Socs3 (suppressor of cytokine signaling 3) - Rat Genome Database

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Gene: Socs3 (suppressor of cytokine signaling 3) Mus musculus
Analyze
Symbol: Socs3
Name: suppressor of cytokine signaling 3
RGD ID: 730834
MGI Page MGI
Description: Enables miRNA binding activity and phosphotyrosine residue binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including branching involved in labyrinthine layer morphogenesis; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasmic side of plasma membrane. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CI; Cis; CIS-3; Cis3; Cish3; cytokine inducible SH2-containing protein 3; E2a-Pbx1 target gene in fibroblasts 10; EF-10; Ef10; SOC; SS; SSI-3; Ssi3; STAT-induced STAT inhibitor 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,856,905 - 117,860,873 (-)EnsemblGRCm39 Ensembl
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBIMGSCv36mm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
8-Br-cAMP  (ISO)
AACOCF3  (EXP)
acetic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atropine  (EXP)
avobenzone  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (EXP)
belinostat  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
berberine  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP)
chloroethene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cycloheximide  (EXP)
cyproconazole  (EXP)
D-glucose  (EXP)
DDE  (ISO)
delta-tocotrienol  (EXP)
deoxynivalenol  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diethyl maleate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimercaprol  (EXP)
dioxygen  (EXP,ISO)
diquat  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
estriol  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fipronil  (ISO)
flavone  (EXP,ISO)
fluoranthene  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
galanthamine  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glucose  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (EXP)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
KT 5720  (ISO)
L-methionine  (EXP,ISO)
Licochalcone B  (ISO)
linagliptin  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
melittin  (EXP)
mesalamine  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrobenzenes  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
PF-3758309  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
potassium cyanide  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
pyrimethamine  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rofecoxib  (ISO)
rolipram  (ISO)
rotenone  (EXP)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salinomycin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selumetinib  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (EXP,ISO)
stattic  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
terbufos  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
topotecan  (ISO)
trans-isoeugenol  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal food intake  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal placenta development  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
absent spongiotrophoblast  (IAGP)
decreased body fat mass  (IAGP)
decreased body weight  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased embryo size  (IAGP)
decreased spongiotrophoblast cell number  (IAGP)
decreased spongiotrophoblast size  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased total body fat amount  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
improved glucose tolerance  (IAGP)
increased erythrocyte cell number  (IAGP)
increased inflammatory response  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased neutrophil cell number  (IAGP)
increased nucleated erythrocyte cell number  (IAGP)
increased response to leptin  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased trophoblast giant cell number  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IAGP)
peritoneal inflammation  (IAGP)
prenatal lethality  (IAGP)
reddish skin  (IAGP)
small liver  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells. Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
2. Twenty proteins containing a C-terminal SOCS box form five structural classes. Hilton DJ, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):114-9.
3. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
4. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
5. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
6. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
7. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
8. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
9. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. Ma C, etal., Pharm Biol. 2017 Dec;55(1):2170-2177. doi: 10.1080/13880209.2017.1396350.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Mori H, etal., Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.
14. Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis. Nakagawa T, etal., Oncol Rep. 2008 Jan;19(1):33-9.
15. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
16. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. O'Connor JC, etal., J Immunol. 2007 Jun 1;178(11):6886-93.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
21. Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. Raghavendra Rao VL, etal., J Neurochem 2002 Dec;83(5):1072-86.
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Rieusset J, etal., Diabetes. 2004 Sep;53(9):2232-41.
25. Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines. Rosell DR, etal., Neuroscience. 2003;122(2):349-58.
26. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Seron K, etal., Biochem Biophys Res Commun. 2006 Oct 6;348(4):1232-8. Epub 2006 Jul 24.
27. Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
28. The dual function of hepatic SOCS3 in insulin resistance in vivo. Torisu T, etal., Genes Cells. 2007 Feb;12(2):143-54.
29. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
30. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
31. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. Wang Y, etal., PLoS One. 2015 Oct 20;10(10):e0141165. doi: 10.1371/journal.pone.0141165. eCollection 2015.
32. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
33. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
34. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
35. Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
Additional References at PubMed
PMID:9032278   PMID:9202125   PMID:9266833   PMID:9344848   PMID:9844915   PMID:9869640   PMID:9889194   PMID:10349636   PMID:10359822   PMID:10374907   PMID:10490101   PMID:10534114  
PMID:10867663   PMID:10882725   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11481489   PMID:11870615   PMID:11907070   PMID:11934677   PMID:12023971   PMID:12055259  
PMID:12089360   PMID:12228220   PMID:12242343   PMID:12396724   PMID:12403768   PMID:12438448   PMID:12459551   PMID:12477932   PMID:12519742   PMID:12554639   PMID:12560330   PMID:12591901  
PMID:12754505   PMID:12754506   PMID:12754507   PMID:12783879   PMID:12847520   PMID:12904583   PMID:12960286   PMID:13679037   PMID:14517242   PMID:14610273   PMID:14611646   PMID:14625101  
PMID:14694187   PMID:14699146   PMID:14742442   PMID:14764533   PMID:14975238   PMID:15069015   PMID:15143188   PMID:15163632   PMID:15173187   PMID:15181014   PMID:15208705   PMID:15213237  
PMID:15220914   PMID:15232610   PMID:15240659   PMID:15304476   PMID:15319356   PMID:15358627   PMID:15489334   PMID:15491991   PMID:15561778   PMID:15561930   PMID:15601820   PMID:15649407  
PMID:15653674   PMID:15677447   PMID:15684405   PMID:15728454   PMID:15728516   PMID:15778369   PMID:15905495   PMID:16000307   PMID:16007096   PMID:16033816   PMID:16040151   PMID:16123385  
PMID:16141072   PMID:16141073   PMID:16185683   PMID:16210657   PMID:16216905   PMID:16239531   PMID:16258063   PMID:16288983   PMID:16289036   PMID:16302975   PMID:16352613   PMID:16473883  
PMID:16474852   PMID:16493033   PMID:16497512   PMID:16505233   PMID:16517610   PMID:16606674   PMID:16616006   PMID:16682639   PMID:16698929   PMID:16710471   PMID:16718380   PMID:16783372  
PMID:16785559   PMID:16831601   PMID:16888100   PMID:16890540   PMID:16905102   PMID:16906166   PMID:16988256   PMID:17008544   PMID:17028185   PMID:17101849   PMID:17114246   PMID:17114459  
PMID:17139252   PMID:17198696   PMID:17205581   PMID:17256754   PMID:17297444   PMID:17317861   PMID:17327450   PMID:17379643   PMID:17404264   PMID:17452461   PMID:17510322   PMID:17579277  
PMID:17581589   PMID:17609432   PMID:17609438   PMID:17621372   PMID:17675476   PMID:17718431   PMID:17920684   PMID:17947670   PMID:17965409   PMID:18025162   PMID:18031698   PMID:18055217  
PMID:18068850   PMID:18077349   PMID:18083102   PMID:18085494   PMID:18158318   PMID:18185532   PMID:18195020   PMID:18216023   PMID:18236210   PMID:18237746   PMID:18321577   PMID:18325991  
PMID:18332140   PMID:18332480   PMID:18400361   PMID:18451094   PMID:18471922   PMID:18489773   PMID:18590740   PMID:18593942   PMID:18614536   PMID:18635606   PMID:18669597   PMID:18679416  
PMID:18713987   PMID:18793717   PMID:18799693   PMID:18799889   PMID:18971287   PMID:19038858   PMID:19056487   PMID:19088199   PMID:19129540   PMID:19164812   PMID:19190337   PMID:19228596  
PMID:19261336   PMID:19385048   PMID:19564419   PMID:19564844   PMID:19592492   PMID:19608279   PMID:19620279   PMID:19672574   PMID:19737863   PMID:19915050   PMID:19919527   PMID:19924141  
PMID:19924142   PMID:19933379   PMID:19996282   PMID:20005813   PMID:20005819   PMID:20068134   PMID:20132230   PMID:20185584   PMID:20351184   PMID:20351777   PMID:20372794   PMID:20400504  
PMID:20435883   PMID:20439489   PMID:20504769   PMID:20508071   PMID:20530874   PMID:20564215   PMID:20564237   PMID:20631305   PMID:20716764   PMID:20799351   PMID:20854017   PMID:20870174  
PMID:20876575   PMID:20876718   PMID:20934424   PMID:20944006   PMID:20949562   PMID:20978125   PMID:21088051   PMID:21308778   PMID:21321188   PMID:21325649   PMID:21368206   PMID:21481788  
PMID:21514445   PMID:21519345   PMID:21624767   PMID:21677750   PMID:21873635   PMID:21898505   PMID:21925110   PMID:22052201   PMID:22056987   PMID:22075701   PMID:22082679   PMID:22093833  
PMID:22248664   PMID:22253420   PMID:22313262   PMID:22361405   PMID:22411837   PMID:22427680   PMID:22574771   PMID:22674086   PMID:22753940   PMID:22791286   PMID:22792286   PMID:22815920  
PMID:22837488   PMID:22872213   PMID:22893467   PMID:22925925   PMID:22961088   PMID:23019338   PMID:23038263   PMID:23115649   PMID:23129128   PMID:23178499   PMID:23197703   PMID:23226414  
PMID:23255598   PMID:23329138   PMID:23386726   PMID:23426178   PMID:23430591   PMID:23454976   PMID:23527226   PMID:23545584   PMID:23585399   PMID:23619236   PMID:23807298   PMID:23853585  
PMID:23891753   PMID:23948778   PMID:23990909   PMID:23996689   PMID:24078776   PMID:24098792   PMID:24101549   PMID:24129709   PMID:24140964   PMID:24210661   PMID:24275663   PMID:24323580  
PMID:24333535   PMID:24354892   PMID:24402091   PMID:24438103   PMID:24502529   PMID:24593051   PMID:24599782   PMID:24619656   PMID:24631457   PMID:24637581   PMID:24818665   PMID:24839265  
PMID:24859004   PMID:24939297   PMID:24956148   PMID:24966052   PMID:25015957   PMID:25136113   PMID:25161884   PMID:25253351   PMID:25348624   PMID:25390684   PMID:25431838   PMID:25448764  
PMID:25458989   PMID:25555992   PMID:25588866   PMID:25642823   PMID:25648699   PMID:25649351   PMID:25737950   PMID:25827060   PMID:25847945   PMID:25937169   PMID:25968579   PMID:25992861  
PMID:26010537   PMID:26047948   PMID:26109062   PMID:26209606   PMID:26243880   PMID:26246577   PMID:26274929   PMID:26318865   PMID:26396267   PMID:26465715   PMID:26598325   PMID:26679195  
PMID:26762764   PMID:26771493   PMID:26795246   PMID:26804026   PMID:26828039   PMID:26865635   PMID:26887316   PMID:26967393   PMID:27015453   PMID:27102647   PMID:27106041   PMID:27126447  
PMID:27183597   PMID:27213690   PMID:27236299   PMID:27306493   PMID:27317261   PMID:27318131   PMID:27383590   PMID:27471877   PMID:27480124   PMID:27494343   PMID:27583437   PMID:27626668  
PMID:27638904   PMID:27702761   PMID:27709605   PMID:27716333   PMID:27721430   PMID:27748374   PMID:27800152   PMID:27814300   PMID:27974197   PMID:28009275   PMID:28077574   PMID:28093521  
PMID:28182772   PMID:28408410   PMID:28416649   PMID:28508554   PMID:28550162   PMID:28554144   PMID:28560450   PMID:28605567   PMID:28642362   PMID:28899903   PMID:28987511   PMID:28993616  
PMID:29158586   PMID:29343476   PMID:29361558   PMID:29393363   PMID:29438518   PMID:29452101   PMID:29458059   PMID:29471302   PMID:29686012   PMID:29763909   PMID:29808009   PMID:29976680  
PMID:30046048   PMID:30098334   PMID:30294880   PMID:30487798   PMID:30617600   PMID:30673296   PMID:30811469   PMID:30939124   PMID:31221818   PMID:31223625   PMID:31255914   PMID:31474976  
PMID:31574508   PMID:31619584   PMID:31694925   PMID:31748225   PMID:31748929   PMID:31875887   PMID:31972211   PMID:32062438   PMID:32144749   PMID:32150249   PMID:32272865   PMID:32325033  
PMID:32398867   PMID:32458800   PMID:32645550   PMID:32718473   PMID:32800922   PMID:33115265   PMID:33372035   PMID:33585485   PMID:33602265   PMID:33739574   PMID:33770504   PMID:33815395  
PMID:33911869   PMID:34075113   PMID:34103328   PMID:34138760   PMID:34184397   PMID:34213074   PMID:34292971   PMID:34586888   PMID:34611611   PMID:34688035   PMID:34870348   PMID:34934045  
PMID:35296090   PMID:35344606   PMID:35729116   PMID:35742928   PMID:35767994   PMID:35985175   PMID:36339257   PMID:36370710   PMID:36455343   PMID:36764461   PMID:36764478   PMID:36765862  
PMID:36808484   PMID:36878279   PMID:37175961   PMID:37283760   PMID:37400916   PMID:37466473   PMID:37582370   PMID:37778648   PMID:37848024   PMID:37956656   PMID:38145323   PMID:38272160  
PMID:38310055   PMID:38324208   PMID:38486105   PMID:38504518   PMID:38754428   PMID:39027371   PMID:39353435  


Genomics

Comparative Map Data
Socs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,856,905 - 117,860,873 (-)EnsemblGRCm39 Ensembl
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBIMGSCv36mm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
SOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBIT2T-CHM13v2.0
Socs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
Socs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,222,455 - 4,225,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,222,455 - 4,225,563 (+)NCBIChiLan1.0ChiLan1.0
SOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,406,250 - 94,409,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,235,744 - 99,239,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,433,206 - 72,436,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,981,752 - 77,985,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,983,389 - 77,984,066 (-)Ensemblpanpan1.1panPan2
SOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,859,267 - 2,859,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,516,096 - 3,516,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,509,383 - 3,512,579 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,510,193 - 3,510,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,533,406 - 3,534,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,657,845 - 3,658,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,738,946 - 3,739,623 (+)NCBIUU_Cfam_GSD_1.0
Socs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,476,572 - 3,479,692 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,933,747 - 2,934,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,932,297 - 2,935,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,643,929 - 3,647,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,643,832 - 3,647,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap12p15NCBI
SOCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,353,099 - 70,356,401 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,354,746 - 70,355,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,479,311 - 41,482,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,840,889 - 7,843,860 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,841,230 - 7,843,912 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Socs3
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1288
Count of miRNA genes:571
Interacting mature miRNAs:711
Transcripts:ENSMUST00000054002, ENSMUST00000123255, ENSMUST00000132295
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
PMC148819P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811117,967,718 - 117,968,230UniSTSGRCm38
MGSCv3711117,829,032 - 117,829,544UniSTSGRCm37
Celera11129,711,439 - 129,711,951UniSTS
Cytogenetic Map11E2UniSTS
Socs3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
cM Map1182.96UniSTS
PMC22025P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811117,968,692 - 117,969,555UniSTSGRCm38
MGSCv3711117,830,006 - 117,830,869UniSTSGRCm37
Celera11129,712,413 - 129,713,276UniSTS
Cytogenetic Map11E2UniSTS
PMC303338P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811117,966,241 - 117,966,479UniSTSGRCm38
MGSCv3711117,827,555 - 117,827,793UniSTSGRCm37
Celera11129,709,962 - 129,710,200UniSTS
Cytogenetic Map11E2UniSTS
PMC148819P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811117,968,094 - 117,968,230UniSTSGRCm38
MGSCv3711117,829,408 - 117,829,544UniSTSGRCm37
Celera11129,711,815 - 129,711,951UniSTS
Cytogenetic Map11E2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF117732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF314501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U88328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000054002   ⟹   ENSMUSP00000059129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11117,856,905 - 117,860,012 (-)Ensembl
GRCm38.p6 Ensembl11117,966,079 - 117,969,186 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123255
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11117,859,701 - 117,860,873 (-)Ensembl
GRCm38.p6 Ensembl11117,968,875 - 117,970,047 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11117,859,760 - 117,860,277 (-)Ensembl
GRCm38.p6 Ensembl11117,968,934 - 117,969,451 (-)Ensembl
RefSeq Acc Id: NM_007707   ⟹   NP_031733
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911117,856,905 - 117,860,192 (-)NCBI
GRCm3811117,966,079 - 117,969,366 (-)NCBI
MGSCv3711117,827,393 - 117,830,680 (-)RGD
Celera11129,709,800 - 129,713,087 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031733   ⟸   NM_007707
- UniProtKB: P97803 (UniProtKB/Swiss-Prot),   Q3U7X5 (UniProtKB/Swiss-Prot),   O35718 (UniProtKB/Swiss-Prot),   Q3U9J8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000059129   ⟸   ENSMUST00000054002
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35718-F1-model_v2 AlphaFold O35718 1-225 view protein structure

Promoters
RGD ID:6848600
Promoter ID:MM_TRO:1854
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   MEF_B4
Transcripts:MTR007597.11.3149.4
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611117,827,951 - 117,829,227 (-)MPROMDB
RGD ID:6822184
Promoter ID:MM_KWN:10757
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000008134,   OTTMUST00000008135,   OTTMUST00000008136
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611117,830,366 - 117,831,067 (-)MPROMDB
RGD ID:8677544
Promoter ID:EPDNEW_M16803
Type:multiple initiation site
Name:Socs3_1
Description:Mus musculus suppressor of cytokine signaling 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16804  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811117,969,183 - 117,969,243EPDNEW
RGD ID:8677546
Promoter ID:EPDNEW_M16804
Type:multiple initiation site
Name:Socs3_2
Description:Mus musculus suppressor of cytokine signaling 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16803  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811117,969,433 - 117,969,493EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201791 AgrOrtholog
Ensembl Genes ENSMUSG00000053113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054002 ENTREZGENE
  ENSMUST00000054002.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SOCS3 UniProtKB/Swiss-Prot
  SOCS3_SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:12702 UniProtKB/Swiss-Prot
MGD MGI:1201791 ENTREZGENE
NCBI Gene 12702 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR10155:SF11 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Socs3 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt O35718 ENTREZGENE
  P97803 ENTREZGENE
  Q3U7X5 ENTREZGENE
  Q3U9J8 ENTREZGENE, UniProtKB/TrEMBL
  SOCS3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P97803 UniProtKB/Swiss-Prot
  Q3U7X5 UniProtKB/Swiss-Prot