Pcsk4 (proprotein convertase subtilisin/kexin type 4) - Rat Genome Database

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Gene: Pcsk4 (proprotein convertase subtilisin/kexin type 4) Mus musculus
Analyze
Symbol: Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
RGD ID: 731802
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Involved in fertilization and sperm capacitation. Acts upstream of or within acrosome reaction and binding activity of sperm to zona pellucida. Located in acrosomal membrane. Is expressed in early conceptus; epididymis; gonad; and neural retina. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0710008O07; AI647044; KEX2-like endoprotease 3; L21221; MGC63195; NEC 3; NEC3; neuroendocrine convertase 3; PC; PC4; prohormone convertase 3; SP; SPC5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,157,117 - 80,165,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,157,117 - 80,165,332 (-)EnsemblGRCm39 Ensembl
GRCm381080,321,283 - 80,329,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,321,283 - 80,329,498 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,784,028 - 79,792,218 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,724,431 - 79,732,602 (-)NCBIMGSCv36mm8
Celera1081,336,155 - 81,344,348 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcsk4Mousecolorectal adenocarcinoma susceptibilityISOPCSK4 (Homo sapiens)152177496DNA:SNP:3'utr: (rs1047854) C>T (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcsk4Mousecerebral creatine deficiency syndrome  ISOPCSK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebral creatine deficiency syndromeClinVarPMID:15108290 and PMID:28492532
Pcsk4Mousecyclic hematopoiesis  ISOPCSK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cyclical neutropeniaClinVarPMID:28492532
Pcsk4MouseNeurodevelopmental Disorders  ISOPCSK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Pcsk4Mouseprogressive myoclonus epilepsy 9  ISOPCSK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Progressive myoclonic epilepsy type 9ClinVarPMID:28492532

1 to 20 of 61 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcsk4Mouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of PCSK4 mRNACTDPMID:28189721 and PMID:28960355
Pcsk4Mouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PCSK4 mRNACTDPMID:39298647
Pcsk4Mouse17beta-estradiol decreases expressionISOPCSK4 (Homo sapiens)6480464Estradiol results in decreased expression of PCSK4 mRNACTDPMID:31614463
Pcsk4Mouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOPcsk4 (Rattus norvegicus)64804642 more ...CTDPMID:28712647
Pcsk4Mouse2,2',5,5'-tetrachlorobiphenyl increases expressionISOPcsk4 (Rattus norvegicus)64804642 more ...CTDPMID:23829299
Pcsk4Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPCSK4 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of PCSK4 mRNACTDPMID:22298810
Pcsk4Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PCSK4 mRNACTDPMID:21570461 more ...
Pcsk4Mouse2,4-dinitrotoluene affects expressionISOPcsk4 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of PCSK4 mRNACTDPMID:21346803
Pcsk4Mouse3,3',4,4',5-pentachlorobiphenyl increases expressionISOPcsk4 (Rattus norvegicus)64804643 more ...CTDPMID:32119087
Pcsk4Mouse3,3',4,4'-tetrachlorobiphenyl multiple interactionsEXP 64804643 more ...CTDPMID:19467301
Pcsk4Mouse4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of PCSK4 mRNACTDPMID:18648102
Pcsk4Mouse6-propyl-2-thiouracil affects expressionISOPcsk4 (Rattus norvegicus)6480464Propylthiouracil affects the expression of PCSK4 mRNACTDPMID:24780913
Pcsk4Mouseaflatoxin B1 decreases expressionISOPCSK4 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of PCSK4 mRNACTDPMID:22100608
Pcsk4Mouseaflatoxin B1 decreases expressionISOPcsk4 (Rattus norvegicus)6480464Aflatoxin B1 results in decreased expression of PCSK4 mRNACTDPMID:33354967
Pcsk4Mouseall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of PCSK4 mRNACTDPMID:16604517
Pcsk4Mouseammonium chloride affects expressionISOPcsk4 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of PCSK4 mRNACTDPMID:16483693
Pcsk4Mousebenzo[a]pyrene multiple interactionsEXP 6480464AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PCSK4 mRNA]CTDPMID:22228805
Pcsk4Mousebenzo[a]pyrene decreases methylationISOPCSK4 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PCSK4 3' UTRCTDPMID:27901495
Pcsk4Mousebenzo[a]pyrene decreases expressionEXP 6480464Benzo(a)pyrene results in decreased expression of PCSK4 mRNACTDPMID:22228805
Pcsk4Mousebis(2-ethylhexyl) phthalate decreases expressionEXP 6480464Diethylhexyl Phthalate results in decreased expression of PCSK4 mRNACTDPMID:33162236

1 to 20 of 61 rows

Biological Process
1 to 11 of 11 rows

  
1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcsk4Mouseacrosomal membrane located_inIDA 2290270 PMID:16371590MGIPMID:16371590
Pcsk4Mouseacrosomal vesicle located_inIDA 2290270 PMID:21302280UniProtPMID:21302280
Pcsk4Mouseendoplasmic reticulum lumen located_inTAS 2290270 ReactomeReactome:R-MMU-181788
Pcsk4MouseGolgi membrane is_active_inIBAPANTHER:PTN000082856 more ...2290270 GO_CentralGO_REF:0000033
Pcsk4Mousetrans-Golgi network is_active_inIBAPANTHER:PTN000082856 more ...2290270 GO_CentralGO_REF:0000033

Molecular Function

  


#
Reference Title
Reference Citation
1. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Puttagunta R, etal., Genome Res 2000 Sep;10(9):1369-80.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:1372895   PMID:1429684   PMID:1448111   PMID:7782070   PMID:7819324   PMID:8020970   PMID:8203153   PMID:8422932   PMID:8698813   PMID:9192653   PMID:9885250   PMID:10341094  
PMID:10349636   PMID:10701998   PMID:11042159   PMID:11076861   PMID:11164898   PMID:12466851   PMID:12477932   PMID:15226823   PMID:16141072   PMID:16141073   PMID:16163737   PMID:16371590  
PMID:19342015   PMID:20059953   PMID:20622265   PMID:21080038   PMID:21267068   PMID:21302280   PMID:21677750   PMID:21873635   PMID:22357636   PMID:22827436   PMID:24194600   PMID:27626380  
PMID:30590051   PMID:38355793  



Pcsk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,157,117 - 80,165,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,157,117 - 80,165,332 (-)EnsemblGRCm39 Ensembl
GRCm381080,321,283 - 80,329,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,321,283 - 80,329,498 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,784,028 - 79,792,218 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,724,431 - 79,732,602 (-)NCBIMGSCv36mm8
Celera1081,336,155 - 81,344,348 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
PCSK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,481,428 - 1,490,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,481,428 - 1,490,752 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,481,427 - 1,490,349 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,432,427 - 1,441,407 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,432,426 - 1,434,843NCBI
Celera191,415,419 - 1,424,399 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,255,223 - 1,264,091 (-)NCBIHuRef
CHM1_1191,481,431 - 1,490,411 (-)NCBICHM1_1
T2T-CHM13v2.0191,451,458 - 1,460,906 (-)NCBIT2T-CHM13v2.0
Pcsk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,032,040 - 10,040,263 (+)NCBIGRCr8
mRatBN7.279,381,366 - 9,389,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,381,361 - 9,389,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,258,291 - 12,266,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,133,633 - 14,141,734 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,000,988 - 12,009,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,247,498 - 12,255,721 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,247,498 - 12,255,719 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,417,102 - 12,425,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,892,705 - 10,900,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,892,704 - 10,900,926 (+)NCBI
Celera77,558,158 - 7,566,382 (+)NCBICelera
Cytogenetic Map7q11NCBI
Pcsk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,453,991 - 6,459,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,424,426 - 6,460,252 (+)NCBIChiLan1.0ChiLan1.0
PCSK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,827,433 - 5,859,561 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,063,109 - 5,090,410 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl191,452,924 - 1,466,438 (-)Ensemblpanpan1.1panPan2
PCSK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,370,035 - 57,376,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,369,328 - 57,375,590 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,162,069 - 57,168,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,101,329 - 58,107,483 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,101,344 - 58,107,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,157,552 - 57,163,690 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,637,009 - 57,643,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,839,018 - 57,845,172 (+)NCBIUU_Cfam_GSD_1.0
Pcsk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,035,019 - 217,041,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588794,227 - 799,663 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588793,615 - 800,038 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,989,544 - 76,997,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,982,806 - 76,996,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,881,928 - 77,888,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,253,729 - 1,264,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,254,276 - 1,263,847 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,588,319 - 7,598,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,208,995 - 7,216,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Pcsk4
141 total Variants

Predicted Target Of
Summary Value
Count of predictions:1781
Count of miRNA genes:506
Interacting mature miRNAs:605
Transcripts:ENSMUST00000020340, ENSMUST00000128653, ENSMUST00000130521, ENSMUST00000135071, ENSMUST00000137177, ENSMUST00000147132
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse

1 to 10 of 49 rows
AI647044  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,321,313 - 80,321,396UniSTSGRCm38
MGSCv371079,784,058 - 79,784,141UniSTSGRCm37
Celera1081,336,185 - 81,336,268UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Whitehead/MRC_RH10916.56UniSTS
L21221  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,321,460 - 80,321,631UniSTSGRCm38
GRCm38145,679,218 - 45,679,373UniSTSGRCm38
MGSCv37145,736,063 - 45,736,218UniSTSGRCm37
MGSCv371079,784,205 - 79,784,376UniSTSGRCm37
Celera1081,336,332 - 81,336,503UniSTS
Celera146,011,668 - 46,011,825UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Whitehead/MRC_RH10914.83UniSTS
Pcsk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
cM Map1039.72UniSTS






1 to 30 of 45 rows
RefSeq Transcripts NM_008793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 45 rows

Ensembl Acc Id: ENSMUST00000020340   ⟹   ENSMUSP00000020340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,157,117 - 80,165,332 (-)Ensembl
GRCm38.p6 Ensembl1080,321,283 - 80,329,498 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128653   ⟹   ENSMUSP00000137809
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,157,117 - 80,165,289 (-)Ensembl
GRCm38.p6 Ensembl1080,321,283 - 80,329,455 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,157,121 - 80,158,961 (-)Ensembl
GRCm38.p6 Ensembl1080,321,287 - 80,323,127 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135071   ⟹   ENSMUSP00000137719
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,157,956 - 80,165,233 (-)Ensembl
GRCm38.p6 Ensembl1080,322,122 - 80,329,399 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,157,117 - 80,165,287 (-)Ensembl
GRCm38.p6 Ensembl1080,321,283 - 80,329,453 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,157,121 - 80,158,960 (-)Ensembl
GRCm38.p6 Ensembl1080,321,287 - 80,323,126 (-)Ensembl
RefSeq Acc Id: NM_008793   ⟹   NP_032819
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,117 - 80,165,307 (-)NCBI
GRCm381080,321,283 - 80,329,473 (-)NCBI
MGSCv371079,784,028 - 79,792,218 (-)RGD
Celera1081,336,155 - 81,344,348 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513358   ⟹   XP_006513421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,562 (-)NCBI
GRCm381080,321,287 - 80,329,727 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513359   ⟹   XP_006513422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,564 (-)NCBI
GRCm381080,321,412 - 80,329,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513360   ⟹   XP_006513423
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,564 (-)NCBI
GRCm381080,321,287 - 80,329,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513361   ⟹   XP_006513424
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,566 (-)NCBI
GRCm381080,321,287 - 80,329,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513362   ⟹   XP_006513425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,566 (-)NCBI
GRCm381080,321,412 - 80,329,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513363   ⟹   XP_006513426
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,559 (-)NCBI
GRCm381080,321,287 - 80,329,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513364   ⟹   XP_006513427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,567 (-)NCBI
GRCm381080,321,412 - 80,329,732 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513365   ⟹   XP_006513428
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,564 (-)NCBI
GRCm381080,321,287 - 80,329,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513368   ⟹   XP_006513431
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,158,926 - 80,165,572 (-)NCBI
GRCm381080,323,092 - 80,329,736 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513369   ⟹   XP_006513432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,561 (-)NCBI
GRCm381080,321,287 - 80,329,726 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244951   ⟹   XP_030100811
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,560 (-)NCBI
GRCm381080,321,287 - 80,329,725 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155689   ⟹   XP_036011582
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,561 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948605
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,568 (-)NCBI
GRCm381080,321,412 - 80,329,733 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948607
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,447 - 80,165,568 (-)NCBI
GRCm381080,321,613 - 80,329,733 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948609
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,571 (-)NCBI
GRCm381080,321,412 - 80,329,736 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948610
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,575 (-)NCBI
GRCm381080,321,412 - 80,329,740 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948611
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,583 (-)NCBI
GRCm381080,321,412 - 80,329,748 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948612
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,583 (-)NCBI
GRCm381080,321,412 - 80,329,748 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948614
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,581 (-)NCBI
GRCm381080,321,412 - 80,329,746 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948615
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,581 (-)NCBI
GRCm381080,321,412 - 80,329,746 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936117
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,568 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936118
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,568 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936119
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,571 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936120
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,571 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936121
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,571 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936122
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,575 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936123
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,575 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936124
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,121 - 80,165,583 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936125
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,581 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936126
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,579 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936127
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,246 - 80,165,579 (-)NCBI
Sequence:
RefSeq Acc Id: XR_380370
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,158,918 - 80,165,571 (-)NCBI
GRCm381080,323,084 - 80,329,735 (-)NCBI
Sequence:
RefSeq Acc Id: XR_380371
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,158,558 - 80,165,571 (-)NCBI
GRCm381080,323,115 - 80,329,735 (-)NCBI
Sequence:
RefSeq Acc Id: XR_380372
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,158,922 - 80,165,571 (-)NCBI
GRCm381080,323,088 - 80,329,735 (-)NCBI
Sequence:
RefSeq Acc Id: XR_380374
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,663 - 80,165,578 (-)NCBI
GRCm381080,321,829 - 80,329,743 (-)NCBI
Sequence:
RefSeq Acc Id: XR_380375
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,157,699 - 80,165,578 (-)NCBI
GRCm381080,321,865 - 80,329,743 (-)NCBI
Sequence:
1 to 5 of 16 rows
1 to 5 of 16 rows
RefSeq Acc Id: NP_032819   ⟸   NM_008793
- Peptide Label: precursor
- UniProtKB: Q62094 (UniProtKB/Swiss-Prot),   P29121 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513428   ⟸   XM_006513365
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_006513432   ⟸   XM_006513369
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006513426   ⟸   XM_006513363
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006513424   ⟸   XM_006513361
- Peptide Label: isoform X4
- Sequence:
Name Modeler Protein Id AA Range Protein Structure
AF-P29121-F1-model_v2 AlphaFold P29121 1-655 view protein structure

RGD ID:6819710
Promoter ID:MM_KWN:4863
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   Brain,   Liver,   Lung
Transcripts:OTTMUST00000045846,   UC007GCR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,785,611 - 79,786,697 (-)MPROMDB
RGD ID:6819800
Promoter ID:MM_KWN:4864
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Kidney,   Liver
Transcripts:ENSMUST00000040081,   ENSMUST00000105357,   ENSMUST00000105358,   OTTMUST00000045839,   OTTMUST00000045841,   OTTMUST00000045842,   OTTMUST00000045843,   OTTMUST00000045844
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,792,576 - 79,793,462 (+)MPROMDB
RGD ID:8672646
Promoter ID:EPDNEW_M14354
Type:initiation region
Name:Pcsk4_1
Description:Mus musculus proprotein convertase subtilisin/kexin type 4 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14355  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381080,323,127 - 80,323,187EPDNEW
RGD ID:8672648
Promoter ID:EPDNEW_M14355
Type:initiation region
Name:Pcsk4_2
Description:Mus musculus proprotein convertase subtilisin/kexin type 4 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14354  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381080,329,415 - 80,329,475EPDNEW


1 to 40 of 40 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000020131 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020340 ENTREZGENE
  ENSMUST00000020340.15 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
InterPro Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Kexin/furin UniProtKB/Swiss-Prot
  P_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
  S8_pro-domain_sf UniProtKB/Swiss-Prot
KEGG Report mmu:18551 UniProtKB/Swiss-Prot
MGD MGI:97514 ENTREZGENE
NCBI Gene 18551 ENTREZGENE
PANTHER PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4 UniProtKB/Swiss-Prot
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot
Pfam P_proprotein UniProtKB/Swiss-Prot
  Peptidase_S8 UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
PhenoGen Pcsk4 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE P_HOMO_B UniProtKB/Swiss-Prot
  SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_ASP UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot
  SSF52743 UniProtKB/Swiss-Prot
UniProt M0QW95_MOUSE UniProtKB/TrEMBL
  M0QWG0_MOUSE UniProtKB/TrEMBL
  P29121 ENTREZGENE, UniProtKB/Swiss-Prot
  Q62094 ENTREZGENE
UniProt Secondary Q62094 UniProtKB/Swiss-Prot
1 to 40 of 40 rows