PCSK5 (proprotein convertase subtilisin/kexin type 5) - Rat Genome Database

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Gene: PCSK5 (proprotein convertase subtilisin/kexin type 5) Pan paniscus
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Symbol: PCSK5
Name: proprotein convertase subtilisin/kexin type 5
RGD ID: 11685502
Description: ENCODES a protein that exhibits endopeptidase activity (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN cardiac septum development (ortholog); cellular response to platelet-derived growth factor stimulus (ortholog); coronary vasculature development (ortholog); ASSOCIATED WITH amenorrhea (ortholog); Anorectal Malformations (ortholog); bone development disease (ortholog); FOUND IN Golgi medial cisterna (ortholog); perikaryon (ortholog); proximal dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100991196; proprotein convertase subtilisin/kexin type 5-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,063,314 - 75,524,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1975,069,756 - 75,532,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0948,480,607 - 48,943,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1974,745,187 - 75,224,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl974,745,761 - 75,220,502 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PCSK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,063,314 - 75,524,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1975,069,756 - 75,532,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0948,480,607 - 48,943,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1974,745,187 - 75,224,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl974,745,761 - 75,220,502 (+)Ensemblpanpan1.1panPan2
PCSK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38975,889,809 - 76,362,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl975,890,644 - 76,362,975 (+)EnsemblGRCh38hg38GRCh38
GRCh37978,505,589 - 78,977,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36977,695,441 - 77,998,164 (+)NCBINCBI36Build 36hg18NCBI36
Build 34975,735,174 - 76,037,889NCBI
Celera949,083,010 - 49,551,972 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef948,336,126 - 48,806,234 (+)NCBIHuRef
CHM1_1978,651,993 - 79,121,401 (+)NCBICHM1_1
T2T-CHM13v2.0988,048,502 - 88,519,580 (+)NCBIT2T-CHM13v2.0
Pcsk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391917,409,678 - 17,815,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1917,409,683 - 17,814,996 (-)EnsemblGRCm39 Ensembl
GRCm381917,432,314 - 17,837,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1917,432,319 - 17,837,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371917,507,322 - 17,912,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361917,499,851 - 17,993,244 (-)NCBIMGSCv36mm8
Celera1918,108,836 - 18,517,555 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1912.86NCBI
Pcsk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,263,823 - 224,694,350 (-)NCBIGRCr8
mRatBN7.21214,837,847 - 215,267,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,837,927 - 215,267,600 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,320,598 - 223,601,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01230,257,142 - 230,537,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,075,150 - 223,355,852 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,031,988 - 236,313,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,339,259 - 243,768,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,961,912 - 221,405,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,283,956 - 221,569,937 (-)NCBI
Celera1212,298,555 - 212,578,355 (-)NCBICelera
Cytogenetic Map1q43NCBI
Pcsk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555122,917,243 - 3,333,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555122,914,834 - 3,333,440 (-)NCBIChiLan1.0ChiLan1.0
PCSK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1182,088,090 - 82,506,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl182,090,664 - 82,555,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha182,554,152 - 83,012,101 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0182,504,812 - 82,963,105 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl182,506,866 - 82,963,633 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1182,293,218 - 82,750,127 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0182,009,456 - 82,467,391 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,737,312 - 83,195,037 (-)NCBIUU_Cfam_GSD_1.0
Pcsk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947129,415,166 - 129,706,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650311,466,950 - 11,896,887 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650311,466,955 - 11,896,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1228,854,595 - 229,308,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11228,854,587 - 229,308,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,618,184 - 255,748,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11286,907,173 - 87,367,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1287,042,557 - 87,367,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603875,357,152 - 75,822,509 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248113,453,218 - 3,862,970 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000030933   ⟹   ENSPPAP00000008297
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl974,745,761 - 75,220,502 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000030935   ⟹   ENSPPAP00000008299
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl974,745,761 - 75,058,544 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000030936   ⟹   ENSPPAP00000008300
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl974,745,761 - 75,040,852 (+)Ensembl
RefSeq Acc Id: XM_024930148   ⟹   XP_024785916
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21175,063,314 - 75,365,524 (+)NCBI
NHGRI_mPanPan1975,069,756 - 75,371,464 (+)NCBI
Mhudiblu_PPA_v0948,641,162 - 48,943,331 (-)NCBI
PanPan1.1974,745,187 - 75,061,075 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034967553   ⟹   XP_034823444
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21175,063,314 - 75,524,928 (+)NCBI
NHGRI_mPanPan1975,069,756 - 75,532,735 (+)NCBI
Mhudiblu_PPA_v0948,480,607 - 48,942,865 (-)NCBI
Protein Sequences
Protein RefSeqs XP_024785916 (Get FASTA)   NCBI Sequence Viewer  
  XP_034823444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000008297.1
  ENSPPAP00000008299
  ENSPPAP00000008299.1
  ENSPPAP00000008300.1
RefSeq Acc Id: XP_024785916   ⟸   XM_024930148
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZTK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034823444   ⟸   XM_034967553
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZWZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000008300   ⟸   ENSPPAT00000030936
RefSeq Acc Id: ENSPPAP00000008299   ⟸   ENSPPAT00000030935
RefSeq Acc Id: ENSPPAP00000008297   ⟸   ENSPPAT00000030933
Protein Domains
P/Homo B   PLAC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027360 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000030933.1 UniProtKB/TrEMBL
  ENSPPAT00000030935.1 UniProtKB/TrEMBL
  ENSPPAT00000030936.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
NCBI Gene PCSK5 ENTREZGENE
PANTHER FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2 UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 5 UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/TrEMBL
Pfam GF_recep_IV UniProtKB/TrEMBL
  P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  SM00261 UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R8ZTK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZTK3_PANPA UniProtKB/TrEMBL
  A0A2R8ZWZ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-08 PCSK5  proprotein convertase subtilisin/kexin type 5  LOC100991196  proprotein convertase subtilisin/kexin type 5-like  Data merged from RGD:11743769 737654 PROVISIONAL