PCSK4 (proprotein convertase subtilisin/kexin type 4) - Rat Genome Database

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Gene: PCSK4 (proprotein convertase subtilisin/kexin type 4) Sus scrofa
Analyze
Symbol: PCSK4
Name: proprotein convertase subtilisin/kexin type 4
RGD ID: 13904475
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN fertilization (ortholog); sperm capacitation (ortholog); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); colorectal adenocarcinoma (ortholog); cyclic hematopoiesis (ortholog); FOUND IN acrosomal membrane (inferred); acrosomal vesicle (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,989,544 - 76,997,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,982,806 - 76,996,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,881,928 - 77,888,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK4Pigcolorectal adenocarcinoma susceptibilityISORGD:13451809068941DNA:SNP:3'utr: (rs1047854) C>T (human)RGDPMID:27354594|REF_RGD_ID:152177496
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK4Pigcerebral creatine deficiency syndrome  ISORGD:13451808554872ClinVar Annotator: match by term: Cerebral creatine deficiency syndromeClinVarPMID:15108290|PMID:28492532
PCSK4Pigcyclic hematopoiesis  ISORGD:13451808554872ClinVar Annotator: match by term: Cyclical neutropeniaClinVarPMID:28492532
PCSK4PigNeurodevelopmental Disorders  ISORGD:13451808554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
PCSK4Pigprogressive myoclonus epilepsy 9  ISORGD:13451808554872ClinVar Annotator: match by term: Progressive myoclonic epilepsy type 9ClinVarPMID:28492532


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK4Pigdeoxynivalenol decreases expressionEXP 6480464deoxynivalenol results in decreased expression of PCSK4 mRNACTDPMID:35307453


Biological Process
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK4Pigacrosome reaction acts_upstream_of_or_withinIEAUniProtKB:P29121|ensembl:ENSMUSP00000020340150520179 EnsemblGO_REF:0000107
PCSK4Pigbinding of sperm to zona pellucida acts_upstream_of_or_withinIEAUniProtKB:P29121|ensembl:ENSMUSP00000020340150520179 EnsemblGO_REF:0000107
PCSK4Pigfertilization acts_upstream_of_or_withinISOMGI:26655129068941 PMID:16371590MGIPMID:16371590
PCSK4Pigfertilization involved_inIEAUniProtKB:P29121|ensembl:ENSMUSP00000020340150520179 EnsemblGO_REF:0000107
PCSK4Pigpeptide hormone processing involved_inIBAMGI:97515|PANTHER:PTN000082901|RGD:3246|UniProtKB:P09958|UniProtKB:P29122|UniProtKB:Q92824|WB:WBGene00002232150520179 GO_CentralGO_REF:0000033
PCSK4Pigprotein processing involved_inIEAUniProtKB:Q6UW60|ensembl:ENSP00000300954150520179 EnsemblGO_REF:0000107
PCSK4Pigproteolysis involved_inIEAInterPro:IPR000209|InterPro:IPR002884|InterPro:IPR036852150520179 InterProGO_REF:0000002
PCSK4Pigproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PCSK4Pigsperm capacitation involved_inIEAUniProtKB:P29121|ensembl:ENSMUSP00000020340150520179 EnsemblGO_REF:0000107
PCSK4Pigsperm capacitation acts_upstream_of_or_withinISOMGI:26655129068941 PMID:16371590MGIPMID:16371590
1 to 10 of 10 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK4Pigacrosomal membrane located_inIEAUniProtKB:P29121|ensembl:ENSMUSP00000020340150520179 EnsemblGO_REF:0000107
PCSK4Pigacrosomal vesicle located_inIEAUniProtKB:P29121|ensembl:ENSMUSP00000020340150520179 EnsemblGO_REF:0000107
PCSK4PigGolgi membrane is_active_inIBAPANTHER:PTN000082856|UniProtKB:P09958|UniProtKB:Q16549150520179 GO_CentralGO_REF:0000033
PCSK4Pigmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
PCSK4Pigtrans-Golgi network is_active_inIBAMGI:97513|PANTHER:PTN000082856|RGD:3272|RGD:620326|SGD:S000005182|UniProtKB:P09958150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK4Pighydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
PCSK4Pigpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PCSK4Pigprotein binding enablesISOUniProtKB:P428589068941 PMID:32814053IntActPMID:32814053
PCSK4Pigprotein binding enablesISOUniProtKB:Q3V1409068941 PMID:11164898UniProtPMID:11164898
PCSK4Pigprotein binding enablesISOUniProtKB:Q12797-69068941 PMID:32296183IntActPMID:32296183
PCSK4Pigserine-type endopeptidase activity enablesIBACGD:CAL0000186377|FB:FBgn0004509|FB:FBgn0004598|MGI:97511|MGI:97512|MGI:97513|MGI:97515|PANTHER:PTN002451026|PomBase:SPAC22E12.09c|RGD:3273|RGD:3274|SGD:S000005182|UniProtKB:G5EB75|UniProtKB:O05461|UniProtKB:P09958|UniProtKB:P16519|UniProtKB:P29122|UniProtKB:Q92824|WB:WBGene00000088|WB:WBGene00001172|WB:WBGene00002232150520179 GO_CentralGO_REF:0000033
PCSK4Pigserine-type endopeptidase activity enablesIEAUniRule:UR001194527150520179 UniProtGO_REF:0000104
PCSK4Pigserine-type endopeptidase activity enablesIEAInterPro:IPR002884|InterPro:IPR036852150520179 InterProGO_REF:0000002
PCSK4Pigserine-type peptidase activity enablesIEAInterPro:IPR000209150520179 InterProGO_REF:0000002
PCSK4Pigserine-type peptidase activity enablesIEAUniProtKB-KW:KW-0720150520179 UniProtGO_REF:0000043
1 to 10 of 10 rows

PMID:22301074   PMID:30032202  



PCSK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,989,544 - 76,997,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,982,806 - 76,996,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,881,928 - 77,888,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,481,428 - 1,490,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,481,428 - 1,490,752 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,481,427 - 1,490,349 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,432,427 - 1,441,407 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,432,426 - 1,434,843NCBI
Celera191,415,419 - 1,424,399 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,255,223 - 1,264,091 (-)NCBIHuRef
CHM1_1191,481,431 - 1,490,411 (-)NCBICHM1_1
T2T-CHM13v2.0191,451,458 - 1,460,906 (-)NCBIT2T-CHM13v2.0
Pcsk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,157,117 - 80,165,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,157,117 - 80,165,332 (-)EnsemblGRCm39 Ensembl
GRCm381080,321,283 - 80,329,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,321,283 - 80,329,498 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,784,028 - 79,792,218 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,724,431 - 79,732,602 (-)NCBIMGSCv36mm8
Celera1081,336,155 - 81,344,348 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Pcsk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,032,040 - 10,040,263 (+)NCBIGRCr8
mRatBN7.279,381,366 - 9,389,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,381,361 - 9,389,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,258,291 - 12,266,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,133,633 - 14,141,734 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,000,988 - 12,009,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,247,498 - 12,255,721 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,247,498 - 12,255,719 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,417,102 - 12,425,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,892,705 - 10,900,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,892,704 - 10,900,926 (+)NCBI
Celera77,558,158 - 7,566,382 (+)NCBICelera
Cytogenetic Map7q11NCBI
Pcsk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,453,991 - 6,459,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,424,426 - 6,460,252 (+)NCBIChiLan1.0ChiLan1.0
PCSK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,827,433 - 5,859,561 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,063,109 - 5,090,410 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl191,452,924 - 1,466,438 (-)Ensemblpanpan1.1panPan2
PCSK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,370,035 - 57,376,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,369,328 - 57,375,590 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,162,069 - 57,168,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,101,329 - 58,107,483 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,101,344 - 58,107,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,157,552 - 57,163,690 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,637,009 - 57,643,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,839,018 - 57,845,172 (+)NCBIUU_Cfam_GSD_1.0
Pcsk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,035,019 - 217,041,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588794,227 - 799,663 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588793,615 - 800,038 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,253,729 - 1,264,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,254,276 - 1,263,847 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,588,319 - 7,598,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,208,995 - 7,216,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PCSK4
164 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
renal system
reproductive system
7 2 5 5 3 5 1 1



Ensembl Acc Id: ENSSSCT00000028148   ⟹   ENSSSCP00000027290
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl276,989,544 - 76,996,509 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000097634   ⟹   ENSSSCP00000080304
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl276,989,544 - 76,995,674 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000099474   ⟹   ENSSSCP00000081041
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl276,989,544 - 76,996,509 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000101171   ⟹   ENSSSCP00000081196
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl276,989,544 - 76,997,766 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000105857   ⟹   ENSSSCP00000077831
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl276,989,544 - 76,996,816 (+)Ensembl
RefSeq Acc Id: XM_005661391   ⟹   XP_005661448
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1276,989,645 - 76,996,507 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661393   ⟹   XP_005661450
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1276,989,645 - 76,995,933 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084236   ⟹   XP_020939895
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1276,982,806 - 76,996,507 (+)NCBI
Sequence:
1 to 12 of 12 rows
Protein RefSeqs XP_005661448 (Get FASTA)   NCBI Sequence Viewer  
  XP_005661450 (Get FASTA)   NCBI Sequence Viewer  
  XP_020939895 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000027290
  ENSSSCP00000027290.3
  ENSSSCP00000077831
  ENSSSCP00000077831.1
  ENSSSCP00000080304.1
  ENSSSCP00000081041.1
  ENSSSCP00000081196.1
  ENSSSCP00045045361.1
  ENSSSCP00055015637.1
1 to 12 of 12 rows
RefSeq Acc Id: XP_020939895   ⟸   XM_021084236
- Peptide Label: isoform X2
- UniProtKB: A0A8D1QD36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661448   ⟸   XM_005661391
- Peptide Label: isoform X1
- UniProtKB: I3LT46 (UniProtKB/TrEMBL),   A0A8D1QD36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661450   ⟸   XM_005661393
- Peptide Label: isoform X3
- UniProtKB: A0A8W4FLT7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000027290   ⟸   ENSSSCT00000028148
Ensembl Acc Id: ENSSSCP00000081196   ⟸   ENSSSCT00000101171
P/Homo B



1 to 40 of 53 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000024379 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00045037187 UniProtKB/TrEMBL
  ENSSSCG00055010079 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028148 ENTREZGENE
  ENSSSCT00000028148.4 UniProtKB/TrEMBL
  ENSSSCT00000097634.1 UniProtKB/TrEMBL
  ENSSSCT00000099474.1 UniProtKB/TrEMBL
  ENSSSCT00000101171.1 UniProtKB/TrEMBL
  ENSSSCT00000105857 ENTREZGENE
  ENSSSCT00000105857.1 UniProtKB/TrEMBL
  ENSSSCT00045064237.1 UniProtKB/TrEMBL
  ENSSSCT00055019816.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
KEGG Report ssc:100626523 UniProtKB/TrEMBL
NCBI Gene PCSK4 ENTREZGENE
PANTHER PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4 UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
1 to 40 of 53 rows