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Gene: Socs3 (suppressor of cytokine signaling 3) Mus musculus
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Symbol: Socs3
Name: suppressor of cytokine signaling 3
Description: Exhibits phosphotyrosine residue binding activity. Involved in several processes, including cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; and placenta development. Predicted to localize to cytoplasm and phosphatidylinositol 3-kinase complex. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (S)-naringenin; 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CIS-3; Cis3; Cish3; cytokine inducible SH2-containing protein 3; E2a-Pbx1 target gene in fibroblasts 10; EF-10; Ef10; SSI-3; Ssi3; STAT-induced STAT inhibitor 3
Orthologs:
Homo sapiens (human) : SOCS3 (suppressor of cytokine signaling 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Socs3 (suppressor of cytokine signaling 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs3 (suppressor of cytokine signaling 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS3 (suppressor of cytokine signaling 3)
Canis lupus familiaris (dog) : SOCS3 (suppressor of cytokine signaling 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs3 (suppressor of cytokine signaling 3)
Sus scrofa (pig) : SOCS3 (suppressor of cytokine signaling 3)
Chlorocebus sabaeus (African green monkey) : SOCS3 (suppressor of cytokine signaling 3)
Heterocephalus glaber (naked mole-rat) : Socs3 (suppressor of cytokine signaling 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBImm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Socs3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730834
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.