liver; nervous system; and retina outer nuclear layer. Orthologous to human SLC25A33 (solute carrier family 25 member 33); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730438N18Rik; MGC4399; mitochondrial carrier protein; novel mitochondrial carrier protein domains containing protein; Pn; Pnc1; solute carrier family 25 member 33
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,828,493 - 149,858,746 (-)NCBIGRCm39mm39
GRCm39 Ensembl4149,828,493 - 149,858,734 (-)Ensembl
GRCm384149,744,036 - 149,774,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,744,036 - 149,774,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,118,145 - 149,148,376 (-)NCBIGRCm37mm9NCBIm37
MGSCv364148,588,275 - 148,617,987 (-)NCBImm8
Celera4152,010,383 - 152,042,111 (-)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chrysene  (EXP)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP)
dioxygen  (EXP)
diuron  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
folic acid  (EXP)
furan  (ISO)
glutathione  (ISO)
leflunomide  (ISO)
mercury dichloride  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
tetraphene  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15226823   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:17596519   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635   PMID:28378742   PMID:31138677   PMID:32581705  


Genomics

Comparative Map Data
Slc25a33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,828,493 - 149,858,746 (-)NCBIGRCm39mm39
GRCm39 Ensembl4149,828,493 - 149,858,734 (-)Ensembl
GRCm384149,744,036 - 149,774,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,744,036 - 149,774,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,118,145 - 149,148,376 (-)NCBIGRCm37mm9NCBIm37
MGSCv364148,588,275 - 148,617,987 (-)NCBImm8
Celera4152,010,383 - 152,042,111 (-)NCBICelera
Cytogenetic Map4E2NCBI
SLC25A33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl19,539,465 - 9,585,173 (+)EnsemblGRCh38hg38GRCh38
GRCh3819,539,465 - 9,585,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,599,524 - 9,645,231 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,522,115 - 9,565,418 (+)NCBINCBI36hg18NCBI36
Celera18,705,513 - 8,748,776 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef18,749,879 - 8,793,232 (+)NCBIHuRef
CHM1_119,588,092 - 9,631,383 (+)NCBICHM1_1
Slc25a33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,195,040 - 160,219,961 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5160,195,042 - 160,219,961 (-)Ensembl
Rnor_6.05166,701,463 - 166,726,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,701,465 - 166,726,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,345,877 - 170,371,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,836,557 - 166,861,525 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5158,464,162 - 158,489,066 (-)NCBICelera
Cytogenetic Map5q36NCBI
Slc25a33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554863,905,001 - 3,921,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554863,905,001 - 3,921,501 (-)NCBIChiLan1.0ChiLan1.0
SLC25A33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.119,493,787 - 9,574,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,541,918 - 9,574,549 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v018,300,384 - 8,343,270 (+)NCBIMhudiblu_PPA_v0panPan3
SLC25A33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,790,116 - 62,825,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,790,157 - 62,825,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,805,827 - 62,841,429 (+)NCBI
ROS_Cfam_1.0563,016,611 - 63,052,345 (+)NCBI
UMICH_Zoey_3.1563,038,606 - 63,074,205 (+)NCBI
UNSW_CanFamBas_1.0562,877,358 - 62,913,252 (+)NCBI
UU_Cfam_GSD_1.0563,281,618 - 63,317,240 (+)NCBI
Slc25a33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,096,589 - 33,118,280 (+)NCBI
SpeTri2.0NW_0049366233,585,372 - 3,603,515 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,934,834 - 69,969,084 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,934,810 - 69,969,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,148,523 - 64,168,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,187,366 - 122,220,903 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,187,637 - 122,220,661 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605426,153,642 - 26,197,329 (-)NCBIVero_WHO_p1.0
Slc25a33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248182,838,700 - 2,868,672 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Slc25a33  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E1UniSTS
cM Map480.15UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137890537151570093Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137946694150592401Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:187
Interacting mature miRNAs:197
Transcripts:ENSMUST00000105686
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_027460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK017628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL626808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW989568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB772382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG063566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ950692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK795124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU459142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000105686   ⟹   ENSMUSP00000101311
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4149,828,493 - 149,858,734 (-)Ensembl
GRCm38.p6 Ensembl4149,744,036 - 149,774,277 (-)Ensembl
RefSeq Acc Id: NM_027460   ⟹   NP_081736
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394149,828,493 - 149,858,724 (-)NCBI
GRCm384149,744,036 - 149,774,267 (-)ENTREZGENE
MGSCv374149,118,145 - 149,148,376 (-)RGD
Celera4152,010,383 - 152,042,111 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036164414   ⟹   XP_036020307
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394149,828,929 - 149,858,723 (-)NCBI
RefSeq Acc Id: XM_036164415   ⟹   XP_036020308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394149,828,929 - 149,858,746 (-)NCBI
RefSeq Acc Id: XM_036164416   ⟹   XP_036020309
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394149,828,929 - 149,858,339 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_081736   ⟸   NM_027460
- UniProtKB: Q3TZX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000101311   ⟸   ENSMUST00000105686
RefSeq Acc Id: XP_036020308   ⟸   XM_036164415
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036020307   ⟸   XM_036164414
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036020309   ⟸   XM_036164416
- Peptide Label: isoform X2

Promoters
RGD ID:6836397
Promoter ID:MM_KWN:40901
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:ENSMUST00000030833,   OTTMUST00000023896
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364149,148,041 - 149,148,541 (-)MPROMDB
RGD ID:6885584
Promoter ID:EPDNEW_M6243
Type:initiation region
Name:Slc25a33_1
Description:Mus musculus solute carrier family 25, member 33 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384149,774,226 - 149,774,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917806 AgrOrtholog
Ensembl Genes ENSMUSG00000028982 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000101311 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000105686 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot
InterPro Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:70556 UniProtKB/Swiss-Prot
MGD MGI:1917806 ENTREZGENE
NCBI Gene 70556 ENTREZGENE
Pfam Mito_carr UniProtKB/Swiss-Prot
PhenoGen Slc25a33 PhenoGen
PROSITE SOLCAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot
UniProt Q3TZX3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q921P8 UniProtKB/Swiss-Prot
  Q9CYJ1 UniProtKB/Swiss-Prot