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Gene: Socs3 (suppressor of cytokine signaling 3) Mus musculus
Symbol: Socs3
Name: suppressor of cytokine signaling 3
Description: Exhibits phosphotyrosine residue binding activity. Involved in several processes, including cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; and placenta development. Predicted to localize to cytoplasm and phosphatidylinositol 3-kinase complex. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (S)-naringenin; 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CIS-3; Cis3; Cish3; cytokine inducible SH2-containing protein 3; E2a-Pbx1 target gene in fibroblasts 10; EF-10; Ef10; SSI-3; Ssi3; STAT-induced STAT inhibitor 3
Homo sapiens (human) : SOCS3 (suppressor of cytokine signaling 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Socs3 (suppressor of cytokine signaling 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs3 (suppressor of cytokine signaling 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS3 (suppressor of cytokine signaling 3)
Canis lupus familiaris (dog) : SOCS3 (suppressor of cytokine signaling 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs3 (suppressor of cytokine signaling 3)
Sus scrofa (pig) : SOCS3 (suppressor of cytokine signaling 3)
Chlorocebus sabaeus (African green monkey) : SOCS3 (suppressor of cytokine signaling 3)
Heterocephalus glaber (naked mole-rat) : Socs3 (suppressor of cytokine signaling 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBImm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Socs3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730834
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.