FURIN (furin, paired basic amino acid cleaving enzyme) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: FURIN (furin, paired basic amino acid cleaving enzyme) Homo sapiens
Analyze
Symbol: FURIN
Name: furin, paired basic amino acid cleaving enzyme
RGD ID: 1323167
HGNC Page HGNC
Description: Enables several functions, including nerve growth factor binding activity; serine-type endopeptidase activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including protein processing; regulation of protein metabolic process; and regulation of transforming growth factor beta1 production. Acts upstream of or within protein processing. Located in several cellular components, including Golgi apparatus; membrane raft; and trans-Golgi network transport vesicle. Biomarker of arteriosclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dibasic processing enzyme; dibasic-processing enzyme; FES upstream region; FUR; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; FURIN/ADAMTS1 fusion; PACE; paired basic amino acid residue-cleaving enzyme; PCSK3; proprotein convertase subtilisin/kexin 3; proprotein convertase subtilisin/kexin type 3; SPC1; subtilisin-like proprotein convertase 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,454 - 91,268,261 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1360148   PMID:1438214   PMID:1571548   PMID:1629222   PMID:1644824   PMID:1713771   PMID:1741956   PMID:2112085   PMID:2251280   PMID:2408021   PMID:2674906   PMID:3023061  
PMID:7508380   PMID:7639757   PMID:7690548   PMID:7721880   PMID:7737999   PMID:7774724   PMID:7781597   PMID:7782070   PMID:8020465   PMID:8163529   PMID:8174106   PMID:8189547  
PMID:8262946   PMID:8546712   PMID:8615794   PMID:8670066   PMID:8804434   PMID:8846780   PMID:8940009   PMID:8995623   PMID:9094426   PMID:9130696   PMID:9166946   PMID:9242664  
PMID:9412467   PMID:9442015   PMID:9521771   PMID:9599222   PMID:9642263   PMID:9653148   PMID:9695949   PMID:9827567   PMID:9927419   PMID:10037747   PMID:10050053   PMID:10225274  
PMID:10373500   PMID:10409610   PMID:10452538   PMID:10526337   PMID:10567353   PMID:10593987   PMID:10887202   PMID:10888676   PMID:10900462   PMID:11071887   PMID:11237874   PMID:11294867  
PMID:11323410   PMID:11331585   PMID:11380615   PMID:11416205   PMID:11422372   PMID:11571266   PMID:11723118   PMID:11799113   PMID:11804956   PMID:11861638   PMID:11861826   PMID:11921231  
PMID:12006600   PMID:12058031   PMID:12058067   PMID:12071862   PMID:12220680   PMID:12354117   PMID:12411321   PMID:12460941   PMID:12477932   PMID:12482870   PMID:12547702   PMID:12584323  
PMID:12586364   PMID:12644459   PMID:12670890   PMID:12736257   PMID:12787574   PMID:14596804   PMID:14644155   PMID:14739277   PMID:14741044   PMID:14744861   PMID:15078902   PMID:15082773  
PMID:15135058   PMID:15240540   PMID:15247425   PMID:15342556   PMID:15371436   PMID:15489334   PMID:15564468   PMID:15584904   PMID:15606899   PMID:15611046   PMID:15637056   PMID:15659365  
PMID:15899807   PMID:15911696   PMID:16407210   PMID:16537537   PMID:16600625   PMID:16627761   PMID:16648485   PMID:16912035   PMID:16942750   PMID:17010968   PMID:17283058   PMID:17301129  
PMID:17360815   PMID:17477394   PMID:17525470   PMID:17641413   PMID:17905608   PMID:17905609   PMID:17909005   PMID:17938254   PMID:17948127   PMID:18037384   PMID:18064302   PMID:18174282  
PMID:18245819   PMID:18323532   PMID:18343183   PMID:18353966   PMID:18467449   PMID:18544638   PMID:18546152   PMID:18665212   PMID:18826955   PMID:19056739   PMID:19152512   PMID:19193799  
PMID:19199708   PMID:19322201   PMID:19477160   PMID:19492430   PMID:19541935   PMID:19913121   PMID:19946888   PMID:19998449   PMID:20055586   PMID:20062797   PMID:20101215   PMID:20489134  
PMID:20605791   PMID:20608975   PMID:20628086   PMID:20634490   PMID:20635860   PMID:20707915   PMID:20811902   PMID:20945401   PMID:21147780   PMID:21152186   PMID:21296375   PMID:21406565  
PMID:21503879   PMID:21550985   PMID:21763278   PMID:21805236   PMID:21805237   PMID:21873635   PMID:21880759   PMID:21889147   PMID:21909115   PMID:21988832   PMID:22038627   PMID:22247010  
PMID:22479394   PMID:22577343   PMID:22679642   PMID:22808247   PMID:22995191   PMID:23065687   PMID:23135270   PMID:23302673   PMID:23390091   PMID:23558288   PMID:23568742   PMID:23598405  
PMID:23653353   PMID:23661674   PMID:23686857   PMID:23744066   PMID:23775089   PMID:23829672   PMID:23835774   PMID:23840860   PMID:23861967   PMID:23936445   PMID:24162774   PMID:24257604  
PMID:24359561   PMID:24436242   PMID:24454770   PMID:24666235   PMID:25026302   PMID:25056061   PMID:25175744   PMID:25355923   PMID:25540379   PMID:25543063   PMID:25552509   PMID:25813623  
PMID:25933376   PMID:26065233   PMID:26137475   PMID:26283728   PMID:26283733   PMID:26346780   PMID:26488448   PMID:26496610   PMID:26569287   PMID:27548722   PMID:27572312   PMID:27647913  
PMID:27760099   PMID:27798871   PMID:28013223   PMID:28259973   PMID:28369813   PMID:28484053   PMID:28514442   PMID:29265076   PMID:29314830   PMID:29465367   PMID:29499969   PMID:29680823  
PMID:29976768   PMID:30021884   PMID:30021905   PMID:30135209   PMID:30333479   PMID:30706700   PMID:31091448   PMID:31253944   PMID:31505793   PMID:31741433   PMID:31936902   PMID:32057769  
PMID:32060422   PMID:32067586   PMID:32139876   PMID:32155444   PMID:32274964   PMID:32275259   PMID:32295904   PMID:32329629   PMID:32344311   PMID:32362314   PMID:32376634   PMID:32512290  
PMID:32512386   PMID:32660959   PMID:32691890   PMID:32703818   PMID:32730764   PMID:32814053   PMID:32840921   PMID:32867305   PMID:32873908   PMID:32920451   PMID:33037310   PMID:33043282  
PMID:33243086   PMID:33413387   PMID:33417835   PMID:33476708   PMID:33493182   PMID:33845483   PMID:33910372   PMID:33961781   PMID:34155192   PMID:34289413   PMID:34356057   PMID:34709727  


Genomics

Comparative Map Data
FURIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,454 - 91,268,261 (+)NCBICHM1_1
Furin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,038,942 - 80,055,188 (-)NCBIGRCm39mm39
GRCm39 Ensembl780,038,333 - 80,055,184 (-)Ensembl
GRCm38780,389,194 - 80,405,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,388,585 - 80,405,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,534,080 - 87,550,317 (-)NCBIGRCm37mm9NCBIm37
MGSCv36780,262,709 - 80,276,275 (-)NCBImm8
Celera777,789,167 - 77,805,351 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Furin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,348,142 - 134,361,182 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)Ensembl
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
Furin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,936,546 - 14,949,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,915,031 - 14,947,634 (+)NCBIChiLan1.0ChiLan1.0
FURIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0panPan3
FURIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,357,491 - 53,368,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,358,045 - 53,365,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,995,115 - 56,006,746 (-)NCBI
ROS_Cfam_1.0353,773,528 - 53,785,153 (-)NCBI
ROS_Cfam_1.0 Ensembl353,773,530 - 53,785,145 (-)Ensembl
UMICH_Zoey_3.1353,292,643 - 53,304,269 (-)NCBI
UNSW_CanFamBas_1.0353,503,862 - 53,515,505 (-)NCBI
UU_Cfam_GSD_1.0353,844,352 - 53,855,974 (-)NCBI
Furin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,182,463 - 130,198,421 (+)NCBI
SpeTri2.0NW_00493648316,136,099 - 16,147,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FURIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FURIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1chlSab2
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl298,979,720 - 8,988,235 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605937,732,423 - 37,745,148 (+)NCBIVero_WHO_p1.0
Furin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,372,754 - 17,387,732 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
G54068  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371591,426,472 - 91,426,610UniSTSGRCh37
Build 361589,227,476 - 89,227,614RGDNCBI36
Celera1567,835,443 - 67,835,581RGD
Cytogenetic Map15q26.1UniSTS
HuRef1567,537,977 - 67,538,115UniSTS
RH1636  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371591,426,895 - 91,427,009UniSTSGRCh37
Build 361589,227,899 - 89,228,013RGDNCBI36
Celera1567,835,866 - 67,835,980RGD
Cytogenetic Map15q26.1UniSTS
HuRef1567,538,400 - 67,538,514UniSTS
GeneMap99-GB4 RH Map15329.08UniSTS
NCBI RH Map15701.7UniSTS
G06349  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371591,425,503 - 91,425,835UniSTSGRCh37
Build 361589,226,507 - 89,226,839RGDNCBI36
Celera1567,834,474 - 67,834,806RGD
Cytogenetic Map15q26.1UniSTS
HuRef1567,537,008 - 67,537,340UniSTS
FURIN_659  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371591,425,983 - 91,426,678UniSTSGRCh37
Build 361589,226,987 - 89,227,682RGDNCBI36
Celera1567,834,954 - 67,835,649RGD
HuRef1567,537,488 - 67,538,183UniSTS
FURIN  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371591,420,803 - 91,421,444UniSTSGRCh37
GRCh371591,418,972 - 91,419,128UniSTSGRCh37
Celera1567,829,774 - 67,830,415UniSTS
Celera1567,827,943 - 67,828,099UniSTS
HuRef1567,530,477 - 67,530,633UniSTS
HuRef1567,532,308 - 67,532,949UniSTS
FURIN  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371591,420,803 - 91,421,444UniSTSGRCh37
GRCh371591,418,972 - 91,419,128UniSTSGRCh37
Celera1567,829,774 - 67,830,415UniSTS
Celera1567,827,943 - 67,828,099UniSTS
HuRef1567,530,477 - 67,530,633UniSTS
HuRef1567,532,308 - 67,532,949UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR24-2hsa-miR-24-3pOncomiRDBexternal_infoNANA21402698
MIR24-1hsa-miR-24-3pOncomiRDBexternal_infoNANA21402698

Predicted Target Of
Summary Value
Count of predictions:2469
Count of miRNA genes:936
Interacting mature miRNAs:1164
Transcripts:ENST00000268171, ENST00000558794, ENST00000559353, ENST00000560018, ENST00000560824
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1 1 2 3
Medium 2428 2956 1721 621 1903 463 4348 2160 3255 417 1435 1604 170 1204 2781 4
Low 3 28 1 2 46 7 33 453 1 13 1 1 7 1 2
Below cutoff 1 1 1 2 1 4 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_168464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A06939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI051906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL555508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM043834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP282138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP283962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S65442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000268171   ⟹   ENSP00000268171
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,868,588 - 90,883,457 (+)Ensembl
RefSeq Acc Id: ENST00000558794   ⟹   ENSP00000453942
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,878,194 - 90,880,756 (+)Ensembl
RefSeq Acc Id: ENST00000559353   ⟹   ENSP00000452730
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,872,878 - 90,876,284 (+)Ensembl
RefSeq Acc Id: ENST00000560018
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,879,584 - 90,880,096 (+)Ensembl
RefSeq Acc Id: ENST00000560824   ⟹   ENSP00000453212
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,875,688 - 90,877,166 (+)Ensembl
RefSeq Acc Id: ENST00000610579   ⟹   ENSP00000484952
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,871,539 - 90,883,458 (+)Ensembl
RefSeq Acc Id: ENST00000618099   ⟹   ENSP00000483552
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,872,878 - 90,883,458 (+)Ensembl
RefSeq Acc Id: ENST00000640725   ⟹   ENSP00000491453
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,879,720 - 90,880,145 (+)Ensembl
RefSeq Acc Id: ENST00000680053   ⟹   ENSP00000506143
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,872,170 - 90,883,564 (+)Ensembl
RefSeq Acc Id: ENST00000680086
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,881,415 - 90,883,457 (+)Ensembl
RefSeq Acc Id: ENST00000680687   ⟹   ENSP00000505177
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,875,582 - 90,883,492 (+)Ensembl
RefSeq Acc Id: ENST00000681804   ⟹   ENSP00000505828
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,875,582 - 90,883,458 (+)Ensembl
RefSeq Acc Id: ENST00000681865   ⟹   ENSP00000505303
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1590,875,688 - 90,883,564 (+)Ensembl
RefSeq Acc Id: NM_001289823   ⟹   NP_001276752
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,871,540 - 90,883,457 (+)NCBI
CHM1_11591,256,344 - 91,268,262 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289824   ⟹   NP_001276753
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,872,854 - 90,883,457 (+)NCBI
CHM1_11591,257,683 - 91,268,262 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382619   ⟹   NP_001369548
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,871,052 - 90,883,457 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382620   ⟹   NP_001369549
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,872,168 - 90,883,457 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382621   ⟹   NP_001369550
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,872,854 - 90,883,457 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382622   ⟹   NP_001369551
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,868,588 - 90,883,457 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002569   ⟹   NP_002560
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,868,588 - 90,883,457 (+)NCBI
GRCh371591,411,885 - 91,426,687 (+)ENTREZGENE
Build 361589,212,889 - 89,227,691 (+)NCBI Archive
HuRef1567,523,022 - 67,538,192 (+)ENTREZGENE
CHM1_11591,253,391 - 91,268,262 (+)NCBI
Sequence:
RefSeq Acc Id: NR_168464
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,871,540 - 90,883,457 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002560   ⟸   NM_002569
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P09958 (UniProtKB/Swiss-Prot),   A0A024RC70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276752   ⟸   NM_001289823
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P09958 (UniProtKB/Swiss-Prot),   A0A024RC70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276753   ⟸   NM_001289824
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P09958 (UniProtKB/Swiss-Prot),   A0A024RC70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001369551   ⟸   NM_001382622
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: NP_001369548   ⟸   NM_001382619
- Peptide Label: isoform 1 preproprotein
RefSeq Acc Id: NP_001369549   ⟸   NM_001382620
- Peptide Label: isoform 1 preproprotein
RefSeq Acc Id: NP_001369550   ⟸   NM_001382621
- Peptide Label: isoform 1 preproprotein
RefSeq Acc Id: ENSP00000268171   ⟸   ENST00000268171
RefSeq Acc Id: ENSP00000453942   ⟸   ENST00000558794
RefSeq Acc Id: ENSP00000452730   ⟸   ENST00000559353
RefSeq Acc Id: ENSP00000484952   ⟸   ENST00000610579
RefSeq Acc Id: ENSP00000453212   ⟸   ENST00000560824
RefSeq Acc Id: ENSP00000491453   ⟸   ENST00000640725
RefSeq Acc Id: ENSP00000483552   ⟸   ENST00000618099
RefSeq Acc Id: ENSP00000505177   ⟸   ENST00000680687
RefSeq Acc Id: ENSP00000505828   ⟸   ENST00000681804
RefSeq Acc Id: ENSP00000506143   ⟸   ENST00000680053
RefSeq Acc Id: ENSP00000505303   ⟸   ENST00000681865
Protein Domains
P/Homo B   Peptidase S8   Peptidase_S8   S8_pro-domain

Promoters
RGD ID:6792353
Promoter ID:HG_KWN:22345
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562
Transcripts:OTTHUMT00000313492
Position:
Human AssemblyChrPosition (strand)Source
Build 361589,212,794 - 89,213,294 (+)MPROMDB
RGD ID:6810758
Promoter ID:HG_ACW:28087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:BEYPOY.AAPR07-UNSPLICED,   FURIN.BAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361589,214,991 - 89,215,857 (+)MPROMDB
RGD ID:6810754
Promoter ID:HG_ACW:28088
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:FURIN.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361589,216,331 - 89,217,242 (+)MPROMDB
RGD ID:7230543
Promoter ID:EPDNEW_H21017
Type:initiation region
Name:FURIN_1
Description:furin, paired basic amino acid cleaving enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21016  EPDNEW_H21018  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,868,592 - 90,868,652EPDNEW
RGD ID:7230545
Promoter ID:EPDNEW_H21018
Type:initiation region
Name:FURIN_3
Description:furin, paired basic amino acid cleaving enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21016  EPDNEW_H21017  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381590,872,766 - 90,872,826EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q26.1-26.3(chr15:89679237-101978958)x3 copy number gain See cases [RCV000052354] Chr15:89679237..101978958 [GRCh38]
Chr15:90222468..102519161 [GRCh37]
Chr15:88023472..100336684 [NCBI36]
Chr15:15q26.1-26.3
pathogenic
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3
pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3 copy number gain See cases [RCV000052347] Chr15:77543797..101843411 [GRCh38]
Chr15:77836139..102383614 [GRCh37]
Chr15:75623194..100201137 [NCBI36]
Chr15:15q24.3-26.3
pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:84169153-101904929)x3 copy number gain See cases [RCV000052352] Chr15:84169153..101904929 [GRCh38]
Chr15:84837905..102445132 [GRCh37]
Chr15:82628909..100262655 [NCBI36]
Chr15:15q25.2-26.3
pathogenic
NM_002569.3(FURIN):c.1489C>T (p.Arg497Cys) single nucleotide variant Malignant melanoma [RCV000070959] Chr15:90880206 [GRCh38]
Chr15:91423436 [GRCh37]
Chr15:89224440 [NCBI36]
Chr15:15q26.1
not provided
GRCh38/hg38 15q25.2-26.3(chr15:83711377-101843270)x3 copy number gain See cases [RCV000135858] Chr15:83711377..101843270 [GRCh38]
Chr15:84380129..102383473 [GRCh37]
Chr15:82171133..100200996 [NCBI36]
Chr15:15q25.2-26.3
pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:87904735-101843270)x3 copy number gain See cases [RCV000135568] Chr15:87904735..101843270 [GRCh38]
Chr15:88447966..102383473 [GRCh37]
Chr15:86248970..100200996 [NCBI36]
Chr15:15q25.3-26.3
pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:82859676-101810992)x3 copy number gain See cases [RCV000136849] Chr15:82859676..101810992 [GRCh38]
Chr15:83528428..102351195 [GRCh37]
Chr15:81325482..100168718 [NCBI36]
Chr15:15q25.2-26.3
pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85826665-101920998)x4 copy number gain See cases [RCV000137264] Chr15:85826665..101920998 [GRCh38]
Chr15:86369896..102461201 [GRCh37]
Chr15:84170900..100278724 [NCBI36]
Chr15:15q25.3-26.3
pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85397539-101888909)x3 copy number gain See cases [RCV000141899] Chr15:85397539..101888909 [GRCh38]
Chr15:85940770..102429112 [GRCh37]
Chr15:83741774..100246635 [NCBI36]
Chr15:15q25.3-26.3
pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3
pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3
pathogenic
GRCh38/hg38 15q26.1-26.3(chr15:88676575-98364743)x3 copy number gain See cases [RCV000142727] Chr15:88676575..98364743 [GRCh38]
Chr15:89219806..98907972 [GRCh37]
Chr15:87020810..96725495 [NCBI36]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q24.2-26.3(chr15:76061144-102429112)x3 copy number gain See cases [RCV000511332] Chr15:76061144..102429112 [GRCh37]
Chr15:15q24.2-26.3
pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3
pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3
likely pathogenic
GRCh37/hg19 15q25.2-26.3(chr15:85089467-102495441)x3 copy number gain See cases [RCV000449119] Chr15:85089467..102495441 [GRCh37]
Chr15:15q25.2-26.3
pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90346994-102354798) copy number loss See cases [RCV000447603] Chr15:90346994..102354798 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:89924847-102429112)x3 copy number gain See cases [RCV000445978] Chr15:89924847..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q25.1-26.3(chr15:80648093-102429112)x3 copy number gain See cases [RCV000445705] Chr15:80648093..102429112 [GRCh37]
Chr15:15q25.1-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86148286-102511616)x3 copy number gain See cases [RCV000448044] Chr15:86148286..102511616 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
GRCh37/hg19 15q25.3-26.1(chr15:88295992-94215607)x1 copy number loss See cases [RCV000448680] Chr15:88295992..94215607 [GRCh37]
Chr15:15q25.3-26.1
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86899001-98734014)x3 copy number gain See cases [RCV000511629] Chr15:86899001..98734014 [GRCh37]
Chr15:15q25.3-26.3
likely pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:89743929-102429112)x3 copy number gain not provided [RCV000683718] Chr15:89743929..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q26.1(chr15:91263414-91502563)x3 copy number gain not provided [RCV000683719] Chr15:91263414..91502563 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q23-26.3(chr15:71329220-102270758)x3 copy number gain not provided [RCV000683703] Chr15:71329220..102270758 [GRCh37]
Chr15:15q23-26.3
pathogenic
GRCh37/hg19 15q24.3-26.3(chr15:77479244-102429112)x3 copy number gain not provided [RCV000683710] Chr15:77479244..102429112 [GRCh37]
Chr15:15q24.3-26.3
pathogenic
GRCh37/hg19 15q26.1(chr15:91269147-91491760)x3 copy number gain not provided [RCV000683720] Chr15:91269147..91491760 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q25.3-26.3(chr15:88385150-102461162)x3 copy number gain not provided [RCV000738864] Chr15:88385150..102461162 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90277151-102376761)x3 copy number gain not provided [RCV000751387] Chr15:90277151..102376761 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q26.1(chr15:91414439-91436965)x1 copy number loss not provided [RCV000751391] Chr15:91414439..91436965 [GRCh37]
Chr15:15q26.1
benign
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q25.2-26.1(chr15:83883823-92165844) copy number loss not provided [RCV000767759] Chr15:83883823..92165844 [GRCh37]
Chr15:15q25.2-26.1
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90288175-102429112)x3 copy number gain not provided [RCV000846885] Chr15:90288175..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q26.1(chr15:91347599-91491931)x1 copy number loss not provided [RCV001006722] Chr15:91347599..91491931 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q26.1(chr15:91229877-93677014)x1 copy number loss not provided [RCV000847986] Chr15:91229877..93677014 [GRCh37]
Chr15:15q26.1
pathogenic
GRCh37/hg19 15q26.1(chr15:91276782-91550953)x1 copy number loss not provided [RCV000849368] Chr15:91276782..91550953 [GRCh37]
Chr15:15q26.1
uncertain significance
NC_000015.10:g.(?_90782812)_(90968837_?)dup duplication Bloom syndrome [RCV001033731] Chr15:91326042..91512067 [GRCh37]
Chr15:15q26.1
uncertain significance
NM_002569.4(FURIN):c.-159-2262C>A single nucleotide variant not provided [RCV001667891] Chr15:90873320 [GRCh38]
Chr15:91416550 [GRCh37]
Chr15:15q26.1
benign
GRCh37/hg19 15q25.3-26.3(chr15:87189245-102429112)x1 copy number loss not provided [RCV001006718] Chr15:87189245..102429112 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86962053-102531392)x1 copy number loss See cases [RCV001263026] Chr15:86962053..102531392 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
NC_000015.9:g.(?_91290623)_(91512067_?)dup duplication Bloom syndrome [RCV001327573] Chr15:91290623..91512067 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q25.3-26.2(chr15:88465861-94411846)x1 copy number loss not provided [RCV001795547] Chr15:88465861..94411846 [GRCh37]
Chr15:15q25.3-26.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8568 AgrOrtholog
COSMIC FURIN COSMIC
Ensembl Genes ENSG00000140564 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000268171 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000453942 UniProtKB/TrEMBL
  ENSP00000483552 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000484952 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000505177 UniProtKB/TrEMBL
  ENSP00000505303 UniProtKB/TrEMBL
  ENSP00000505828 UniProtKB/TrEMBL
  ENSP00000506143 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000268171 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000558794 UniProtKB/TrEMBL
  ENST00000610579 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000618099 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000680053 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000680687 UniProtKB/TrEMBL
  ENST00000681804 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000681865 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000140564 GTEx
HGNC ID HGNC:8568 ENTREZGENE
Human Proteome Map FURIN Human Proteome Map
InterPro Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kexin/furin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5045 ENTREZGENE
OMIM 136950 OMIM
Pfam P_proprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32894 PharmGKB
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RC70 ENTREZGENE, UniProtKB/TrEMBL
  A0A7P0T8P1_HUMAN UniProtKB/TrEMBL
  A0A7P0T8U2_HUMAN UniProtKB/TrEMBL
  A0A7P0T9X7_HUMAN UniProtKB/TrEMBL
  FURIN_HUMAN UniProtKB/Swiss-Prot
  H0YNB5_HUMAN UniProtKB/TrEMBL
  P09958 ENTREZGENE
UniProt Secondary Q14336 UniProtKB/Swiss-Prot
  Q6LBS3 UniProtKB/Swiss-Prot
  Q9UCZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 FURIN  furin, paired basic amino acid cleaving enzyme    furin (paired basic amino acid cleaving enzyme)  Symbol and/or name change 5135510 APPROVED
2011-08-16 FURIN  furin (paired basic amino acid cleaving enzyme)  FURIN  furin (paired basic amino acid cleaving enzyme)  Symbol and/or name change 5135510 APPROVED