Pcsk4 (proprotein convertase subtilisin/kexin type 4) - Rat Genome Database

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Gene: Pcsk4 (proprotein convertase subtilisin/kexin type 4) Rattus norvegicus
Analyze
Symbol: Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
RGD ID: 620325
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; peptide hormone processing; and sperm capacitation. Predicted to be located in acrosomal membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KEX2-like endoprotease 3; NEC 3; neuroendocrine convertase 3; PC4; prohormone convertase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,032,040 - 10,040,263 (+)NCBIGRCr8
mRatBN7.279,381,366 - 9,389,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,381,361 - 9,389,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,258,291 - 12,266,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,133,633 - 14,141,734 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,000,988 - 12,009,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,247,498 - 12,255,721 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,247,498 - 12,255,719 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,417,102 - 12,425,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,892,705 - 10,900,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,892,704 - 10,900,926 (+)NCBI
Celera77,558,158 - 7,566,382 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Seidah NG, etal., Mol Endocrinol 1992 Oct;6(10):1559-70.
Additional References at PubMed
PMID:9192653   PMID:12477932   PMID:16040806   PMID:16371590   PMID:19342015   PMID:21080038   PMID:21302280  


Genomics

Comparative Map Data
Pcsk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,032,040 - 10,040,263 (+)NCBIGRCr8
mRatBN7.279,381,366 - 9,389,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,381,361 - 9,389,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,258,291 - 12,266,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,133,633 - 14,141,734 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,000,988 - 12,009,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,247,498 - 12,255,721 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,247,498 - 12,255,719 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,417,102 - 12,425,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,892,705 - 10,900,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,892,704 - 10,900,926 (+)NCBI
Celera77,558,158 - 7,566,382 (+)NCBICelera
Cytogenetic Map7q11NCBI
PCSK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,481,428 - 1,490,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,481,428 - 1,490,752 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,481,427 - 1,490,349 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,432,427 - 1,441,407 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,432,426 - 1,434,843NCBI
Celera191,415,419 - 1,424,399 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,255,223 - 1,264,091 (-)NCBIHuRef
CHM1_1191,481,431 - 1,490,411 (-)NCBICHM1_1
T2T-CHM13v2.0191,451,458 - 1,460,906 (-)NCBIT2T-CHM13v2.0
Pcsk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,157,117 - 80,165,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,157,117 - 80,165,332 (-)EnsemblGRCm39 Ensembl
GRCm381080,321,283 - 80,329,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,321,283 - 80,329,498 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,784,028 - 79,792,218 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,724,431 - 79,732,602 (-)NCBIMGSCv36mm8
Celera1081,336,155 - 81,344,348 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Pcsk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,453,991 - 6,459,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,424,426 - 6,460,252 (+)NCBIChiLan1.0ChiLan1.0
PCSK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,827,433 - 5,859,561 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,063,109 - 5,090,410 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl191,452,924 - 1,466,438 (-)Ensemblpanpan1.1panPan2
PCSK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,370,035 - 57,376,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,369,328 - 57,375,590 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,162,069 - 57,168,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,101,329 - 58,107,483 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,101,344 - 58,107,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,157,552 - 57,163,690 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,637,009 - 57,643,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,839,018 - 57,845,172 (+)NCBIUU_Cfam_GSD_1.0
Pcsk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,035,019 - 217,041,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588794,227 - 799,663 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588793,615 - 800,038 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,989,544 - 76,997,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,982,806 - 76,996,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,881,928 - 77,888,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,253,729 - 1,264,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,254,276 - 1,263,847 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,588,319 - 7,598,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,208,995 - 7,216,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcsk4
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:111
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000022358
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
AI576245  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,384,203 - 9,384,306 (+)MAPPERmRatBN7.2
Rnor_6.0712,250,336 - 12,250,438NCBIRnor6.0
Rnor_5.0712,420,131 - 12,420,233UniSTSRnor5.0
RGSC_v3.4710,895,543 - 10,895,645UniSTSRGSC3.4
Celera77,560,997 - 7,561,099UniSTS
RH 3.4 Map725.3UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 113 90 89 59 24 59 6 213 92 93 45 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000022358   ⟹   ENSRNOP00000022358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,381,361 - 9,389,585 (+)Ensembl
Rnor_6.0 Ensembl712,247,498 - 12,255,719 (+)Ensembl
RefSeq Acc Id: NM_133559   ⟹   NP_598243
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,032,040 - 10,040,263 (+)NCBI
mRatBN7.279,381,366 - 9,389,589 (+)NCBI
Rnor_6.0712,247,498 - 12,255,721 (+)NCBI
Rnor_5.0712,417,102 - 12,425,518 (+)NCBI
RGSC_v3.4710,892,705 - 10,900,928 (+)RGD
Celera77,558,158 - 7,566,382 (+)RGD
Sequence:
RefSeq Acc Id: NP_598243   ⟸   NM_133559
- Peptide Label: precursor
- UniProtKB: A6K8M5 (UniProtKB/TrEMBL),   D3ZKU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022358   ⟸   ENSRNOT00000022358
Protein Domains
P/Homo B   Peptidase S8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q78EH2-F1-model_v2 AlphaFold Q78EH2 1-678 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695023
Promoter ID:EPDNEW_R5548
Type:multiple initiation site
Name:Pcsk4_1
Description:proprotein convertase subtilisin/kexin type 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,247,478 - 12,247,538EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620325 AgrOrtholog
BioCyc Gene G2FUF-34936 BioCyc
Ensembl Genes ENSRNOG00000016405 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022358.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456182 IMAGE-MGC_LOAD
InterPro Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kexin/furin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171085 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114269 IMAGE-MGC_LOAD
NCBI Gene 171085 ENTREZGENE
PANTHER PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcsk4 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016405 RatGTEx
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6K8M5 ENTREZGENE, UniProtKB/TrEMBL
  A6K8M6_RAT UniProtKB/TrEMBL
  A6K8M7_RAT UniProtKB/TrEMBL
  D3ZKU8 ENTREZGENE, UniProtKB/TrEMBL
  PCSK4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1A4C9 UniProtKB/Swiss-Prot
  Q07213 UniProtKB/Swiss-Prot
  Q07214 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pcsk4  proprotein convertase subtilisin/kexin type 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pcsk4  proprotein convertase subtilisin/kexin type 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in testis; expressed in pachytene spermatocytes and the round spermatids 633734