PCSK5 (proprotein convertase subtilisin/kexin type 5) - Rat Genome Database

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Gene: PCSK5 (proprotein convertase subtilisin/kexin type 5) Homo sapiens
Analyze
Symbol: PCSK5
Name: proprotein convertase subtilisin/kexin type 5
RGD ID: 732125
HGNC Page HGNC:8747
Description: Enables serine-type endopeptidase activity. Involved in several processes, including embryonic digestive tract development; protein processing; and renin secretion into blood stream. Acts upstream of or within protein processing. Located in Golgi apparatus. Biomarker of colon adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; prohormone convertase 5; proprotein convertase 5; proprotein convertase 6; proprotein convertase PC5; protease PC6; SPC6; subtilase; subtilisin/kexin-like protease PC5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38975,889,809 - 76,362,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl975,890,644 - 76,362,975 (+)EnsemblGRCh38hg38GRCh38
GRCh37978,505,589 - 78,977,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36977,695,441 - 77,998,164 (+)NCBINCBI36Build 36hg18NCBI36
Build 34975,735,174 - 76,037,889NCBI
Celera949,083,010 - 49,551,972 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef948,336,126 - 48,806,234 (+)NCBIHuRef
CHM1_1978,651,993 - 79,121,401 (+)NCBICHM1_1
T2T-CHM13v2.0988,048,502 - 88,519,580 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
PCSK5HumanAnorectal Malformations  ISOPcsk5 (Mus musculus)11556204protein:decreased expression:somiteRGD 
PCSK5HumanCarotid Artery Injuries  ISOPcsk5 (Rattus norvegicus)11556213mRNA and protein:increased expression:artery:RGD 
PCSK5HumanCarotid Atherosclerosis  IEP 11556214protein:increased expression:myofibroblast:RGD 
PCSK5Humancolon adenocarcinoma  IEP 11556207mRNA:decreased expression:colon:RGD 
PCSK5HumanIntestinal Neoplasms  ISOPcsk5 (Mus musculus)11556207mRNA:decreased expression:intestine:RGD 
PCSK5Humansciatic neuropathy  ISOPcsk5 (Rattus norvegicus)11556234mRNA and protein:increased expression:nerve:RGD 
PCSK5HumanVACTERL association  ISOPcsk5 (Mus musculus)11556208DNA:mutation:exon:p.C470R(mouse)RGD 
Object Symbol
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Original Reference(s)
PCSK5Humanamenorrhea  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
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Original Reference(s)
PCSK5Humanbone development disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humancaudal regression syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5HumanCurrarino syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humanheart septal defect  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humanimperforate anus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5HumanJaw Abnormalities  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humankidney disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5HumanLower Extremity Deformities, Congenital  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humanlung disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5HumanMouth Abnormalities  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5HumanTracheoesophageal Fistula  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humanumbilical hernia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5HumanVACTERL association  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
PCSK5Humanventricular septal defect  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18519639
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PCSK5Humanprimary ciliary dyskinesia  ISSPcsk5 (Mus musculus)13592920 MouseDO 
PCSK5HumanVACTERL association  ISSPcsk5 (Mus musculus)13592920OMIM:192350 more ...MouseDO 
PCSK5Humanvisceral heterotaxy  ISSPcsk5 (Mus musculus)13592920OMIM:306955 more ...MouseDO 

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Original Reference(s)
PCSK5Human1,2-dichloroethane increases expressionISOPcsk5 (Mus musculus)6480464ethylene dichloride results in increased expression of PCSK5 mRNACTDPMID:28189721 and PMID:28960355
PCSK5Human1,2-dimethylhydrazine affects expressionISOPcsk5 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of PCSK5 mRNACTDPMID:22206623
PCSK5Human17beta-estradiol increases expressionISOPcsk5 (Mus musculus)6480464Estradiol results in increased expression of PCSK5 mRNACTDPMID:19484750
PCSK5Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with Progesterone] results in increased expression of PCSK5 mRNACTDPMID:20660070
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PCSK5 mRNACTDPMID:17101203 and PMID:21296121
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPcsk5 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of PCSK5 mRNACTDPMID:32109520
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PCSK5 mRNACTDPMID:19692669 more ...
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPcsk5 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PCSK5 mRNACTDPMID:26290441
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPcsk5 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PCSK5 mRNACTDPMID:25975270
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPcsk5 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of PCSK5 mRNACTDPMID:22298810 and PMID:34747641
PCSK5Human2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PCSK5 mRNACTDPMID:22298810
PCSK5Human2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOPcsk5 (Rattus norvegicus)64804642 more ...CTDPMID:32109520
PCSK5Human2,4-dinitrotoluene affects expressionISOPcsk5 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of PCSK5 mRNACTDPMID:21346803
PCSK5Human2-hydroxypropanoic acid decreases expressionEXP 6480464Lactic Acid results in decreased expression of PCSK5 mRNACTDPMID:30851411
PCSK5Human3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:19692669
PCSK5Human4,4'-sulfonyldiphenol increases expressionISOPcsk5 (Mus musculus)6480464bisphenol S results in increased expression of PCSK5 mRNACTDPMID:30951980
PCSK5Human4,4'-sulfonyldiphenol decreases methylationEXP 6480464bisphenol S results in decreased methylation of PCSK5 geneCTDPMID:31601247
PCSK5Human4,4'-sulfonyldiphenol decreases expressionISOPcsk5 (Mus musculus)6480464bisphenol S results in decreased expression of PCSK5 mRNACTDPMID:39298647
PCSK5Human4-hydroxyphenyl retinamide increases expressionISOPcsk5 (Mus musculus)6480464Fenretinide results in increased expression of PCSK5 mRNACTDPMID:28973697
PCSK5Human4-hydroxyphenyl retinamide decreases expressionISOPcsk5 (Mus musculus)6480464Fenretinide results in decreased expression of PCSK5 mRNACTDPMID:28973697

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Biological Process
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PCSK5Humananterior/posterior pattern specification involved_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humananterior/posterior pattern specification involved_inIMP 150520179 PMID:18519639BHF-UCLPMID:18519639
PCSK5Humancardiac septum development acts_upstream_of_or_withinIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humancell-cell signaling involved_inTAS 150520179 PMID:8901832PINCPMID:8901832
PCSK5Humancellular response to platelet-derived growth factor stimulus  ISOPcsk5 (Rattus norvegicus)9068941 RGDPMID:11882580 and REF_RGD_ID:11556216
PCSK5Humancoronary vasculature development acts_upstream_of_or_withinIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humancytokine precursor processing involved_inISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5Humancytokine precursor processing involved_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humandetermination of left/right symmetry acts_upstream_of_or_withinIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanembryo implantation involved_inISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5Humanembryo implantation involved_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanembryonic digestive tract development involved_inISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5Humanembryonic digestive tract development involved_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanembryonic digestive tract development involved_inIMP 150520179 PMID:18519639BHF-UCLPMID:18519639
PCSK5Humanembryonic skeletal system development involved_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanembryonic skeletal system development involved_inISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5Humanembryonic skeletal system development involved_inIMP 150520179 PMID:18519639BHF-UCLPMID:18519639
PCSK5Humanfemale pregnancy involved_inIEAUniProtKB-KW:KW-0635150520179 UniProtGO_REF:0000043
PCSK5Humanheart development involved_inISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5Humanheart development involved_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
PCSK5Humanendomembrane system located_inIEAUniProtKB-SubCell:SL-0147150520179 UniProtGO_REF:0000044
PCSK5Humanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-6784676
PCSK5Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
PCSK5Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
PCSK5Humanextracellular space located_inIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanextracellular space located_inISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5HumanGolgi apparatus located_inIDA 150520179 HPAGO_REF:0000052
PCSK5HumanGolgi apparatus located_inTAS 150520179 PMID:8947550BHF-UCLPMID:8947550
PCSK5HumanGolgi lumen located_inTAS 150520179 ReactomeReactome:R-HSA-187020
PCSK5HumanGolgi medial cisterna  ISOPcsk5 (Rattus norvegicus)9068941 RGDPMID:10906713 and REF_RGD_ID:11556238
PCSK5HumanGolgi membrane is_active_inIBAPANTHER:PTN000082856 more ...150520179 GO_CentralGO_REF:0000033
PCSK5Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
PCSK5Humanperikaryon  ISOPcsk5 (Rattus norvegicus)9068941 RGDPMID:10408612 and REF_RGD_ID:11556235
PCSK5Humanproximal dendrite  ISOPcsk5 (Rattus norvegicus)9068941 RGDPMID:10408612 and REF_RGD_ID:11556235
PCSK5Humantrans-Golgi network  ISOPcsk5 (Rattus norvegicus)9068941 RGDPMID:11882580 and REF_RGD_ID:11556216
PCSK5Humantrans-Golgi network is_active_inIBAMGI:97513 more ...150520179 GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
PCSK5Humanendopeptidase activity enablesEXP 150520179 PMID:16109723 and PMID:20581395ReactomePMID:16109723 and PMID:20581395
PCSK5Humanendopeptidase activity enablesIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
PCSK5Humanpeptidase activity enablesIDA 150520179 PMID:15606899MGIPMID:15606899
PCSK5Humanpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PCSK5Humanpeptide binding enablesIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanpeptide binding enablesISSUniProtKB:Q04592150520179 PMID:8940009BHF-UCLPMID:8940009
PCSK5Humanprotein binding enablesIPIUniProtKB:A8MQ03 more ...150520179 PMID:32296183IntActPMID:32296183
PCSK5Humanprotein binding enablesIPIUniProtKB:O75716 more ...150520179 PMID:25416956IntActPMID:25416956
PCSK5Humanserine-type endopeptidase activity enablesIEAUniProtKB:Q04592 and ensembl:ENSMUSP00000025618150520179 EnsemblGO_REF:0000107
PCSK5Humanserine-type endopeptidase activity enablesIBACGD:CAL0000186377 more ...150520179 GO_CentralGO_REF:0000033
PCSK5Humanserine-type endopeptidase activity enablesIEAUniRule:UR001194527150520179 UniProtGO_REF:0000104
PCSK5Humanserine-type endopeptidase activity enablesIDA 150520179 PMID:8901832BHF-UCLPMID:8901832
PCSK5Humanserine-type endopeptidase activity enablesIEAInterPro:IPR002884 and InterPro:IPR036852150520179 InterProGO_REF:0000002
PCSK5Humanserine-type peptidase activity enablesIEAUniProtKB-KW:KW-0720150520179 UniProtGO_REF:0000043
PCSK5Humanserine-type peptidase activity enablesIEAInterPro:IPR000209150520179 InterProGO_REF:0000002
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Original Reference(s)
PCSK5HumanPrimary amenorrhea  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106

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#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing. Marcinkiewicz M, etal., Brain Res Mol Brain Res. 1998 Aug 31;59(2):229-46.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling. Stawowy P, etal., Circulation. 2004 Feb 17;109(6):770-6.
6. Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo. Stawowy P, etal., Histochem Cell Biol. 2003 Mar;119(3):239-45. Epub 2003 Feb 20.
7. The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Sun X, etal., Mol Cancer. 2009 Sep 8;8:73. doi: 10.1186/1476-4598-8-73.
8. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Szumska D, etal., Genes Dev. 2008 Jun 1;22(11):1465-77. doi: 10.1101/gad.479408.
9. PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations. Tsuda T, etal., Eur J Pediatr Surg. 2011 Aug;21(4):238-41. doi: 10.1055/s-0031-1273691. Epub 2011 Apr 8.
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PMID:7782070   PMID:8125298   PMID:8615794   PMID:8620001   PMID:8670066   PMID:8755538   PMID:8755541   PMID:8889548   PMID:8901832   PMID:8940009   PMID:8947550   PMID:9067430  
PMID:9521771   PMID:10037747   PMID:10409610   PMID:10657249   PMID:10888676   PMID:10900462   PMID:11063880   PMID:11076863   PMID:11230166   PMID:11256614   PMID:11380615   PMID:11723118  
PMID:11776387   PMID:12477932   PMID:12787574   PMID:14702039   PMID:15146197   PMID:15489336   PMID:15522936   PMID:15601911   PMID:15606899   PMID:15911696   PMID:16109723   PMID:16189514  
PMID:16344560   PMID:16381901   PMID:16713569   PMID:16912035   PMID:17242158   PMID:18039650   PMID:18061232   PMID:18096669   PMID:18245819   PMID:18343183   PMID:19010793   PMID:19764806  
PMID:19884766   PMID:19913121   PMID:20031622   PMID:20379614   PMID:20555025   PMID:20581395   PMID:20628086   PMID:20881960   PMID:21078624   PMID:21094132   PMID:21116278   PMID:21273245  
PMID:21700711   PMID:21805236   PMID:21805237   PMID:21873635   PMID:21971156   PMID:22679642   PMID:22740495   PMID:22959728   PMID:23088713   PMID:23149075   PMID:23319000   PMID:23409034  
PMID:23563607   PMID:23686857   PMID:23775089   PMID:24252756   PMID:24667918   PMID:25350918   PMID:25416956   PMID:25429785   PMID:26055999   PMID:26077903   PMID:26186194   PMID:28468828  
PMID:28514442   PMID:29126984   PMID:29507755   PMID:30561431   PMID:32296183   PMID:33961781   PMID:34857952   PMID:35045102   PMID:35748872   PMID:36949045   PMID:38777146   PMID:38972101  



PCSK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38975,889,809 - 76,362,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl975,890,644 - 76,362,975 (+)EnsemblGRCh38hg38GRCh38
GRCh37978,505,589 - 78,977,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36977,695,441 - 77,998,164 (+)NCBINCBI36Build 36hg18NCBI36
Build 34975,735,174 - 76,037,889NCBI
Celera949,083,010 - 49,551,972 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef948,336,126 - 48,806,234 (+)NCBIHuRef
CHM1_1978,651,993 - 79,121,401 (+)NCBICHM1_1
T2T-CHM13v2.0988,048,502 - 88,519,580 (+)NCBIT2T-CHM13v2.0
Pcsk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391917,409,678 - 17,815,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1917,409,683 - 17,814,996 (-)EnsemblGRCm39 Ensembl
GRCm381917,432,314 - 17,837,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1917,432,319 - 17,837,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371917,507,322 - 17,912,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361917,499,851 - 17,993,244 (-)NCBIMGSCv36mm8
Celera1918,108,836 - 18,517,555 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1912.86NCBI
Pcsk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,263,823 - 224,694,350 (-)NCBIGRCr8
mRatBN7.21214,837,847 - 215,267,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,837,927 - 215,267,600 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,320,598 - 223,601,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01230,257,142 - 230,537,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,075,150 - 223,355,852 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,031,988 - 236,313,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,339,259 - 243,768,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,961,912 - 221,405,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,283,956 - 221,569,937 (-)NCBI
Celera1212,298,555 - 212,578,355 (-)NCBICelera
Cytogenetic Map1q43NCBI
Pcsk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555122,917,243 - 3,333,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555122,914,834 - 3,333,440 (-)NCBIChiLan1.0ChiLan1.0
PCSK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,063,314 - 75,524,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1975,069,756 - 75,532,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0948,480,607 - 48,943,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1974,745,187 - 75,224,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl974,745,761 - 75,220,502 (+)Ensemblpanpan1.1panPan2
PCSK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1182,088,090 - 82,506,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl182,090,664 - 82,555,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha182,554,152 - 83,012,101 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0182,504,812 - 82,963,105 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl182,506,866 - 82,963,633 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1182,293,218 - 82,750,127 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0182,009,456 - 82,467,391 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,737,312 - 83,195,037 (-)NCBIUU_Cfam_GSD_1.0
Pcsk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947129,415,166 - 129,706,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650311,466,950 - 11,896,887 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650311,466,955 - 11,896,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1228,854,595 - 229,308,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11228,854,587 - 229,308,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,618,184 - 255,748,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11286,907,173 - 87,367,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1287,042,557 - 87,367,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603875,357,152 - 75,822,509 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248113,453,218 - 3,862,970 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in PCSK5
143 total Variants

1 to 10 of 155 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q21.13-21.2(chr9:72224348-77332127)x1 copy number loss See cases [RCV000052906] Chr9:72224348..77332127 [GRCh38]
Chr9:74839264..79947043 [GRCh37]
Chr9:74029084..79136863 [NCBI36]
Chr9:9q21.13-21.2		 pathogenic
GRCh38/hg38 9q21.13-21.31(chr9:73706686-80370629)x1 copy number loss See cases [RCV000052907] Chr9:73706686..80370629 [GRCh38]
Chr9:76321602..82985544 [GRCh37]
Chr9:75511422..82175364 [NCBI36]
Chr9:9q21.13-21.31		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
NM_001190482.1(PCSK5):c.250G>A (p.Val84Ile) single nucleotide variant Malignant melanoma [RCV000068704] Chr9:75932436 [GRCh38]
Chr9:78547352 [GRCh37]
Chr9:77737172 [NCBI36]
Chr9:9q21.13		 not provided
NM_001190482.1(PCSK5):c.385C>T (p.Pro129Ser) single nucleotide variant Malignant melanoma [RCV000068705] Chr9:75986219 [GRCh38]
Chr9:78601135 [GRCh37]
Chr9:77790955 [NCBI36]
Chr9:9q21.13		 not provided
NM_001190482.1(PCSK5):c.2240G>A (p.Cys747Tyr) single nucleotide variant Malignant melanoma [RCV000068706] Chr9:76184715 [GRCh38]
Chr9:78799631 [GRCh37]
Chr9:77989451 [NCBI36]
Chr9:9q21.13		 not provided
NM_001190482.1(PCSK5):c.2383G>T (p.Ala795Ser) single nucleotide variant Lung cancer [RCV000108391] Chr9:76189096 [GRCh38]
Chr9:78804012 [GRCh37]
Chr9:9q21.13		 uncertain significance
1 to 10 of 155 rows

Predicted Target Of
Summary Value
Count of predictions:2517
Count of miRNA genes:1121
Interacting mature miRNAs:1381
Transcripts:ENST00000376752, ENST00000376767, ENST00000424854, ENST00000455778, ENST00000545128
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 86 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597608734GWAS1665594_HCachexia QTL GWAS1665594 (human)6e-17Cachexia97615870376158704Human
597031700GWAS1127774_Hattempted suicide QTL GWAS1127774 (human)0.000005attempted suicide97621652776216528Human
597617179GWAS1674039_Hsoft tissue disease QTL GWAS1674039 (human)1e-12soft tissue disease97605597676055977Human
597071763GWAS1167837_Hinflammatory bowel disease QTL GWAS1167837 (human)0.000007inflammatory bowel disease97630246276302463Human
596976669GWAS1096188_Hbody height QTL GWAS1096188 (human)3e-12body height97608687776086878Human
597312531GWAS1408605_HBMI-adjusted waist circumference QTL GWAS1408605 (human)4e-11body size trait (VT:0100005)97589077675890777Human
597097756GWAS1193830_Hdiverticular disease QTL GWAS1193830 (human)2e-08diverticular disease97612543776125438Human
596953503GWAS1073022_Hsize QTL GWAS1073022 (human)8e-33size97589697375896974Human
597165843GWAS1261917_Hopen-angle glaucoma QTL GWAS1261917 (human)4e-15open-angle glaucoma97590408375904084Human
597269527GWAS1365601_HBMI-adjusted hip circumference QTL GWAS1365601 (human)1e-08BMI-adjusted hip circumferencehip circumference (CMO:0000014)97589697375896974Human

1 to 10 of 86 rows
D9S276  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,506,403 - 78,506,586UniSTSGRCh37
GRCh37978,506,405 - 78,506,528UniSTSGRCh37
Build 36977,696,223 - 77,696,406RGDNCBI36
Celera949,083,853 - 49,084,032RGD
Celera949,083,855 - 49,083,974UniSTS
Cytogenetic Map9q21.3UniSTS
HuRef948,336,994 - 48,337,111UniSTS
HuRef948,336,992 - 48,337,169UniSTS
Marshfield Genetic Map967.93RGD
Genethon Genetic Map966.0UniSTS
TNG Radiation Hybrid Map926182.0UniSTS
Whitehead-YAC Contig Map9 UniSTS
D9S1807  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,882,777 - 78,882,969UniSTSGRCh37
Build 36978,072,597 - 78,072,789RGDNCBI36
Celera949,459,852 - 49,460,040RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,714,186 - 48,714,374UniSTS
Marshfield Genetic Map973.03RGD
Marshfield Genetic Map973.03UniSTS
Genethon Genetic Map971.6UniSTS
deCODE Assembly Map972.2UniSTS
Whitehead-YAC Contig Map9 UniSTS
WI-15571  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,810,643 - 78,810,768UniSTSGRCh37
Build 36978,000,463 - 78,000,588RGDNCBI36
Celera949,387,726 - 49,387,851RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,642,052 - 48,642,177UniSTS
GeneMap99-GB4 RH Map9259.79UniSTS
Whitehead-RH Map9301.6UniSTS
RH48203  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,809,887 - 78,810,050UniSTSGRCh37
Build 36977,999,707 - 77,999,870RGDNCBI36
Celera949,386,970 - 49,387,133RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,641,296 - 48,641,459UniSTS
GeneMap99-GB4 RH Map9261.94UniSTS
G35008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,513,265 - 78,513,533UniSTSGRCh37
Build 36977,703,085 - 77,703,353RGDNCBI36
Celera949,090,711 - 49,090,979RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,343,824 - 48,344,092UniSTS
RH122958  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,844,192 - 78,844,485UniSTSGRCh37
Build 36978,034,012 - 78,034,305RGDNCBI36
Celera949,421,270 - 49,421,563RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,675,603 - 48,675,896UniSTS
TNG Radiation Hybrid Map926332.0UniSTS
RH123466  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,701,388 - 78,701,714UniSTSGRCh37
Build 36977,891,208 - 77,891,534RGDNCBI36
Celera949,278,773 - 49,279,099RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,532,410 - 48,532,736UniSTS
TNG Radiation Hybrid Map926270.0UniSTS
SHGC-142784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,965,520 - 78,965,837UniSTSGRCh37
Build 36978,155,340 - 78,155,657RGDNCBI36
Celera949,540,213 - 49,540,530RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,794,484 - 48,794,801UniSTS
TNG Radiation Hybrid Map926399.0UniSTS
SHGC-146362  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,575,922 - 78,576,259UniSTSGRCh37
Build 36977,765,742 - 77,766,079RGDNCBI36
Celera949,153,365 - 49,153,702RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,406,572 - 48,406,909UniSTS
TNG Radiation Hybrid Map926225.0UniSTS
SHGC-146910  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,770,026 - 78,770,298UniSTSGRCh37
Build 36977,959,846 - 77,960,118RGDNCBI36
Celera949,347,086 - 49,347,358RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,601,546 - 48,601,818UniSTS
TNG Radiation Hybrid Map926292.0UniSTS
SHGC-148548  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,936,418 - 78,936,764UniSTSGRCh37
Build 36978,126,238 - 78,126,584RGDNCBI36
Celera949,511,098 - 49,511,444RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,765,374 - 48,765,720UniSTS
TNG Radiation Hybrid Map926370.0UniSTS
SHGC-148973  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,936,351 - 78,936,698UniSTSGRCh37
Build 36978,126,171 - 78,126,518RGDNCBI36
Celera949,511,031 - 49,511,378RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,765,307 - 48,765,654UniSTS
TNG Radiation Hybrid Map926374.0UniSTS
G34998  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,513,213 - 78,513,499UniSTSGRCh37
Build 36977,703,033 - 77,703,319RGDNCBI36
Celera949,090,659 - 49,090,945RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,343,772 - 48,344,058UniSTS
SHGC-37380  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,808,171 - 78,808,295UniSTSGRCh37
Build 36977,997,991 - 77,998,115RGDNCBI36
Celera949,385,250 - 49,385,374RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,639,576 - 48,639,700UniSTS
TNG Radiation Hybrid Map926300.0UniSTS
Stanford-G3 RH Map92307.0UniSTS
NCBI RH Map9705.7UniSTS
GeneMap99-G3 RH Map92262.0UniSTS
SHGC-155149  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,869,300 - 78,869,640UniSTSGRCh37
Build 36978,059,120 - 78,059,460RGDNCBI36
Celera949,446,378 - 49,446,718RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,700,704 - 48,701,044UniSTS
TNG Radiation Hybrid Map926344.0UniSTS
SHGC-32247  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,708,032 - 78,708,180UniSTSGRCh37
Build 36977,897,852 - 77,898,000RGDNCBI36
Celera949,285,418 - 49,285,566RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,539,054 - 48,539,202UniSTS
Stanford-G3 RH Map92303.0UniSTS
Whitehead-RH Map9302.6UniSTS
NCBI RH Map9706.0UniSTS
GeneMap99-G3 RH Map92258.0UniSTS
D9S1974  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,825,376 - 78,825,485UniSTSGRCh37
Build 36978,015,196 - 78,015,305RGDNCBI36
Celera949,402,459 - 49,402,568RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,656,785 - 48,656,894UniSTS
Whitehead-RH Map9302.8UniSTS
Whitehead-YAC Contig Map9 UniSTS
NCBI RH Map9690.6UniSTS
D9S1997  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37978,525,206 - 78,525,341UniSTSGRCh37
Build 36977,715,026 - 77,715,161RGDNCBI36
Celera949,102,651 - 49,102,786RGD
Cytogenetic Map9q21.3UniSTS
HuRef948,355,729 - 48,355,864UniSTS
Whitehead-YAC Contig Map9 UniSTS
L17877  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic MapYp11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map1q23.1UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map6p22UniSTS
Cytogenetic Map6q14.1UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map5q31.3UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic MapXq21.1UniSTS
Cytogenetic Map15q22UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map18q21.31UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map20pter-q12UniSTS
Cytogenetic Map12q13.11-q14.3UniSTS
Cytogenetic Map9q21.3UniSTS
Cytogenetic Map20q11.22-q11.23UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map11q12.2UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map8q13.2UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map19qUniSTS
Cytogenetic Map4p16UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map16p13.11UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map18q12.2UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map17q25.3UniSTS
D9S276  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q21.3UniSTS
Marshfield Genetic Map967.93UniSTS
Genethon Genetic Map966.0UniSTS
Whitehead-YAC Contig Map9 UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2434 2788 2233 4947 1721 2304 6 622 1478 463 2248 6843 6015 41 3726 1 846 1733 1573 175 1


1 to 30 of 46 rows
RefSeq Transcripts NG_029445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_120409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017014800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054363075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054363076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054363077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054363078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054363079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_929806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_929807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI379031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL589653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX805769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 46 rows

Ensembl Acc Id: ENST00000376752   ⟹   ENSP00000365943
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl975,890,673 - 76,195,889 (+)Ensembl
Ensembl Acc Id: ENST00000376767   ⟹   ENSP00000365958
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl975,890,670 - 76,175,562 (+)Ensembl
Ensembl Acc Id: ENST00000424854   ⟹   ENSP00000411654
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl976,095,977 - 76,358,970 (+)Ensembl
Ensembl Acc Id: ENST00000455778   ⟹   ENSP00000407239
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl976,188,639 - 76,194,960 (+)Ensembl
Ensembl Acc Id: ENST00000545128   ⟹   ENSP00000446280
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl975,890,644 - 76,362,339 (+)Ensembl
Ensembl Acc Id: ENST00000673745   ⟹   ENSP00000501224
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl976,296,748 - 76,321,577 (+)Ensembl
Ensembl Acc Id: ENST00000674117   ⟹   ENSP00000500971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl975,890,673 - 76,362,975 (+)Ensembl
RefSeq Acc Id: NM_001190482   ⟹   NP_001177411
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,362,975 (+)NCBI
GRCh37978,505,560 - 78,977,255 (+)ENTREZGENE
HuRef948,336,126 - 48,806,234 (+)ENTREZGENE
CHM1_1978,651,993 - 79,121,401 (+)NCBI
T2T-CHM13v2.0988,049,366 - 88,519,580 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001372043   ⟹   NP_001358972
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,362,975 (+)NCBI
T2T-CHM13v2.0988,049,366 - 88,519,580 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006200   ⟹   NP_006191
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,195,889 (+)NCBI
GRCh37978,505,560 - 78,977,255 (+)ENTREZGENE
Build 36977,695,441 - 77,998,164 (+)NCBI Archive
HuRef948,336,126 - 48,806,234 (+)ENTREZGENE
CHM1_1978,651,993 - 78,957,360 (+)NCBI
T2T-CHM13v2.0988,049,366 - 88,354,504 (+)NCBI
Sequence:
RefSeq Acc Id: NR_120409
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,195,889 (+)NCBI
CHM1_1978,651,993 - 78,957,360 (+)NCBI
T2T-CHM13v2.0988,049,366 - 88,354,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011518769   ⟹   XP_011517071
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,362,975 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011518770   ⟹   XP_011517072
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38976,134,219 - 76,362,975 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047423454   ⟹   XP_047279410
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,889,809 - 76,362,975 (+)NCBI
RefSeq Acc Id: XM_047423455   ⟹   XP_047279411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,199,470 (+)NCBI
RefSeq Acc Id: XM_047423456   ⟹   XP_047279412
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 76,189,746 (+)NCBI
RefSeq Acc Id: XM_054363075   ⟹   XP_054219050
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0988,049,366 - 88,519,580 (+)NCBI
RefSeq Acc Id: XM_054363076   ⟹   XP_054219051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0988,048,502 - 88,519,580 (+)NCBI
RefSeq Acc Id: XM_054363077   ⟹   XP_054219052
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0988,292,862 - 88,519,580 (+)NCBI
RefSeq Acc Id: XM_054363078   ⟹   XP_054219053
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0988,049,366 - 88,358,259 (+)NCBI
RefSeq Acc Id: XM_054363079   ⟹   XP_054219054
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0988,049,366 - 88,348,360 (+)NCBI
1 to 30 of 31 rows
Protein RefSeqs NP_001177411 (Get FASTA)   NCBI Sequence Viewer  
  NP_001358972 (Get FASTA)   NCBI Sequence Viewer  
  NP_006191 (Get FASTA)   NCBI Sequence Viewer  
  XP_011517071 (Get FASTA)   NCBI Sequence Viewer  
  XP_011517072 (Get FASTA)   NCBI Sequence Viewer  
  XP_047279410 (Get FASTA)   NCBI Sequence Viewer  
  XP_047279411 (Get FASTA)   NCBI Sequence Viewer  
  XP_047279412 (Get FASTA)   NCBI Sequence Viewer  
  XP_054219050 (Get FASTA)   NCBI Sequence Viewer  
  XP_054219051 (Get FASTA)   NCBI Sequence Viewer  
  XP_054219052 (Get FASTA)   NCBI Sequence Viewer  
  XP_054219053 (Get FASTA)   NCBI Sequence Viewer  
  XP_054219054 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA91807 (Get FASTA)   NCBI Sequence Viewer  
  AAC50643 (Get FASTA)   NCBI Sequence Viewer  
  AAH12064 (Get FASTA)   NCBI Sequence Viewer  
  AFI24907 (Get FASTA)   NCBI Sequence Viewer  
  BAG51646 (Get FASTA)   NCBI Sequence Viewer  
  CAD39178 (Get FASTA)   NCBI Sequence Viewer  
  CAE75579 (Get FASTA)   NCBI Sequence Viewer  
  CAE75580 (Get FASTA)   NCBI Sequence Viewer  
  EAW62575 (Get FASTA)   NCBI Sequence Viewer  
  EAW62576 (Get FASTA)   NCBI Sequence Viewer  
  EAW62577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000365943
  ENSP00000365943.4
  ENSP00000411654
  ENSP00000446280
  ENSP00000446280.1
  ENSP00000500971
1 to 30 of 31 rows
1 to 5 of 20 rows
1 to 5 of 20 rows
RefSeq Acc Id: NP_001177411   ⟸   NM_001190482
- Peptide Label: isoform PC6B preproprotein
- UniProtKB: Q13527 (UniProtKB/Swiss-Prot),   F5H2G7 (UniProtKB/Swiss-Prot),   Q96EP4 (UniProtKB/Swiss-Prot),   Q92824 (UniProtKB/Swiss-Prot),   Q5JSG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_006191   ⟸   NM_006200
- Peptide Label: isoform PC6A preproprotein
- UniProtKB: Q92824 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011517071   ⟸   XM_011518769
- Peptide Label: isoform X1
- UniProtKB: Q5JSG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011517072   ⟸   XM_011518770
- Peptide Label: isoform X3
- UniProtKB: Q5JSG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001358972   ⟸   NM_001372043
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A669KA35 (UniProtKB/TrEMBL),   Q5JSG7 (UniProtKB/TrEMBL)
P/Homo B   Peptidase S8   PLAC

Name Modeler Protein Id AA Range Protein Structure
AF-Q92824-F1-model_v2 AlphaFold Q92824 1-1860 view protein structure

RGD ID:7215277
Promoter ID:EPDNEW_H13385
Type:initiation region
Name:PCSK5_1
Description:proprotein convertase subtilisin/kexin type 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38975,890,673 - 75,890,733EPDNEW
RGD ID:6807977
Promoter ID:HG_KWN:63704
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:ENST00000376754,   ENST00000376767,   ENST00000396108,   OTTHUMT00000052716,   UC004AKA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36977,695,124 - 77,695,624 (+)MPROMDB


1 to 40 of 66 rows
Database
Acc Id
Source(s)
COSMIC PCSK5 COSMIC
Ensembl Genes ENSG00000099139 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000376752 ENTREZGENE
  ENST00000376752.9 UniProtKB/Swiss-Prot
  ENST00000424854 ENTREZGENE
  ENST00000545128 ENTREZGENE
  ENST00000545128.5 UniProtKB/Swiss-Prot
  ENST00000674117 ENTREZGENE
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/Swiss-Prot
GTEx ENSG00000099139 GTEx
HGNC ID HGNC:8747 ENTREZGENE
Human Proteome Map PCSK5 Human Proteome Map
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  Furin_repeat UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  GF_recep_IV UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Kexin/furin UniProtKB/Swiss-Prot
  P_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
  S8_pro-domain_sf UniProtKB/Swiss-Prot
KEGG Report hsa:5125 UniProtKB/Swiss-Prot
NCBI Gene 5125 ENTREZGENE
OMIM 600488 OMIM
PANTHER FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 UniProtKB/Swiss-Prot
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot
Pfam GF_recep_IV UniProtKB/Swiss-Prot
  P_proprotein UniProtKB/Swiss-Prot
  Peptidase_S8 UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
PharmGKB PA33093 PharmGKB
1 to 40 of 66 rows